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朴秀淵 中央醫學社 1940 中央醫學 Vol.9 No.2
As the structural unit of the hepatic tissue, Wepfer (1664) and Malpighi (1666) termed the parenchymal units attached to the intrahepatic portal venules hepatic acini by the macroscopic dissection. Kiernan (1883) associated the three-dimensional structural unit of the liver with its secretory function. Brissaud and Sabourin (1886) reported the area of the hepatic parenchymal tissue draining into a bile duct in the portal trigone as the secretory unit of the liver. Mall (1906) proposed that the columnar structure around the portal field was the portal unit; he was supported by Arey (1932) and Opie (1944). Rappaport et al. (1954) defined the small irregular morular parenchymal tissue mass attached to the portal terminal venules accompanying with the intrahepatic arteries and bile duct in the livers of dogs and house rabbits as the structural and functional unit, of the liver, and called it the simple liver acinus. Rappaport (1958) termed the hepatic parenchymal tissue consisting of the simple liver acini around the preterminal portal vessel in man the complex acinus and the larger parenchymal tissue of the- simple liver and complex acini formed around the portal stem the acinar agglomerate. Recently the studies of the liver concerning the function of it in the histological and histochemical fields were carried out by many authors. Padykula (1953) reported that the patterns of distribution of hepatic mitochondria, Golgi apparatus and glycogen in various mammals, and the secretion of bile were associated with enzyme activity of hepatic succinic dehydrogenase in the histochemical way. Additionally he described the fact that his result was similar with them presented by Deane (1944), and Seligman and Rutenberg (1951). The technique, as presented by Wachstein and Meisel (1957), outlines bile canaliculi sharply and completely with the histochemical way of adenosine triphosphatase (ATP-ase) and diphosphatase (ADP-ase), as well as bile ducts, endothelium, and fibrous tissue, and can thus be effectively used as special stain for canaliculi, as well as an indicator of liver cell function. Smith and Coote (1863) studied the impairment of succinic dehydrogenase and other enzymes in the rat's liver given carbon tetrachloride in their histochemical study. Schumacher (1957) studied the action of respiratory enzymes; succinic dehydrogenase, cytochrome oxidase, triphosphopyridine nucleotide diaphorase and diphosphopyridine diaphorase in the livers of the horse, pig and cattle, and observed that the distribution was identical with the earlier reports on the former enzymes, but that it was in direct contrast to the former 2 enzymes in that the latter 2 enzymes were generally distributed to the pericentral area around the central vein. The author has attempted this experiment in order to study the hepatic structural and function unit of the mouse by observing the histological and histochemical or functional characters of the hepatic cells in different parts of hepatic lobule in the points; the distribution of mitochondria (2) the enzyme activity of succinic dehydrogenase (3) the enzyme activities of adenosine triphosphatase and diphosphatase, (4) the enzyme activities of diphosphopyridine nucleotide (NADH,) diaphorase and triphosphopyridine nucleotide (NADPH,) diaphorase, to accomplish the transfer of hydrogen from the reduced coenzymes to the cytochrome system and to other metabolic processes, and (5) the enzyme change of succinic dehydrogenase and histochemical change of hepatic glycogen of the mouse given carbon tetrachloride.
성상세포에서 메테오린에 의한 TSP-1 발현조절에 PKCδ 신호경로의 연관성
박수연,이혜신,고금재,박정애 대한약학회 2009 약학회지 Vol.53 No.3
Meteorin in astrocytes has antiangiogenic activities via thrombospondin-1 (TSP-1), however, the regulatory mechanism has been unclear. Here we report that Meteorin upregulates TSP transcriptionally through luciferase reporter assays in astrocytes. Moreover, Meteorin activates PKCδ and ERK1/2 in astrocytes. Inhibition of PKCδ and ERK1/2 activities attenuated expression of TSP-1 by Meteorin in astrocytes. We, therefore, demonstrate that Meteorin activates PKCδ signaling and, in turn, increases TSP-1 expression in astrocytes to inhibit angiogenesis in the brain.
박수연,이우인,김영식,강소영,서진태,이희주 대한진단검사의학회 2003 Annals of Laboratory Medicine Vol.23 No.4
배경 : 치료적 혈장 교환술은 원심분리 및 막을 이용하여 혈액내의 병적 성분을 분리 제거함으로써 임상증상을 호전시키는 데목적을 두는 시술이다. 그러나 시술 중 정상 성분도 함께 제거되는 단점이 있어 이와 같은 부작용을 최소화하기 위해 막을 이용하여 병적 성분만을 선택적으로 제거하는 방법이 고안되었다. 저자들은 원심분리 후 여과법을 이용한 방법(post centrifugal plas-ma filtration, PCPF)의 경험과 함께 단순 혈장 교환술(simpleplasma exchange, SPE)과의 차이를 분석해 보고자 하였다.방법 : 16명의 환자들로부터 얻은 129개의 혈장으로 일반 화학및 면역학적 항목의 농도를 측정하였고 임상기록을 검토하였다.검체의 측정치를 시술 전과 시술 후 수치로 나누어 비교하였고시술 전과 후의 변화치를 구하여 SPE와 PCPF군간통계학적 유의성을 지닌 차이여부를 조사하였다.결과 : 모든 검사 항목에 대해 시술 방법과 상관없이 시술 후수치가 시술 전에 비해 감소하였으며 두 개의 항목에서 통계학적유의성이 관찰되었다. IgG와 IgM으로 주로 구성된 RF에서는SPE군이 PCPF군 보다 유의한 소실을 보였다(IgG: P=0.0009,RF: P=0.02).
박수연,김은빈,김재영,이수민,유성은 한국퍼실리티매니지먼트학회 2013 한국퍼실리티매니지먼트학회지 Vol.8 No.2
remendous changes such as global economy, organizational change, changes in workers demographics and in their lifestyle choices, changes in technology and etc. are influencing work itself and workplace. The purpose of this study is to analyze the factors that cause changes in work and workplace and how these factors affect the way employees work, where they work from, and the environment they work in. In response to diverse aspects, organizations need to change and their work environments need to become more flexible, empowering, communicative, and pleasing. In smartwork environment work types are divided into interaction, intensive work, learning and training, and collaborative work. And work spaces that supports both of these types of work are needed.