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( In Hyuk Baek ),( Hyung Joon Kim ),( Hyun Woong Lee ),( M Ok Song ),( Thoi Cong Truong ),( Seung Kew Yoon ),( Hee Young Lee ),( Dong Hwa Shon ),( In Sik Chung ),( Wonyong Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Recently, hepatitis A has become increasingly important because its incidence is dramatically increasing in adolescents and adults in South Korea. HAV infection is now recognized as a public health burden. This situation has resulted in the need for genetic and epidemiological evaluation of hepatitis A virus (HAV) infection. We performed a comparative HAV genetic analysis between non-endemic period and endemic period. Methods: HAV IgM-positive fecal samples were collected from patients with acute hepatitis A at two university hospitals in South Korea during the two study periods of 2002 (n=34) and 2011 (n=45) and their genetic variability was characterized. Results: From a total of 79 specimens, the nucleotide sequences of the VP1 and 2A regions were successfully amplified in 27 (34.2%) samples and subjected to sequence analysis. Phylogenetic analysis showed that most strains belonged to genotype I, which is the major genotype worldwide. The subgenotype IA (93.3%, 13/14) was predominant in 2002, whereas the subgenotype IIIA (69.2%, 9/13) was the major subgenotype in 2011. Notably, a IIIA strain was detected in 2002 from a patient who had a history of travel to India. Conclusions: Genetically, there was a dramatic shift in circulating HAV subgenotypes from IA to IIIA during the past ten years. This report provides new insight into the genetic variation and relatedness of HAV circulating in South Korea.
( In Hyuk Baek ),( Hyung Joon Kim ),( Hyun Woong Lee ),( Mi Ok Song ),( Thoi Cong Truong ),( Seung Kew Yoon ),( Hee Young Lee ),( Dong Hwa Shon ),( In Sik Chung ),( Won Yong Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Recently, hepatitis A has become increasingly important because its incidence is dramatically increasing in adolescents and adults in South Korea. HAV infection is now recognized as a public health burden. This situation has resulted in the need for genetic and epidemiological evaluation of hepatitis A virus (HAV) infection. We performed a comparative HAV genetic analysis between non-endemic period and endemic period. Methods: HAV IgM-positive fecal samples were collected from patients with acute hepatitis A at two university hospitals in South Korea during the two study periods of 2002 (n=34) and 2011 (n=45) and their genetic variability was characterized. Results: From a total of 79 specimens, the nucleotide sequences of the VP1 and 2A regions were successfully amplified in 27 (34.2%) samples and subjected to sequence analysis. Phylogenetic analysis showed that most strains belonged to genotype I, which is the major genotype worldwide. The subgenotype IA (93.3%, 13/14) was predominant in 2002, whereas the subgenotype IIIA (69.2%, 9/13) was the major subgenotype in 2011. Notably, a IIIA strain was detected in 2002 from a patient who had a history of travel to India. Conclusions: Genetically, there was a dramatic shift in circulating HAV subgenotypes from IA to IIIA during the past ten years. This report provides new insight into the genetic variation and relatedness of HAV circulating in South Korea.