비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할

도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

연령증가에 따른 혈압요소들의 좌심실비대 및 관동맥질환과의 관련성

박재석,박창규,박미영,박재형,김용현,나진오,신성희,서순용,홍순준,박성미,임홍의,김응주,서홍석,오동주,노영무 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

회귀분석(regression analysis)을 이용한 개인별 혈중알콜농도의 감소율 계산

홍성욱,권미아,최혜진,박용훈,인상환,김동우,정주연,우상희,박혜성 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

취업대비 기사자격증 취득을 위한 효과적 학습지도 방안에 관한 연구

홍순욱,윤상원,서용성 永同大學校 1997 硏究論叢 Vol.3 No.1

지난 2년간 STC를 수행하면서 경험한 바에 의하면, 기사시럼을 준비하기 위하여 시중에서 구입한 연습 문제집에 실린 일부 문제들이 내포한 모호성 때문에 많은 학생들이 어려움을 겪고 있다는 것을 알게 되었다. 이는 학생들이 전공지식을 학습하는데 있어서 비효율을 초래하는 주요 요인들 가운데 하나일 것이다. 본 논문은 학생들이 스스로 자신들의 지식을 확장하고 조직화할 수 있도록 「기출문제 수정출제법(PRST)」이라는 새로운 개념을 도입함으로써 그와 같은 부정적인 효과를 최소화하려는 구체적인 노력을 보여주고 있다. PRST는 5단계로 구성되어 있는데, 이를 통하여 학생들과 지도교수는 모호성을 제거하고 문제를 개선하는 작업을 함께 하게 된다. 이를 위하여 시스템적 접근의 관점에서 Dick의 모형을 채택하는데, 이 모형은 교수설계를 위한 기본틀을 제공해 주며, 본 연구에서 다룰 하나의 기능은 그러한 교수설계 모형 가운데 일부가 된다. 교수설계 모형에 있어서 8개의 기능 가운데, 일련의 개선된 연습 문제들을 제작하는 것이 학생들에게 우선적으로 도움이 될 것이라는 관점에서 수업교재의 개발이라는 기능이 가장 긴급하다고 판단되었다. 본 연구의 목적에 부합하는 적절한 연구의 방향과 범위를 결정하기 위하여 기존 문제들에 대한 사전 조사연구가 수행되었다. 그리고 두 과목에 대한 연습 문제집의 제작과 학생들의 학습 동기부여를 위하여 여름방학 STC기간에 PRST가 시험적으로 적용되었다. 제작된 연습 문제집 가운데 하나가 문제집의 양호도라는 측면에서 6개의 7점 Likert척도로 학생들에 의하여 인지적으로 평가되었다. 그 결과, 새로 구성된 연습 문제집이 기존의 연습 문제집보다 여러 각도에서 더 양호하다고 판정된다. 이것은 통계적 적용상의 한계에도 불구하고, 본 연구에서 제안된 PRST 뿐만 아니라 제작된 연습문제집의 질적 부분의 타당성은 최소한 뒷받침된다는 것을 의미한다고 하겠다. By what we have experienced in STC for the last two years, we can see that a number of students have been suffering from the ambiguities of some problems contained in exercise books which are available at the market for preparing the National Certificate of Engineering. This seems one of the primary factors that bring on inefficiencies in learning expertise. This paper reports our concrete efforts to minimize such a negative force by introducing a new concept of「process for Revise of Sample Test(PRST)」, so that students can be able to organize and expand their knowledge in a good manner. PRST consists of five stages that enable students and the instructor work together on improving problems by getting rid of ambiguities. From the viewpoint of systems approach, Dick's model is adopted to provide a framework for an instructional design which designates a function we deal with in this study. Among the eight functions in the model, the development of class material is considered to be most urgent in that it would be of highly benefit to students to make series of improved exercise problems. Preliminary investigation of existing problems is conducted to figure out right direction and scope for the purpose of our research. PRST is, then, tentatively applied during the summer STC not only to produce exercise books for two different subjects, but to motivate students. One of the produced exercise books is examined perceptively by students in terms of goodness using six seven-point Likert scales. The result shows that the newly constructed exercise book is, on the perception basis, likely to be better than existing books. This implies that the quality of the produced book, as well as the proposed PRST, is validated at least positively in spite of statistical limitation.

철도 차량의 동적 안정성에 관한 연구

홍용기,유원희,박영필,박해성 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.1

The object of this study is to analyze the dynamic characteristic of lateral damper for the railway vehicle. The vibration characteristics are studied from eigenvalue analysis for critical velocity, and frequency analysis for the effects of the damper. Critical velocity of the model passenger car is found to be a) 20 m/s for damping force of 0 kg s/m, b) 64 m/s for damping force of 1,500 kg s/m, c) 60∼74 m/s for damping force of 730∼2,500 kg s/m. In high speed running, damping force should be decreased for high critical velocity. Lateral damping force should be greater than 730 kg s/m for stable running.

초음파 공명 분광법(RUS)을 이용한 SiC 입자강화 Al 기지복합재료의 탄성계수 해석

홍순형,주영상,정용무,정현규 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.3

SiC 입자강화 2124Al 금속복합재료의 강화재 부피분율에 따른 탄성 stiffness를 초음파 공명 스펙트로스코피(resonant ultrasound spectroscopy: RUS) 방법을 이용하여 측정하였다. RUS 방법은 한 개의 소형 시편으로 9개의 독립변수를 가진 사방정계(orthorhombic) 탄성계수를 간단한 실험으로 측정가능함을 보여주었다. SiC 강화재 부피분율 변화에 따른 탄성계수를 측정하였는데 이 경우 초기 추정 탄성계수를 구하기 위해서 부피분율에 따른 미세조직 사진으로부터 강화재의 형상(aspect ratio)과 방향을 고려한 유효 aspect ratio 개념을 도입하였고, Mori-Tanaka 이론식에 의한 계산결과를 이용하였다. 이로부터 계산된 공진주파수와 RUS의 측정 공진주파수 사이를 최소화함으로 정확한 탄성계수를 측정하였다. 측정된 stiffnesses로부터 공학적 탄성계수인 Young's modulus를 계산하였으며, 계산된 Young's modulus와 압출방향으로 인장시험한 Young's modulus를 비교분석하였다. SiC 입자의 부피분율이 증가함에 따라 탄성계수가 증가함을 나타내었고, 탄성 stiffness의 거동은 강화재가 많이 첨가될수록 횡등방성(transversely isotropic) 이 강하게 나타났으며 이것은 압출공정에 의해 강화재 입자의 방향성 재배열에 기인한다. 한편 일정크기 시편에 있어서 기본 공진주파수가 강화재 부피분율에 따라 고주파수 영역으로 이동하는 현상이 관찰되었으며, 이로 부터 비파괴적으로 강화재 부피분율을 예측할 수 있는 가능성을 제시하였다. The dynamic elastic properties of metal matrix composites were investigated by resonant ultrasound spectroscopy(RUS). The composites used in this study consisted of 2124 aluminum alloy reinforced with different concentrations of SiC particles. RUS can determine the nine independent elastic stiffness(C )for the orthorhombic symmetry on a small specimen simultaneously. The elastic constants were determined as a function of the volume fraction. A concept of effective aspect ratio, which combine the aspect ratio and the orientation of reinforcement, was used to calculate the initial moduli from Mori-Tanaka theory for the input of RUS minimization code. Young's moduli can be obtained from the measured stiffnesses. The results show that the elastic stiffness increases with increment of the particle content. The behavior of elastic stiffness indicates that the particle redistribution induced by the extrusion process enlarges the transversely isotropic symmetry as the fraction of reinforced particles increase. This relationship could be used for determination of the volume fractions of reinforcement as a potential tool of nondestructive material characterization.

중ㆍ고등학생 응급처치 지식수준에 관한 실태 조사

홍경용,남철현,최상복,위광복,김기열 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

This study was conducted to examine middle and high school students' knowledge level of first aid, health promotion, and safety. Data were collected from 1.165 students from March 6, 2000 to April 4, 2000. The results of this study are summarized as follows. 1.80.1% of the respondents felt the necessity of first aid. The sources of information about methods of first arid were school (43.9%), mass media (15.6%), and self-study (10.5%). 30.0% of them never leaned the methods of first aid. 2.In the case of obtaining information on first aid through mass media, 58.2% of them got it from TV. 7.3% of them obtained it from magazines, while 5.8% of them got it from newspapers. According to their viewpoints of adequate time to teach the methods of first aid, 38.6% of them thought that the methods had to be taught in the primary school and 25.2% of them thought that they had to be taught in the kindergarten. 24.9% of them replied that the methods had to be taught in the middle school, while 11.3% of them replied that they had to be taught in the high school. 3.The points for knowledge of first aid were 98.29±20.91 on the basis of 150 points (65.5 points on the basis of 100 points). The points showed significant differences in the variables of sex, education level, numbers of siblings, parents' education level, and guardian's occupation.

운동선수의 임장불안에 대한 연구

홍관이,이광재,김두경,부기원,노성규,한상준,박기동,오수일,문병용,이철규,박장평,엄기진,박남환 江原大學校附設 體育科學硏究所 1984 江原大學校附設體育科學硏究所論文集 Vol.- No.9

This study is designed to grasp the elements and situations of stage fright in order to propose a part of ways to cope with it. We make 511 top-class high school players, male and female, in the central districts (Seoul, Inchon, Kyungki, Chungbuk, and Kangweon Province) on object of questionnaire, and get the following results. Through players generally have all-round characters they show weakness in the superiority and emotional stability while showing strength in the sonformity. This fact comes to be related to the elements which cause stage fright. Physiological changes also have many effects on the symptom of stage fright. Especially, stage fright increases when players show sensitive reaction to the self-consciousness of final consequence which comes from the tension or uneasiness of sympathetic nerve, Thus, it turns out that players make use of reducing psychological burden by physical exercise or adjusting the level of demanded result in order to release the stage fright.