일차성 식도이완불능증의 풍선확장술후 치료효과의 객관적 평가지표

손영해,나호영,조성범,주영은,김현수,최성규,유종선,김세종 全南大醫大 2001 전남의대학술지 Vol.37 No.2

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

통조림罐의 內面腐蝕에 미치는 有機酸의 影響

孫泰華,崔鍾旭,權榮澤,金聲達 경북대학교 1981 새마을 硏究論叢 Vol.1 No.-

This experiment was carried out to research the effect of kinds and concentration of organic acid food component on the internal can corrosion, stored at room temperature (25℃) and low temperature (0℃). The criterion for the degree of the internal can corrosion was tin contents in the pure acid solution. The result of this research can be summarized as followes. The intension which effect the rate of the tin dissolution was furmaric>malic>citric, were respectively. The rate of the dissolution were increased rapidly at 30days after treatment, and the higher concentration of malic acid, the more dissolved of tin from the can body. The amounts of tin dissolved from can body at room temperature were slightly stronger than low temperature.

純粹한 肺動脈 辨狹窄症 : 二例 報告와 支獻 考察 2 Case Report and Literature Review

孫宜錫,林成律,李永麟 육군의무장교단 1960 육군의무장교단잡지 Vol.7 No.1

소아에서 체외 막형산화기의 이용

손영상 한국소아심장연구회 2004 소아심장 Vol.8 No.1

진행된 자궁경부암 및 재발암에서 vincristine, bleomycin, mitomycin-C 및 cisplatin의 치료성적에 관한 연구

손영선,강길전,남상륜 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Seventeen patients with advanced or recurrent cervical cancer were treated with vincristine, bleomycin, mitomyicin-C and cisplatin between February, 1986 and January, 1989. 1. Among evaluable patients, response rate was 55.6%(patial responses in all). Response rates of advanced and recurrent group were 71% and 0%, respectively. 2. Medium survival for responders and nonresponders were 26 months and 25 months: there was no statistically significant difference(p>0.05) 3. Median survival for preoperative or preradiational chemotherapy and postoperative chemotherapy were 26 months and 23 months (p>0.05). 4. Nausea and vomiting were observed in most patients (88%), but easily controlled, and were followed in frequency by ferer, alopecia, leukopenia, stomatitis, diarrhea, but there was no serious toxicities. In addition, combination chemotherapy with vincristine, bleomycin, mitomycin-C and cisplatin in patients with advanced cervical vancer seemed to be relatively effective and well tolerable, but more cases need to be evaluated in patients with recurrent cervical cancer.

FactoryCAD를 이용한 보일러 제조업체의 설비배치 사례연구

손권익,김성준,김완영 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.B

This paper deals with a case study on the process improvement and the layout design of a boiler factory with FactoryCAD. Firstly, two alternatives of job reallocation are suggested with the understanding of problems in current process. The layout planning for these new alternatives is carried out by simple procedure and the detailed analyses are performen by the aid of FactoryCAD program. The result shows that the new layout plan brings on about 10% reduction of travel distance. The utilization of FactoryCAD program can simplify the process of layout design.

THI에 의한 서울시 지하철 역사 근로자의 신체 및 심리적 증상에 관한 연구

손종렬,김선철,변상훈,문경환,김영환 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

This paper reports an investigaion for the health status of subway workers in the 67 subway stations in the Seoul area during from September 15th to Nobimber 15th, 2002 . Prevalence of subuective complaints was surveyed of 400 subway workers applied by a general health questionnaire-the Todai Health index(THI). The basic tool employed in this present study was the THI which is modified Comell Medical Index(CMI) and was developed by Tokyo University Research Team in Japan, and had been used to evaluate manufacturing workers, iron workers and other workers by Kim(1979), Chung(1982), Lym(1987), Lee(1996) in Korea. The results were summarized as follows; 1. The physical and psychological complaints were much higher in the 20~29 age group than other age groups. 2. The physical and psychological complaints showed a high tendency of increased incidence in all items as length of service decreased, and the 3~5 years group was higher than less 1 year group with regard to the symptoms of Digestive(C), Aggressiveness(F), Nervousness(E). 3. The physical and psychological complaints showed much higher tendency in the station staff(S?S) group than other groups. 4. The physical and psychological complaints showed much higher tendency in the under station(Un.S) and upper station (Un.S) groups than other groups. 5. The responses of physical and psychological complaints by monthly pay showed much higher tendency in he income of 10.1~1.50 millions won group than other groups. 6. The responses of physical and psychological complaints by smoker or non-smoker showed much higher tendency in the smoker group than non-smoker group. Therefore, it can be concluded that the worker of subway studied was perceived as acceptable the importance of health status, and suggested that the goverment of related subway need to be effort to control the health of subway workers in environment of indoor.

구진상괴사성 결핵진 3례

손보성,송준영,정재봉,김병천,이상숙,류영욱,이규석 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Papulonecrotic tuberculid is an eruption of necrotizing papules, particularly affecting the extremities and occurring in more or less symmetrical crops, and responding to antituberculosis therapy. Individual lesions heal with scarring. Histologically, vascular involvement is seen in early lesions. Late lesions are divided into two forms. In superficial forms, wedge shaped area of necrosis forms in epidermis and upper dermis. Epithelial and lymphoid cells gather around its periphery. In deep forms, with no epidermal change, granulomatous changes surrounded by well defined palisading histiocyte and lymphoid, epithelioid cells are seen. In mid-dermis and perivascular area, vessel shows vasculitis. In the first case, leukocytoclastic vasculitis and early granuloma formation were seen. In the second case, palisading granuloma formation was seen. In the third case, tuberculoid granuloma formation was seen. We report three cases of papulonecrotic tuberculid showing three different stages of histological finding, in individual cases.

Bi₂Sr₂Ca(Cu_1-xNix)₂O_8+δ단결정의 전류 변화에 대한 활성화 에너지

손인호,김영국,전칠원,문성희,오재근 경남대학교 공업기술연구소 2000 硏究論文集 Vol.18 No.-

Bi□Sr□Ca(Cu□-□Ni□)□O□+δ (x=0, 0.003) 단결정을 개선된 방향성 응고법을 이용하여 성장시켰으며, 표준 4단자법으로 ab-면의 비저항을 측정하였고, Direct four-probe법을 이용해서 c-축의 비저항을 측정하였다. Arrhenius plot slopes의 기울기는 활성화 에너지를 나타내는데 이의 온도 의존성에 대하여 조사하였다. 자기장을 인가하여 활성화 에너지를 측정하면, 고온과 저온에 서로 다른 두개의 TAFF 영역이 나타나는 것을 볼 수 있고, 이들 활성화에너지는 고온 영역에서는 lnB에 비례하고, 저온 영역에서는 B□□ 에 비례하였다. By making use of the improved directional solidification method and, standard and direct four-prove methods respectively. We grow Bi□Sr□Ca(Cu1-□Ni□)2O8+δ (x=0, 0.003) single crystal and measure its resitivities in ab-plane and c-axis. The temperature at the activation energy, which is described by a slope in the Arrhenius plot, is examined. The activation energy measured by applying the external magnetic field, exhibits two different TAFF regimes at low and high temperatures. It is shown that the activation energy is propotional to lnB and B□□ at high and low temperature regimes, respectively.