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12주간 복합운동이 난소절제 쥐 골밀도, 골대사 지표 및 OPG/RANKL mRNA 발현에 미치는 영향
박세환,김상배,지용석,윤진환 국민체육진흥공단 한국스포츠정책과학원 2019 체육과학연구 Vol.30 No.3
[Purpose] Osteoporosis is a systemic metabolic bone disease characterized by gradual decrease of bone mass and damage of the bone microstructure. In particular, postmenopausal osteoporosis is the most common type in women after menopause. This study aims to investigate the effects of combined exercise training on bone mineral density (BMD) and OPG/RANKL mRNA levels in ovariectomized rats. [Method] A total of 40 Sprague-Dawley female rats were randomly divided into four groups: (1) CON (sham-operation, n=10), (2) OVX (ovariectomy, n=10), (3) OVX-REX (ovariectomy-resistance exercise, n=10), and (4) OVX-ARE (ovariectomy-combined aerobic and resistance exercise, n=10). Combined exercise training was performed on a treadmill and ladder adapted to rats in alternate days (4 days/wk, for 12 wk). [Results] Compared to the OVX group, all exercise treatments increased BMD and bone breaking force(p<0.05). In the bone turnover markers, serum C-terminal telopeptides of type-1 collagen (CTX-1) was significantly decreased in the exercise groups compared with OVX group and osteocalcin (OC) level was increased in the exercise groups (p<0.05). Additionally, in the exercise groups, expression of OPG mRNA was significantly increased compared with OVX group (p<0.05), and RANKL mRNA was slightly decreased but no significant between groups. Furthermore, OVX-ARE group showed more effects than OVX-REX group. [Conclusions] These results suggest that combined exercise may be a more effective therapeutic strategy to prevent and delay postmenopausal osteoporosis than resistance-only training. [목적] 골다공증은 점진적인 골량 감소 및 골 미세구조의 손상으로 특징되는 대사성 골 질환이다. 특히, 폐경기성 골다공증은 폐경 후 중년 여성에게서 흔히 발생된다. 이 연구의 목적은 난소절제 쥐를 대상으로 12주간의 복합운동이 골밀도, 골대사 지표 및 OPG/RANKL mRNA 발현에 미치는 영향을 규명하고자 하였다. [방법] 총 40마리 SD계열 암컷 쥐를 통제군(CON, n=10), 난소절제군(OVX, n=10), 난소절제-저항성 운동군(OVX-REX, n=10), 난소절제-복합운동군(OVX-ARE, n=10)으로 무선배정 하였다. 복합운동은 트레드밀 운동과 사다리 등반 운동을 격일제로 12주 동안 주 4회 실시하였다. [결과] 난소절제군과 비교하여 모든 운동 처치군의 골밀도 및 골강도는 유의하게 높은 것으로 나타났다(p<0.05). 골 대사 지표에서, 혈청 CTX-1 농도는 난소절제군과 비교하여 모든 운동 처치군에서 유의한 감소(p<0.05)가 나타났으며, 혈청 osteocalcin 농도는 유의하게 증가하였다(p<0.05). 추가적으로 OPG mRNA 발현은 운동 처치군이 난소절제군과 비교하여 유의한 증가를 나타내었고, 반면, RANKL mRNA 발현 수준은 감소하는 경향을 보였으나, 그룹 간 유의한 차이는 없었다. 특히, 복합운동군이 단일 형태의 저항성 운동군과 비교하여 모든 측정 변인에서 더 긍정적인 효과를 나타내었다. [결론] 이상의 결과를 종합해 볼 때, 복합운동은 폐경기성 골다공증의 지연 및 예방을 위한 더 효율적인 운동 중재 전략으로 판단된다.
Development of InSb Semiconductor Detector for High Resolution Radiation Measurement
박세환,김한수,신희성,김호동,조윤호,김용균 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.6
Indium Antimonide (InSb) has possibility to be developed as the next generation radiation detector due to its small energy bandgap and high electron mobility. In general, the InSb crystal has been used for infrared applications, and a studies to grow the InSb crystal for the radiation detector application are rare. The dependency of the crystal growth speed on the crystal quality was studied in the present work. The InSb crystal was grown using the Bridgman method at various crystal growth speeds. The grown crystal was cut into 2-mm-thick wafers, and the defects in the lattice structure of the crystal were analyzed with X-Ray diffraction (XRD) and Fourier transform infraRed spectroscopy (FT-IR). The wafer was made into a Schottky-type diode, and the I-V curves were measured at various temperatures. An InSb detector was also made with a commercial InSb wafer, and the crystal characteristics were measured and compared with the grown one. Our work could be helpful in developing an InSb radiation detector.