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위암에서 E-cadherin과 $\beta-catenin$ 발현과 유전자 돌연변이에 관한 연구
김광일,박성혜,한선애,채양석,김인선,Kim Kwang Il,Park Sung-Hye,Han Sun-Ae,Chae Yang-Seok,Kim Insun 대한위암학회 2001 대한위암학회지 Vol.1 No.4
Purpose: When cancer cels invade the stroma, they should be dissociated from the adjacent cells at first. E-cadherin and $\beta-catenin$ constitute an important protein complex associated with cellular adhesion, development, and differentiation, especially in epithelial cells. The role of E-cadherin and $\beta-catenin$ in gastric carcinogenesis were studied. Materials and Methods: The expression of E-cadherin and $\beta-catenin$ in gastric adenocarcinomas by using immunohistochemical staining and the mutation by using polymerase chain reaction- single stranded conformation polymorphism (PCR-SSCP) and sequencing were performed in 40 adenocarcinomas and 5 dysplasia of stomach. Thirteen cases, which had lymph node metastasis, were also included for immunohistochemical staining. Results: Inappropriate cytoplasmic and/or nuclear expression of a E-cadherin-$\beta-catenin$ complex was more frequent in poorly differentiated, diffuse type signet ring cell carcinomas than in well-differentiated, intestinal type adenocarcinomas (P<0.05). However, the expression was not related with clinical stage or lymph node metastasis. Mutation of E-cadherin was detected in 4 cases by using PCR-SSCP, whereas mutation of $\beta-catenin$ was detected in 2 cases. Conclusion: E-cadherin and $\beta-catenin$ seem to be important in gastric carcinogenesis, especially in poorly differentiated diffuse type.
사라진 중국책, 일본에서 살아남다 ― 일존서(佚存書) 전승의 문화적 배경과 그 의미
김광일 한국중국어문학회 2008 中國文學 Vol.57 No.-
在朱子學、 陽明學、 古學、 國學等多種學派爭鳴中, 18世紀日本學術日益發展. 當時, 日本學術的視野、 觀點、 方法論和基礎力量已經超過朝鮮. 日本學界?什?能勾取得了那?輝煌的成果? 首先要提到就是, 他們不但擁有許多文獻資料可以得手, 幷且具備知識和能力能勾利用那些資料. 本文從“佚存書”角度來探討這一點. 佚存書是亡于中國、 但尙存在日本的特殊文獻, 例如≪古文孝經≫、 ≪群書治要≫等. 這些文獻, 日本律令國家時代東渡到日本, 然後?倉、 室町時代保存得比較良好, 最後到江戶時代回歸中國. 在江戶時代各種學派中, 尤其是古學派與佚存書有着非常密切的關系. 首先, 佚存書推動了古學派的?起, 因爲這種文獻給?提供了有力的學術依據. 而且, 隨着古學的發展, 人們重新發現了佚存書所蘊藏的文化意義.