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( Milljae Shin ),( Doopyo Hong ),( Zhengyun Zhang ),( You Min Kim ),( Wookjong Lee ),( Jong Man Kim ),( Choon Hyuck David Kwon ),( Jae Won Joh ),( Sung Joo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Purpose: Erythropoietin (Epo), through its specific erythropoietin receptor (Epo-R) may induce responses in a variety of non-hematopoietic tissues including malignant cells. In this study, we examined the expression of Epo-R in hepatocellular carcinoma (HCC) and tested the correlations of Epo-R expression with clinicopathological properties of HCC and with tumor recurrence. Methods: The study included 134 patients who underwent curative hepatectomy for HBV-related primary HCC. The medical records and laboratory or pathologic data from these patients were collected and analyzed. The expression of Epo-R mRNA and protein were evaluated by RT-PCR and western blot analysis, respectively. Results: We found intense expression of Epo-R mRNA in both non-tumor cirrhotic liver and HCC. Expression of Epo-R mRNA in the cirrhotic liver correlated significantly and negatively with tumor size, and positively with tumor cell differentiation and p53 staining; Epo-R mRNA expression in the HCC correlated with differentiation and p53 staining. The expression of Epo-R mRNA in cirrhotic liver or HCC was positively correlated with disease-free survival. Tumor recurrence showed stronger dependence on the expression of Epo-R protein in non-malignant cirrhotic liver than in the HCC. Conclusion: In HBV-related HCC, levels of Epo-R mRNA and protein in the non-malignant cirrhotic liver were positively correlated with tumor cell differentiation and p53 expression, which are favorable predictors of disease-specific survival.