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( Jiaofen Nan ),( Liangliang Zhang ),( Qiqiang Chen ),( Nannan Zong ),( Peiyong Zhang ),( Xing Ji ),( Shaohui Ma ),( Yuchen Zhang ),( Wei Huang ),( Zhongzhou Du ),( Yongquan Xia ),( Ming Zhang ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.1
Background/Aims The Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C. Methods The voxel-wise analysis of the diffusion parameters was used to quantify the white matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a comparison group with 19 healthy controls by tract-based spatial statistics. The correlations between diffusive parameters and clinical symptoms were evaluated using a Pearson’s correlation. Results In comparison to healthy controls, FC patients showed a decrease of fractional anisotropy (FA) and an increase of radial diffusivity (RD) in multiple major fibers encompassing the corpus callosum (CC, P = 0.001 at peak), external capsule (P = 0.002 at peak), corona radiata (CR, P = 0.001 at peak), and superior longitudinal fasciculus (SLF, P = 0.002 at peak). In contrast, IBS-C patients showed FA and RD aberrations in the CC (P = 0.048 at peak). Moreover, the direct comparison between FC and IBS-C showed only RD differences in the CR and SLF. In addition, FA and RD in the CC were significantly associated with abdominal pain for all patients, whereas FA in CR (P = 0.016) and SLF (P = 0.040) were significantly associated with the length of time per attempt and incomplete evacuation separately for FC patients. Conclusion These results may improve our understanding of the pathophysiological mechanisms underlying different types of constipation. (J Neurogastroenterol Motil 2018;24:107-118)
Dynamic analysis of a train-bridge system under multi-support seismic excitations
Nan Zhang,He Xia,Guido De Roeck 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.11
A numerical solution for the dynamic responses of a train-bridge interaction system subjected to multi-support seismic loads was studied. The train vehicle was modeled by the rigid-body dynamics method, and the bridge was modeled by the finite element method. The vertical and lateral wheel-rail interaction forces were defined according to the wheel-rail corresponding assumption and the simplified Kalker creep theory. Three-dimensional seismic accelerations were incorporated using the large mass method. In a case study, the dynamic responses were simulated for a high-speed train traversing a steel truss cable-stayed bridge with different seismic intensities and different train speeds, and train safety was evaluated.
Theory, Simulation, and Experiment on Extended Mixed-Mode S-Parameters in Three-Conductor Lines
Zhang, Nan,Kim, Kwangho,Lee, Hosang,Nah, Wansoo [Institute of Electrical and Electronics Engineers 2017 IEEE transactions on electromagnetic compatibility Vol.59 No.6
<P>This paper proposes novel mixed-mode S-parameters, which are dubbed as 'extended mixed-mode S-parameters.'The extended mixed-mode S-parameters were applied to three-conductor transmission lines, resulting in the independent differential and common modes using the current division factor of three-conductor transmission lines. By contrast to the conventional mixed-mode S-parameters, there are no cross-mode S-parameters in the extended mixed-mode S-parameters, even in the asymmetrical conductor transmission lines. In addition, two new mode conversion matrices, which contain the current division factor, are also proposed to convert the extended mixed-mode S-parameters to the standard S-parameters. The validity of the proposed extended mixed-mode S-parameters and the mode conversion method were confirmed by comparing the S-parameters from the theory, EM-simulation, and experiment as well.</P>
Zhang, Nan,Wang, Dong,Zhu, Yu,Wang, Jian,Lin, Hong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Lamellarin D (LamD) is a marine alkaloid with a pronounced cytotoxicity against a large panel of cancer cells, affecting cell growth and inducing apoptosis. However, the molecular mechanisms of action of this compound are poorly understood. In this study, the anticancer efficacy of LamD was investigated in human leukemia K562 cells. The results showed suppressed cell proliferation and induction of G0/G1-phase arrest,while expression of CDK1, and activity of smad3 and smad5 were reduced, but that of p27, p53 and STGC3 was increased. LamD induced cell apoptosis through activation of caspases-8/-3, inhibition of survivin and Bcl-2, suggesting that this compound may also act through a caspase-independent pathway. Moreover, LamD inhibited the secretion of TGF-${\beta}$, IL-$1{\beta}$, IL-6, IL-8 and other inflammatory cytokines and the transcriptional activity of transcription factor NF-${\kappa}B$ in human leukemia K562 cells.Taken together, our results suggest that LamD-mediated inhibition of leukemia cell proliferation may be related to the induction of apoptosis and the regulation of cell cycle, tumor-related gene expression and cytokine expression, which may provide a new way of thinking for the treatment leukemia.
Development and Research Trends of TBM Manufacturing Technology in China
Nan Zhang,정호영,전석원 한국자원공학회 2018 한국자원공학회지 Vol.55 No.4
Chinese TBM industry has rapidly developed over the past decade, while China can beregarded as the most remarkable TBM market in the world. After sixty years of development, China already has a complete set of technologies in all domains of TBM, including design, manufacturing, operation and tunnel construction, which are still evolving. The growth of the technology is a result of continuous research and development by the industry and academia under the strongly support from Chinese government. Inorder to complete independent technology development and play a leading role in the global TBM market, the strategy of China has a good reference value for Korea. The history of TBM technology in China was reviewed, and the major research projects and achievements were summarized. Finally, through the implications from the Chinese case, the research and development of TBM technology in Korea and its future research topics were discussed.
The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability
Zhang Nan,Shen Yan,Li Huan,Chen Ying,Zhang Ping,Lou Shifeng,Deng Jianchuan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
N6-methyladenosine (m6A) is the most abundant posttranscriptional modification of mRNA in eukaryotes. Recent evidence suggests that dysregulated m6A-associated proteins and m6A modifications play a pivotal role in the initiation and progression of diseases such as cancer. Here, we identified that IGF2BP3 is specifically overexpressed in acute myeloid leukemia (AML), a subtype of leukemia associated with poor prognosis and high genetic risk. IGF2BP3 is required for maintaining AML cell survival in an m6A-dependent manner, and knockdown of IGF2BP3 dramatically suppresses the apoptosis, reduces the proliferation, and impairs the leukemic capacity of AML cells in vitro and in vivo. Mechanistically, IGF2BP3 interacts with RCC2 mRNA and stabilizes the expression of m6A-modified RNA. Thus, we provided compelling evidence demonstrating that the m6A reader IGF2BP3 contributes to tumorigenesis and poor prognosis in AML and can serve as a target for the development of cancer therapeutics.