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피막과 팽윤을 이용한 고분자 기질에서의 약물의 조절방출
김영하,변영로,장호남 한국화학공학회 1989 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.27 No.4
약물의 열적 불안정성과 용매와의 반응성을 피하기 위하여 고분자 기질을 팽윤시켜 약물을 봉입하는 방법을 고안하여 고분자 기질로 된 약제를 제조하였다. 고분자 기질은 hydrogel인 p-HEMA로 제조하여 모델약물인 citidine diphosphate coline(중추신경제)의 방출기전을 연구하였다. 또한 고분자사슬에 이온을 갖지 않는 p-HEMA와 음이온을 갖는 polyacrylate에 대해 pH에 따른 약물 방출기전의 차이를 분석하였다. 그 결과 p-HEMA는 팽윤이 일어남으로써 약물 방출곡선에 분계점이 나타났으며 polyacrylate는 음이온을 가짐으로써 pH에 따라 팽윤도가 변하였고 pH가 높을수록 팽윤도와 약물의 방출속도가 증가하였다. HEMA와 methlmethacrylate의 공중합체에 생체분해성 고분자인 polylactide로 코팅 막을 형성한 제형을 제시하였으며 이 시스템에서의 약물 방출기전 및 고분자 기질의 두께에 따른 변화를 고찰하였다. 이 제형은 생체분해성 막이 초기의 약물 방출속도를 억제함으로써 sustained release pattern을 유도하였다. In order to avoid a thermal instability and a reaction of drug with solvents, a method was devised to load a drug in a polymer matrix by swelling. Using p-HEMA hydrogel as polymer matrix, the release mechanism of a model drug, citidine diphosphate coline (CNS stimulant), was studied. Also analyzed was the difference in the pH-related release mechanism of p-HEMA which has a non-ionic polymer chain and polyacrylate which has negative ions on the polymer side chain. For p-HEMA, its break-point on the drug release curve occured due to swelling and degree of swelling did not change pH. On the other hand, swelling polyacrylate differed pH: the higher the pH, the higher the degree of swelling and faster the release rate. A formulation with a bioerodible coating membrane of polylactide was introduced to the co-polymer of HEMA and methylmethacrylate. The difference in the drug release mechanism and changes relative to the polymer thickness in this system was observed. The formulation allows the bioerodible membrane to suppress the initial rate of drug release mechanism, which led to the sustained release pattern.
金英厦 단국대학교 1993 論文集 Vol.27 No.-
Capitalization cause having cities growing is citizen population overcentralization and to follow of this the construction thing's the numberical preparation for construction's quantity to improve more the numberical building to extendings are squares rate and floor area ratio built have been increased. But, this floor area ratio and squares rates growen up that constructed land square site's increased and low floor constructions total number of increasing cause the daily living circular with personality living invading, and public pollution cause the environment corrupts and other many problems occuring. And also for this problem to solve and favority injuries to prevent for civil petition system to held, that originates of purposting have difference the income level's increase and human valution conceptions having changing cause that personal profits for the lawful limits over intrude which civil petition now affairing to solve this problems. Accordingly this studies are the problem to solute for the civil petition's essentialically purpose to understand and this petition as concerns construction law of regulation and literary reserch, and real place to investigates to through have estabilishing as sample area's petition to remember which those happings are for daily living circular, and civil living right to invading which petition have every element to classify to analysis and more rationally petition to composing for the basic of material to given shows that this having purpose.
金英厦 단국대학교 1990 論文集 Vol.24 No.-
This study inquired into possibility of the establishment of Arcitecture & Urban planning graduate school in process of being subdinided into related study and variety of function in city. Especially, consulting a curriculum of Architectare & Urban planning graduate school in America, the independence of urban planning graduate school in needed in our country, which is able to find appropriteness at the interrelationship as followings. First ; A case of Architecture & Urban planning graduate school is able to maintain and develop into educational industrial complex with university laboratory and industrial proups of society centering around laboratory system. Second ; Related curriculum with Architecture & Urban planning is in possible condition with mutual cooperation of the other study because of being specialized with major course in curriculum of graduate school. Third ; Transforming into interrationalized society with the change of times, relation to connected study with urban planning and as a bridge of international society, the establishment of urban planning graduate school should be considered as a independent area.