신원방우황청심원의 뇌허혈 및 중추신경계에 미치는 영향

조태순,이선미,이은방,조성익,김용기,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Pill(NSCH) and Wonbang Woohwangchungsimwon Pill (SCH), the effects of NSCH and SCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed preventive effects of NSCH and SCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by SCH treatment. In contrast to what was seen with ATP, lipid peroxide were elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NSCH and SCH treatments. While NSCH and SCH had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by eletric shock and strychnine. NSCH and SCH showed sedative effect in rotarod and spontaneous activity test. Furthermore, NSCH and SCH showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCH on cerebral ischemia and central nervous system are similar to those of SCH.

藥理學者가 바라는 臨床藥學

趙台淳 藥業新聞社 1978 醫藥情報 Vol.1978 No.9

Famotidine이 propranolol 대사에 미치는 작용

조태순,박두순,박미정,이선미 한국환경독성학회 1994 환경독성보건학회지 Vol.9 No.1

The H₂-antagonist, cimetidine, has been shown to retard the hepatic elimination of low and high clearance drugs, and this has been attributed to inhibition of microsomal cytochrome P-450. This study was done to determine the effects of low (50㎍) and high (1mg) dose of famotidine, another histamine H₂-receptor antagonist, on hepatic elimination of propranolol compared with cimetidine in the isolated perfused rat liver. Both lows and high dose of cimetidine not only inhibited the elimination of propranolol but also increased the area under the perfusate propranolol concentration time curve (AUC). In contrast, low and high dose of famotidine did not affect hepatic elimination of propranolol. Our findings suggest that famotidine has not a propensity for hepatic microsomal inhibition.

신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

尙州地方蠶業의 立地分析과 그 現況

趙泰順 이화여자대학교 사범대학 사회생활과 1970 綠友會報 Vol.- No.12

H_2-Antagonists의 Cholinergic 效果 및 Cholinesterase 抑制作用

趙台淳,崔源哲,李範九 성균관대학교 약학연구소 1990 成均藥硏論文集 Vol.2 No.1

Abstract-The effects of histamine H_2-receptor antagonist on acetylcholinesterase activities in human serum and erythrocyte were studied. AChE estimated from median inhibitory dose was in the following order of decreasing activities; ranitidine〉cimetidine〉famotidine. In the studies of isolated guinea-pig ileal muscle contraction, cimetidine and famotidine showed no effect, but ranididine exhibited potent stimulating effect on contraction whose pattern was simillar to the physostigmine and blocked by atropine and pyrilamine but not by hexamethonium. Cimetidine and famotidine has no effects on the ACh and histamine activites, on the otherhand, ranitidine augmented ACh activity but not histamines.

5-Phenyl-2, 4-Pentadienoic Acid Amide 유도체의 중추 억제작용에 관한 연구

조태순,임중기,신용회,신대희 대한약학회 1987 약학회지 Vol.31 No.1

In order to find out the pharmacologically active but less toxic compounds than piperine, the actions of several amide derivatives of 5-phenyl-2, 4-pentadienoic acid on the CNS depressant activities were examined. The nine amide derivatives were investigated by using ICR mice as an experimental amimals on acute toxicities, anticonvulsant, sedative, analgesic and antipyretic effects. In the case of acute toxicities, all derivatives were weaker than piperine except compound III. Compound I showed strong anticonvulsant activity. On the other hand, compound I, III and IV significantly prolonged the sleeping time induced by hexobarbital in mice. Compound I, III and IV exhibited better analgesic effect than aspirin while compound II, V, VII and IX showed similar antipyretic activity to aspirin.

Guinea pig의 腹腔動脈과 前腸間膜動脈에 관하여

金鍾涉,朴重錫,曺台純 慶尙大學校 1980 論文集 Vol.19 No.1

In order to investigate the variation in the pattern of origin of the celiac and the cranial mesenteric arteries, forty-four specimens (guinea pig) anesthetized by ethyl ether were heparinized and exsanguinated. Neoprene latex solution was injected into common carotid artery of thirty-two specimens for gross dissection. Twelve specimens angiography were prepared by injecting fifty per cent of barium sulfate solution into exsanguinated animals and then radiographed on a soft X-ray apparatus (Shimadzu Waltes 60). 1. The celiac artery and the cranial mesenteric artery were observed to be arosed mostly from a common trunk of the abdominal aorta, the celiac-cranial mesenteric trunk(68.2%), but in three animals from thirty specimens an anastomotic branch was examined between the abdominal aorta and the celiac artery(6.8%). 2. The celiac artery and the cranial mesenteric artery were branched from separated origin of the abdominal aorta(31.8%), and an anastomotic branch was examined between the celiac artery and the celiac-cranial mesenteric trunk(6.8%) in three animals from thirty specimens. 3. the hepatic artery was arosed from three different origin such as celiac artery branched from celiac-cranial mesenteric trunk(45.4%), celiac-cranial mesenteric trunk(22.2%) and the celiac artery branched from the abdominal aorta(31.8%).

토끼 담낭절펼에 대한 Caerulein의 작용

조태순,이우주,홍사석,Cho, T.S.,Lee, W.C.,Hong, S.S. 대한약리학회 1974 대한약리학잡지 Vol.10 No.1

The isolated rabbit gall bladder strips were prepared according to the technique described by Amer and Becvar (1969). The strips were placed in a bath containing 100 ml of Locke-Ringer solution maintained at $38^{\circ}C$. Oxygen was continuously bubbled through the solution. The tension of the muscle strip was initially adjusted to 0.7g. The contractile response was measured isometrically by a force-displacement transducer connected to a polygraph. The effect of a number of autonomic drugs were studied for their interaction with caerulein (Prof. V. Erspamer, F.I. 6934 Caerulein, Farmitalia, Italia), a gastrin or CCK.PZ like peptide, on isolated rabbit gall bladder strips. In this preparation caerulein produced contractions of CCK-PZ type, but the relative potency on a weight basis was 40 times that of CCK-PZ. The response of caerulein was not modified by either cholinergic or alpha or beta adrenergic blockade. However, the response of caerulein and of barium on the strips were prevented by papaverine or aminophylline. Isoproterenol, papaverine or aminophylline alone relaxed the preparation whereas caerulein, CCK-PZ, acetylcholine, serotonin, histamine or barium chloride contracted the preparation. In summary, it is concluded that caerulein on the gall bladder strip seems to act independently of the autonomic nervous system and mediated via mechanisms apparently similar to those involved in the action of barium chloride.

신원방우황청심원의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.