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Luciferase Assay to Screen Tumour-specific Promoters in Lung Cancer
Xu, Rong,Guo, Long-Jiang,Xin, Jun,Li, Wen-Mao,Gao, Yan,Zheng, You-Xian,Guo, You-Hong,Lin, Yang-Jun,Xie, Yong-Hua,Wu, Ya-Qing,Xu, Rui-An Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Objective: Specific promoters could improve efficiency and ensure the safety of gene therapy. The aim of our study was to screen examples for lung cancer. Methods: The firefly luciferase gene was used as a reporter, and promoters based on serum markers of lung cancer were cloned. The activity and specificity of seven promoters, comprising CEACAM5 (carcinoembryonic antigen, CEA), GRP (Gastrin-Releasing Peptide), KRT19 (cytokeratin 19, KRT), SFTPB (surfactant protein B, SP-B), SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA), SELP (Selectin P, Granule Membrane Protein 140kDa, Antigen CD62, GMP) and DKK1 (Dickkopf-1) promoters were compared in lung cancer cells to obtain cancer-specific examples with strong activity. Results: The CEACAM5, DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB promoters were cloned. Furthermore, we successfully constructed recombinant vector pGL-CEACAM5 (DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB) contained the target gene. After cells were transfectedwith recombinant plasmids, we found that the order of promoter activity from high to low was SERPINB3, DKK1, SFTPB, KRT19, CEACAM5, SELP and GRP and the order for promoters regarding specificity and high potential were SERPINB3, DKK1, SELP, SFTPB, CEACAM5, KRT19 and GRP. Conclusion: The approach adopted is feasible to screen for new tumour specific promoters with biomarkers. In addition, the screened lung-specific promoters might have potential for use in lung cancer targeted gene therapy research.
An Exploration of Underlying Consciousness of Chuan Di Xia′s Settlement Environment
Xu, Xian-sheng Korean Institute of Landscape Architecture 2001 Journal of the Korean institute of landscape archi Vol.1 No.-
Beijing Chuan Di Xia can be traced back to Ming and Qing Dynasties. It is located beside the old post way in the west of Beijing. At present, there are more than seventy units of traditional courtyard houses of Ming and Qing Dynasties and the antique features of the surroundings still survive. The dwelling suited to the historical and regional context and the profound cultural values accumulations etc., have precious historic and cultural values. Associated with the investigation of Chuan Di Xia, the paper explores the site selection, the layout, the spatial constructiveness and the underlying consciousness of Chinese traditional dwellings, unveils the common philosophic basis of traditional dwellings and offers new though for sustainable human settlements.
Xu Liao,Xian Li,Yu-Ming Xu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.2
To evaluate the fracture behavior of steel structures under some severe corrosion environments, experiments on eight artificially pitting corroded Q345 steel plates and numerical investigations on 200 finite element models of randomly pitting damaged steel were conducted. The effects of the distribution, diameter and depth of the corrosion pits on the tensile behavior were investigated and a probability density function of randomly pitting corroded steel strength was developed. The results indicate that both the yield strength and the ultimate strength of steel plates with random pitting corrosion were lower than those of uniformly corroded steels with the same corrosion ratios. The effects of pitting depth on the yield strength and the ultimate strength were more significant than those of pitting diameter. The influences of pitting distribution on ultimate strength were greater than that on yield strength. The residual tensile strength of steel plates with random pitting corrosion was found to well conform to the Gamma distribution, and thus the probability density functions of the residual yield strength and the ultimate strength were proposed based on the Gamma distribution.
Xian Xu,Shaoxiong Huang,Tingting Shu,Yafeng Wang,Yao-Zhi Luo 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.4
A two-step topology-fi nding method based on mixed integer programming and nonlinear programming is proposed for tensegrity structures. In the fi rst step, feasible and symmetric strut connectivities are obtained through a ground structure method combined with mixed integer programming; in the second step, the cable connectivities are optimized through nonlinear programming to obtain a feasible tensegrity structure. The same ground structure used in the fi rst step is adopted in the second step, which is benefi cial to fi nd a more symmetric cable layout. The independent continuous mapping method is used in the second step to convert the 0–1 binary variables of cable connectivities to continuous variables to transform the combinatorial optimization problem into a nonlinear programming problem. The number of strut lengths is adopted as a control parameter and a symmetry objective function is proposed to generate a variety of regular and symmetric tensegrity structures. A multi-stage computation scheme is proposed to improve the computational effi ciency. Typical examples are carried out to validate the proposed method. The computational effi ciency of the method is benchmarked with existing methods fully based on mixed integer programming. Results demonstrate that the computational effi ciency of the proposed method is signifi cantly improved compared to the existing methods.
Xu, Hao,Mei, Xiao-Peng,Xu, Li-Xian The Korean Dental Society of Anesthsiology 2018 Journal of Dental Anesthesia and Pain Medicine Vol.18 No.1
In recent years, with continuous research efforts targeted at studying the effects of pre- and after-treatment of inhaled anesthetics, significant progress has been made regarding the common clinical use of low concentrations of inhaled sevoflurane and its effect on induced central ischemia tolerance by pre- and post-treatment. In this study, we collected, analyzed, classified, and summarized recent literature regarding the effect of sevoflurane on central ischemia tolerance and its related mechanisms. In addition, we provide a theoretical basis for the clinical application of sevoflurane to protect the central nervous system and other important organs against ischemic injury.
Xu, Hao,Mei, Xiao-Peng,Xu, Li-Xian The Korean Dental Society of Anesthsiology 2017 Journal of Dental Anesthesia and Pain Medicine Vol.17 No.1
Cleft palate is one of the most common congenital malformations of the oral and maxillofacial region, with an incidence rate of around 0.1%. Early surgical repair is the only method for treatment of a cleft lip and palate. However, because of the use of inhalation anesthesia in children and the physiological characteristics of the cleft palate itself combined with the particularities of cleft palate surgery, the incidence rate of postoperative emergence agitation (EA) in cleft palate surgery is significantly higher than in other types of interventions. The exact mechanism of EA is still unclear. Although restlessness after general anesthesia in children with cleft palate is self-limiting, its effects should be considered by clinicians. In this paper, the related literature on restlessness after surgery involving general anesthesia in recent years is summarized. This paper focuses on induction factors as well as prevention and treatment of postoperative restlessness in children with cleft palate after general anesthesia. The corresponding countermeasures to guide clinical practice are also presented in this paper.
Modeling and Simulation of the Magnetic Method for High Voltage Direct Current Inspection Robot
Xian-jin Xu,Cheng-hui Liu,Yu Yan,Hao-da Chen,Lei Fang,Yun-long Wang,Long-hui Wu 한국자기학회 2018 Journal of Magnetics Vol.23 No.3
In order to solve the slipping problem of a two-arm-wheel combined inspection robot, a maglev system based on the magnetic field of a high voltage direct current (HVDC) is proposed. The magnetic system comprises of two parts: a magnetic levitation system and a magnetic drive system. The levitation component overcomes the gravity of the robot by the Ampere force generated by current-carrying coils in the magnetic field of HVDC. The drive component utilizes the Ampere force generated by current-carrying coils in the magnetic field of HVDC as the driving force. Simulation results of the model are compared with the calculated values. The results show that the magnetic levitation method and the magnetic drive method are theoretically feasible, and the model is accurate and effective, which is of great practical significance to the physical realization of the inspection robot.
Xian Gaopeng,Huang Rong,Xu Minhui,Zhao Hengli,Xu Xingbo,Chen Yangchao,Ren Hao,Xu Dingli,Zeng Qingchun 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Calcific aortic valve disease (CAVD) is becoming an increasingly important global medical problem, but effective pharmacological treatments are lacking. Noncoding RNAs play a pivotal role in the progression of cardiovascular diseases, but their relationship with CAVD remains unclear. Sequencing data revealed differential expression of many noncoding RNAs in normal and calcified aortic valves, with significant differences in circHIPK3 and miR-182-5p expression. Overexpression of circHIPK3 ameliorated aortic valve lesions in a CAVD mouse model. In vitro experiments demonstrated that circHIPK3 inhibits the osteogenic response of aortic valve interstitial cells. Mechanistically, DEAD-box helicase 5 (DDX5) recruits methyltransferase 3 (METTL3) to promote the N6-methyladenosine (m6A) modification of circHIPK3. Furthermore, m6A-modified circHIPK3 increases the stability of Kremen1 (Krm1) mRNA, and Krm1 is a negative regulator of the Wnt/β-catenin pathway. Additionally, miR-182-5p suppresses the expression of Dickkopf2 (Dkk2), the ligand of Krm1, and attenuates the Krm1-mediated inhibition of Wnt signaling. Activation of the Wnt signaling pathway significantly contributes to the promotion of aortic valve calcification. Our study describes the role of the Krm1-Dkk2 axis in inhibiting Wnt signaling in aortic valves and suggests that noncoding RNAs are upstream regulators of this process.