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Smallanthus sonchifolius leaf attenuates neuroinflammation
( Suji Baek ),( Nan Hee Choi ),( Kang-pa Lee ),( Hyunjhung Jhun ),( Jisu Kim ) 한국운동영양학회 2018 Physical Activity and Nutrition (Phys Act Nutr) Vol.22 No.2
[Purpose] Yacon, Smallanthus sonchifolius, has anti-hypertensive, anti-inflammatory, and anti-cancer potential. However, its neuroprotective and anti-neu-roinflammatory effects are unknown. Moreover, activation of microglia has been considered a mechanism in the development of Alzheimer’s disease. Therefore, the aim of this study was to determine the neuroprotective effects of an ethanolic yacon leaf extract (YLE) on lipopolysaccharide (LPS)-induced neuroinflammation in vitro and in vivo. [Methods] The viability of microglial BV2 cells was tested with 2,3-bis[2-methyloxy-4-nitro-5-sulfophenyl]- 2H-tetrazolim-5-carboxanilide. The production of nitric oxide (NO) was determined by the Griess reagent. mRNA expression and protein levels of inflammatory mediators were evaluated by the real-time polymerase chain reaction and immunohistochemistry, respectively. In addition, we performed histological analysis in mice treated with an intraperitoneal injection of LPS (250 μg/ kg). [Results] Our results showed that treatment with YLE significantly reduced NO production in LPS-stimulated BV2 cells. YLE also decreased mRNA levels of the inflammatory factors tumor necrosis factor alpha, inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-1 beta. In vivo, YLE (40 mg/kg daily for seven days) significantly diminished LPS-induced tissue damage in the dentate gyrus and cornu amonis regions of the hippocampus by regulating the levels of inflammatory factors. [Conclusion] Our findings support the protective effects of YLE against the development of neurodegeneration.
The Utilization and Policy Frameworks for Cultural Landscape Resources in Gyeongju’s East Coast
Lee Gi-Baek,Kim Suji 차세대컨버전스정보서비스학회 2022 Journal of Digital Media & Culture Technology Vol.2 No.2
Gyeongju City is implementing various cultural tourism projects based on local cultural and landscape resources and is striving to create a maritime tourism base for the east coast of Gyeongju, which is rich in historical and natural resources in addition to the historic district in downtown Gyeongju. However, the east coast of Gyeongju is geographically inaccessible and there are aspects that lack interest and awareness compared to the Gyeongju Historic District. The purpose of this paper is to identify the value and importance of the east coast area of Gyeongju as a cultural landscape resource and to investigate related measures and draws suggestions for a development plan that can overcome biased development plans and geographical weaknesses. To overcome these limitations, the study underscores the value and importance of cultural landscape resources and advocates for inclusive development plans that encompass the distinct attributes of the East Coast region.
대학 신입생의 학업 생활 지원을 위한 온-오프라인 블랜디드 서비스
박수진(Sujin Park),최수지(Suji Choi),김현경(Hyoun Kim),백준상(JoonSang Baek) 한국HCI학회 2021 한국HCI학회 학술대회 Vol.2021 No.1
본 연구에서는 COVID-19 이후 2020 학년도에 연세대학교에 입학하여 학업 생활의 대부분을 온라인 교류를 통해 활동하고 있는 신입생들을 대상으로 하며 온-오프라인 연계 방식의 온-오프라인 블랜디드 서비스를 제안하였다. 본 연구에서 제안하는 서비스인 ‘연수리’는 지속적인 모임 활동을 장려하며 온-오프라인 블랜디드를 방식을 가지고 있는 학업 생활중심의 소모임 & 멘토 찾기 서비스이다. 본 연구에서는 5명의 신입생 인터뷰와 학교 관계자 1명, 이후 5 명의 MVP 테스트를 실시하여 총 11 명의 인터뷰를 시행하였다. COVID-19이후 전면 온라인수업으로 변경되면서 2020 년도에 새로 입학한 학생들이 집에서 혼자 공부하는 시간이 길어지면서 겪는 고립감과 학업 생활 중 어려움이 있어도 편하게 물어볼 곳을 찾지 못하는 애로사항, 그리고 미래 진로에 대한 막연한 불안감을 가지고 있음을 확인할 수 있었다. 본 연구에서는 학생들의 불안감과 고립감을 해소 시킬 수 있는 온-오프라인 블랜디드 서비스를 제안하며 COVID-19시대에서 학생 스스로의 관점과 다양한 접근 방법을 통해 공부하는 방법을 습득하고 학우와 대학 생활을 함께 할 수 있는 서비스 제안에 의의를 둔다.
Systematic analysis of the pharmacological function of Schisandra as a potential exercise supplement
( Bok Sil Hong ),( Suji Baek ),( Myoung-ryu Kim ),( Sun Mi Park ),( Bom Sahn Kim ),( Jisu Kim ),( Kang Pa Lee ) 한국운동영양학회 2021 Physical Activity and Nutrition (Phys Act Nutr) Vol.25 No.4
[Purpose] Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person’s exercise capacity. Schisandra chinensis (SC) is a natural product with various physiologically active effects. In this study, we analyzed SC using a pharmacological network and determined whether it could be used as an exercise supplement. [Methods] The active compounds of SC and target genes were identified using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). The active compound and target genes were selected based on pharmacokinetic (PK) conditions (oral bioavailability (OB) ≥ 30%, Caco-2 permeability (Caco-2) ≥ -0.4, and drug-likeness (DL) ≥ 0.18). Gene ontology (GO) was analyzed using the Cytoscape software. [Results] Eight active compounds were identified according to the PK conditions. Twenty-one target genes were identified after excluding duplicates in the eight active compounds. The top 10 GOs were analyzed using GO-biological process analysis. GO was subsequently divided into three representative categories: postsynaptic neurotransmitter receptor activity (53.85%), an intracellular steroid hormone receptor signaling pathway (36.46%), and endopeptidase activity (10%). SC is related to immune function. [Conclusion] According to the GO analysis, SC plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid receptors. Therefore, we suggest SC as an exercise supplement with nutritional and anti-fatigue benefits.
( Wonjin Park ),( Yi-yong Baek ),( Joohwan Kim ),( Dong Hyun Jo ),( Seunghwan Choi ),( Jin Hyoung Kim ),( Taesam Kim ),( Suji Kim ),( Minsik Park ),( Ji Yoon Kim ),( Moo-ho Won ),( Kwon-soo Ha ),( Jeo 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.5
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the therapeutic mechanisms and effects of the tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a VEGFR2 inhibitor, in the development of vascular permeability and choroidal neovascularization (CNV). In cultured human retinal microvascular endothelial cells (HRMECs), treatment with RLYE blocked VEGF-Ainduced phosphorylation of VEGFR2, Akt, ERK, and endothelial nitric oxide synthase (eNOS), leading to suppression of VEGFA- mediated hyper-production of NO. Treatment with RLYE also inhibited VEGF-A-stimulated angiogenic processes (migration, proliferation, and tube formation) and the hyperpermeability of HRMECs, in addition to attenuating VEGF-A-induced angiogenesis and vascular permeability in mice. The anti-vascular permeability activity of RLYE was correlated with enhanced stability and positioning of the junction proteins VE-cadherin, β-catenin, claudin-5, and ZO-1, critical components of the cortical actin ring structure and retinal endothelial barrier, at the boundary between HRMECs stimulated with VEGF-A. Furthermore, intravitreally injected RLYE bound to retinal microvascular endothelium and inhibited laser-induced CNV in mice. These findings suggest that RLYE has potential as a therapeutic drug for the treatment of CNV by preventing VEGFR2-mediated vascular leakage and angiogenesis.
Yun, Jung-A,Kim, Joohwan,Baek, Yi-Yong,Park, Wonjin,Park, Minsik,Kim, Suji,Kim, Taesam,Choi, Seunghwan,Jeoung, Dooil,Lee, Hansoo,Won, Moo-Ho,Kim, Ji-Yoon,Ha, Kwon-Soo,Kwon, Young-Guen,Kim, Young-Myeon American Society for Pharmacology and Experimental 2019 Molecular pharmacology Vol.96 No.6
<P>The tetrapeptide Arg-Leu-Tyr-Glu (RLYE), a vascular endothelial growth factor (VEGF) receptor-2 antagonist, has been used previously either alone or in combination with chemotherapeutic drugs for treating colorectal cancer in a mouse model. We analyzed the half-life of the peptide and found that because of degradation by aminopeptidases B and N, it had a short half-life of 1.2 hours in the serum. Therefore, to increase the stability and potency of the peptide, we designed the modified peptide, N-terminally acetylated RLYE (Ac-RLYE), which had a strongly stabilized half-life of 8.8 hours in serum compared with the original parent peptide. The IC<SUB>50</SUB> value of Ac-RLYE for VEGF-A-induced endothelial cell migration decreased to approximately 37.1 pM from 89.1 pM for the parent peptide. Using a mouse xenograft tumor model, we demonstrated that Ac-RLYE was more potent than RLYE in inhibiting tumor angiogenesis and growth, improving vascular integrity and normalization through enhanced endothelial cell junctions and pericyte coverage of the tumor vasculature, and impeding the infiltration of macrophages into tumor and their polarization to the M2 phenotype. Furthermore, combined treatment of Ac-RLYE and irinotecan exhibited synergistic effects on M1-like macrophage activation and apoptosis and growth inhibition of tumor cells. These findings provide evidence that the N-terminal acetylation augments the therapeutic effect of RLYE in solid tumors via inhibition of tumor angiogenesis, improvement of tumor vessel integrity and normalization, and enhancement of the livery and efficacy of the coadministered chemotherapeutic drugs.</P><P><B>SIGNIFICANCE STATEMENT</B></P><P>The results of this study demonstrate that the N-terminal acetylation of the tetrapeptide RLYE (Ac-RLYE), a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor, significantly improves its serum stability, antiangiogenic activity, and vascular normalizing potency, resulting in enhanced therapeutic effect on solid tumors. Furthermore, the combined treatment of Ac-RLYE with the chemotherapeutic drug, irinotecan, synergistically enhanced its antitumor efficacy by improving the perfusion and delivery of the drug into the tumors and stimulating the conversion of the tumor-associated macrophages to an immunostimulatory M1-like antitumor phenotype.</P>
Lee, Dong-Youb,Won, Kyung-Jong,Lee, Kang Pa,Jung, Seung Hyo,Baek, Suji,Chung, Hyun Woo,Choi, Wahn Soo,Lee, Hwan Myung,Lee, Byeong Han,Jeon, Byeong Hwa,Kim, Bokyung Elsevier 2018 Toxicology and applied pharmacology Vol.347 No.-
<P><B>Abstract</B></P> <P>Angiotensin II (Ang II) is implicated in the development of cardiovascular disorders including hypertension and atherosclerosis. However, the role of Ang II in the interaction between apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and sphingosine-1-phosphate (S1P) signals in relation to vascular disorders remains to be clarified. This study aimed to determine whether APE/Ref-1 plays a role in epigenetic regulation of the S1P receptor (S1PR) in response to Ang II in vascular smooth muscle cell (VSMC) migration and vascular neointima formation. Ang II augmented the expression of S1PR1 in aortic smooth muscle cells of Sprague Dawley rats (RASMCs), which was attenuated by Ang II receptor (AT) 1 inhibitors, antioxidants, and APE/Ref-1 knockdown with small interference RNA. Ang II stimulation produced H<SUB>2</SUB>O<SUB>2</SUB>, and exogenous H<SUB>2</SUB>O<SUB>2</SUB> elevated S1PR1 expression in RASMCs. Moreover, Ang II caused translocation of cytoplasmic APE/Ref-1 into the nucleus in RASMCs. H3 histone acetylation and APE/Ref-1 binding at the S1PR1 promoter were increased in RASMCs treated with Ang II. In addition, Ang II induced migration in RASMCs, which was suppressed by AT1 and S1PR1 inhibitors. The expression of S1PR1, and colocalization of APE/Ref-1 and acetylated histone H3 in vascular neointima, were greater in Ang II-infused rats compared with a control group. These findings demonstrate that Ang II stimulates the epigenetic regulation of S1PR1 expression via H<SUB>2</SUB>O<SUB>2</SUB>-mediated APE/Ref-1 translocation, which may consequently be involved in Ang II-induced VSMC migration and vascular neointima formation. Therefore, APE/Ref-1-mediated overexpression of S1PR1 may be implicated in the vascular dysfunction evoked by Ang II.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ang II increased S1PR1 expression and H<SUB>2</SUB>O<SUB>2</SUB> generation in VSMCs. </LI> <LI> H<SUB>2</SUB>O<SUB>2</SUB> elevated S1PR1 expression in VSMCs. </LI> <LI> Ang II epigenetically enhanced S1PR1 expression via APE/Ref-1 translocation by H<SUB>2</SUB>O<SUB>2</SUB>. </LI> <LI> These events may be linked to Ang II-increased VSMC migration and vascular neointima. </LI> </UL> </P>