Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

응급실에 내원한 환자에서 어지럼증의 원인과 임상양상의 분석

문원식,정경운,위준선,문정미,전병조,김용권,소정일,류진호,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: Recently, The number of patients who have been complaining of the vertigo or dizziness has been increasing due to rapid growth of elderly population and senile disease. The differentiation of dizzy patients is not familiar to most emergency physicians. This study was designed to differentiate true vertigo and to investigate the clinical difference among central vertigo, peripheral vertigo, and other causes of dizziness. Methods: The authors analyzed the cases of 237 dizzy patients who visited the emergency department of Chonnam University Hospital during the recent 2 years. For the base of dizziness, associated past illnesses, severity, nystagmus type, and the causes of central and peripheral vertigo. Results: Female patients were 142(59.9%) and male patients were 95(40.1%). The most common age group was the 6th decade. The origin of dizziness was classified as peripheral cause(25.3%), central cause(32.9%), and others(41.8%). As to nature of the dizziness, the rotatory sense was dominant in peripheral vertigo and the floating sense and blurred vision in central vertigo. Peripheral vertigo was triggered by position change of head and body, and central vertigo by the eye movement. Audiograms I showed that most patients with central vertigo had normal hearing, but 46.7% of thoswith peripheral vertigo had an abnormal hearing disturbance. Nystagmus was more prevalent in peripheral vertigo Conclusion: History taking and physical examination played an important role in the diagnosis of dizzy patients. An important part of the diagnosis of a dizzy patient could be to evaluate the peripheral origin, the central origin and others causes. Because central vertigo may be associated with a significant neurological pathology, spectral radiological studies, including MRI and CT, are mandatory to rule out a devastating brain lesion.

소화성 궤양 환자에 대한Lansoprazole의 치료 효과

정현용,김진희 최신의학사 1997 最新醫學 Vol.40 No.6

호수원의 상수원화를 위한 수처리 공정 개선에 관한 연구

정두식,이태진,이용택 경희대학교 환경연구소 1994 環境硏究 論文集 Vol.5 No.-

This study researched the improvement of water treatment process for lake water to drinking water. Especially, we examined water in Lake Shin Gal located nearby Kyung Hee University and investigated the possilbility of the treated water for drinking purpose. Analysis of the treated water gave the satisfactory results for the standard values of drinking water except the several items. However, the water pollution will become serious if the number of factories increase. Therfore, in order to keep possibility of the water in Lake Shin Gal, the number of factories musts be restricted and the application of membrane separation process with general water treatments must be considered.

도메인이름의 無斷占有 關聯 새로운 立法에 對한 小考

鄭震溶 법무부 2004 선진상사법률연구 Vol.- No.24

A Specific Domain name is only exsisting one through the world. Therefore as what the Domain name is, there is possibility which many people wants to register the Domain name at the same time. By not having restrict, the Domain name is registered by the rules of "first come, first served". And once it is registered, the man who registered it has a monopoly status and uses it over and over just by renual. Because of this, a conflict arises between the Domain name registrant and the trade mark possessors. The trademark possessors have tried to solve this problems by the Trademarks Law and the Unfair Competition Law. But these laws were not enacted for this Domain name dispute, The trademark possessors have been through so many difficulties till this time especially on the matter of cybersquatting. So Korea enacted the Internet Domain Name Law on 29 January 2004, and remanded the Unfair Competition Law on 20 January 2004 which restrict cybersquatting. This treatise is written to think about the problems that happen when the existing Trademarks Law and the Unfair Competition Law are applied to cybersquatting, the way that we construct new Internet Domain Name Law and Unfair Competition Law which is not applied to real case yet, the problems that new Internet Domain Name Law and Unfair Competition Law have. 상표권자에게 판매할 목적 또는 상표권자의 등록을 방해할 목적 등의 부정한 목적으로 상표권자의 상표와 동일 또는 유사한 도메인이름을 등록만 하였을 뿐 그 도메인이름 하에 웹사이트를 개설하지 않았거나 개설하였다 할지라도 웹사이트에 실질적인 내용이 없는 경우를 상표법, 부정경쟁방지법 등의 기존 법률로 규율할 수 있는가에 대하여 많은 논의가 행하여졌으나 학설, 판례는 이하에서 설명하는 것과 같은 이유로 이를 부정하는 것이 일반적이었다. 이에 2004. 1. 20. 법률 제7095호로 개정된 부정경쟁방지법 제2조 제1호 아목과 2004. 1. 29. 법률 제7142호로 제정된 인터넷주소자원에관한법률 제12조는 도메인이름의 무단점유에 대한 구제수단을 규정하고 있다. 이러한 시점에 쓰여진 이 논문은 도메인이름의 무단점유에 기존의 상표법, 부정경쟁방지법을 적용하면 어떠한 문제가 발생하기에 위와 같은 새로운 입법이 있었던 것인지를 살핀 후, 국내에서는 아직 적용 사례가 없는 부정경쟁방지법 제2조 제1호 아목, 인터넷주소자원에관한법률 제12조의 요건을 어떻게 해석할 것인가를 통일도메인이름분쟁해결방침(Uniform Domain Name Resolution Policy, 이하 "UDRP"라 한다), 반사이버스쿼팅소비자보호법(Anticybersquatting Consumer Protection Act, 이하 "ACPA"라 한다) 등의 적용사례에 비추어 생각하여 보고, 2중 입법의 의문, 등록이전청구권의 부재, UDRP결정에 대한 불복수단의 부재등 새로운 입법의 문제점에 대하여 생각하여 보는 것을 목적으로 작성되었다.

감과실에서 분리한 효모의 특성

정용진,김주현,이명희 東國專門大學 1997 金龜論叢 Vol.4 No.1

감과실에서 분리하여 탄닌물질에 내성이 있고 알콜발효력이 우수한 Saccharomyces cerevisiae YJK 20과 Saccharomyces kluyveri DJ 97의 배양학적 특성을 조사하였다. 그 결과 배양은도 30℃ YJK 20, DJ 97은 알콜수율이 95.62%, 94.43%로 가장 높았으며, 초기 pH의 영향은 YJK 20은 pH 6.0에서 DJ 97은 pH 5.0에서 각각 95.76%, 95.23%로 가장 높았다. 그리고 진탕속도의 영향은 두균주 모두 150rpm 이상에서 수율이 감소하는 경향이었다. 또한 초기 당농도에 의한 영향에서는 YJK 20은 150g/ℓ의 농도에서 97.55%, DJ 97은 100g/ℓ의 농도에서 96.55%로 가장 높은 수율을 나타내었다. 따라서 두균주는 식초의 기질이 되는 감알콜발효의 수율을 높일 수 있는 우수한 균주로 선별할 수 있었다.

"부유" 단감의 묘목 생산에 관한 연구

정순재,이용재,김혜진,이영병,이용문 東亞大學校附設 農業生命科學硏究所 1999 農業生命資援硏究 Vol.8 No.1

'부유' 단감의 접목시기별 묘목의 생장과 토양 깊이별 접목 후의 생장을 알고자 시험한 결과는 다음과 같다. 대목싹은 접목시기가 늦을수록 많은 경향을 나타내었다. 접목 활착율은 시기별로 보아 5월 21일까지는 차이가 없었고 5월 30일은 7%정도 약간 낮았다. 접목일수와 접목활착일의 차이는 접목시기가 늦을수록 단축되었다. 접목 일자가 빠른 4월 25일, 5월 1일 접목구의 신초장은 상지보다 하지가 5.17cm 5.33cm가 더 길었다. 그리고 그 외는 대부분 상지가 하지보다 좋은 현상을 나타내었다. 시기별 접목에 관계하지 않고 근의 직경이 큰 구가 신초 신장이 큰 효과를 나타내었다. 토양의 깊이별 묘목 생장은 25cm 구가 신초의 직경이 크고 신초장이 가장 길었다. The study was conducted to assess the growth and development of 'Fuyu' grafted nursery plant according to various grafting time and soil depth. The earlier grafting time was taken, the more shoots were got rid. The cv. 'Fuyu' was grafted on the rootstock of Kyungsan Bansi cv. After grafting, graft-take rates was not showed any difference until on may 21 however it was little bit low on may 30. The later grafting time was taken, the more graft-take days were shortened. Bottom shoot length of scion was 5.17cm longer than top's on April 25 and 5.33cm longer than top's on April 1. Top shoot length was longer than bottom shoot length most of other days. The growth and development of persimmon seeding was related to root weight. The growth and development of persimmon tree according to the soil depth showed beter results in the 25cm treatment than any other treatments.

Multiple Spinal Intradural Schwannomas Combined with Sequestered Lumbar Disc Herniation

김대용,김진욱,정주호,조재훈 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

In this report, we describe a case of multiple intradural schwannomas in the spine combined with a upward sequestered disc herniation at L4-L5. It is often difficult to differentiate this tumor from lumbar disc herniation, especially a sequestered hernia. Gadolinium-enhanced MR images were a useful preoperative examination modality for differentiating these lesions from other diseases. Microscopically, the intradural tumors were successfully removed. The dura maters of the L2 and S1 were opened microsurgically, allowing the nerve fibers involved in the tumor to be identified. The involved fibers were cut around the tumor, and the lesion was resected while the intact nerve fibers were preserved. An upward sequestered lumbar disc herniation at L4-L5 was also successfully removed. Based on histological examination of the resected specimen, the tumors were diagnosed as schwannomas. Microsurgery allowed the tumors to be removed with minimal impairment from cutting of nerve fibers in the each nerve root.

둔상에 의한 기관지 파열 1례

정진용,심성보,권종범,박건 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

Traumatic rupture of the major airways may be caused by blunt or penetrating injury. The incidence of blunt trauma has risen dramatically in this century with the increase in modern high-velocity transportation. Clinical presentation of bronchial injuries in blunt trauma is varied, and the initial diagnostic evaluation is often misleading. The emphasis in management of these injuries is on early diagnosis and intervention. We experienced a case of bronchial rupture caused by blunt trauma. A 5-year-old male visited Emergency Room complaining of severe dyspnea and chest pain after traffic accident. Chest X-ray showed left tension pneumothorax. After emergent closed-thoracostomy, persistent air leakage and collapse of the left lung were noted. Chest CT revealed cut-off of left main bronchus and "dropped lung". Bronchoscopic examination confirmed the rupture of left main bronchus including proximal part of upper lobe bronchus. The patient underwent left upper lobectomy and bronchoplasty by using interrupted 4-0 Vicryl sutures. The postoperative course was uneventful.