Tissue distribution of sialic acid-linked influenza virus receptors in beagle dogs

Zhang-Yong Ning,Xin-Tao Wu,Yan-Fen Cheng,Wen-Bao Qi,Yu-Fu An,Heng Wang,Gui-Hong Zhang,Shou-Jun Li 대한수의학회 2012 Journal of Veterinary Science Vol.13 No.3

Reports of influenza A virus infections in dogs has received considerable attention from veterinarians, virologists, and epidemiologists. Interaction between influenza viral hemagglutinin and cell oligosaccharides containing sialic acid residues results in infection. Sialic acids have an α-2,3-linkage to the penultimate galactose in the avian influenza virus receptor and an α-2,6-linkage in the human receptor. To date,there are no detailed data on the tissue distribution or histological features of either type of sialic acid-linked influenza virus receptors in beagle dogs, which are common laboratory animals and pets. We conducted the current study to visualize the in situ tissue distribution of both sialic acid-linked influenza virus receptors in various organs of beagle dogs using Maackia amurensis lectin II and Sambucus nigra agglutinin. Both α-2,3- and α-2,6-sialic acid-linked receptors were detected in the endothelial cells of the respiratory tract and other organs. Endothelial cells of most gastrointestinal organs were negative for α-2,3-sialic acid-linked receptors in the dogs. Our results suggested that these canine organs may be affected by influenza virus infection. The findings from our study will also help evaluate the occurrence and development of influenza virus infections in dogs.

Jiangsu 지역의 사회경제적 발전을 위한 연구

( Yong Tao Zhang ) 전남대학교 지역개발연구소 2004 지역개발연구 Vol.36 No.2

Macrophages Promote Coal Tar Pitch Extract-induced Tumorigenesis of BEAS-2B Cells and Tumor Metastasis in Nude Mice Mediated by AP-1

Zhang, Peng,Jin, Yue-Fei,Zhang, Qiao,Wu, Yi-Ming,Wu, Wei-Dong,Yao, Wu,Wu, Yong-Jun,Li, Zhi-Tao,Zhao, Yong,Liu, Yu,Feng, Fei-Fei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12

Background: We sought to evaluate the role of tumor associated macrophages (TAMs) on the promotion of coal tar pitch extract (CTPE)-induced tumorigenesis of human bronchial epithelial cells (BEAS-2B) and tumor metastasis in nude mice, and related mechanisms. Materials and Methods: BEAS-2B cells were first treated with 2.4 mg/mL CTPE for 72 hours. After removal of CTPE, the cells were continuously cultured and passaged using trypsin-EDTA. THP-1 cells were used as macrophage-like cells. BEAS-2B cells under different conditions (n=6/group) were injected into the back necks of nude mice, and alterations of tumor xenograft growth, indicative of tumorigenicity, and tumor metastasis were determined. Pathological changes (tumor nests and microvascular lesions) of HE-stained tumor tissues were also evaluated. The expression of AP-1(c-Jun) in xenografts and metastatic tumors was determined using immunohistochemistry. Results: Tumor size and weight in nude mice transplanted with the mixture of CTPE-induced passage 30 BEAS-2B and THP-1 cells (2:1) were increased compared to those from the CTPE-treated BEAS-2B cells at passage 30 alone at different observation time points. Tumor metastasis to lymph nodes and liver was only detected after transplantation of a mixture the two kinds of cells. The numbers of tumor nests and microvascular lesions, and the expression levels of AP-1 (c-Jun) in tumors from the mixture of two kinds of cells were increased apparently in contrast to those in tumor from the CTPE-treated BEAS-2B cells of passage 30 alone. In addition, there was positive correlation between AP-1 (c-Jun) expression level and the number of microvascular lesions, or between AP-1 (c-Jun) expression level and tumor metastasis in these two groups. Conclusions: TAMs not only facilitate tumorigenesis transformation of CTPE-induced BEAS-2B cells, but also promote tumor growth, angiogenesis and metastasis in nude mice in vivo, which may be mediated by AP-1.

Mathematical Model Relating Dynamic Dewatering Process of Fresh Mortar and Its Composition

Tao Ji,Xiaoying Zhang,Xiong Zhang,Yong-juan Zhang,Caiyong Gu,Weihua Li 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.2

The composition and properties of raw materials have significant influences on water retention capacity of mortar, but the basic origin remains unclear. To clarify the movement of water inside mortar and the mechanism of water retention, the dynamic dewatering experiment was designed and the mathematical model describing the dewatering process of mortar was set up in this work. The model proved to be effective according to the results from dynamic dewatering experiment. The study demonstrated that capillary gradual contraction model is suitable for describing early dewatering process of fresh mortar and the parameters in the dewatering equation are relevant to the properties of raw materials, which certify that the model is of physical significance. Moreover, influencing factors such as water properties and binding materials properties were obtained and their relationship with water retention of mortar were discussed theoretically based on capillary gradual contraction model.

The Efficacy of Continuous Positive Airway Pressure Therapy on Nocturia in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Tao Wang,Wei Huang,Huantao Zong,Yong Zhang 대한배뇨장애요실금학회 2015 International Neurourology Journal Vol.19 No.3

Purpose: To assess the efficacy of the continuous positive airway pressure (CPAP) on nocturia in patients with obstructive sleep apnea (OSA). Methods: A literature review was performed to identify all published clinical trials of CPAP for the treatment of nocturia. The search included the following databases: MEDLINE, Embase, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated. Results: Five publications involving a total of 307 patients were used in the analysis, which compared the number of incidents of nocturia before and after CPAP treatment. We found that patients with OSA and nocturia who were treated with CPAP had a significant decrease in the frequency of nocturia and the volume of urine associated with it. The mean number of nocturia incidents (standardized mean difference [SMD], –2.28; 95% confidence interval [CI], –2.42 to –2.15; P<0.00001) and the associated urine volume (SMD, –183.12; 95% CI, –248.27 to –117.98; P<0.00001) indicated that CPAP was effective. Besides, the Epworth Sleepiness Scale (SMD, –5.88; 95% CI, –6.56 to –5.21; P<0.00001) and the CPAP apnea-hypopnea index (SMD, –31.57; 95% CI, –33.87 to –29.28; P<0.00001) indicated that CPAP significantly improved the quality of sleep. Conclusions: This meta-analysis indicates that CPAP maybe an effective treatment for reducing nocturia associated with OSA and improving the quality of life of such patients.

Clinical Study on Carboplatin for Treating Pediatric Patients with Wilms Tumors

Zhang, Yong,Sun, Ling-Li,Li, Tao,Sun, Hui,Mao, Guo-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

This analysis was conducted to evaluate the efficacy and safety of carboplatin based chemotherapy in treating pediatric patients with Wilms tumors. Methods: Clinical studies evaluating the efficacy and safety of carboplatin based regimens on response and safety for pediatric patients with Wilms tumors were identified using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In carboplatin based regimens, 4 clinical studies which including 127 patients with advanced Wilms tumors were considered eligible for inclusion. With this carboplatin based chemotherapy, 2 clinical studies included carboplatin, ifosfamide and etoposide. Systemic analysis suggested that, in all patients, the pooled PR was 64.5% (82/127) in carboplatin based regimens. Thrombocytopenia and leukocytopenia were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred with carboplatin based treatment. Conclusion: This systemic analysis suggests that carboplatine based regimens are associated with a reasonable response rate and accepted toxicities for treating pediatric patients with Wilms tumors.

Review of the Synthetic Techniques and Applications of the Quantum Dots/Graphene Composites

Yong Duan,Tianjian Zeng,Tao Sun,Ling Tong,Anran Chen,Jin Zhang,Rongfei Wang,Chong Wang,Yu Yang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.5

The Quantum Dots/Graphene (QDs/GR) composites have attracted numerous interests caused by its unique physical and chemical properties in past few decades. The shortages of the single QD and graphene materials could be remedied by the synergistic effects from QDs/GR composite materials; meanwhile, some unique phenomena and superior physical properties were also produced. The QDs/GR composites processed better photocatalytic activities, higher photon capture abilities and excellent optical responsibilities. Therefore, they were widely applied in various techniques. Here, we reviewed and discussed recent research progresses about the QDs/GR composites and focused on their industrial preparation and commercial applications. Among these synthetic methods, ion beam sputtering deposition (IBSD) and molecular beam epitaxy (MBE) were discussed in detail because they could be directly applied in commercial industry for preparing size-tunable quantum dots. In another part, the applications of the QDs/GR composites were also discussed, the advanced physical and chemical properties promoted these composites to have numerous potential for being applied in photodetectors, lithium ion batteries, solar cells, supercapacitors and other devices. The appropriate synthetic method for QDs/GR materials is highly dependent on the requirements of its applications. We firmly believe that the direct synthesis technique of ideal QDs/GR composite for specific applications is a challenge and research emphasis for scientist and engineers in future.

Motion Control Point Optimization of Dental Arch Generator

Zhang Yong-De,Gu Jun-Tao,Jiang Jin-Gang,Sun Xue-Lian 보안공학연구지원센터(IJUNESST) 2013 International Journal of u- and e- Service, Scienc Vol.6 No.5

Experimental and numerical investigation on the behavior of concrete-filled rectangular steel tubes under bending

Tao Zhang,Yong-zhi Gong,Fa-xing Ding,Xue-mei Liu,Zhi-wu Yu 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.78 No.3

Pure bending loading conditions are not frequently occurred in practical engineering, but the flexural researches are important since it’s the basis of mechanical property researches under complex loading. Hence, the objective of this paper is to investigate the flexural behavior of concrete-filled rectangular steel tube (CFRT) through combined experimental and numerical studies. Flexural tests were conducted to investigate the mechanical performance of CFRT under bending. The load vs. deflection curves during the loading process was analyzed in detail. All the specimens behaved in a very ductile manner. Besides, based on the experimental result, the composite action between the steel tube and core concrete was studies and examined. Furthermore, the feasibility and accuracy of the numerical method was verified by comparing the computed results with experimental observations. The full curves analysis on the moment vs. curvature curves was further conducted, where the development of the stress and strain redistribution in the steel tube and core concrete was clarified comprehensively. It should be noted that there existed bond slip between the core concrete and steel tube during the loading process. And then, an extensive parametric study, including the steel strength, concrete strength, steel ratio and aspect ratio, was performed. Finally, design formula to calculate the ultimate moment and flexural stiffness of CFRTs were presented. The predicted results showed satisfactory agreement with the experimental and FE results. Additionally, the difference between the experimental/FE and predicted results using the related design codes were illustrated.

Structural performance of GFRP-concrete composite beams

Yong Yang,Yicong Xue,Tao Zhang,Jing Tian 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.68 No.4

This paper presents the results of an experimental study on the structural performance of an innovative GFRP-concrete composite beam construction, which is reinforced with longitudinal GFRP pultruded box-profile and transverse steel stirrups. GFRP perfobond (PBL) shear connectors are employed to enhance the bonding performance between the GFRP profile and the concrete portion. To investigate the shear and flexural performance of this composite system, eight specimens were designed and tested under three-point and four-point bending. The main variables were the height of the composite beam and the shear span-to-depth ratio. The test results indicated that bonding cracks did not occur at the interface between the GFRP profile and the concrete until the final stage of the test. This shows that the specimens performed well as composite beams during the test and that the GFRP PBL connectors were reliable. Based on the test results, two calculation methods were used to determine the flexural and shear capacity of the composite beams. A comparative study of the test and theoretical results suggests that the proposed methods can reasonably predict both the flexural and shear capacities of the specimens, whereas the provisions of ACI 440 are relatively conservative on both counts.