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        Intermittent Self-catheterization in Older Adults: Predictors of Success for Technique Learning

        Claire Hentzen,Rebecca Haddad,Samer Sheikh Ismael,Benoit Peyronnet,Xavier Gamé,Pierre Denys,Gilberte Robain,Gérard Amarenco 대한배뇨장애요실금학회 2018 International Neurourology Journal Vol.22 No.1

        Purpose: The main goal of this retrospective study is to explore the predictors of success in learning clean intermittent selfcatheterization (CISC) in patients over 65 years of age. The secondary goal is to assess whether in this population, the risk of failure to perform CISC is greater, compared with patients under 65 with similar pathologies. Methods: All patients older than 65 consulting between January 2011 and January 2016 for learning CISC were included. A control population younger than 65 matching with sex, body mass index, and pathology was selected. Results: One hundred sixty-nine of the 202 patients (83.7%) over 65 succeeded in learning CISC. Obesity (P<0.05), low pencil and paper test (PP test) (P<0.01) and low functional independence measure (FIM) (P<0.01) scores were risk factors of failure. No significant differences were found with sex or pathology. In multivariate analysis, low PP test perineum access (odds ratio [95% confidence interval], 2.30 [1.32–4.42]), low FIM motor (1.04 [1.01–1.08]), and FIM cognition (1.18 [1.03–1.37]) scores were independent factors of learning failure. Compared to control group, age over 65 was not predictive of failure (P=0.15). Conclusions: Our study shows that success in learning CISC does not depend on age but on difficulties in mobility, access to perineum and probably cognitive disorders.

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        A prospective, observational study of rivaroxaban for stroke prevention in atrial fibrillation: the XANAP Korea

        ( Jaemin Shim ),( Young Keun On ),( Sun U. Kwon ),( Gi-byoung Nam ),( Moon-hyoung Lee ),( Hyung-wook Park ),( Keun-sik Hong ),( Nam-ho Kim ),( Pierre Amarenco ),( Seung-woon Rha ),( Dong-gu Shin ),( J 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.4

        Background/Aims: Atrial fibrillation (AF)-related stroke accounts for 20% of ischemic strokes. Rivaroxaban use in AF patients for preventing stroke and systemic embolism was approved in 2013 in Korea. This study was to investigate the safety and effectiveness of rivaroxaban use in Korean patients with non-valvular AF in a real-world setting. Methods: This was an analysis of the Korean patients in Xarelto for Prevention of Stroke in Patients with Atrial Fibrillation in Asia-Pacific (XANAP), which was a prospective, observational cohort study including patients with non-valvular AF starting rivaroxaban treatment to prevent stroke or non-central nervous system systemic embolism (non-CNS SE), conducted in 10 Asian countries. Results: A total of 844 patients were enrolled in the Korean portion of the XANAP study. In XANAP Korea, the mean age was 70.1 years and 62.6% were males. The mean CHADS<sub>2</sub> score was 2.5 and the mean CHA<sub>2</sub>DS<sub>2</sub>-VASc score was 3.8. 47% of the patients had experienced prior stroke or non-CNS SE or transient ischemic attack. 73.6% of the patients had CHADS<sub>2</sub> score ≥ 2. Incidence proportions of 0.8% of the patients (1.1 per 100 patient-years) developed adjudicated treatment-emergent major bleeding. Death was observed in 1.2% of the patients. The incidence of non-major bleeding as well as thromboembolic event were 8.4% (11.6 per 100 patient-years) and 1.5% (2.0 per 100 patient-years), respectively. Conclusions: This study reaffirmed the consistent safety profile of rivaroxaban. We found consistent results with overall XANAP population for rivaroxaban in terms of safety in non-valvular AF patients for the prevention of stroke and non- CNS SE.

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