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Pulmonary toxicity screening of triclosan in rats after intratracheal instillation.
Kwon, Jung-Taek,Yang, Young-Su,Kang, Min-Sung,Seo, Gyun-Baek,Lee, Dong Hun,Yang, Mi-Jin,Shim, Ilseob,Kim, Hyun-Mi,Kim, Pilje,Choi, Kyunghee,Lee, Kyuhong 日本トキシコロジ-學會 2013 JOURNAL OF TOXICOLOGICAL SCIENCES Vol.38 No.3
<P>Triclosan (TCS) is a chemical compound used in household products as biocide. However, their pulmonary toxicity has been unclear. Thus, the purpose of this study was to investigate the possibility of injury to the lung by inhalation of TCS. Rats were exposed to TCS by single intratracheal instillation of 10 ?g/B.W. kg for the low-dose group and 1,000 ?g/B.W. kg for the high-dose group, respectively. TCS induced increase in the level of total cell (TC) count, polymorphonuclear leukocytes (PMNs), total protein (TP), lactate acid dehydrogenase (LDH), tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in bronchoalveolar lavage fluid (BALF) at 1 day after instillation. However, most pulmonary toxicity marker levels except TP in BALF were restored 14 days after instillation. In addition, TCS led to reduction of cell viability with morphological change in lung eptiehelial cells (L2 cell). Therefore, TCS may affect responses of acute inflammation and permeability in the lung.</P>
SBD(Self Bag Drop) Systems의 보안 및 운영 개선 방안에 대한 연구
김하나,권필제,이강석,Kim, Ha-na,Kwon, Pilje,Lee, Kang-seok 한국항공운항학회 2018 한국항공운항학회지 Vol.26 No.3
The SBD systems have made it possible that all boarding procedures are completed by passengers. With the SBD, air tickets can be issued and baggage can be consigned without the help of airline officers. This way, the SBD can improve the passenger circulation speed as well as decrease the time for passengers to wait for check-in, which is connected to the reduction of airlines' operaitonal costs. However, given that the SBD is a new technology, it has potentials to be used as a tool for air terrorism. This study purposes to determine methods to enhance the security and operation of SBD systems. With the aim, this paper investigated the existing literature on SBDs, self-check-in, airport security, air terrorism, risk management, aviation accidents, and information security. In order to compile real-time information about the SBD operations, twelve airports in North America, Europe, and Asia were analyzed based on existing studies on international SBD trends.
Lung Transplantation in Six Patients with Idiopathic Pulmonary Artery Hypertension
( Hyeonhwa Kim ),( Dongkwan Kim ),( Sehoon Choi ),( Geundong Lee ),( Dongkyu Oh ),( Hocheol Kim ),( Jaeseung Lee ),( Sungho Jung ),( Pilje Kang ),( Won Kim ),( Seungil Park ),( Sangbum Hong ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Idiopathic pulmonary artery hypertension (IPAH) is an incurable and invariably fatal disease. Lung transplantation is a useful therapeutic option in patients who are unresponsive to medical treatment; however, lung transplantation performed for pulmonary hypertension is associated with significantly high perioperative mortality rates. We report a case series of six patients who underwent lung transplantation for IPAH between October 2008 and June 2021. Patients’ median age was 28.5 years, and the study included 5 of 6 women (83%). Pre-transplantation hemodynamic parameters showed mean right atrial pressure of 12.0±7.1 mmHg and mean pulmonary artery pressure of 62.2±29.5 mmHg. Two of six patients received extracorporeal membrane oxygenation (ECMO) therapy as a bridge to transplantation over 14 and 17 days, and four patients underwent elective transplantation. Two patients required prolonged postoperative venoarterial (V-A) ECMO support. Grade 3 primary graft dysfunction occurred in one patient; however, the clinical course improved following prolonged V-A ECMO therapy. Five patients (83.3%) required intervention for postoperative bleeding control; one of these patients died of uncontrolled bleeding concomitant with disseminated intravascular coagulation, on the 14th postoperative day, and we observed no other perioperative deaths. One patient died of carbapenem-resistant Acinetobacter baumannii bacteremia, a year postoperatively. The 1-month, 6-month, and 1-year survival rates were 83.3%, 83.3%, and 66.7%, respectively. In view of the poor prognosis of IPAH, lung transplantation (1-year mortality rates <40%) merits consideration as a useful therapeutic option in this patient population. However, postoperative bleeding tends to occur in most patients; therefore, close monitoring is important during post-transplantation management.