pH-Sensitive Polypeptide Conjugated with Carborane Clusters and Cyanine for NIR Bioimaging and Multi-Therapies

Zheng Ruan,Pan Yuan,Titao Jing,Tao Xing,Lifeng Yan 한국고분자학회 2018 Macromolecular Research Vol.26 No.3

A novel pH-sensitive carborane and cyanine dye conjugated polypeptide and its micelles has been designed and synthesized for potential near infrared fluorescence imaging-guided boron neutron capture therapy (BNCT). The amphiphilic polymer we synthesized with tertiary amine as functional group could self-assemble to micelle nanoparticles at neutral pH, and responsive to acidic solution for the disassembly of the micelles for drug release. The tertiary amine sensitive induced process was observed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). The efficiency of cell killing ability is studied by MTT assays and fluorescence microscope measurement, indicating a new intelligent system for potential NIR imaging-guided therapy.

Multi-Antenna Transmission With Artificial Noise Against Randomly Distributed Eavesdroppers

Tong-Xing Zheng,Hui-Ming Wang,Jinhong Yuan,Towsley, Don,Moon Ho Lee Institute of Electrical and Electronics Engineers 2015 IEEE Transactions on Communications Vol. No.

<P>In this paper, we study the secure multi-antenna transmission with artificial noise (AN) under slow fading channels coexisting with randomly located eavesdroppers. We provide a comprehensive secrecy performance analysis and system design/optimization under a stochastic geometry framework. Specifically, we first evaluate the secrecy outage performance, and derive a closed-form expression for the optimal power allocation ratio of the information signal power to the total transmit power that minimizes the secrecy outage probability (SOP). Subject to a SOP constraint, we then propose a dynamic parameter transmission scheme (DPTS) and a static parameter transmission scheme (SPTS) to maximize secrecy throughput, and provide explicit solutions on the optimal transmission parameters, including the wiretap code rates, the on-off transmission threshold and the power allocation ratio. Our results give new insight into secure transmission designs. For example, secrecy rate is a concave function of the power allocation ratio in DPTS, and AN plays a significant role under SOP constraints and in dense eavesdropper scenarios. In SPTS, transmission probability is a concave function of the power allocation ratio, and secrecy throughput is a quasi-concave function of the secrecy rate. Numerical results are demonstrated to validate our theoretical analysis.</P>

Resource Allocation for Heterogeneous Service in Green Mobile Edge Networks Using Deep Reinforcement Learning

( Si-yuan Sun ),( Ying Zheng ),( Jun-hua Zhou ),( Jiu-xing Weng ),( Yi-fei Wei ),( Xiao-jun Wang ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.7

The requirements for powerful computing capability, high capacity, low latency and low energy consumption of emerging services, pose severe challenges to the fifth-generation (5G) network. As a promising paradigm, mobile edge networks can provide services in proximity to users by deploying computing components and cache at the edge, which can effectively decrease service delay. However, the coexistence of heterogeneous services and the sharing of limited resources lead to the competition between various services for multiple resources. This paper considers two typical heterogeneous services: computing services and content delivery services, in order to properly configure resources, it is crucial to develop an effective offloading and caching strategies. Considering the high energy consumption of 5G base stations, this paper considers the hybrid energy supply model of traditional power grid and green energy. Therefore, it is necessary to design a reasonable association mechanism which can allocate more service load to base stations rich in green energy to improve the utilization of green energy. This paper formed the joint optimization problem of computing offloading, caching and resource allocation for heterogeneous services with the objective of minimizing the on-grid power consumption under the constraints of limited resources and QoS guarantee. Since the joint optimization problem is a mixed integer nonlinear programming problem that is impossible to solve, this paper uses deep reinforcement learning method to learn the optimal strategy through a lot of training. Extensive simulation experiments show that compared with other schemes, the proposed scheme can allocate resources to heterogeneous service according to the green energy distribution which can effectively reduce the traditional energy consumption.

Physical Layer Security in Wireless Ad Hoc Networks Under A Hybrid Full-/Half-Duplex Receiver Deployment Strategy

Tong-Xing Zheng,Hui-Ming Wang,Jinhong Yuan,Zhu Han,Moon Ho Lee INSTITUTE OF ELECTRICAL AND ELECTRONICS ENGINEERS 2017 IEEE Transactions on Wireless Communications Vol. No.

<P>This paper studies physical layer security in a wireless ad hoc network with numerous legitimate transmitter-receiver pairs and eavesdroppers. A hybrid full-duplex (FD)/half-duplex receiver deployment strategy is proposed to secure legitimate transmissions, by letting a fraction of legitimate receivers work in the FD mode sending jamming signals to confuse eavesdroppers upon their information receptions, and letting the other receivers work in the half-duplex mode just receiving their desired signals. The objective of this paper is to choose properly the fraction of FD receivers for achieving the optimal network security performance. Both accurate expressions and tractable approximations for the connection outage probability and the secrecy outage probability of an arbitrary legitimate link are derived, based on which the area secure link number, network-wide secrecy throughput, and network-wide secrecy energy efficiency are optimized, respectively. Various insights into the optimal fraction are further developed, and its closed-form expressions are also derived under perfect self-interference cancellation or in a dense network. It is concluded that the fraction of FD receivers triggers a non-trivial tradeoff between reliability and secrecy, and the proposed strategy can significantly enhance the network security performance.</P>

Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2

Dongwei Yuan,Li Qing,Lu Xing,Lan Jianfeng,Qiu Zhidong,Wang Xuehong,Wang Junnan,Zheng Xiaojiao,Chen Sifan,Zhang Chong,Jin Junfei 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury. A functional study confirmed that CERK and C1P attenuate hepatic injury both in vitro and in vivo through antioxidant effects. Mechanistic studies have shown that CERK and C1P positively regulate the protein expression of NRF2, which is a crucial protein that helps maintain redox homeostasis. Furthermore, our results indicated that C1P disrupted the interaction between NRF2 and KEAP1 by competitively binding to KEAP1, which allowed for the nuclear translocation of NRF2. In addition, pull-down assays and molecular docking analyses revealed that C1P binds to the DGR domain of KEAP1, which allows it to maintain its interaction with NRF2. Importantly, these findings were verified in human primary hepatocytes and a mouse model of hepatic ischemia‒reperfusion injury. Taken together, our findings demonstrated that CERK-mediated C1P metabolism attenuates acute liver injury via the binding of C1P to the DGR domain of KEAP1 and subsequently the release and nuclear translocation of NRF2, which activates the transcription of cytoprotective and antioxidant genes. Our study suggested that the upregulation of CERK and C1P expression may serve as a potential antioxidant strategy to alleviate acute liver injury.

Investigation of the Photoinduced Anisotropy of the Bacteriorhodopsin/Polymer Composite Film by Using Probing-Pumping Beams of Various Wavelengths

Liang-Yao Chen,Su-Xing Pan,Yun-Fei Wu,Lai Wei,Yu-Xiang Zheng,You-Yuan Zhao,De-Wang Ma 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.4

We have investigated the probing beam transmitance due to the photon-induced anisotropy effect in the bacteriorhodopsin/polymer composite film(bR/PC film) by using the probing-pumping beam method under different laser wavelengths. By using a theoretical simulation, we give the characteristics of the birefringence Δn and the dichroism ΔD for various wavelengths of the probing and the pumping beams.

Constraints on aZ′boson within minimal flavor violation

Kim, C. S.,Yuan, Xing-Bo,Zheng, Ya-Juan American Physical Society 2016 Physical review. D Vol.93 No.9

<P>We explore a Z' boson coupled only with the Standard Model (SM) fermions (Z'f (f) over bar) in the framework of minimal flavor violation. We study its effects on the processes with lepton flavor violation l(j) -> l(i)l(k)(l) over bar (l), l(j) -> l(i)gamma, mu N- -> e(-)N, quark flavor-changing neutral currents b -> sl (l) over bar, neutral B and K meson mixing, and e(+)e(-) -> f (f) over bar at the LEP experiment to constrain the parameter space of Z' mass and couplings. We find that among those relevant processes, mu -> e gamma, mu -> 3e, mu-e conversion and e(+)e(-) -> f (f) over bar can put more stringent bounds on Z'f (f) over bar couplings normalized by Z' mass. The implications for various processes are obtained, such as B and K mixing and B/K -> Ml(1)(l) over bar (2) decays. In addition, we also analyze Z' signatures at the LHC with root s = 8 and 13 TeV.</P>

Physical Layer Security in Heterogeneous Cellular Networks

Hui-Ming Wang,Tong-Xing Zheng,Jinhong Yuan,Towsley, Don,Moon Ho Lee IEEE 2016 IEEE TRANSACTIONS ON COMMUNICATIONS Vol.64 No.3

<P>The heterogeneous cellular network (HCN) is a promising approach to the deployment of 5G cellular networks. This paper comprehensively studies physical layer security in a multitier HCN where base stations (BSs), authorized users, and eavesdroppers are all randomly located. We first propose an access threshold-based secrecy mobile association policy that associates each user with the BS providing the maximum truncated average received signal power beyond a threshold. Under the proposed policy, we investigate the connection probability and secrecy probability of a randomly located user and provide tractable expressions for the two metrics. Asymptotic analysis reveals that setting a larger access threshold increases the connection probability while decreases the secrecy probability. We further evaluate the network-wide secrecy throughput and the minimum secrecy throughput per user with both connection and secrecy probability constraints. We show that introducing a properly chosen access threshold significantly enhances the secrecy throughput performance of a HCN.</P>

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Li, Shu-Hong,Guo, Zhi-Xing,Xiao, Cheng-Zuo,Wei, Wei,Shi, Ming,Chen, Zhi-Yuan,Cai, Mu-Yan,Zheng, Lie,Guo, Rong-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Background: Prognostic factors of postoperative early and late recurrence in patients with hepatocellular carcinoma (HCC) undergoing curative resection remain to be clarified. The aim of this study was to identify risk factors for postoperative early (${\leq}$ 2 year) and late (> 2 year) intrahepatic recurrences in patients with single HCCs without macrovascular invasion. Methods: A total of 280 patients from December 2004 to December 2007 were retrospectively included in this study. Intrahepatic recurrence was classified into early (${\leq}$ 2 year) and late (> 2 year) and the Chi-Square test or Fisher's exact test and multivariate logistic regression analysis were performed to determine significant risk factors. Results: During the follow-up, 124 patients had intrahepatic recurrence, early and late in 82 and 42 patients, respectively. Multivariate logistic regression analysis showed that microvascular invasion (p=0.006, HR: 2.397, 95% CI: 1.290-4.451) was the only independent risk factor for early recurrence, while being female (p = 0.031, HR: 0.326, 95% CI: 0.118-0.901), and having a high degree of cirrhosis (P=0.001, HR: 2.483, 95% CI: 1.417-4.349) were independent risk factors for late recurrence. Conclusions: Early and late recurrence of HCC is linked to different risk factors in patients with single HCC without macrovascular invasion. This results suggested different emphases of strategies for prevent of recurrence after curative resection, more active intervention including adjuvant therapy, anti-cirrhosis drugs and careful follow-up being necessary for patients with relevant risk factors.

Novel HMW glutenin genes from Aegilops tauschii and their unique structures

Wen-Jie Chen,Zhong-Wei Yuan,Lian-Quan Zhang,Xing Fan,Ze-Hong Yan,Ji-Rui Wang,You-Liang Zheng,Huai-Gang Zhang,Deng-Cai Liu 한국유전학회 2012 Genes & Genomics Vol.34 No.3

A pair of novel high-molecular-weight glutenin subunits (HMW-GS) 1Dx5.3t and 1Dy12.1**t were revealed and characterized from Ae. tauschii accession PI554324. SDS-PAGE band of 1Dx5.3t was between those of 1Bx6 and 1Bx7, while 1Dy12.1**t with slightly faster migration rate than that of 1Dy12. The lengths of 1Dx5.3t and 1Dy12.1**t were 2115 bp and 1986 bp, encoding 703 and 660 amino acid residues,respectively. Their authenticity was confirmed by successful expression of the coding regions in Escherichia coli. 1Dx5.3t is the shortest of the known Dx-type alleles. 1Dy12.1**t is also a special subunit since it has an additional cysteine in the front of the central repetitive domain. This cysteine that is not existed in previously reported Dy-type genes may be useful for improving bread wheat quality. Median-joining Network analysis indicated that 1Dy12.1**t may be a key site in the genealogy of the Glu-Dy.