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사람 태반조직 Peroxidase의 부분정제 및 특성에 관한 연구
황윤영,차인돈,이희성 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.1
The purification and some properties of peroxidase of human term placenta was made in this study. The activity of peroxidase was measured by the method of Pu‥tter(1974). The results were summarized as follows; 1. The activity of peroxidase in cytosolic fraction of human term placenta was found to be 31.09 units per g wet tissue. 2. The peroxidase from human term placenta was purified about 22-fold by ammonium sulface precopitation and DEAE-cellulose column chromatography. 3. The most rapidly oxidized substrate was o-dianisidine. Benzidine, ascordic acid and guaiacol were oxidized with decreasing order of rats, while oxidation of dihydrooxyphenols and trihydrooxyphenol were very slow. 4. The partially purified peroxidase was strongly inhibited by i.omM of sulfhydryl reagents and cyanide. 5. The optimal tempreature for enzyme astivity was 40℃ and the optimal pH was 5.5. 6. The half life of the enzyme astivity was 30 min. at 60℃. 7. the Km values for hydrogen peroxid and guaiacol of peroxidase were 0.50mM and 0.44mM, respectively. 8. The purified enzyme was a typical hemoprotein.
난소암 환자의 복수내 인슐린양 성장인자 및 인슐린양 성장인자 결합단백의 농도에 관한 연구
김경태,이기헌,황윤영 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.1
Based on the facts that expression of insulin-like growth factors(IGFs), their receptors, and insulin-like growth factor binding proteins(IGFBPs) have been found in many different types of malignancies including human ovarian cancer and their potent mitogenic effects in vitro, a role for IGFs mediated autocrine loop in oncogenesis and growth regulation of human malignancies was suggested. Since ascites support the biological environment for advanced ovarian cancer, it seemed to be resonable to measure the level of growth factors or cytokines in ascites for understanding precise mechanism of those factors in tumor biology. To investigate their roles and to evaluate prognostic significance in ovarian cancer, the IGFs/IGFBPs system were studied in the ascites, not in sera or cystic fluids, from 22 patients with ovarian cancer, who underwent surgical staging and subsequent cis-platinum based systemic chemotherapyery at the Department of Obstetrics and Gnecology, Hanyang University Hospital from Jan. 1989 through Dec. 1994. Ascites from 7 patients with benign disease were used as the control. IGF-Ⅰ, Ⅱ, IGFBP-1, and 3 were measured by immunoradiometric assay. The IGF-Ⅰ level was significantly higher in ascites with ovarian cancer compared with those of benign disease(63.3 11.1 vs 17.9 6.2ng/ml, p=0.0098), but the level of IGF-Ⅱ was not significantly different(70.5 13.9 vs 70.8 31.5 ng/ml, p=0.2827). IGFBP-1 levels were tend to be lower in ascites of patients with ovarian cancer than that of control(25.2 9.5 vs 58.6 28.2ng/ml, p=0.0637). However, IGFBP-3 levels had no statistically significant difference between two groups(779.7 110.6 vs 674.7 175.1ng/ml, p=0.8328). Although growth hormone levels were significantly higher in ascites with metastatic ovarian cancer than those of primary epithelial ovarian cancer, the levels of IGF-Ⅰ, Ⅱ, IGFBP-1 and 3 in ascites were not significantly different between two groups. IGF-Ⅰ levels were correlated with the levels of IGFBP-3 in ascites with ovarian cancer(Y=8.83X-2.0, r=0.745, p=0.0000). High level of IGF-Ⅰ in ascites of patients with ovarian cancer in this study was suggested that IGF-Ⅰ had an important role on growth regulation of ovarian cancer. As majority of ascites were obtained from advanced and poorly differentiated ovarian cancer patients, IGF-Ⅰ in ascites seemed to be related with intraperitoneal metastasis. Further large number of study including data from sera or cystic fluid will be needed to elucidate the role of the IGFs and IGFBPs in ascites of patients with ovarian cancer.
선행 화학요법과 광범위 자궁적출술을 시행한 자궁경부암에서 재발 위험 인자에 대한 연구
김승룡,이정한,황정혜,문영진,김경태,조삼현,문형,황윤영 대한부인종양 콜포스코피학회 2001 Journal of Gynecologic Oncology Vol.12 No.1
Objective: This study was done to assess long-term survival and risk factors for recurrence after neoadjuvant chemotherapy and radical hysterectomy for locally advanced cervical cancer patients. Methods: Between August 1983 and May 1990, 80 cervical cancer stage IB-IIB patients with tumor diameter 4cm or more received neoadjuvant VBP chemotherapy and radical hysterectomy. After follow-up more than 10 years for these patients, survival rate and risk factors for recurrence were analyzed. Results: Seventy eight of 80 patients were followed for 10 years. During this period, 20,5% patients(16/78) had recurrences and all of them died of recurrence. Five and 10 year survival rates were 82%(64/78) and 79.4%(62/78), respectively. High risk factor for recurrence was pelvic lymph node invasion. However, clinical stage, initial tumor mass size, number of neoadjuvant chemotherapy, clinical response, or residual tumor size were not clinically significant risk factors for recurrence. Initial tumor size was correlated with pelvic lymph node metastasis. In recurrent patients, site of recurrence was not different according to pelvic lymph node status. For node positive patients, combination of chemotherapy and radiation seemed to be more effective in reducing recurrence compared to chemotherapy or radiation only. Conclusion: For locally advanced stage IB-IIB cervical cancer patients who received neoadjuvani chemotherapy and radical hysterectomy, pelvic lymph node metastasis was high risk factor for recurrence and initial tumor size was closely correlated with pelvic lymph node invasion even after neoadjuvant chemotherapy.