구내 표준 방사선사진을 이용한 구내방사선촬영기의 선질 평가

이상섭,권혁락,심우현,오승현,이지연,전국진,김기덕,박창서 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.3

Purpose : This study was to evaluate the beam quality of intraoral X-ray equipments used at Yonsei University Dental Hospital (YUDH) using the half value layer (HVL) and the characteristic curve of intraoral standard X-ray film. Materials and Methods : The study was done using the intraoral X-ray equipments used at each clinical department at YUDH. Aluminum filter was used to determine the HVL. Intraoral standard film was used to get the characteristic curve of each intraoral X-ray equipment. Results : Most of the HVLs of intraoral X-ray equipments were higher than the least recommended thickness, but the REX 601 model used at the operative dentistry department and the X-707 model used at the pediatric dentistry department had HVLs lower than the recommended thickness. The slopes of the characteristic curves of films taken using the PANPAS 601 model and REX 601 model at operative dentistry department, the X-705 model of prosthodontic dentistry department, and the REX601 model at the student clinic were relatively low. Conclusion : HVL and the characteristic curve of X-ray film can be used to evaluate the beam quality of intraoral X-ray equipment. In order to get the best X-ray films with the least radiation exposure to patients and best diagnostic information in clinical dentistry, X-ray equipment should be managed in the planned and organized fashion. (Korean J Oral Maxillofac Radiol 2000; 30: 183-188)

염증성 근섬유모세포종의 증례보고

은상아,박혁,차인호,김현실,정호걸,김기덕,박창서 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.3

The inflammatory myofibroblastic tumor (inflammatory pseudotumor) is a rarely occurring soft tissue lesion of unknown etiology. It can be of any location, but commonly it is found in lungs. It has been considered as a nonneoplastic reactive inflammatory lesion, but nowadays, confusion and dispute about its character is increasing due to its high recurrence rate and metastasis. We present a patient who had been diagnosed with an inflammatory pseudotumor in the right maxilla area, 1 year before visiting our hospital. After that, her pain and swelling did not resolved and she visit our hospital. On radiographic examination, aggressively infiltrative growth of the lesion with destruction of adjacent bony structure was noted. We found unusual aggressiveness of the inflammatory myofibroblastic tumor of the head and neck region. Because the typical behavior of the inflammatory myofibroblastic tumor is not defined yet, we recommend the surgical excision of the lesion and close follow-up.

치수 치근단 병소의 전구 위험요인으로서의 제 2 형 당뇨의 역할에 관한 소고

김진희,배광식,서덕규,홍성태,이윤,홍삼표,금기연 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.3

Diabetes Mellitus (DM) is a syndrome accompanied with the abnormal secretion or function of insulin, a hormone that plays a vital role in controlling the blood glucose level (BGL). Type 1 and 2 DM are most common form and the prevalence of the latter is recently increasing. The aim of this article was to assess whet her Type 2 DM could act as a predisposing risk factor on the pulpo-periapical pathogenesis. Previous literature on the pathologic changes of blood vessels in DM was thoroughly reviewed. Furthermore, a histopathologic analysis of artificially-induced periapical specimens obtained from Type 2 diabetic and DM-resistant rats was compared. Histopathologic results demonstrate that the size of periapical bone destruction was larger and the degree of pulpal inflammation was more severe in diabetic rats, indicating that Type 2 DM itself can be a predisposing risk factor that makes the host more susceptible to pulpal infection. The possible reasons may be that in diabetic state the lumen of pulpal blood vessels are thickened by atheromatous deposits, and microcirculation is hindered. The function of polymorphonuclear leukocyte is also impaired and the migration of immune cells is blocked. leading to increased chance of pulpal infection. Also, lack of collateral circulation of pulpal blood vessels makes the pulp more susceptible to infection. These decrease the regeneration capacity of pulpal cells or tissues, delaying the healing process. Therefore, when restorative treatment is needed in Type 2 DM patients, dentists should minimize irritation to the pulpal tissue under control of BGL. 당뇨(Diabetes Mellitus)란 혈당을 조절하는 인슐린의 분비나 기능에 장애를 야기하는 질환으로 인슐린 의존성 여부에 따라 제 1 형과 제 2 형으로 분류된다. 본 종설은 최근 증가 추세에 있는 제 2 형 당뇨가 치수 치근단 병소의 병인 과정에 전구 위험 요인으로 작용할 수 있는지를 평가 하고자 문헌고찰을 통해 당뇨의 병인 과정에서 특징적으로 나타나는 혈관 합병증에 관해 알아보고, 부가적으로 제 2 형 당뇨 쥐 모델에서 인위적인 치수감염 후 얻은 치근단 조직의 조직병리학적 분석을 시행하였다. 조직학적 관찰 결과 제 2 형 당뇨 쥐에서 대조군에 비해 치수 치근단 병소의 크기가 증가하였고, 치수 염증 반응도 심하게 나타난 것으로 보아 당뇨 자체가 숙주를 감염에 취약한 상태로 만드는 전구 위험요소로 작용하였음을 알 수 있었다. 이러한 이유로는 첫째, 당뇨 시 전반적으로 나타나는 혈관 내 죽상 침착(atheromatous deposits)에 의해 혈관 내벽의 두께가 두꺼워져 미세 순환의 장애는 물론 탐식 세포의 기능 저하, 면역 세포의 혈류 이동이 차단되어 치수 감염 시 쉽게 치근단 병소로 이환될 가능성이 높고, 둘째 치수 혈관에서 특징인 측부 순환(collateral circulation)의 부재에 따른 살균성 다형핵 백혈구의 활동 억제를 포함한 미세 혈관계의 취약성으로 인해 치수 조직의 재생능이 저하되어 추가적인 감염원의 공격에 대한 방어 및 치유 저하를 더욱 심화시키기 때문인 것으로 사료된다. 따라서 제 2 형 당뇨 환자의 수복치료 시 치과의사는 당뇨 조절 하에서 치수 조직의 자극을 최소화하기 위한 세심한 처치가 필요하다.

중풍으로 유발된 배뇨,배변장애에 양격산화탕을 위주로 한 치험 1례

김상진 ( Kim Sang Jin ),김민수 ( Kim Min Su ),서부일 ( Seo Bu Il ),구덕모 ( Gu Deog Mo ),서해경 ( Seo Hae Gyeong ),안희덕 ( An Hui Deog ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3

Objectives : We got a good effect on one patient with urinary and bowel dysfunction following cerebrovascular accident by oriental medical methods. Methods : We employed oriental medical treatments; herb-medication ( YungkyLLksanwh-tang), acupuncture. moxibustion and cupping therapy. Results : Urinary and bowel dysfunction was recovered after this treatments. Sense of urination and defecation was improved, also urinary and fecal incontinence was dtxreased. Conclusions : U e expected that therapeutic value of treatment according to symptom -complex(證) of urinary and bowel dysfunction following cerebrovascular accident will be higher if more clinical studiesand researches are accomplished.

Characterization of a Small Plaque Variant Derived from Genotype V Japanese Encephalitis Virus Clinical Isolate K15P38

Kim Woo-Jin,Lee Ah-Ra,Hong Su-Yeon,Kim Sang-Hyun,Kim Jae-Deog,Kim Sung Jae,Oh Jae Sang,Shim Sang-Mu,Seo Sang-Uk 한국미생물·생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.8

Genotype V (GV) Japanese encephalitis virus (JEV) has been predominantly reported in the Republic of Korea (ROK) since 2010. GV JEV exhibits higher virulence and distinct antigenicity compared to other genotypes, which results in reduced efficacy of existing vaccines. Research on GV JEV is essential to minimize its clinical impact, but the only available clinical strain in the ROK is K15P38, isolated from the cerebrospinal fluid of a patient in 2015. We obtained this virus from National Culture Collection for Pathogens (NCCP) and isolated a variant forming small plaques during our research. We identified that this variant has one amino acid substitution each in the PrM and NS5 proteins compared to the reported K15P38. Additionally, we confirmed that this virus exhibits delayed propagation in vitro and an attenuated phenotype in mice. The isolation of this variant is a critical reference for researchers intending to study K15P38 obtained from NCCP, and the mutations in the small plaque-forming virus are expected to be useful for studying the pathology of GV JEV.

Biofilm-forming associated genotypic and phenotypic characteristics of <i>Staphylococcus</i> spp. isolated from animals and air

Seo, Yeon-Soo,Lee, Deog Yong,Rayamahji, Nabin,Kang, Mi Lan,Yoo, Han Sang Elsevier 2008 Research in veterinary science Vol.85 No.3

<P><B>Abstract</B></P><P>Biological monitoring is performed to detect and analyze microorganisms that have continuously made an effort to survive in the environment. Of such microorganisms, <I>Staphylococcus</I> spp. is considered a common cause of nosocomial and environmental infections., Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) are required for the adhesion and biofilm formation of Staphylococci. Thirty-six and thirty-five Staphylococci isolated from animals and air, respectively, were analyzed. Biofilm formation and ten MSCRAMM genes were investigated using Congo red agar, tissue culture plate methods, and PCR. Airborne isolates were shown to have higher adherence and stronger biofilm formation than those from animals. The prevalence of MSCRAMM genes from air isolates was also higher than those from animals. Of the genes, <I>eno</I> was mainly associated with biofilm formation in both animals and airborne isolates (<I>P</I><0.05). Moreover, the rate of airborne isolates harboring the <I>eno</I> gene was higher than in animal isolates. These results indicated that analysis of MSCRAMM genes with a phenotypic assay might be a helpful bacterial control system for the environment.</P>

급성림프구성백혈병의 면역학적 분류 및 림프아세포의 시험관내 분화유도에 관한 연구

서인석,조덕연,강원권,김삼용,이복희,이복수,백상기,김영진,이천배 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

The theory that various hematologic malignancies, such as acute and chronic leukemias and lymphomas, are characterized by monoclonal expansion of neoplastic cells arrested at different levels along the hemo-lymphopoietic differentiation pathway is widly accepted. It has also been supported by immunoglobulin gene rearrangement and phenotyping with specific antibodies to surface markers of lymphocytes concerning the lymphoid malignancies. In cope with these developments, the immunologic classification of acute lymphocytic leukemia had become more clarified. The author studied the immunologic classification of 15 patients with acute lymphocytic leukemia(ALL) with monoclonal antibodies against surface markers for lymphoid cells, and tried the in vitro induction of differentiation of progenitor-B cell ALL and T-cell ALL with TPA(12-0-tetradecanoyl phobol-13-acetate), a well known tumor promoter and known as a differentiation inducer also. Monoclonal antibodies for surface markers, used in this study, were Leu-9 for T-cell All and anti-Ia, anti-CALLA, anti-SIg(surface immunoglobulin), anti-BI, and anti-B4 for B-cell lineage ALL. Leu-9 positive cases were classified as T-cell ALL, Ia only positive cases were classified as progenitor-B cell ALL, Ia and CALLA positive cases were classified as common ALL, and Ia and SIg positive cases were classified as B-cell ALL. The results were as followings. 1. In this study, 5 cases were classified as common ALL, 3 each cases were B-cell and progenitor-B cell ALL, and 4 cases were T-cell ALL. 2. All 3 cases of B-cell ALL were L2 by FAB classification, and this findings was discordant with the conventional knowledge. 3. Leukocyte count in pheripheral blood of T-cell ALL patients at diagnosis was higher than that of non-T cell ALL(p<0.05). 4. All 5 cases of common ALL and 3 cases of B-cell ALL, 2 of 3 cases of progenitor-B cell ALL, and 1 of 4 cases of T-cell ALL achieved complete remission. So, T-cell ALL showed lower remission rate than that of common ALL and B-cell ALL. 5. One case of progenitor-B cell ALL, which is positive to only Ia, newly expressed B4, CALLA, BI and SIg after culture with TPA. This results suggest that TPA induce the differentiation of progenitor B-cells to more differentiated stage. 6. One case of T-cell ALL, which is positive to only Leu-9, newly expressed T3 after culture TPA and PHA. This results suggest that TPA and PHA induce the differentiation of early thymocyte to mature thymocyte.

Diagnosis of Sjögren's syndrome from a xerostomia case accompanied by multiple dental caries.

Seo, Deog-Gyu,Kim, Jin,Lee, Chan-Young,Park, Sung-Ho University of Washington, School of Dentistry] 2009 Operative dentistry Vol.34 No.3

Relationship between biofilm formation and the antimicrobial resistance in the Staphylococcus spp. isolated from animal and air

Seo, Yeon-Soo,Lee, Deog Young,Kang, Mi Lan,Lee, Won Jung,Yoo, Han Sang The Korean Society of Veterinary Science 2009 大韓獸醫學會誌 Vol.49 No.3

Biofilm has been described as a barrier, which produced by microorganisms to survive and protect themselves against various environments, like antibiotic agents. Staphylococcus spp. is a common cause of nosocomial and environmental infection. Thirty-six and thirty-five Staphylococci were isolated from animals and air, respectively. Based on the biofilm forming ability of the bacterium reported in our previous report, relationship between biofilm formation and antibiotic-resistance was investigated in this study. Regarding antibiotics susceptibility, cefazolin was the most effective agent to the bacteria. Strong biofilm-forming Staphylococcus spp. isolates might have a higher antibiotic resistance than weak biofilm isolates regardless of the presence of antibiotic resistance genes (p < 0.05). This result suggested that the chemical complexity of the biofilm might increase the antibiotic resistance due to the decrease of antibiotic diffusion into cells through the extensive matrix.

Safety and efficacy of nilotinib in adult patients with chronic myeloid leukemia: a post-marketing surveillance study in Korea

Seo-Yeon Ahn,Sang Kyun Son,Gyu Hyung Lee,Inho Kim,June-Won Cheong,Won Sik Lee,Byung Soo Kim,Deog-Yeon Jo,Chul Won Jung,Chu Myoung Seong,Jae Hoon Lee,Young Jin Yuh,Min Kyoung Kim,Hun-Mo Ryoo,Moo-Rim Pa 대한혈액학회 2022 Blood Research Vol.57 No.2

Background Nilotinib is a tyrosine kinase inhibitor approved by the Ministry of Food and Drug Safety for frontline and 2nd line treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This study aimed to confirm the safety and efficacy of nilotinib in routine clinical practice within South Korea. Methods An open-label, multicenter, single-arm, 12-week observational post-marketing surveillance (PMS) study was conducted on 669 Korean adult patients with Ph+ CML from December 24, 2010, to December 23, 2016. The patients received nilotinib treatment in routine clinical practice settings. Safety was evaluated by all types of adverse events (AEs) during the study period, and efficacy was evaluated by the complete hematological response (CHR) and cytogenetic response. Results During the study period, AEs occurred in 61.3% (410 patients, 973 events), adverse drug reactions (ADRs) in 40.5% (271/669 patients, 559 events), serious AEs in 4.5% (30 patients, 37 events), and serious ADRs in 0.7% (5 patients, 8 events). Furthermore, unexpected AEs occurred at a rate of 6.9% (46 patients, 55 events) and unexpected ADRs at 1.2% (8 patients, 8 events). As for the efficacy results, CHR was achieved in 89.5% (442/494 patients), and minor cytogenetic response or major cytogenetic response was achieved in 85.8% (139/162 patients). Conclusion This PMS study shows consistent results in terms of safety and efficacy compared with previous studies. Nilotinib was well tolerated and efficacious in adult Korean patients with Ph+ CML in routine clinical practice settings.