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Nicotine 이 人體 淋巴球에 미치는 影響에 關한 細胞遺傳學的 硏究
鄭然泰,韓斗錫,金丁中 圓光大學校 醫科學硏究所 1985 圓光醫科學 Vol.1 No.1
The frequency of sister chromatid exchange (SCE) in chromosomes of human lymphocytes from heavy smokers and nonsmokers grown for two replication cycles in medium containing 5-bromodeoxyuridine was detected after staining with Hoechst 33258 and giemsa. In the present experiment, to investigate the SCE response of lymphocytes from heavy smokers and nonsmokers both in vivo and in vitro, the human lymphocytes were exposed to nicotine. In an in vivo study, the SCE frequencies were found to 12.37 ± 0.31 in smoker group and 8.52 ± 0.02 in nonsmoker group. In an in vivo study, the SCE frequencies of nonsmoker group were 10.49 ± 0.23, 16.38 ± 0.35 and smoker group were 13.54 ± 0.29, 20.36 ± 0.42 treated with final concentrations of nicotine 10^-4M and 10^-3M respectively. The SCE frequency of heavy smoker group showed significantly higher than of nonsmoker group both in vivo and in vitro.