Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

하악 무치악 부위의 임플란트 이식을 위한 전산화단층촬영 영상의 비교 평가

선경훈,정호걸,박혁,박창서,김기덕 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : The purpose of this study was to evaluate the clinical usefulness of the recently developed multi-detector computed tomography and cone beam computed tomography in pre-operative implant evaluation, by comparing them with the single detector computed tomography, already confirmed for accuracy in this area. Materials and Methods : Five partially edentulous dry human mandibles, with 1×1 mm gutta percha cones, placed in 5 mm intervals posterior to the mental foramen on each side of the buccal part of the mandible, were used in this study. They were scanned as follows: 1) Single detector computed tomography: slice thickness 1 mm, 200 mA, 120 kV 2) Multi-detector computed tomography: slice thickness 0.75 mm, 250 mA, 120 kV 3) Cone beam computed tomography: 15 mAs, 120 kV Axial images acquired from three computed tomographies were transferred to personal computer, and then reformatted cross-sectional images were generated using V-Implant 2.0 (CyberMed Inc., Seoul, Korea) software. Among the cross-sectional images of the gutta percha cone, placed in the buccal body of the mandible, the most precise cross section was selected as the measuring point and the distance from the most superior border of the mandibular canal to the alveolar crest was measured and analyzed 10 times by a dentist. Results : There were no significant intraobserver differences in the distance from the most superior border of the mandibular canal to the alveolar crest (p>0.05). There were no significant differences among single detector computed tomography, multi-detector computed tomography and cone beam computed tomography in the distance from the most superior border of the mandibular canal to the alveolar crest (p>0.05). Conclusion : Multi-detector computed tomography and cone beam computed tomography are clinically useful in the evaluation of pre-operative site for mandibular dental implants, with consideration for radiation exposure dose and scanning time.

대장직장종양에 있어서 Hand-Assisted Laparoscopic Surgery (HALS)의 초기 경험

조호영,최선근,구지회,허윤석,이건영,김세중,조영업,안승익,홍기천,신석환,김경래,우제홍 대한내시경복강경외과학회 2003 대한내시경복강경외과학회지 Vol.6 No.-

表面活性化法에 의한 異種材料의 低溫接合에 관한 硏究

임선빈,최병기,기준호,장만 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.1

본 논문은 서로 다른 재료를 표면활성화법을 이용하여 저온에서 접합할 목적으로 이들 재료의 접합 가능성을 검토하고 이들 접합계면에서의 접합 메카니즘을 검토할 목적으로 연구하였으며 연구 결과는 다음과 같다. 1) 10-7 Torr대의 진공도에서도 알루미늄은 알루미나, 질화 알루미늄, 질화규소, 지르코늄 등의 세라믹스와 양호한 접합이 가능하였다. 2) 알루미늄, 동, 은은 같은 금속끼리의 접합이 가능하였고, 또 알루미늄과 동의 이종재료의 접합도 가능하였다. 3) 실리콘은 알루미늄, 동, 은, 금 등과의 접합 실험결과 모든 금속과 접합이 가능하였다. In this paper considered it possible to bond different materials in low temperature using surface activated method. To do so, it was examined the possibility of bonding different materials and applied the bonding mechanism on the bonding surface. The followings are the result. 1) It was possible that aluminum could be bonded well with ceramics such as alumina, nitrification aluminum, nitrification silicon, and zirconium at the vaccum level of 10-7 Torr. 2) It was possible that aluminum, copper, and copper could be bonded with each other and aluminum and copper could be bonded with other metals. 3) Silicon was bonded with aluminum, copper, silver, and gold which were tested before.

우각차단을 동반한 급사증후군 2예

박상선,남기병,최기준,송재관,김재중,박승정,박종훈,김유호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.5

영어 화제와 초점의 억양 실현 양상

강선미,옥유름,김기호 한국음성과학회 2003 음성과학 Vol.10 No.4

This paper investigates the tonal patterns of English infomation structure composed of topic and focus. It has been argued in previous theories that there is a significant relationship between English topic-focus structure and intonation. The English topic is marked with L+H* pitch accent and focus is marked with H* pitch accent These theories, however, are oversimplified ones since they do not consider the contextual differences of topic and focus. To examine more concrete tonal patterns of English topic and focus, we classified topic into two subcategories of reminding topic and oldinformation topic. Focus was categorized into three: information focus, contrastive focus, and reference focus. The overall results show that native English speakers are inclined to use both the L+H* and H* pitch accent for the topic and focus of an utterance. We also observe a tendency to deaccentuate the topics given as old information and to mark the topics given as noun phrase with H* pitch accent. As for the intonation of focus, H* pitch accent is the most frequent type of accent, but L+H* also shows a high percentage of implementation especially in the context of correction or contrast.

한국 자생란에서 난 균근균의 분리와 유묘난에 접종

오창호,이태수,이상선,백기엽 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 1998 연구보고서 Vol.3 No.-

한국의 춘란 자생지의 춘란(Cymbidium goeringii) 뿌리에서 공생하는 10개의 균근균을 분리하였다. 분리된 난 균근균을 PDA에서 배양한 결과 균총은 다양한 색깔을 나타내었으며, 생장 속도도 달랐다. 분리된 난 균근균을 현미경으로 관찰한 결과 Rhizoctonia repens 또는 R. endophytica var endophytica로 동정되었다. R. repens는 자생란인 춘란의 뿌리에서 많이 분리되었으며, R. endophytica var endophytica는 상업적으로 재배되는 외국산의 난 뿌리에서 분리되었다. 분리된 균들 중에 R. repens와 유사한 5개의 분리균을 oatmeal agar에 접종하고 배양한 후 여러종의 난 유묘를 이식하여 난의 생장을 관찰하였다. 그 결과 난의 생장은 분리 균에 따라서 다양하였으나 대부분의 난은 생장촉진 반응을 나타내서, 분리균과 각각의 난과의 공생 관계를 관찰할 수 있었다. Ten isolates of the orchid mycorrhizal fungi were isolated from the roots of Korean native orchid plants (cymbidium goeringii) which inhabitate mainly in southern and western areas of Korea. The growth rates and color of the isolates in potato dextrose agar (PDA) were various. Microscopic observations of the hyphae isolated were identified as Rhizoctonia repens and R. endophytica var endophytica or their related species. R. repens was isolated from the roots of the Korean native orchids, but R. endophytica var endophytica was only isolated from the roots of the commercial orchids introduced from foreign countries. Also, the polymorphic patterns of genomic DNA extracted from selected isolates were compared with those of DNA extracted from the orchid mycorrhizal fungi isolated previously and similar band patterns were observed among those isolates. Five isolates of R. repens were selected and cultured at the oatmeal agar for investigating their symbiosis with orchid plants. The symbiotic specificity between orchid plants and isolated orchid mycorrhizal fungi was observed by growing orchids about six months in the greenhouse. The symbiotic responses of the commercial orchid plants with selected isolates were quite different from different isolates due to the genetic variations.

춘난 자생지 토양으로 난재배

백기엽,오창호,선정훈,이상선 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 1997 연구보고서 Vol.2 No.-

For cultivations of orchid plants, the Korean native orchid plant inhabiting (KNO) soils were collected from the Southern and Western areas in Korea, and employed for understanding the role of symbiotic fungi on the orchids. The parameters related to growth of the orchid plant were investigated after the young nurseries (plantlets) of Cymbidium goeringii, C. kanran, and Neofinetia falcata planted on the sterilized or unsterilized soils of KNO under the conditions of green house. The fresh weights or dried weights of all orchid plants grown on the unsterilized soil for 17 months were highly heavier than those grown on the sterilized soils. Thus, the differences of the plant growth were not found among the four different KNO soils. The various stages of peletons in the root cells of the orchid plants were distinguished from unsterilized soils, while those not quite often in the sterilized soils. Mineral nutrients (K, Ca, Mg, P) related to nitrogen were also measured in the individual plantlets for understanding the plant symbiosis. The nitrogen of the orchid plants absorbed in the unsterilized soils were measured to be comparatively greater than those in sterilized soils during the orchid plant growth. The other minerals of the orchid plants absorbed in the unsterilized soils were also measured to be comparatively greater than those in the sterilized soils. The metabolism of nitrogen were concluded to be much important, and were considered to stimulate the other mineral absorptions in growth of the orchid plants symbiotic with the fungi.

남북한 방송 언어의 운율 특성 비교연구 : 억양을 중심으로

김기호,홍종선,이용재 서울대학교 어학연구소 1996 語學硏究 Vol.32 No.3

This paper is to compare North and South Korean media languages acoustically and to describe its main prosodic characteristics. The result of the acoustic experiments shows that North and South Korean media languages share the same prosodic features. That is, in general report style, they both show ⅰ) the same basic accentual phrase (AP) pattern ((LH) LH) like Seoul dialect's and ⅱ) the same closing boundary tone, or L%. However, acoustically, they differ in the following aspects: in comparison with South Korean media language, the North Korean one tends to show ⅰ) more APs, ⅱ) wider pitch variation between the first and the second syllable of the AP, ⅲ) wider maximum pitch variation between the adjacent syllables, ⅳ) a more radical falling slope in that closing boundary tone, and, of more importance, it does not show clearly the downdrift phenomena ⅴ) between the intonational phrases as well as ⅵ) between the APs, which are the prosodic characteristics of South Korean dialects. On the other hand, in Kim Il-sung-related reports, the North Korean media language shows somewhat different prosodic features, i.e. in addition to the basic (LH)LH AP pattern, it shows another AP pattern, or LHL^0, similar to the Honam dialect (LHL) and it also shows a rather different closing boundary tone, or LHL%.

두개골의 3차원 영상 분석을 위한 전산화단층촬영 방법의 비교 : 상층 두께가 3차원 영상의 계측에 미치는 영향

정호걸,김기덕,박혁,김동욱,정해조,김희중,유선국,김용욱,박창서 대한구강악안면방사선학회 2004 Imaging Science in Dentistry Vol.34 No.3

Purpose : To evaluate the quantitative accuracy of three-dimensional (3D) images by means of comparing distance measurements on the 3D images with direct measurements of dry human skull according to slice thickness and scanning modes. Materials and Mathods : An observer directly measured the distance of 21 line items between 12 orthodontic landmarks on the skull surface using a digital vernier caliper and each was repeated five times. The dry human skull was scanned with a Helical CT with various slice thickness (3, 5, 7 mm) and acquisition modes (Conventional and Helical). The same observer measured corresponding distance of the same items on reconstructed 3D images with the internal program of V-works 4.0 (Cybermed Inc., Seoul, Korea). The quantitative accuracy of distance measurements were statistically evaluated with Wilcoxons’ two-sample test. Results : 11 line items in Conventional 3 mm, 8 in Helical 3mm, 11 in Conventional 5 mm, 10 in Helical 5 mm, 5 in Conventional 7 mm and 9 in Helical 7 mm showed no statistically significant difference. Average difference between direct measurements and measurements on 3D CT images was within 2 mm in 19 line items of Conventional 3 mm, 20 of Helical 3 mm, 15 of Conventional 5 mm, 18 of Helical 5 mm, 11 of Conventional 7mm and 16 of Helical 7 mm. Conclusion : Considering image quality and patient’s exposure time, scanning protocol of Helical 5 mm is recommended for 3D image analysis of the skull in CT.