리더십과 과학의 아름다운 하모니 KAIST 리더십 교육의 성과와 의의

엄상용,박정조,권소영,이호진 한국방위산업진흥회 2022 國防과 技術 Vol.- No.516

Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences

엄상용,임지애,김용대,최병선,황명실,박정덕,김헌,권호장 한국독성학회 2016 Toxicological Research Vol.32 No.3

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher’s exact test and fixation index (FST), respectively. The Korean population was genetically similar to the CHB and JPT populations (FST < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation (FST > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest FST value between the Korean and African populations was cystathionine-β-synthase rs234709 (FST: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

실리콘밸리의 혁신적 사고방식, Design thinking [Ⅱ]

엄상용,김도영,최민식 한국방위산업진흥회 2015 國防과 技術 Vol.- No.441

Transcatheter Closures for Fistula Tract and Paravalvular Leak after Mitral Valve Replacement and Tricuspid Annuloplasty

엄상용,김진용,Yong Hoon Yoon,Sinwon Lee,김영학,송재관 대한심장학회 2014 Korean Circulation Journal Vol.44 No.1

Paravalvular leaks (PVLs) often occur after surgical valve replacement. Surgical reoperation has been the gold standard of therapy forPVLs, but it carries a higher operative risk and an increased incidence of re-leaks compared to the initial surgery. In high surgical risk pa-tients with appropriate geometries, transcatheter closure of PVLs could be an alternative to redo-surgery. Here, we report a case of success-ful staged transcatheter closures of a fistula tract between the aorta and right atrium, and mitral PVLs after mitral valve replacement andtricuspid annuloplasty.

Lead, Mercury, and Cadmium Exposure in the Korean General Population

엄상용,이영섭,이슬기,서미나,최병선,김용대,임지애,황명실,권호장,김유미,홍영습,손석준,박경수,표희수,김호,김헌,박정덕 대한의학회 2018 Journal of Korean medical science Vol.33 No.2

Background: Lead (Pb), mercury (Hg), and cadmium (Cd) are well-known environmental pollutants. They are unnecessary in the biological processes of humans. This study was performed to estimate the representative background exposure levels to the metals by measuring concentrations in whole blood of the Korean general population. Methods: This population-based cross-sectional study included 4,000 subjects (1,886 males and 2,114 females) 0–83 years of age in 2010 and 2011. Adult subjects (≥ 19 years of age) were collected by sex- and age-stratified probability method, and preschool- and school-aged subjects were recruited by a cluster sampling method. Written consent was provided prior to blood sampling. Pb and Cd blood concentrations were determined by a flameless atomic absorption spectrophotometry, and blood Hg was analyzed by a direct Hg analyzer. Results: The geometric mean, median and 95th percentile of blood Pb was 1.82 µg/dL, 1.83 µg/dL, and 3.78 µg/dL, respectively. The respective values were 2.92 µg/L, 2.87 µg/L, 9.12 µg/L for Hg, and 0.56 µg/L, 0.59 µg/L, 2.20 µg/L for Cd. Blood Pb and Hg were higher in males than in females, but no sex difference was observed, respectively, in subjects 0–4 years of age for Pb and in subjects less than 20 years for Hg. However, blood Cd was higher in females than in males and no sex difference was observed in subjects < 30 years of age. Conclusion: This study provides representative data of human exposure to Pb, Hg, and Cd covering whole age groups of the general population in Korea.

1년간의 규칙적인 운동이 남성 치매환자의 일상생활도와 지질성분에 미치는 영향

엄상용,곽이섭,Um Sang-Yong,Kwak Yi-Sub 한국생명과학회 2005 생명과학회지 Vol.15 No.5

이상의 결과를 통하여 볼 때, 1년간의 규칙적인 운동은 남성 치매환자의 일상생활도 향상에 매우 효과적임을 알 수 있었고, TC, TC, LDL-C을 감소시키고 HDL-C을 증가시킴으로써 결과적으로 동맥경화와 심장병을 방지할 뿐만 아니라 독립적이고도 책임 있는 일상생활을 통해 치매환자의 삶의 질을 높이는데 큰 도움을 줄 것으로 기대된다. The purpose of this study was to investigate effects of regular exercise on ADL (activities of daily living) and lipid profiles (total cholesterol, triglyceride, HDL-C, LDL-C) in male patients with dementia. The subjects were consisted of 24 male patients with dementia, they were divided into two groups. the exercise group (EC, n=12) and the control group (CG, n=12). The exercise group participated in regular exercise program, and their ADL, lipid profiles levels were evaluated at baseline (pre, 0 mo), after 6 months (mid, 6 mo), and after 12 months (post, 12 mo). The subjects carried on exercising $30\∼60$ minutes a day, $2\∼3$ times per week for 12 months. Statistical techniques for data analysis was paired samples t-test. The level of statistical significance was $p\leq.0.5$. The results of this study were summarized as follows: In the case of EG, mid and post ADL values significantly higher than that of pre value, whereas there was no significant difference in the CG. Mid and post values of TC, TG, and LDL-C were significantly lower than that of pre value in the EG. However, mid and post HDL-C values were higher in the EG compared to pre value. In conclusion, these results suggest that regular exercise have an positive effect on ADL and lipid profiles in male patient with dementia. In addition, regular exercise may be helpful to reduce the incidence of heart disease and coronary sclerosis.

치매환자를 위한 운동치료

엄상용 한국코칭능력개발원 2003 코칭능력개발지 Vol.5 No.1

본 연구는 치매환자를 대상으로 운동치료를 통하여 혼자 이동할 수 있고 일상생활을 영위할 근력을 강화시키며 낙상과 근육 경직을 예방하여 독립적인 생활을 할 수 있도록 도움을 주고, 나아가 치매요양원이나 가정에서 실제적으로 활용할 수 있는 기초 자료를 제공하는데 목적이 있다. 운동치료의 주요 목적은 근력과 근지구력 및 균형능력의 증진과 기능부전을 예방하여 삶의 질을 높이는데 있다. 운동치료의 일반원칙을 살펴보면, 환자의 특성상 단순한 동작을 되풀이해야 하고 격려와 보상이 있어야 하며 그룹운동이 권장되고 오전이나 오후에 운동을 해야 한다 운동 강도보다 시간과 빈도가 중요하고 시간과 빈도보다는 순응도가 더 중요하다. 치매환자의 운동검사에는 심폐지구력 (6분 걷기), 근지구력 (앉았다 일어서기), 근력 (악력), 유연성 (좌전 굴), 평형성 (눈뜨고 외발서기), 민첩성 (누웠다 일어서기) 검사가 있으며 분기별로 측정하여 평가하고 검사가 불가능한 경우 검사를 생략하고 가장 낮은 단계의 운동부터 시작한다. 치매환자의 운동량은 주당 2-3회 빈도, 최대심박수의 60-80% 즉 , VO₂max 42-70% 강도, 일회 20-60 분이 효과적이다. 치매환자를 대상으로 한 운동치료는 환자에게 할 수 있다는 자신감과 성취감을 줄뿐만 아니라 불안 과 우울증을 완화시켜 치매의 진행속도를 지연시키는데 매우 효과적일 것으로 기대된다.

Effects of Intronic and Exonic Polymorphisms of Paraoxonase 1 (PON1) Gene on Serum PON1 Activity in a Korean Population

엄상용,김윤식,이충종,이철호,김용대,김헌 대한의학회 2011 Journal of Korean medical science Vol.26 No.6

Paraoxonase 1 (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces lipid peroxide accumulation, and PON1 genetic polymorphisms in the coding region modulate serum PON1 activity. In this study, we investigated the association between 3 polymorphisms of PON1 located in intron 5 (17899insdelTT and 17974CT) and exon 6 (192QR) and serum PON1 activity. The genetic polymorphisms and serum activity of PON1 were analyzed in 153 healthy Koreans by using a direct sequencing assay and spectrophotometric method, respectively. A significant linkage disequilibrium (LD) was observed between all tested single nucleotide polymorphisms, with the strongest LD observed between 17899insdelTT and 192QR (D’ = 0.984). The 17899insdelTT, 17974CT and 192QR genetic polymorphisms were associated with significant differences in serum paraoxonase activity. In multiple regression analyses, smoking, triglyceride level, highdensity lipoprotein (HDL) level, and the 17899insdelTT and 192QR genetic polymorphisms were significant determinants of serum paraoxonase activity, while age, smoking,triglyceride level, HDL level, and the 192QR genetic polymorphism were significant determinants of serum arylesterase activity. These results suggest that although the 192QR genetic polymorphism in the coding region of PON1 is primarily associated with serum PON1 activity, the intronic polymorphisms are also involved in serum PON1 activity, and this association may be mediated by LD.

실리콘밸리의 혁신적 사고방식, Lean thinking [Ⅲ]

엄상용,김연태,김도영 한국방위산업진흥회 2015 國防과 技術 Vol.- No.442

미래 성장동력 ICT의 세 가지 분야 : IoT, Wearable Device, Big Data - 제3편 : Big Data, 관찰과 데이터를 기반으로 분석하라

엄상용,김도영,문현호,정진호 한국방위산업진흥회 2016 國防과 技術 Vol.- No.445