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        신생아중환자의 약동학적 다양성에 영향을 미치는 요인

        안숙희 한국임상약학회 2017 한국임상약학회지 Vol.27 No.2

        Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. Theaim of this study was to investigate the factors affecting the pharmacokinetic parameters of drugs, which are commonly used incritically ill neonates. Factors that reflect physiologic maturation such as gestational age, postnatal age, postconceptional age, birthweight, and current body weight were correlated with pharmacokinetic parameters in neonates, especially preterm infants. Comorbiditycharacteristics affecting pharmacokinetics in critically ill neonates were perinatal asphyxia, hypoxic ischemic encephalopathy, patentductus arteriosus (PDA), and renal dysfunction. Administration of indomethacin or ibuprofen in neonates with PDA was associated withthe reduced clearance of renally excreted drugs such as vancomycin and amikacin. Therapeutic hypothermia and extracoporealmembrane oxygenation were influencing factors on pharmacokinetic parameters in critically ill neonates. Dosing adjustment and carefulmonitoring according to the factors affecting pharmacokinetic variability is required for safe and effective pharmacotherapy in neonatalintensive care unit.

      • KCI등재

        유방마사지가 산욕초기 어머니의 유방 통증, 유즙 소디움, 신생아 흡유 횟수에 미치는 효과

        안숙희,김진희,조정숙 한국간호과학회 2011 Journal of Korean Academy of Nursing Vol.41 No.4

        Purpose: In this study the effects of breast massage on breast pain, breast-milk sodium, and newborn suckling in early postpartum mothers were investigated. Methods: The design was a non-synchronized nonequivalent control group pretest-posttest design. Sixty postpartum mothers who were admitted to a postpartum care center and had problems with breastfeeding were recruited. Of these mothers, 44 were assigned to the intervention group and received two 30-minute breast massages within 10 days of postpartum period. The others were assigned control group and received only routine care. Breast pain was measured using a numeric pain scale and number of times newborns suckled was observed throughout breastfeeding. Breast milk was self-collected to evaluate breast-milk sodium. Results: Mean age of postpartum mothers was 30 years old. Compared to the control group, women in the intervention group reported significant decreases in breast pain (p<.001), increases in number of times newborns suckled after the first and second massage (p<.001), and a decrease in breast-milk sodium after the first massage (p=.034). Conclusion: Breast massage may have effects on relieving breast pain, decreasing breast-milk sodium, and improving newborn suckling. Breast massage can be used to solve breast problems. Further research is needed to validate our findings.

      • KCI등재

        신생아중환자의 안전한 약물사용을 위한 약료서비스

        안숙희,An, Sook Hee 한국임상약학회 2020 한국임상약학회지 Vol.30 No.3

        Objective: This study aimed to investigate pharmaceutical care for critically ill neonates and suggest targeted strategies compatible with the Korean health-system pharmacy. Methods: Articles that reported pharmacy practices for critically ill neonates were reviewed. Pharmaceutical care practices and roles of neonatal pharmacists were identified, and criteria were developed for neonates in need of specialized care by clinical pharmacists. Results: Neonatal pharmacists play many roles in the overall medication management pathway. For clinical decision support, multidisciplinary ward rounds, clinical pharmacokinetic services, and consultation for pharmacotherapy and nutrition support were conducted. Prevention and resolution of drug-related problems through review of medication charts contributed to medication safety. Pharmaceutical optimization of intravenous medication played an important role in safe and effective therapy. Information on the use of off-label medicine, recommended dosage and dosing schedules, and stability of intravenous medicine was provided to other health professionals. Most clinical practices for neonates in Korea included therapeutic drug monitoring and nutrition support services. Reduction in medication errors and adverse drug reactions, shortening the duration of weaning medicines, decreasing the use and cost of antimicrobials, and improvement in nutrition status were reported as the outcomes of pharmacist-led interventions. The essential criteria of pharmaceutical care, including for patients with potential high-risk factors for drug-related problems, was developed. Conclusion: Pharmaceutical care for critically ill neonates varies widely. Development and provision of standardized pharmaceutical care for Korean neonates and a stepwise strategy for the expansion of clinical pharmacy services are required.

      • KCI등재후보

        한반도 영향 태풍의 이동경로에 따른 재해특성

        안숙희,이성로,김백조,김호경 한국방재학회 2008 한국방재학회논문집 Vol.8 No.3

        excluding the South Sea around the Korean Peninsula. First, Korean peninsula-afecting typhoons were divided into their track pat-terns of pasing through the Korean West Sea and East Sea based on typhoon data from 1951 to 2006 provided by Regional Spe-cialized Meteorological Center(RSMC)-Tokyo. Then, annual and monthly frequency and intensity of typhoon in each patern wasexamined. In particular, typhoon related damages during the period of 1973 to 2006 were analyzed in each case. Results showedthat since early 1970, in the West Sea case, typhoon becomes weaker without significant change in frequency, while in the East Seacase, it becomes stronger with an increasing trend. It is also found that the high amount of typhoon damage results from the sub-mergence of houses and farmlands in the East Sea case, while it is due to the breakdown of houses, ships, roads and bridges in thesas-ters that the main cause of occurring typhoon disasters seem to be qualitatively related to strong wind in the West Sea case andheavy rainfall in the East Sea case. 본 연구의 목적은 동 · 서해를 중심으로 한반도 주변 해역을 통과하는 태풍과 관련된 재해 특성을 조사하는 것이다. 먼저, 1951년부터 2006년까지 Regional Specialized Meteorological Center (RSMC)-Tokyo의 태풍 자료를 이용하여 한반도에 영향을 준 태풍을 우리나라의 서해와 동해를 통과하는 사례로 구분하고, 각 사례별로 연도별 및 월별의 빈도와 강도에 대해 분석하였다. 특히, 1973년부터 2006년까지의 기간에 대해서는 사례별 태풍 재해의 규모를 파악하여 비교하였다. 서해를 통과하는 태풍의 발생빈도는 거의 변화가 없고 강도가 약한 반면에 동해를 통과하는 태풍의 발생빈도는 증가하는 추세를 보이고 강도가 점차 강해지고 있다. 동해를 통과하는 태풍의 경우에는 집중호우에 의한 침수면적과 농경지 피해가 크게 나타난 반면에, 서해를 통과하는 경우에는 주택, 선박, 도로 및 교량 등 강풍에 의한 시설물 파손에 의한 피해가 크게 발생하였다. 태풍 재해 발생과 관련하여 강수량과 최대풍속 자료를 비교 · 분석한 결과, 동해를 통과한 태풍의 경우는 집중호우에 의한 영향이, 서해를 통과한 태풍은 강한 바람에 의한 영향이 크게 나타난 것으로 보였다.

      • KCI등재

        여름철 강우 시 도로관리를 위한 수막발생구간 예측정보의 정책적 활용방안: 서울시 내부순환로와 올림픽대로를 대상으로

        안숙희,양호진,이채연 한국환경정책학회 2019 환경정책 Vol.27 No.4

        The purpose of this study is to suggest a plan that can be applied to road management and accident prevention by utilizing the prediction of the potential area for hydroplaning during the summer rainfall. Hydroplaning is a condition that can exist when a layer of water builds between the tires of the vehicle and surface of the road, the tire has lost its grip on the road. To calculate the water depth, the British Road Research Laboratory (RLL) methodology was applied using the road geometry and rainfall intensity. Levels of caution for hydroplaning were presented using three levels: normal, caution, and danger. As a result of verifying the forecasts using the observational data of Seoul Facilities Corporation (SFCMC), the model’s predictions and the locations of the observations were found to be largely consistent. Therefore, the results of the model will be available for road management in case of rainfall. 본 연구의 목적은 여름철 강우 시 수막발생위험도 예측 결과를 활용하여 도로관리 및 사고예방에 적용할 수 있는 방안을 제시하는 것이다. 수막현상이란, 물에 젖은 노면을 자동차가 고속으로 달릴 때 타이어와 노면사이에 형성된 수막으로 인해 타이어가 노면 접지력을 상실하는 것을 말한다. 도로의 기하구조와강우강도를 사용하여 수막두께를 산정하는 영국 RLL(British Road Research Laboratory)의 방법론을적용하였으며, 수막두께에 따른 3단계(보통, 주의, 위험)의 수막발생위험도를 제시하였다. 서울시설공단(Seoul Facilities Corporation, SFCMC)의 수막발생 관측지점 자료를 활용하여 예측결과를 검증한 결과, 대체로 수막발생위치와 모델의 값이 일치하였으며, 이를 통해 도로관리 시 활용가능성을 확인하였다.

      • KCI등재
      • KCI등재
      • KCI등재

        산후 3개월 동안 체중저류 양상과 관련요인

        안숙희,김미옥 한국모자보건학회 2005 한국모자보건학회지 Vol.9 No.1

        Objectives : The purpose of this prospective study was to explore the pattern of postpartum weight retention during 3 months postpartum period and to examine demographic and obstetric factors that influence weight retention in the postpartum. Methods : The study used a correlational, longitudinal design to address the questions posed. After delivery, a convenience sample of 77 mothers with newborn infants was recruited at three hospitals in P city and followed for 3 months postpartum. The mothers' postpartum weight loss and obstetric and demographic variables were measured at three time points: during hospitalization (T1: 1∼2 days following delivery), 6 weeks (T2), and 3 months (T3) postpartum. Results : Mean total weight gain during pregnancy was 12.8±3.4㎏ (range: 6∼24㎏). At 6 weeks (T2) weight loss compared to weight at term pregnancy was 8.7±2.3㎏ and range was wide from 5 to 15㎏. Weight retention was 4.1±3.0㎏ at 6 weeks and 2.6±3.3㎏ at 3 months postpartum. The difference in body weight between 6 weeks and 3 months bodyweight was only 1.6㎏, indicating weight loss was progressed very slowly after the 6 weeks of postpartum. Weight change was different by measurement time and group of Body Mass Index (BMI) at pre-pregnancy. Weight retention at 6 weeks postpartum was greater when woman was primipara, and woman had low or normal BMI at pre-pregnancy, infants with no health problem, and breastfeeding. Significant predictors for more weight retention were greater weight gain during pregnancy and lower BMI at pre-pregnancy. Conclusions : The first 6 weeks of postpartum is the most critical time to lose weight that gained during pregnancy and there is a need to develop well-designed weight control program for puerperal women in the context of Korean postpartum care style.

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