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디스크 확산법을 이용한 Teicoplanin(??)의 시험관내 항균력에 대한 연구
최삼임,황평한,김정수,윤미애,이양근 대한감염학회 1993 감염 Vol.25 No.1
An increasing frequency of gram-positive bacterial infection has been observed in recent years. Methicillin resistant Staphylococcus aureus (MRSA) and Coagulase negative staphylococcus (CNS) which show serious antimicrobial resistance and also an important cause of nosocomial infections with gram-negative bacilli. Teicoplanin is a new glycopeptide antibiotic obtained from the actinomycete Actinoplanes teichomycetius Molecular structure and spectrum of antimicrobial activity of teicopanin is-similar to those of vancomycin, which is active against many gram-positive organisms. Antimicrobial potency of teicoplanin was measured by disc diffusion method. 396 specimens of eight gram-positive strains isolated from patients in 1992 at Chonbuk National University Hospital were enrolled in this study. The overall antibacterial potency of teicoplanin against gram positive organisms was next to that of vancomycin, but was significantly higher than those of other antimicrobial agents like certriaxone, sultamicillin, ofloxacin, cephalothin, amikin. Organisms resistant to teicoplanin and/or vancomycin were not observed. Teicoplanin, like vancomycin, could also be recommended as the first line antibiotics against gram-positive bacteria especially for MRSA and CNS.
최삼임,김영준,이호,이동근,최호열,김상호 의과학연구소 1995 全北醫大論文集 Vol.19 No.1
To investigate the proliferative activity and relation to malignancy using proliferating cell nuclear antigen(PCNA)-labeled indices and number of silver stained nucleolar organizer regions(AgNORs) per cell in gastric cancer versus precancerous lesion, PCNA immunohistochemistry and AgNORs silver staining was performed in cases of gastric cancer(30 cases), flat adenoma(5 cases), adenomatous polyp(5 cases), and control(15 cases).
최삼임,이순,김효열,김창곤,윤병택,이혜수,최호열 의과학연구소 1989 全北醫大論文集 Vol.13 No.4
To investigate the side effects of the adriamycin on bone marrow and peripheral blood morphologically, all ADR-treated rabbits were given a dose of 0.6mg/kg on alternate days, three times a week, achieving a total cumulative dose of 11mg/kg to 44mg/kg. In each group, the bone marrow tissue and peripheral blood are obtained 24 hours after termination of injection, and stained with Wright-Giemds & perexidase in bone marrow, H-E & reticulin in peripheral blood. The results are as follows: 1. The cellularity of the bone marrow was decreased as the dosage of ADR was increased. The most prominent group revealed the changes similar to the findings of aplastic anemia. That is, the marrow was nearly filled with plasma cells, lymphocytes, and histiocytes. But the fibrosis of the marrow was not seen. 2. One month after termination of treatment of the ADR, the cellularity of the marrow was increased to 30% and all the cells of the marrow were recovered. 3. After treatment of ADR, the platelet of the peripheral blood were decreased rapidly, but the myeloid and erythroid cells were decreased progressively. The degree of the change was more marked in larger dosage group. After stop of the treatment, all cells were recovered to nearly normal state rapidly.
Enteropathogenic E. coli가 肝臟組織에 미치는 形態學的 變化에 關한 硏究
崔三任,李東根,金洙烈,金福伊,崔湖烈,金象皓 의과학연구소 1988 全北醫大論文集 Vol.12 No.3
Enteropathogenic E.coli(EPEC) induce a number of reactions in experimental animals, so we need to study for the mechanism of action of EPEC. EPEC was administered to mice intravenously, with or whitout pretreatment with sheep erythrocytes. Twenty four hours after administration of EPEC, histologic(HE) and histochemical(PAS, methylgreen pyronin, and reticulin stains) examinations for the liver tissue were done. The results were as follows. 1.Kupffer cells were markedly proliferated and showed PAS-positive phagocytic material in the cytoplasm. 2.Inflammatory cells were infiltrated in the hepatic sinusoids in diffuse or nodular patterns, and formation of granulomas was also noted. 3.Coagulative necrosis of hepatocytes were more prominent and diffuse in sheep erythrocytes-pretreated group. 4.Histochemically, marked reduction of PAS-positive granules and pyroninophilia in the cytoplasm of hepatocytes was noted. From these results, EPEC is cleared by Kupffer cells, and general metabolic changes induced by EPEC are followed by hepatic lesion.
白鼠 幹 迷走神經 切斷後 長期間에 걸친 胃液의 酸度와 血淸 Gastrin値 및 胃粘膜의 組織學的 免疫細胞化學的 變化에 關한 硏究
최삼임,이신웅,김상호 의과학연구소 1993 全北醫大論文集 Vol.17 No.2
To investigate gastric acidity, serum gastrin level and changes of gastric endocrine cell population and morphology of the stomach following truncal vagotomy, measurement of gastric juice pH by pH meter, serum gastrin level by radioimmunoassay, gastric endocrine cells(G and D cells) by avidin-biotinylated complex(ABC) technique, and histological examinations(hematoxylin-eosin, HE : periodic acid Schiff, PAS : alcian blue stain) of the stomach with napping terhnique were perfomed at 6, 7, 8, 9, 10, 11, 12 and 14 month safter truncal vagotomy in rats. The results were as follows. 1. Gastric acidity was somewhat, but not signiscantly decreased in the vagotomized groups. 2. Serum gastrin level was markedly elevated in the vagotomized groups without regard to the time. 3. Histologically, in the vagotomized groups, inflammatory cells were infiltrated in the gastric mucosa. Distribution of mucous cells stained by PAS and alcian blue did not show any differences between control and vagotomized groups. 4. In the vagotomized groups, the total mucosal length of antrum and the thickness of mucosa of body portion were increased signifcantly, but the thickness of the antral mucosa was not siglifcantly different from control group. 5. The total numbers of antral G cells and the numbers of G cells per unit area were increased significantly in the vagotomized groups, and the distribution of G cells in antrum of the vagotomized stomach was somewhat different from that of control. 6. The total numbers of D cells were significantly increased in body portion of the vagotomized stomach mucosa, but not in antral mucosa. According to these results, biochemical and morphological findings, namely gastric acidity, serum gastrin level, endocrine cell populations, and histological changes are not significantly different between the vagotomized groups(from 6 months to 14 months after vogotomy). Increased numbers of G cells might be resulting from increased antral mucosal length and increased G cells per unit area. Increase in area of body portion of the gastric mucosa might be one of the causes of increased D cells in body mucosa.
Enteropathogenic E. coli가 肺臟組織에 미치는 組織學的 및 組織化學的 變化에 關한 硏究
최삼임,전영경,김영선,김복이,윤병택,김상호 의과학연구소 1989 全北醫大論文集 Vol.13 No.4
Bacterial endotoxin(lipopolysaccharide, LPS) induces pulmonary hypertension and edema, but the mechanism is not clearly known. So we have to study for this mechanism and morphological changes of the lung. LPS was injected intravenously to mice with or without pretreatment with sheep erythrocytes. Twenty four hours after injection of LPS, histologic(HE stain) and histochemical(PAS, reticulin, and van Gieson stains) examinations for the pulmonary tissue were done. The results were as follows. 1. Histologically, LPS induced edema of interalveolar septa, infiltration of inflammatory cells such as segmented neutrophils, lymphocytes, and macrophages, especially around the vessels and small bronchial trees, and formation of granulomas in the lung. Occasionally, sever vasculitis was also noted. 2. These histological changes were more marked in the sheep erythrocyte-pretreated group, so completely occluded vessels with thrombi and cental necrosis of the granulomas were noted. 3. histochemically, reticulin fibers were increased in amount in interalveolar septa and granuloma, and disruption of continuity of collagen fibers of blood vessels was noted These results suggest that LPS induces inflammatory reaction in the lung and pulmonary circulatory disturbance, especially it induces increase of the vascular permeability.