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Dynamic System Identification Using a Recurrent Compensatory Fuzzy Neural Network
Chi-Yung Lee,Cheng-Jian Lin,Cheng-Hung Chen,Chun-Lung Chang 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.5
This study presents a recurrent compensatory fuzzy neural network (RCFNN) for dynamic system identification. The proposed RCFNN uses a compensatory fuzzy reasoning method, and has feedback connections added to the rule layer of the RCFNN. The compensatory fuzzy reasoning method can make the fuzzy logic system more effective, and the additional feedback connections can solve temporal problems as well. Moreover, an online learning algorithm is demonstrated to automatically construct the RCFNN. The RCFNN initially contains no rules. The rules are created and adapted as online learning proceeds via simultaneous structure and parameter learning. Structure learning is based on the measure of degree and parameter learning is based on the gradient descent algorithm. The simulation results from identifying dynamic systems demonstrate that the convergence speed of the proposed method exceeds that of conventional methods. Moreover, the number of adjustable parameters of the proposed method is less than the other recurrent methods.
Yen-Yang Chen,Chen-Chi Wang,Ying-Cheng Lin,John Y Kao,Chun-Yi Chuang,Yung-An Tsou,Ja-Chih Fu,Sheng-Shun Yang,Chi-Sen Chang,Han-Chung Lien 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.1
Background/AimsHypopharyngeal multichannel intraluminal impedance-pH (HMII-pH) technology incorporating 2 trans-upper esophageal sphincter impedance channels has been developed to detect pharyngeal reflux. We used the HMII-pH technique to validate the candidate pharyngeal acid reflux (PAR) episodes based on the dual-pH tracings and determined the interobserver reproducibility. MethodsWe conducted a cross-sectional study in tertiary centers in Taiwan. Ninety patients with suspected laryngopharyngeal reflux and 28 healthy volunteers underwent HMII-pH test when off acid suppressants. Candidate PAR episodes were characterized by pharyngeal pH drops of at least 2 units and reaching a nadir pH of 5 within 30 seconds during esophageal acidification. Two experts manually independently identified candidate PAR episodes based on the dual-pH tracings. By reviewing the HMII-pH tracings, HMII-pH-proven PAR episodes were subsequently confirmed. The consensus reviews of HMII-pH-proven PAR episodes were considered to be the reference standard diagnosis. The interobserver reproducibility was assessed. ResultsA total of 105 candidate PAR episodes were identified. Among them 84 (80.0%; 95% CI, 71.0-87.0%) were HMII-pH-proven PAR episodes (82 in 16 patients and 2 in 1 healthy subject). Patients tended to have more HMII-pH-proven PAR episodes than healthy controls (median and percentile values [25th, 75th, and 95th percentiles]: 0 [0, 0, 3] vs 0 [0, 0, 0], P = 0.067). The concordance rate in diagnosing HMII-pH-proven PAR episodes between 2 independent observers was 92.2%. ConclusionOur preliminary data showed that 80.0% (71.0-87.0%) of the proposed candidate PAR episodes were HMII-pH-proven PAR episodes, among which the interobserver reproducibility was good.
Hua-Nong Luo,Chen-Chi Wang,Ying-Cheng Lin,Chun-Yi Chuang,Yung-An Tsou,Ja-Chih Fu,Sheng-Shun Yang,Chi-Sen Chang,Han-Chung Lien 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.2
Background/AimsDiagnosis of isolated laryngopharyngeal reflux symptoms (ILPRS), ie, without concomitant typical reflux symptoms (CTRS), remains difficult. Mean nocturnal baseline impedance (MNBI) reflects impaired mucosal integrity. We determined whether esophageal MNBI could predict pathological esophagopharyngeal reflux (pH+) in patients with ILPRS. MethodsIn this cross-sectional study conducted in Taiwan, non-erosive or low-grade esophagitis patients with predominant laryngopharyngeal reflux symptoms underwent combined hypopharyngeal multichannel intraluminal impedance-pH monitoring when off acid suppressants. Participants were divided into the ILPRS (n = 94) and CTRS (n = 63) groups. Asymptomatic subjects without esophagitis (n = 25) served as healthy controls. The MNBI values at 3 cm and 5 cm above the lower esophageal sphincter (LES) and the proximal esophagus were measured. ResultsDistal but not proximal esophageal median MNBI values were significantly lower in patients with pH+ than in those with pH– (ILPRS in pH+ vs pH–: 1607 Ω vs 2709 Ω and 1885 Ω vs 2563 Ω at 3 cm and 5 cm above LES, respectively; CTRS in pH+ vs pH–: 1476 vs 2307 Ω and 1500 vs 2301 Ω at 3 cm and 5 cm above LES, respectively, P < 0.05 for all). No significant differences of any MNBI exist between any pH– subgroups and healthy controls. The areas under the receiver operating characteristic curve in the ILPRS group were 0.75 and 0.80, compared to the pH– subgroup and healthy controls (P < 0.001 for both), respectively. Interobserver reproducibility was good (Spearman correlation 0.93, P < 0.0001). ConclusionDistal esophageal MNBI predicts pathological reflux in patients with ILPRS.
The simple and easy way to manufacture counter electrode for dye-sensitized solar cells
Jo-Lin Lan,Yung-Yun Wang,Chi-Chao Wan,Tzu-Chien Wei,Hsien-Ping Feng,Chao Peng,Hai-Peng Cheng,Ya-Huei Chang,Wen-Chi Hsu 한국물리학회 2010 Current Applied Physics Vol.10 No.2
We previously developed poly-N-vinyl-2-pyrrolidone (PVP)-capped Pt nanoclusters on ITO glass via a simple ‘‘2-step dip coating process” as counter electrode for DSSC. This new counter electrode was examined by transmission electron microscopy (TEM), inductively coupled plasma-atomic emission spectroscopy (ICP-AES), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and current–voltage curve (I–V curve). The TEM results revealed that PVP-capped Pt nanoclusters’ size is about 3 nm, and the amount of Pt deposited on ITO glass is about 5 ㎍/㎠. Comparing with sputtered Pt and Solaronix thermal cluster Pt-catalyst T/SP, the PVP-capped Pt counter electrode has lower amount of Pt deposited on TCO glass,more positive potential of tri-iodide reduction, and better performance for the charge-transfer resistance (RCT) and the cell efficiency (g).
Holistic Life-cycle Cost-benefit Analysis of Green Buildings: A China Case Study
Xiaojuan Li,Mingchao Lin,Wanjun Xie,Chi Yung Jim,Jiyu Lai,Liping Cheng 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11
Green buildings, compared with conventional ones, can mitigate the rapid growth of China's carbon emissions. They offer many advantages, such as saving resources and reducing negative environmental impacts. However, few studies have assessed their incremental costs and social benefits. This study comprehensively analyzed the incremental costs and benefits of green buildings in China through the life cycle stages of preparation, design, construction, and operation-management. The Analytic Hierarchy Process and Matter Element Analysis were jointly applied to establish a comprehensive green-building cost-benefit evaluation system. Based on expert judgment, an embracive two-level index scheme and a three-step grading strategy were developed. A residential case study tested the applicability of the model. It yielded the largest share of incremental cost in the construction phase at 90.5%. The economic benefits accounted for the largest proportion of incremental benefits at 72.22%, meeting the green building criteria and achieving the highest 3-star rating. The study has developed a full life-cycle costing methodology for green building design and quantified the benefits at each stage. The findings offer the theoretical and practical basis to refine the assessment of green building projects and improve green building performance to meet sustainable development goals.
혈청 농도가 다제내성 억제제 BIBW 22 의 nucleoside 수송에 미치는 영향
이동권(Dong Kwon Rhee),(Hong Xing Chen),(Uwe Bamberger),(Yung Chi Cheng) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
Some multidrug resistance inhibitors have been known to be influenced by the serum concentration. In this study, effect of serum concentration on inhibition of nucleoside transport by BIBW22, a new multidrug resistance inhibitor derived from dipyridamole (DPM), was studied. When 5% or 100% (v/v) of fetal bovine serum (FBS) was contained in the culture, DPM dose for which nucleoside transport was inhibited by 50% (ID_(50)) was 0.42μM or 1.17μM, respectively. BIBW22 also showed the same trend as DPM did in response to increase of FBS concentration. However, ID_(50) value for DPM in the absence or presence of human plasma was 0.007μM or 1.02μM respectively showing 145times increase of ID_(50) value. ID_(50) value for BIBW22 in the presence of human plasma was 0.028μM showing only 5times increase in ID_(50) value. This result suggests that potency of BIBW22 was much less affected by the plasma concentration and BIBW22 could be a good candidate for a clinical use in multidrug resistance treatment.
LIU, SU-YING,HWANG, BYUNG-DOO,HARUNA, MITSUMASA,IMAKURA, YASUHIRO,LEE, KUO-HSIUNG,CHENG, YUNG-CHI 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-
Several derivatives of podophyllotoxin with modifications at the C-4 position of ring C, in addition to demethylation at the C-4' position of ring E, were examined for inhibitory activity against DNA topoisomerase Ⅱ and tubulin polymerization, generation of protein-linked DNA breaks, and cytotoxicity against KB cells and VP-16-resistant KB variants. Substitution of podophyllotoxin with a group in the β configuration at the C-4 position of ring C resulted in compounds with greater inhibitory activity against DNA topoisomerase Ⅱ and lower inhibitory activity against tubulin polymerization than those with an α configuration. These active analogs exhibited the same mechanism of DNA topoisomerase Ⅱ inhibition as the epipodophyllotoxin derivative VP-16, which causes protein-linked DNA breaks in vitro as well as in cells. Two analogs selectively inhibited DNA topoisomerases Ⅱ to a greater extent than tubulin polymerization. These analogs were cytotoxic towards KB cells in addition to VP-16-resistant KB cell lines, which indicated limited cross-resistance with VP-16 in VP-16-resistant KB variants.
Yue Yan Katherine Fan,Ka Lam Wong,Ka Lai Cally Ho,Tai Leung Daniel Chan,Oswald Joseph Lee,Chi Yui Yung,Kin Shing Lun,Mo Chee Elaine Chau,Shui Wah Clement Chiu,Lik Cheung Cheng,Wing Kuk Timmy Au 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.4
Background: The year 2022 marks the 30th anniversary of heart transplant service in Hong Kong (HK). In this study, we describe prevailing trends and outcomes of advanced heart failure (AHF), including heart transplantations (HTx), in HK over the past 30 years. Methods: Trends in heart failure prevalence in HK from 1993 to 2021 were analyzed based on data from the Hospital Authority Clinical Data and Reporting System. All AHF patients referred for HTx consideration between 1992 and 2021 were reviewed. The bridge-to-transplant (BTT) utilization of short-term mechanical circulatory support (ST-MCS) devices, including venoarterial extracorporeal membrane oxygenation (VA-ECMO) and durable left ventricular assist devices (LVADs), from 2010 to 2021 was reviewed. Results: Overall, 237 heart transplants were performed in HK, with 10-year posttransplant and median survival of 68.1% and 18.7 years, respectively. An increase in AHF clinic referrals was correlated with increasing heart failure prevalence (R2=0.635, P<0.001). In total, 146 referrals were made for ST-MCS, and an observed increase in ST-MCS referrals was correlated with increasing VA-ECMO utilization (R2=0.849, P<0.001). Among 62 patients accepted for AHF therapy, those with durable LVAD implementation had better 1-year survival (71.5%) than those receiving an extracorporeal CentriMag (Levitronix) device as BTT (40%, P=0.008). In total, 143 LVADs were implanted, with 130 as BTT or bridge-to-candidacy (BTC) methods. The survival rate among the 130 BTT/BTC LVAD patients resembled that of HTx recipients (73.8% vs. 69.8% at 9 years, P=0.296). Conclusions: The burden of AHF management has increased and gained complexity over the past 30 years in Hong Kong.