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      저자 : ( Ramon L. De Vera ) (검색결과 1 건)
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      • Clinical Profile, Prognostic Factors, and Survival of Patients with Hepatocellular Carcinoma in Two Philippine Tertiary Centers

        ( Mara Teresa T. Panlilio ),( Rei Joseph P. Prieto ),( Angela D. Djajakusuma ),( Neil S. Bacaltos ),( Cynthia A. Balagot ),( Jade D. Jamias ),( Ramon L. De Vera ),( Janus P. Ong ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

        Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the Philippines and in the world. Most burden of disease is seen in developing countries, with highest incidence reported in hyperendemic regions for Hepatitis B infection. This study identified the prognostic factors and overall survival of patients with HCC. Methods: This retrospective study included adult patients diagnosed with HCC at two Philippine tertiary hospitals from 2007 to 2014. Demographics, tumor characteristics, risk factors, and treatment outcomes were retrieved through review of medical records. STATA v12 was used to perform univariate and multivariate logistic regression. Overall survival was also determined. Results: Four hundred twenty-nine patients, with a mean age of 59.6+13.2 years (M:F ratio 3.6:1), were included. Almost half (49%) had advanced HCC on diagnosis. Fifty-two percent had documented HBV infection, and liver cirrhosis was present in 56%. Furthermore, tumors were usually solitary (59%). Only 57% were able to proceed with treatment. Significant predictors of survival were surgical resection (OR 0.12, p-value <0.001), Child Turcotte Pugh (CTP) classification (CTP B: OR 2.26, p-value 0.024; CTP C: OR 5.54, p-value 0.013), liver cirrhosis (OR 2.56, p-value 0.007), and portal vein thrombosis (PVT) (OR 2.68, p-value 0.035). Forty-two percent of the patients died, with a median overall survival of 16 months. Conclusions: CTP classification, liver cirrhosis, PVT, and surgical resection were identified as significant predictors of survival in HCC. Due to innate limitations of retrospective studies, a prospective study will help in determination of association between severity of disease and treatment outcomes.

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