한국 영유아를 위한 일과기반 발달검사 MEISR 타당화

김주현,김주현,박혜원 인지발달중재학회 2024 인지발달중재학회지 Vol.15 No.1

Objective: The Measure of Engagement, Independence, and Social Relationships (MEISR) is a tool designed to assess the engagement, independence, and social interactions of infants and toddlers during daily activities. This study aimed to develop Korean version of MEISR (K-MEISR) and evaluate its reliability and validity. Methods: Korean version of MEISR was developed through the translation and modification of items of the MEISR following a pilot study (N = 44). Two studies were conducted with parents of infants and toddlers up to 36 months old using online (N = 124) and offline (N = 134) versions. Data were analyzed using SPSS 27.0 and AMOS 25.0. Item difficulty and discrimination, as well as passing rates were calculated; and internal consistency, correlations among the routine and total scales, factor analyses, and correlations with K-DST ratings were analyzed to determine the reliability and validity of K-MEISR. Results: Analyses of item difficulty and passing rates identified characteristics of items for determining the item order for K-MEISR. High correlations between the total of each routine and the total of all items were found in both the online (r = .896~.992) and the offline (r = .874~.988) versions. Reliabilities of all total scale items were high for both the online (r = .998) and the offline (r = .997) versions. Reliabilities of routine items were also high, ranging from .913 to .985 for the online and .914 to .985 for the offline version. Correlations between K-DST and K-MEISR were high for both the online (r = .981) and offline (r = .959), showing high concurrent validity. Conclusions: The items of the total scale, and routines and functional domains showed high internal consistency and high correlations with K-DST, revealing the concurrent validity of K-MEISR. Recommendations for further research and clinical use of the assessment tool are discussed.

Clinical Characteristics and Management of Saccular Cysts: A Single Institute Experience

김주현,김명희,안홍근,최홍식,변형권 대한이비인후과학회 2019 Clinical and Experimental Otorhinolaryngology Vol.12 No.2

Objectives. A saccular cyst is defined as a dilated saccule of the larynx, filled with mucus, and is located between the false vocal cords and the thyroid cartilage. Although this uncommon laryngeal condition is benign in nature, it could lead to dyspnea, stridor, and airway obstruction, depending on its size and location. Furthermore, some saccular cysts have been associated with laryngeal carcinoma. This study aimed to characterize this rather uncommon laryngeal condition to aid in determining the proper management of this pathology. Methods. Medical records were retrospectively reviewed of all patients with saccular cysts diagnosed and treated between 2006 and 2017 at a tertiary otolaryngologic care center. Results. Seven patients with saccular cysts were identified (male:female=2:5; mean age, 34.1 years); two were pediatric patients. Surgical intervention was performed in all patients by laryngo-microsurgery using CO2 laser. There was no recurrence after the initial surgical treatment. Conclusion. Saccular cysts can be managed endoscopically using CO2 laser, without requiring an external approach. Therefore, an endoscopic approach should be actively considered for an optimal treatment outcome.

Synthesis of π-conjugated polymers and oligomers for polymer light emitting diodes and polymer solar cells

김주현 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.2

비판적 사고와 미술 비평 교육

김주현 한국미술교육학회 2014 美術敎育論叢 Vol.28 No.3

현대 맥락주의 예술 존재론에서 미술 담론은 작품의 내적 요소이다. 미술 창작, 기획, 감상에서 글쓰기는 작품 정체성을 확인하고 평가하는 서사이다. 그러나 한국 미술계에 발표되는 수많은 글들은 '평가와 추동'이라는 본연의 역할을 제대로 수행하고 있지 못하다. 한국 미술계의 글쓰기 관행을 개선하는 일은 대학의 기초 교과목인 의사소통 교육과 심화 교과목인 전공 글쓰기 교육에서 시작할 수 있다. 대학은 학부의 기초교양 필수 교과목인 의사소통 교육을 강화하고, 더불어 예술대학과 대학원은 비판적 사고, 실천적 추리, 논증적 글쓰기 교과목을 통해 창작, 기획, 비평, 이론의 역량을 강화해 나가야 한다. 본고는 그 사례로 한국예술종합학교 미술원에서 개설된 비판적 사고와 비평 수업을 제시한다. 수업 모형과 수강생 예문을 통해 미술계 담론의 현 상황을 진단하고, 글쓰기 교육 강화를 통해 비평의 책무를 재점검하고 대중의 심미적 권리확장을 모색한다. In the contextualist ontologies, artistic discourse is an internal factor of contemporary art. Because it is a narrative of artistic identification and evaluation. The critics and many practitioners in Korean art world write about current arts constantly, but they have nearly taken the leading part in the field. In order to improve our writing convention in art world, it should begin with the intensifying the education of communication in basic design class of liberal art and the advanced class of the field of major. The subjects of the critical thinking, the practical reasoning and the argumentative writing offer for the students in college of fine arts. In this essay, I suggest the model of class of criticism and metacriticism on the basis of the teaching experience in the master's course in the Korea National University of Arts. I expect my educational vision to remind the critics of their responsibilities and give multitude the opportunities to enjoy their aesthetic rights.

면류 섭취 여부에 따른 영양소 섭취와 건강지표의 관련성 - 2010 국민건강영양조사 자료를 바탕으로 -

김주현,양윤경 한국식생활문화학회 2016 韓國食生活文化學會誌 Vol.31 No.4

The purpose of this study was to evaluate the nutrient intake, diversity and prevalence of diseases according to noodle consumption using data from the Korean National Health and Nutrition Examination Survey (KNHANES) of 2010. Korean adults (>20) were classified into two groups, noodle group (NG) and non-noodle group (NNG). NG was found to have higher intakes of protein, calcium, iron, sodium, potassium, and niacin. The DVS and DDS according to noodle consumption were found to be 21.76 and 3.51 for NG, and 18.56 and 3.40 for NNG, this result was thought to show that the diet of NG was more satisfactory than that of NNG in terms of dietary diversity. In the bone mass of entire subjects, NG showed higher figures in the femoral neck and lumbar spine than NNG. For bone mineral density, NG exhibited higher figures in the femoral neck, and for T-scores, the values of NG was significantly higher in the femoral neck than those of NNG. However, the prevalence of osteoporosis of NG and NNG was 11.6% and 9.5%. The prevalence of osteopenia of NG and NNG was 43.0% and 51.7%. Thus, these results showed that overall bone health of NG was better than that of NNG. Dietary balance and quality were also more satisfactory in NG. These results showed that noodle consumption may have an impact on the prevalence of chronic diseases.

한국인에서의 사이트린 결핍증의 경험

김주현,김구환,유한욱,Kim, Ju-Hyun,Kim, Gu-Hwan,Yoo, Han-Wook 대한유전성대사질환학회 2006 대한유전성대사질환학회지 Vol.6 No.1

Citrin deficiency resulting from mutations of SLC25A13is associated with two major clinical phenotypes; neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and adult-onset type 2 citrullinemia (CTLN2). In Korea, 7 cases of citrin deficiency have been diagnosed based on biochemical and molecular findings. Four NICCD cases were identified by newborn screening using MS/MS or presenting symptoms like cholestatic jaundice. They are all males, presenting with conjugated hyperbilirubinemia, elevated liver enzymes, hypoalbuminemia, mild hyperammonemia, elevated citrullin, methionine and threonine. All of them have been spontaneously recovered from hepatic manifestation by the age of 6-8 months. Mutation analysis has been performed using their genomic & cDNAs obtained from skin fibroblasts. They turned out to be compound heterozygotes carrying each of 851del4, IVS11+1G>A, and IVS13+1G>A. Three CTLN2 patients were identified. Two adult male patients presented with a sudden loss of consciousness, seizure, vomiting, hyperammonemia and citrullinemia in their twenties. They carried an IVS13+1G>A, 851del4, and IVS11+1G>A mutant alleles. The other CTLN2 patient was 52 year old female patient, manifesting lethargy, altered consciousness, irritability and hyperammonemia. Similar clinical symptoms had recurred at the delivery of first and second babies in her past medical history. She was managed by hemodialysis and survived with neurological sequellae. Also, we screened the presence of 9 common mutations in 500 Korean newborns using dried blood spot of filter papers. Only a allele carried 854del4 mutation. In conclusion, the entire picture of citrin deficiency in Korea including incidence, genotype, clinical features and natural courses, is still vague at the present time.

특집: 유기광.전자 소재 및 소자 기술 - 유기발광전자 소재 및 소자 기술

김주현,강재욱,Kim, Ju-Hyeon,Gang, Jae-Uk 재료연구소 2011 機械와 材料 Vol.23 No.2

공액 이중결합으로 이루어져 있는 유기 화합물을 형광체로 이용하는 유기발광 소자는 최근 모바일용 디스플레이의 사용화를 시작으로 TV, PC용 디스플레이, 플렉시블 디스플레이로의 사용화에 대한 관심을 불러일으키고 있다. 본 글에서는 지금까지 개발된 다양한 기능성 소재 및 발광 소재에 대하여 소개 하고자 한다.

<천희당시화>의 성격과 위상

김주현 한국어문학회 2006 語文學 Vol.0 No.91

]This paper has the aim to explain the feature of Cheonheedangsihwa and to adjust the place of it. Cheonheedangsihwa is one of the most important poetics at Korea in 1900s. It had been appeared anonymously in The Korea Daily News from November 09, 1909 to December 04, 1909. Cheonheedangsihwa is a talk and an essay on poetry, not so much as poetics. I have especially concern about the historical meaning of Danjae's Cheonheedangsihwa. Danjae established Cheonheedangsihwa by succeeding to nationalism of Yi Gyu-bo and identities of Korean pragmatists for instance, Hong Dae-yong, Park Ji-won, Yi Ik, etc. and by acepting Liang Ch'ich'ao's Eumbingsilsihwa. So, he created greatly characteristic poetics. Cheonheedangsihwa is the practical literary theory that makes a writer's responsibility clear in a turbulent period. Also it is an great essay on poetry that has an insight into a history of Korean poetry.

「天喜堂詩話」와 그 주석

김주현 한국문학언어학회(구 경북어문학회) 2012 어문론총 Vol.56 No.-

HS-23, a standardized extract of the dried flower buds of Lonicera japonica, has no major impact on drug transporters and on the pharmacokinetics of ceftriaxone and levofloxacin in rats

김주현,권미화,권순상,김영목,홍성운,연성흠,송임숙,이혜숙 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.1

Concurrent administration of herbal drugs that modulate drug transporter activities can cause herb–drug interactions in the process of the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. For this reason, regulatory agencies have instituted guidelines for the investigation of potential herb–drug interactions during the drug development process. Therefore, the purpose of this study was to investigate the herb–drug interaction potential of HS-23, an extract of the dried flower buds of Lonicera japonica, which is being evaluated for use in the treatment of sepsis in a phase II clinical study. The inhibitory effects of HS-23 on the transport functions of organic cation transporter (OCT)1, OCT2, organic anion transporter (OAT)1, OAT3, organic anion transporting polypeptide (OATP)1B1, OATP1B3, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) were investigated in HEK293 and LLC-PK1 cells. The effects of HS-23 on the pharmacokinetics of ceftriaxone and levofloxacin, common combination drugs for sepsis treatment were also examined in rats.HS-23 (up to 100 lg/mL) did not inhibit the in vitro transport activities ofOCT1/2,OAT1/ 3, OATP1B1/1B3, P-gp, and BCRP or the pharmacokinetics of ceftriaxone and levofloxacin in vivo after a single intravenous dose of 40 mg/kg. In conclusion, HS-23 may not have significant herb–drug interactions with the prevalently used ceftriaxone and levofloxacin, in rats even at its effective dose.