http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Prakash Bhatt ),( V. Kumar ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Hepatocellular carcinoma (HCC) is the most mortal cancer (5 year survival under 11%) and HCC is the 3 most frequent cause of cancer related death in male and 6th most common in women. Still, the treatment of HCC is limited. Systemic chemotherapy for HCC, either as single drug therapy or in combination therapy, radiofrequency ablation or recently introduced tyrosine kinase inhibitors, e.g. sorafenib, are some promising options. The aim of the current study was to scrutinize the synergistic chemo-protective effect of metformin (5 mg/kg) in combination with quercetin in diethylnitrosamine (DEN) induced HCC rats. Methods: Single intraperitoneal injection of DEN (160 mg/kg) was used for the induction of HCC. The rats divided into different groups and received the combination of metformin and quercetin. Hepatic, antioxidant, pro-inflammatory, inflammatory mediators and apoptosis marker were estimated. Morphological and histopathological component of hepatic tissue were estimated. Results: Combination therapy of metformin and quercetin down-regulated the AFP (83%) level along-with the hepatic nodules. Combination therapy reduced the hepatic parameters AST (74.5%), ALP (68.5%), ALT (73.4%), CEA (43.5%); antioxidant parameter LPO (64.5%), CAT (73.4%), SOD (65.4%), GST (56.3%), GPx (59.4%), respectively. Combination therapy reduced the inflammatory mediators such as COX-2 (65.5%), PGE2 (63.4%), NF-kB (73.4%) and apoptosis marker such as caspase-3 (54.5%) and caspase-9 (65.5%), respectively. Histopathological investigation support the above hepatic cancer effect of combination therapy. Conclusions: Our result shows that this remarkable combination has remarkable treatment for HCC in rats via inflammatory and apoptosis pathway.
Prakash C. Phondani,Indra D. Bhatt,Vikram S. Negi,Bhagwati P. Kothyari,Arvind Bhatt,Rakesh K. Maikhuri 국립중앙과학관 2016 Journal of Asia-Pacific Biodiversity Vol.9 No.1
The present paper discusses the development of a participatory approach to promote medicinal and aromatic plant (MAP) cultivation as a tool for biodiversity conservation and livelihood enhancement in Champawat district of Uttarakhand state in India. People perception analysis revealed that farmers were dependent solely on the wild collection of MAPs before the initiation of the National Agriculture Innovation Project. However, they later engaged in cultivation practices. During the course of study, the propagation protocols of 11 selected MAPs of that area were developed and a cost-benefit analysis was performed. A series of meetings and exposure visits were organized and a memorandum of understanding was simultaneously signed between farmers and traders for promoting a buy-back system of MAPs. One hundred thirty-two farmers adopted MAP cultivation in 14 hectares of land. This approach provides opportunities for farmers to build skills, knowledge, and self confidence, and conserve MAP diversity in their natural habitat.