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( Sun-wei Guo ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
In the last two decades, numerous genetic association studies, including genome-wide genetic association studies, aimed to identify DNA variants conferring risk of endometriosis have been published and many polymorphisms have been identified. However, each and every one of the identified polymorphism invariably has a small, even miniscule, effect on the risk of developing endometriosis, explaining merely a minute percentage of the heritability. More disconcertingly, these publications have so far contributed little, if any, to our understanding of the pathogenesis or pathophysiology of endometriosis. As with many other complex diseases or traits, there have been a glaring gap between the estimated heritability of the disease and the disease risk variability that can be explained by the identified DNA variants, a phenomenon called “the missing heritability”. In this talk, I shall first provide a primer on genetic studies of complex diseases such as endometriosis, explaining the methods for demonstration of genetic components for a disease, and methods to identify the genes or genetic variants, and then provide some explanations as why there are so much heat but not much light in this field.
Transmembrane Protein 166 Expression in Esophageal Squamous Cell Carcinoma in Xinjiang, China
Sun, Wei,Ma, Xiu-Min,Bai, Jing-Ping,Zhang, Guo-Qing,Zhu, Yue-Jie,Ma, Hai-Mei,Guo, Hui,Chen, Ying-Yu,Ding, Jian-Bing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Objective: Transmembrane protein 166 (TMEM166) expression in esophageal squamous cell carcinoma (ESCC) and remote normal esophageal tissues was examined to assess any role in tumour biology. Methods: TMEM166 mRNA expression in 36 cases with ESCC (36 tumour samples, 36 remote normal esophageal tissue samples) was detected by RT-PCR. TMEM166 protein expression was analysed in paraffin-embedded tissue samples from the same cases by immunohistochemistry. Results: Semi-quantitative analysis showed TMEM166 mRNA expression in ESCCs to be significantly lower than in remote normal esophageal tissues ($0.759{\pm}0.713$ vs. $2.622{\pm}1.690$, P=0.014). TMEM166 protein expression was also significantly reduced (69.4% vs. 94.4%, P<0.01). Conclusion: TMEM166 mRNA and protein expression demonstrated significant reduction in ESCCs compared with remote esophageal tissues, albeit with no correlation with tumour size, differentiation, stage, and lymph node metastasis, suggesting a role in regulating autophagic and apoptotic processes in the ESCC.
Analysis the role of arabidopsis CKRC6/ASA1 in auxin and cytokinin biosynthesis
Dong-Wei Di,Lei Wu,Pan Luo,Li Zhang,Tian-Zi Zhang,Xue Sun,Shao-Dong Wei,Chen-Wei An,Guang-Qin Guo 한국식물학회 2016 Journal of Plant Biology Vol.59 No.2
The crosstalk between auxin and cytokinin (CK) is important for plant growth and development, although the underlying molecular mechanisms remain unclear. Here, we describe the isolation and characterization of a mutant of Arabidopsis Cytokinin-induced Root Curling 6 (CKRC6), an allele of ANTHRANILATE SYNTHASE ALPHA SUBUNIT 1 (ASA1) that encodes the á-subunit of AS in tryptophan (Trp) biosynthesis. The ckrc6 mutant exhibits root gravitropic defects and insensitivity to both CK and the ethylene precursor 1-aminocyclopropane-1-carboxylicacid (ACC) in primary root growth. These defects can be rescued by exogenous indole-3-acetic acid (IAA) or tryptophan (Trp) supplementation. Furthermore, our results suggest that the ckrc6 mutant has decreased IAA content, differential expression patterns of auxin biosynthesis genes and CK biosynthesis isopentenyl transferase (IPT) genes in comparison to wild type. Collectively, our study shows that auxin controls CK biosynthesis based on that CK sensitivity is altered in most auxin-resistant mutants and that CKs promote auxin biosynthesis but inhibit auxin transport and response. Our results also suggest that CKRC6/ASA1 may be located at an intersection of auxin, CK and ethylene metabolism and/or signaling.
Interactions between Filamin A and MMP-9 Regulate Proliferation and Invasion in Renal Cell Carcinoma
Sun, Guo-Gui,Wei, Cui-Da,Jing, Shao-Wu,Hu, Wan-Ning Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
This study aimed to analyze the expression, clinical significance of filamin A (FLNA) in renal cell carcinoma (RCC) and biological effects in a cell line by regulating FLNA expression. Immunohistochemistry and Western blotting were used to analyze FLNA protein expression in 70 cases of RCC and normal tissues to study the relationship with clinical factors. FLNA lentiviral and empty vectors were transfected into RCC to study the influence of up-regulated expression of FLNA. FLNA siRNA was transiently transfected into ACHN kidney carcinoma cells by a liposome-mediated method and protein was detected by Western blotting. The level of expression was found to be significantly lower in RCC than normal tissues (p<0.05). No correlation was noted with gender, age, tumor size or pathological types (p>0.05), but links with lymph node metastasis, clinic stage and histological grade were noted (p<0.05). Loss of FLNA expression correlated significantly with poor overall survival time by Kaplan-Meier analysis (p<0.05). Results for biological function showed that ACHN cells transfected with FLNA had a lower survival fraction, significant decrease in migration and invasion, higher cell apoptosis, higher percentage of the G0/G1 phases, and lower MMP-9 protein expression compared with ACHN cells untransfected with FLNA (p<0.05). However, renal 786-0 cells transfected with FLNA siRNA had a higher survival fraction, significant increase in migration and invasion, and higher MMP-9 protein expression compared (p<0.05). In conclusion, FLNA expression was decreased in RCC and correlated significantly with lymph node metastasis, clinic stage, histological grade and poor overall survival, suggesting that FLNA may play important roles as a a tumor suppressor in RCC by promoting degradation of MMP-9.
Wei Qiu,Guo-Yue Lv,Chao Jiang,Ping Zhang,Xiao-Dong Sun,Xiao-Ju Shi,Xue-Yan Liu,Guang-Yi Wang 한국간담췌외과학회 2016 한국간담췌외과학회지 Vol.20 No.1
Acute graft-versus-host disease (GVHD) following liver transplantation is a rare but fatal complication. The correct diagnosis and management of GVHD after liver transplantation are still major challenges. Herein, we reported successful salvage treatment of acute GVHD by withdrawal of immunosuppression in a patient who presented with fever, skin rashes, and decreased blood cell counts after liver transplantation. This case highlights the need for awareness of drug-induced liver injury if liver function tests are elevated during treatment, especially in patients taking multiple potentially hepatotoxic drugs, such as broad-spectrum antibiotics. When occurs, an artificial liver support system is a useful tool to provide temporary support of liver function for the patient in the event of drug-induced liver injury.
Wei Sun,Junzhou Huo,Jing Chen,Zhen Li,Xu Zhang,Li Guo,Haifeng Zhao,Yu Zhao 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.2
In rock TBM design the disc cutters’ layout design of the full-face rock tunnel boring machine (TBM) is one of the key technologies. However, there are few published papers in literatures for various reasons. In this paper, based on the engineering technical requirements and the corresponding cutter head’s structure design requirements, a nonlinear multi-objective disc cutters’ layout mathematical model with complex constraints and the corresponding multi-stage solution strategy are presented, in which the whole disc cutters’ layout design process is decomposed into the disc cutters’ spacing design and the disc cutters’ plane layout design. A numerical simulation method based on the FEM theory is adopted to simulate the rock chipping process induced by three TBM disc cutters to determine the optimal cutter spacing. And a cooperative coevolutionary genetic algorithm (CCGA) is adopted to solve the disc cutters’ plane layout design problem. Finally, a disc cutters’ layout design instance of the TBM is presented to demonstrate the feasibility and effectiveness of the proposed method. The computational results show that the proposed method can be used to solve the disc cutters’ layout design problem of the TBM and provide various layout schemes within short running times for the engineers to choose from.
Chemical Constituents from the Aerial Parts of Isodon coetsa and their Cytotoxicity
Wei Zhao,Jian Xin Pu,Xue Du,Yong Zhao,Fei He,Hai Bo Zhang,Yong Bo Xue,Wei Lie Xiao,Han Dong Sun,Ying Li Wu,Guo Qiang Chen 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.12
Three new compounds (1-3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5-9, 11-13, 16-17, and 19-23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC50 values of 2.52, 3.06, 2.14 μM, respectively.
Improved Variable Step Size (IVSS) LMS for Active Noise Control System
SUN Jinwei,HUANG Boyan,WEI Guo,LIU Dan 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Adaptive filters based on the least-mean-square (LMS) algorithm in active noise control (ANC) system have an important limitation that the selection of a certain value for the step size implies compromise between speed of convergence and steady-state misadjustment. Traditional variable step size (VSS) LMS algorithms aiming at thisproblem have little efficiency in the high filter order case because of the small step variable range limited by the convergence condition. A proposed algorithm based on a novel principle is established to overcome this shortcoming.By increasing the variable range of the step size, it raises the convergence speed and tracking ability in the steady state of the system and lowers the steady-state misadjustment error in the high filter order case in ANC system.