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정규원,정규원 경찰대학 범죄수사연구원 2022 범죄수사학연구 Vol.8 No.1
With the progress of scientific technology in the field of genetics, the genetic information for use has been expanded and widely used for various purposes in many fields. Genetic genealogy is the use of DNA testing in combination with traditional genealogy methods to infer genetic relationships between individuals. This is currently used for not only inferring biological ancestors in their pedigree in research but also kinship testing and forensic investigation in practices. With the growing industry of DTC services, genetic genealogy is expanding, which proved its promising use by playing an important role in solving multiple cold cases in the US. However it was revealed that there were legal and ethical issues in the process regarding the control and use of genetic information generated with the informed consent of the purpose of the specific service. This situation made the discussion on issues related to the use of genetic genealogy and legal regulation in the US. In Korea, the situation is not such severe possibly due to a gap of genetic data available in countries. However, it is unpredictable for further application regarding the possible range of genetic information for use in genetic genealogy with highly advanced techniques in the future. Therefore, it is important to discuss possible risk and countermeasures able to be taken in advance. Here, we reviewed the precedent cases with potential issues in other countries, and discussed the current system in Korea. It is very important to continue discussing how to protect private information and genetic privacy, and to consider the advanced level of science and technology at the time of the discussion.
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정규원,정환국,선희식,노재철 대한소화기학회 1977 대한소화기학회지 Vol.9 No.1
Among 1,526 cases performed gastrofiberscopy, 141 patients of upper gastrointestinal bleeding who were admitted to the Department of Internal Medicine, St. Marys Hospital of Catholic Kfedical College during the past 2 years 2 and 6 months from March l, 1974 to September 6,. 1976 were clinically observed. The results were as follows: 1. The incidence of upper gastrointestinal bleeding among 1,526 cases performed gastrofiber copy was 9.2%. The sex distribution was 114 in male and 27 in female with a mean age of 4b. The ratio of male to female was 4. 2: 1. 2. The sources of bleeding were gastric ulcer (27.7%), duodenal ulcer (17.7%), gastric carcnoima (17%) rupture of esophageal varices (13.5%), erosive gastritis (12. 1%), gastroducdenitis (3.5%), miscel Janeous (5.7%), and unknown origin (2.1%) in order. 3. The endoscopic accuracy in patients with upper gastrointestinal bleeding was gastric ulcer CG9. 2%3, gastric carcinoma (96.0%), erosive gastritis (88.2%) 3, and duodenal ulcer, gastroauodenitis, and rupture of esophageal varices were 100%. 4. The success rates in identifving the site of bleeding in relation to time of endoscopy after upper gastrointestinal bleeding were 63.2% within 24 houss, 47.1% in 24-48 hours, 17.6% in 48 72 hours, and 6.3% after 7 days. The success rate fell with increasing time after upper gastrointestinal bleeding. 5. The presence of more than one source of upper gastrointestinal bleeding site was found much in cur patients. The early endoscopy was more reliable than radiology for determining the origin of upper gastrointestinal bleeding, and multiple lesions were found only by endoscopic examination. 6. Complication of endoscopy for the diagnosis of upper gastrointestinal bleeding was 2 out of 141 cases (l.4%) one was arterial bleeding from the lesion of gastric biopsy and the other was aggravation of gastric ulcer bleeding. Both of these was reversible.
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정규원,원영주,공현주,오창모,신애선,이진수 대한암학회 2013 Cancer Research and Treatment Vol.45 No.3
Purpose Although the cancer stage at diagnosis is the most important prognostic factor for patients’ survival, there are few population-based estimates of stage-specific survival outcome, especially in Asian countries. Our study aims to estimate stage-specific survival for Korean patients. Materials and Methods We analyzed the Korea National Cancer Incidence Database data on 626,506 adult patients aged ≥ 20 years, who were diagnosed between 2006 and 2010 with stomach,colorectal, liver, lung, breast, cervix, prostate, and thyroid cancers. Patients were followed up to December 2011, and the 5-year relative survival rates (RSRs) were calculated for gender and age group by Surveillance, Epidemiology, and End Results (SEER) stage at diagnosis. Results The 5-year RSRs for all localized-stage cancers, except for lung and liver, exceeded 90% with that for thyroid cancer being the highest at 100.4%. These values for distant stage liver, lung, and stomach cancers were very dismal at 2.5%, 4.8%, and 5.5%,respectively, while it was 69.1% for thyroid cancer, and was in the range of 18.3-36.4% for colorectal, cervix, breast and prostate cancers. Overall, the 5-year RSRs for all cancer types decreased with aging across all the disease stages with exception of prostate cancer, which suggests biologic difference in these cancer types in a young age group. When compared with US SEER data, Korean patients had better stagespecific survival rates for stomach, colorectal, liver, and cervical cancers. Conclusion Korean cancer patients showed relatively favorable stage distribution and 5-year RSRs, which suggests potential contribution of the national cancer screening program.
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