새로운 Ca^2+ 길항제의 혈압강하효과

함원훈,임태균,정윤성,정윤호,양재권,최원철 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1

Diltiazem and nifedipine, have been used throughout the world as an effective antianginal and antihypertensive agent. In order to increase the activity of these drugs, we synthesized the diltiazem-nifedipine coupling compounds. These compounds^(1-8) were tested for antihypertensive effect. Unfortunately, these compounds didn't show any promising activities.

ER유체를 이용한 댐퍼의 설계 및 성능에 관한 연구

박성태,양헌석 울산대학교 2001 공학연구논문집 Vol.32 No.1

본 논문에서는 ER(electrorheological)유체의 동역학적 특성치를 실험적으로 구하고, 그 특성치와 빙햄 플라스틱 모델을 이용한 ER댐퍼의 해석 방법을 제시하였다. 또한 실린더형상의 전극을 가지는 Poiseuille 유동형 ER댐퍼에 대하여 평판 모델에 의한 근사적 해석과 실린더 모델의 해석결과를 비교하였다. 그리고 실제 Poiseuille유동형 ER댐퍼의 설계 및 제작으로 그 성능에 대한 고찰과 이러한 모델의 타당성을 검증하였다. 동시에 속도뿐만 아니라 전기장의 제어로도 넓은 범위의 감쇠력이 제어 가능함을 알 수 있었다. 따라서 본 연구를 통해 ER댐퍼의 성능에 대한 고찰과 제시된 해석 방법은 ER댐퍼의 초기 설계에 직접 응용될 수 있을 것이다. In this paper, the dynamic properties of ER(electrorheological) fluid and the analysis technique of ER damper using Bingham plastic model were presented. And approximation parallel plate model was introduced for Poiseuille flow ER dampers with cylindrical geometry. The approximation parallel plate model analysis compared with the cylindrical axisymmetric model analysis. To validate this analysis, the Poiseuille flow ER damper was designed, fabricated and tested. Also the result of test with ER damper showed that the damping force of ER damper was varied with the piston velocity and the intensity of electric field. Therefore the proposed analysis technique which is using Bingham plastic model can be used for initial development stage of ER damper. Key Words : Bingham plastic model, ER(electrorheological) fluid, Poiseuille mode

예도(銳刀)의 미시사적 관점으로 바라본 무예실제에 관한 분석

송일훈,이태현,장성호,장경태,김대양 龍仁大學校 武道硏究所 2011 武道硏究所誌 Vol.22 No.1

예도(銳刀)에 관한 보다 정확한 고찰은 오늘날 전통무예단체들이 『武藝圖譜通志』를 통한 전통무예의 실제를 복원 및 재현함에 있어 크나큰 도움이 될 것이다. 이는 예도(銳刀)가 전통무예사에 대한 단초적 역할을 제공할 수 있는 초석이 될 수 있기 때문이다. 따라서 이 연구에서는 예도의 설(說: 해설(解說))과 기(技: 기예(技藝))의 형식적 분석과 전통무예의 복원에 관한 이론적 배경을 정립하기 위하여 고서와 도록 등의 다양한 자료를 검토‧분석하였는데 이는 다음과 같은 결론을 도출하였다. 첫째, 예도(銳刀)의 종합적 분석을 통한 예도의 형식은 병기도식(兵器圖式)․설(設) 11개․예도보(銳刀譜)․예도총보(銳刀總譜)와 예도총도(銳刀總圖)로 구성되어 있음을 알았다. 둘째, 예도는 본국검과 더불어 조선을 대표하는 한국 고유의 전통검법으로 임진왜란을 계기로 새롭게 발굴 정립되었으며 정조가 재위했던 1800년대까지 약 200년 걸쳐 전승되면서 민족의 재산과 생명을 지켜왔던 국방무예(24반 무예)였다. 셋째, 국난을 극복하고 국토를 수호하려는 선조들의 의지로 완성된 24반 무예 속에 녹아 든 활달한 몸짓 속에는 민족자존의 의지와 불굴에 투혼이 배어 있다. 이와 같이 오늘날 한․중․일의 칼 쓰는 법을 비교해 볼 때, 『武藝圖譜通志』의 예도가 갖는 의미와 가치는 대단히 귀중하다 할 수 있겠다. 이상과 같이 종합해 볼 때, 앞으로 이 한국무예 예도(銳刀)에 관한 심도 있는 연구가 이루어질 때 비로소 예도(銳刀)가 세계적인 보편무예로 발전하는 중요한 기반이 될 것으로 기대하는 바이다.

차체구조용 박육부재의 정적 압궤특성에 관한 실험적 연구

임성훈,김태식,양광영 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1

In this paper, collapse test of thin-walled structural member widely used for automobiles is carried out under static compression load to observe the effects of cross-sectional shape and material on the absorbing-energy capacity in the viewpoint of crashworthiness. specimens tested consist of two sorts(Aluminium, CFRP) and configurations(Cylinder, Square) with variation in thickness. Also, comparisons of Al cylinder and square specimens are made th find the influence of difference in shape on the absorbing-energy capability according as the thickness of specimen varies.

잡음환경을 적용한 음성인식기 구현

김태윤,권태휘,권영헌,양성일,이건상 한양대학교 이학기술연구소 2002 이학기술연구지 Vol.4 No.-

조용한 환경에서 훈련된 음성인식시스템은 여러 종류의 잡음이 섞인 실생활에서 적용될 경우 급격히 성능이 저하된다. 본 연구에서는 여러 대역별 소음을 추가한 음성으로 훈련된 모델들을 가지고서, 다양한 잡음에 대한 인식실험을 수행하여 잡음환경에 따른 인식률의 상관관계를 구하였다. 깨끗한 음성에 비해 40-45snr의 잡음을 인식엔진에 추가하였을 경우 17%의 인식률 향상을 보였다. A Speech recognition systems trained in the silent environment may seriously degrade performance at real world wit various. In this paper, we make a recognition experiment for the various noises using the model trained with a multiple range of noises and find the correlation between noise environment and recogniton rate. Comparing with clean speech, there is an impovement by 17% when we insert noise into recognition engine with 40-45snr

3차 의료기관 응급실로 내원한 안면부 열상 환자에 대한 임상적 고찰

김양원,안성훈,류석용,김홍용,전병민,김기태 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: Facial laceration is a common clinical problem in the emergency room that is frequently associated with other craniofacial injuries. It elicits an emotional response from the patient because of the underlying concern of permanent scar and secondary facial disfigurement, so they demand prompt and adequate treatment. The aim of this study is to analyze the incidence, etiology, depth, and site of facial lacerations to provide basic data for further understanding. Method: This study reviewed 1,043 facial-laceration patients treated in the emergency room at Pusan Paik Hospital between March 1999 and February 2000. This retrospective study was done by reviewing and analyzing the sex and age distributions, the monthly and daily distributions, the causes of injury, the types of injury, the sites of injury, the lengths of the lacerations, and associated injuries. Results: The sex ratio of men to wemen was 2.4:1, and the 0~10 age group was at the top of the age distribution. The number of patients was the highest on sundays and during March. About 9.2% of the patients visited the emergency room between 10:00 P.M. and 11:00 P.M. Falls(38.1%) were the most common cause of facial laceration, and deep laceration(51.8%) was the most common type of facial laceration. The most common laceration site was the forehead, followed by the chin and the nose. The most common associated craniofacial injury was facial bone fracture(39%), Facial-lacerations were sutured by plastic surgeons(80%), emergency physicians(10%), and oromaxillofacial surgeons(10%). We found statistical significance in the types and lengths of lacerations between men and women, among age groups(p<0.05). Conclusion: Facial laceration is one of the most common craniofacial injuries in the emergency room. By now, most lacerations have been repaired by plastic surgeons, But, the causes of lacerations are diverse and many patients are admitted due to the associated injuries. Therefore, emergency physicians should participate more aggressively in the care of facial-laceration patients to improve the outcome of the patients.

하지수술에서 희석된 고비중 Bupivacaine의 효과

소금영,양인호,안태훈,이준영 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Background: Although lidocaine seems to be one of the most suitable spinal anesthesias for ambulatory surgery, the safety of lidocaine spinal anesthesia has been called into question by report of both permanent and transient neurologic toxicity. The purpose of this study is to investigate the possibility of adapting the longer acting spinal bupivacaine in short duration of lower extremity operation. Methods: Forty five patient were randomly assigned to three groups for spinal anesthesia, Group Ⅰ (15㎎ bupivacaine), 3㎖ of 0.5% spinal bupivacaine in 8% dextrose; Group Ⅱ (10㎎ bupivacaine), 2㎖ of the 0.5% spinal bupivacaine +1㎖ saline; Group Ⅲ (7.5㎎ bupivacaine), 1.5㎖ of the 0.5% spinal bupivacaine +1.5㎖ saline. Dural puncture were performed at the L3-L4 with 25 gauge needle in lateral position after which the patients were turned to the supine horizontal position. We checked peak sensory level and height, time to two segment regression and S2 sensory regression via pin-prick test and motor block level by modified Bromage scale. Results: There were significantly difference with regard to peak sensory level and height, time to two segment regression and S2 regression, and motor blockade level between Group Ⅰ, Ⅱ and Group Ⅲ. Conclusions: Dilute Bupivacaine in spinal anesthesia provided the combination of adequate depth of anesthesia and rapid recovery. We conclude that 0.5% bupivacaine 7.5㎎ with normal saline 1.5㎖ is effective in spinal anesthesia for short-duration lower extremity surgery.

신혈역학적 상황에 따른 수출소동맥 저항의 사구체여과율에 미치는 영향

민영기,김태웅,양훈모 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

It is generally known that efferent arteriolar constriction increases GFR. However, it has been shown in methemadical studies that increases in efferent arteriolar resistance beyond some extent causes GFR to decrease. The aim of the present study was to investigate the possibility that the deterioration of GFR by efferent constriction occurs in physiological and/or pathophysiological conditions. The renal hemodynamic data obtained by several investigators were analyzed with a mathematical model of single nephron GFR (SNGFR). The data analyzed are from rats which has been shown to achieve filtration pressure equilibrium (FPE) during filtration along the glomerular capillary. The glomerular model is based on a simulation of flow along a glomerular capillary with negligible resistance and uniform ulitrafiltration coefficient (Kf, 0.09 nl·sec-1·mmHg-1). The hemodynamic states of rat kidney is characterized by a high Kf and low RBF and high vascular resistance. In these animals, inhibition of the renin-angiotensin system was associated with increases in GFR. This was mainly contributed to by the increase in Kf. Analysis with the present model has shown that lowered efferent arteriolar resistance during angiotensin inhibition augmented GFR response to Kf. The analysis of the data obtained by manipulating efferent resistance during aortic constriction demonstrated the important of pregiomerular resistance(RPRE) relative to efferent resistance(RE). in this hemodynamic condition. The FPE which determines the sensitivity of SNGER to SNBF and Kf is attained nearer the afferent end as RPRE increases further: On the other hand, RPRE had no effect on FPE. In conclusion, certain physiological manipulation affects RPRE and Kf in such fashion that a decrease in RE may have a beneficial effect on GFR and vice versa. This analysis indicates that it is not limited to theoretical importance; it demonstrated that in rat kidney which has low flow and high afferent resistance the efferent arteriolar dilation can be associated with the promotion of GFR.

5일 보존용 채혈백에 따른 보존일자별 농축혈소판의 생화학 및 성상 분석

이동범,유태종,김태전,김승곤,신종관,양대형,고광임,박성훈 임상병리검사과학회 2002 임상병리검사과학회지 Vol.34 No.2

Biochemical changes and icon of platelets on platelet concentrates preserved for a 5day term in several plastic containers were investigated. The authors evaluated the TOTM-PVC second generation container produced by Green Cross Medical Corp. and Boin medica. Blood obtained from 40 persons was manufactured for platelet concentrates within 4 hours and each divided into 20 units of platelet concentrations. Samples were taken at 0, 3, and 5days and the platelet count, pH, pO_(2), pCO_(2), HCO_(3)-, glucose, LDH, lactate, electrolytes, and mineral element were tested The number and MPV, for platelets icon, were well preserved on two different platelet concentrates during storage. A test for biochemical function appeared to be effective data. pH was maintained above 6.8 on two different platelet concentrates during storage. The results suggest that the TOTM-PVC second generation platelets storage container produced by Green Cross Medical Corp. and Boin medica was able to preserve platelets for at least five days without lesion and was it concluded to have biochemical efficacy on patients with transfusions.

미소결함의 형상인식을 위한 디지털 신호처리 적용에 관한 연구

김재열,홍석주,이규태,김병현,김훈조,김양중 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.1

In this study, the classified researches the artificial and natural flaws in welding pails are performed using the pattern recognition technology. For this purpose the signal pattern recognition package including the user defined function was developed and the total procedure including the digital signal processing, feature extraction, feature selection and classifi-er selection is treated by bulk. Specially it is composed with and discussed using the statistical classifier such as the linear discriminant function the empirical Bayesian classifier. Also, the pattern recognition technology is applied to classifica-tion problem of natural flaw(i.e multiple classification problem - crack, lack of penetration, lack of fusion, porosity, and slag inclusion, the planar and volumetric flaw classification problem). According to this results, it is possible to acquire the recognition rate of 83% above even through it is different a little according to domain extracting the feature and the classifier.