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RISS 인기검색어
- 검색키워드
- 저자 : ( Soon Hong Yuk ) (검색결과 65 건)
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陸昌洙,洪淳達,金雄柱,鄭勳采 충북대학교 엽연초연구소 1983 煙草硏究 Vol.10 No.-
Experiment was conducted to investigate the relation of growth characteristics, nutrient amount absorbed by tobacco plant, chemical components, changes of NH4 -N and NO3-N in the soil, yield, quality and price per 10a. Nc2326 and Burley 21-tobacco plant grew in sandy loam and clay loam by treated different levels of nitrogen, phosphorous and potassium fertilizers. the results were summarized as follows. 1.The plant height, length and width of the largest leaf, fresh weight and dry weight of tobacco leaves and stem of NC2326 and Burley21 were greater in clay loam than those in the sandy loam during growing. 2.The amount of nitrogen and phosphorous in tobacco leaves and stem absorbed by NC 2326 grown in clay loam were increased by 60days after transplanting, and then decreased, and amount absorbed by Burley 21 increased continuously in sandy loam and clay loam till the harvesting time. 3.The contents of potassium, calsium and magnesium in the leaves of NC 2326 and Burley 21 were increased continously during growing period and the amount of patassium uptake was greatest. 4.Total nitrogen, total alkaloid and reducing sugar in the dry leaves of NC 2326 and Burley 21 showed no differences between the plot of sandy loam and clay, but Burley 21 showed higher content of total nitrogen and alkaloid than NC2326. 5.Changes of NH4-N and NO3 -N in soil decreased gradually during growing period. Amount of NH4 -N in the plot of Burley 21 was higher than that in NC 2326 during glowing period. 6.The best yield was shown in the NC 2326 glowing in clay loam soil and quality was highest in the sandy loam. The highest price per 10a, 590, 400, was shown in clay loam with 10-10-20kg/10a fertilization.
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Yuk, Soon Hong,Oh, Keun Sang,Park, Jinah,Kim, Soon-Joong,Kim, Jung Ho,Kwon, Il Keun Elsevier 2012 SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS Vol.13 No.2
<P>The mixture of poly(lactide-co-glycolide) (PLGA) and poly(ethylene vinyl acetate) (PEVA) forms a homogeneous liquid in an organic solvent such as tetrahydrofuran, and a phase-separated PLGA/PEVA composite can be prepared from it by evaporating the organic solvent. Exploiting this phenomenon, we designed a novel method of preparing a drug-loaded PLGA/PEVA composite and used it for coating drug-eluting stents (DESs). Paclitaxel (PTX), an anticancer drug, was chosen as a model drug. PLGA acts as a microdepot for PTX, and PEVA provides mechanical strength to the coating material. The presence of PLGA in the PLGA/PEVA composite suppressed PTX crystallization in the coating material, and PTX showed a sustained release rate over more than 30 days. The mechanical strength of the PLGA/PEVA composite was better than that of PEVA used as a control. After coating the stent with a PLGA/PEVA composite using ultrasonic atomizing spray, the morphology of the coated material was observed by scanning electron microscopy, and the release pattern of PTX was measured by high-performance liquid chromatography.</P>
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Yuk, Soon Hong,Oh, Keun Sang,Cho, Sun Hang,Kim, Sang Yoon,Oh, Sangkwon,Lee, Jin Ho,Kim, Kwangmeyung,Kwon, Ick Chan American ChemicalSociety 2012 Molecular pharmaceutics Vol.9 No.2
<P>An enhancement of tumor-targeting capability was demonstrated with paclitaxel (PTX)-loaded Pluronic nanoparticles (NPs) with immobilized glycol chitosan and heparin. The PTX-loaded Pluronic NPs were prepared as described in our previous report by means of a temperature-induced phase transition in a mixture of Pluronic F-68 and liquid polyethylene glycol (PEG; molecular weight: 400) containing PTX. The liquid PEG is used as the solubilizer of PTX, and Pluronic F-68 is the polymer that encapsulates the PTX. The glycol chitosan and heparin were immobilized on the surface of the Pluronic NPs in an aqueous medium, and a powdery form of the glycol chitosan/heparin immobilized Pluronic NPs (composite NPs) was obtained by freeze-drying. Field emission scanning electron microscopy and a particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. To apply the composite NPs as a delivery system for the model anticancer drug PTX, the release pattern and pharmacokinetic parameters were observed, and the tumor growth was monitored by injecting the composite NPs into the tail veins of tumor-bearing mice. An enhancement of tumor-targeting capability of NPs was verified by using noninvasive live animal imaging technology to observe the time-dependent excretion profile, the in vivo biodistribution, circulation time, and the tumor-targeting capability of composite NPs.</P>
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Yuk, Soon Hong,Oh, Keun Sang,Cho, Sun Hang,Lee, Beom Suk,Kim, Sang Yoon,Kwak, Byung-Kook,Kim, Kwangmeyung,Kwon, Ick Chan American Chemical Society 2011 Biomacromolecules Vol.12 No.6
<P>We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin network to form the composite NPs. To induce the ionic interaction between the iron oxide nanoseeds and glycol chitosan, gold was deposited on the surface of iron oxide nanoseeds. After the immobilization of gold-deposited iron oxide NPs into the glycol chitosan network, the NPs were stabilized with heparin based on the ionic interaction between cationic glycol chitosan and anionic heparin. FE-SEM (field emission-scanning electron microscopy) and a particle size analyzer were used to observe the formation of the stabilized composite NPs, and a Jobin-Yvon Ultima-C inductively coupled plasma-atomic emission spectrometer (ICP-AES) was used to measure the contents (%) of formed iron oxide nanoseeds as a function of reaction temperature and formed gold deposited on the iron oxide nanoparticles. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor-targeting ability of the composite NPs using a noninvasive NIR fluorescence imaging technology. To observe the MRI contrast characteristic, the composite NPs were injected into the tail veins of tumor-bearing mice to demonstrate their selective tumoral distribution. The MR images were collected with conventional T<SUB>2</SUB>-weighted spin echo acquisition parameters.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-6/bm200413a/production/images/medium/bm-2011-00413a_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm200413a'>ACS Electronic Supporting Info</A></P>
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One-way membrane for transdermal drug delivery systems : Ⅱ. System optimization
Yuk, Soon Hong,Lee, Seung Jin,Okano, Teruo,Berner, Bret,Kim, Sung Wan 梨花女子大學校 藥學硏究所 1992 藥學硏究論文集 Vol.- No.2
Effective flux of steroid solute through skin can be achieved by the use of ethanol as a co-solvent and penetration enhancer. To maintain constant drug release from a reservoir-type transdermal device and permeation through the skin, the composition of ethanol in the reservoir must remain constant. Ethanol permeability is much higher than that of either drug or water; any decrease in ethanol content may result in decreased drug flux. In an attempt to design a transdermal delivery device with constant ethanol enhancing activity, a model system was designed with separate ethanol reservoir, drug/solvent reservoir and receiver compartments. The ethanol and drug/solvent reservoir compartments were separated by a polydimethylsiloxane copolymer laminate membrane. This 'one-way' rate-controlling membrane(Yuk et al., Int. J. Pharm., 77(1991) 2210229) optimized ethanol flux while preventing drug and water back flux. Permeation studies with model steroid solutes in this system demonstrated consistent ethanol enhancing activity with constant solute flux across the skin.
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Soon Hong Yuk,Sang Il Jeon,Mu Shik Jhon Korean Chemical Society 1984 Bulletin of the Korean Chemical Society Vol.5 No.3
The self-diffusion experiment of THO was performed across a series of copolymer hydrogel membranes at different temperatures. Copolymer hydrogel membranes were prepared by copolymerizing 2-hydroxyethyl methacrylate (HEMA) and 2-aminoethyl methacrylate (AEMA) in the presence of the solvent and the crosslinker, ethylene glycol dimethacrylate (EGDMA). By changing the crosslinker content and the ratio of HEMA and AEMA monomer, two series of copolymer hydrogel membranes were synthesized. The tagging material was THO and efflux of THO was counted on a Liquid Sc-intillation Counter. The experimental data show that the permeability decreases as the amount of EGDMA and the mole fraction of HEMA increase, and the permeability is proportional to the temperature. The partition coefficient shows a parallel trend with permeability. Using the relationship between viscosity and diffusivity, the viscosity of water within the membrane was obtained. According to the result, the viscosity of watler within the membrane has the same value with those of supercooling water. And we obtained the activation energy of THO for transport in the membrane by using Arrhenius plotting.
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A Semi-Interpenetrating Network for Temperature-Sensitive Polymer System
Yuk, Soon-Hong,Cho, Sun-Hang The Polymer Society of Korea 2000 Korea polymer journal Vol.8 No.2
A semi-interpenetrating network (IPN) was prepared for a temperature-sensitive polymer system composed of sodium alginate and poly (N, N-dimethylaminoethyl methacrylate (DMAEMA)-co-ethyl acrylamide (EAAm)). The role of sodium alginate is to provide crosslinked network and that of poly(DMAEMA-co-EAAm) is to provide temperature responsiveness to the polymer system. Semi-IPN gel shows temperature-induced swelling transition at the same temperature of the lower critical solution temperature of poly(DMAEMA-co-EAAm) and its swelling kinetics is manipulated by the control of crosslinking densitv.
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