Acute Pulmonary Edema after Cardioversion for Torsade de Pointes:A Case Report

Na Rae Ha,Duk Joo Lee,Tae Hyung Kim,Ho Joo Yoon,Dong Ho Shin,Jang Won Sohn,Sung Soo Park Korean Society of Critical Care Medicine 2007 Acute and Critical Care Vol.22 No.1

Cardioversion used for the treatment of various cardiac arrhythmias is a safe and effective procedure with infrequent complication. The restoration of sinus rhythm is followed by a improvement in hemodynamics, but acute pulmonary edema has been reported as a rare complication following successful electrical reversion of various tachyarrhythmia to normal sinus rhythm. This report describes a 42-year-old woman with a history of schizophrenia who experienced pulmonary edema after cardioversion for torsade de pointes. She had taken chlorpromazine and haloperidol for schizophrenia. The antipsychotic drugs were suspected to induce QT interval prolongation and resultant torsade de pointes. Two hours after cardioversion, pulmonary edema developed on chest X-ray and chest computed tomography. She responded to conservative treatment including oxygen therapy and the pulmonary edema improved on the second hospital day. The mechanism of pulmonary edema after cardioversion is still uncertain and remains controversial.

장천공과 간문맥 내 가스 소견으로 발견된 크론병

하나래 ( Na Rae Ha ),이항락 ( Hang Lak Lee ),이오영 ( Oh Young Lee ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 ( Joon Soo Hahm ),이동후 ( Dong Hoo Lee ),이민호 ( Min Ho Lee ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.5

Crohn`s disease is characterized by its chronic course and transmural inflammation of gastrointestinal tract. The accompanying fibrous reaction and adhesion to adjacent viscera appears to limit the complication of free perforation. The true incidence of free bowel perforation is difficult to assess, however, the anticipated occurrence rate is 1-2% during the course of illness. Moreover, portal venous gas is also an uncommon event in the natural history of Crohn`s disease. Portal venous gas occurs when intraluminal gas from the gastrointestinal tract or gas-forming bacteria enters the portal venous circulation. The finding of portal venous gas associated with Crohn`s disease does not always mandate surgical intervention. We experienced a case of Crohn`s disease presenting with free perforation and portal venous gas. The literatures on the cases with perforation and portal venous gas associated with Crohn`s disease were reviewed. (Korean J Gastroenterol 2007;50:319-323)

담쟁이덩굴 줄기 추출물의 세포 보호 작용과 항산화 활성

조나래 ( Na Rae Jo ),박민아 ( Min A Park ),채교영 ( Kyo Young Chae ),박수아 ( Su Ah Park ),전소하 ( So Ha Jeon ),하지훈 ( Ji Hoon Ha ),박수남 ( Soo Nam Park ) 대한화장품학회 2012 대한화장품학회지 Vol.38 No.3

본 연구에서는 담쟁이덩굴 줄기 추출물의 HaCaT 세포와 사람 적혈구 세포에서의 세포 보호 효과 및 항산화능을 측정하였다. HaCaT 세포를 이용한 실험에서, 담쟁이덩굴 줄기 추출물의 에틸아세테이트 분획과 아글리콘 분획은 각각 50 μ g/mL 및 25 μ g/mL의 농도에서 독성을 나타내지 않았다. 10 mM의 H₂O₂ 및 30 μ M의 rose bengal을 HaCaT 세포에 처리하였을 때, 에틸아세테이트 분획(6.25 ∼ 50 μ g/mL) 및 아글리콘 분획(6.25 ∼ 25 μ g/mL)은 농도 의존적으로 세포를 보호하였다. 적혈구 광용혈에서 담쟁이덩굴 줄기 추출물은 10 μ g/mL의 농도에서 대표적인 지용성 항산화제인 α-토코페롤보다도 큰 세포보호효과를 나타내었다. 담쟁이덩굴 줄기 추출물 에틸아세테이트 분획의 free radical(1,1-diphenyl-2- picrylhydrazyl , DPPH) 소거활성(FSC₅₀)은 18.5 μ g/mL를 나타내었다. Luminol-의존성 화학발광법을 이용한 Fe³⁺-EDTA/H₂O₂계에서 생성된 활성산소종(reactive oxygen species, ROS)에 대한 담쟁이덩굴 줄기 추출물의 총항산화능(OSC₅₀)은 에틸아세테이트 분획의 경우 1.72 μg/mL, 아글리콘 분획은 1.53 μg/mL로 대표적 항산화제인 L-ascorbic acid (OSC₅₀ = 1.50 μg/mL)와 유사한 항산화능의 크기를 나타내었다. 이상의 결과들은 담쟁이덩굴 줄기 추출물이 ROS에 대항하여 세포를 보호함으로써 생체계, 특히 태양 자외선에 노출된 피부에서 세포보호제 및 천연항산화제로서 작용할 수 있음을 가르킨다. In this study, the cellular protective effects on HaCaT cells and human erythrocytes and antioxidative effects of P. tricuspidata stem extracts were investigated. The ethyl acetate (50 μ g/mL) and aglycone fraction (25 μ g/mL) of P. tricuspidata stem extracts doesn't show any characteristics of cytotoxicity. When HaCaT cells were treated with 10 mM H₂O₂ and 30 μ M rose bengal, the ethyl acetate (6.25 ∼ 50 μ g/mL) and aglycone (6.25 ∼ 25 μ g/mL) fraction protected the cells against the oxidative damage in a concentration dependent manner. The P. tricuspidata stem extracts showed more prominent cellular protective effect than (+)-α-tocopherol, known as lipid antioxidant at 10 μ g/mL. The ethylacetate fraction of P. tricuspidata stem extracts (18.5 μ g/mL) showed more free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (FSC5₅₀). Reactive oxygen species (ROS) scavenging activity (OSC₅₀) of P. tricuspidata stem extracts on ROS generated in Fe³⁺-EDTA/H₂O₂ system was investigated using the luminol-dependent chemiluminescence assay. The ethyl acetate (1.72 μ g/mL) and the aglycone fraction (1.53 μ g/mL) showed similar ROS scavenging activity of L-ascorbic acid (1.50 μ g/mL). These results indicate that extract/fractions of P. tricuspidata stem extracts can function as natural cytoprotective agents and antioxidants in biological systems, particularly skin exposed to UV radiation by protecting cellular membrane against ROS.

피부 흡수 증진을 위한 담쟁이덩굴 줄기 추출물 함유 나노에멀젼 및 이의 항균활성 연구

조나래 ( Na Rae Jo ),박민아 ( Min A Park ),전소하 ( So Ha Jeon ),박수남 ( So Ha Jeon ) 한국미생물생명공학회(구 한국산업미생물학회) 2013 한국미생물·생명공학회지 Vol.41 No.3

In a previous study, we investigated the antioxidative and cellular protective effects of Parthenocissus tricuspidata stem extracts. In this study, we prepared nano-emulsion containing P. tricuspidata stem extract to improve skin permeation. The particle size of the nano-emulsion using the microfluidizer was 302 nm. Its loading efficiency was over 86%. The size distribution of the nano-emulsion took a monodispersed form and the nano-emulsion was more stable than typical emulsion without using microfluidizer during a 2 week period. In vitro skin permeation study of nano-emulsion containing P. tricuspidata stem extracts was carried out using Franz diffusion cell. The 1,3-butylene glycol used as a control group had 32.59% skin permeation efficiency. The skin permeation efficiency of the nano-emulsion was 42.47%. Also, we observed the antibacterial activity of the ethyl acetate fraction on skin flora for prospective applications as a natural antimicrobial. The ethyl acetate fraction had antibacterial activities higher than methyl paraben on Staphylococcus aureus, and Bacillus subtilis. These results indicate that nanoemulsion containing P. tricuspidata stem extracts could possess valued applications in cosmetic formulations for improving skin permeation. Also, based on the antibacterial activities on skin flora, antioxidative and cellular protective effects shown in our previous study, we suggest that P. tricuspidata stem extracts could be used as functional cosmetic materials.

레스베라트롤의 세포보호 및 항산화 효과

조나래 ( Na Rae Jo ),박수아 ( Su Ah Park ),전소하 ( So Ha Jeon ),하지훈 ( Ji Hoon Ha ),박수남 ( Soo Nam Park ) 한국공업화학회 2013 공업화학 Vol.24 No.5

In this study, the cellular protective effect of resveratrol on oxidative damage and its antioxidative activity were investigated. The free radical-scavenging activity (FSC50) of resveratrol was measured to be 103 μM. The reactive oxygen species-scavenging activity (OSC50) of resveratrol on the ROS generated in a Fe 3+ -EDTA/H2O2 system was investigated using the luminol-dependent chemiluminescence assay. Resveratrol displayed 0.042 μM ROS scavenging activity, which is 9.6-fold higher than that of L-ascorbic acid (0.405 μM) and had a more prominent cellular protective effect than (+)-α-tocopherol. When HaCaT cells were exposed to 800 mJ/cm 2 of UVB or treated with 30 μM rose bengal, resveratrol protected the cells against oxidative stress in a concentration-dependent manner; however, it was unable to protect the cells when the damage was induced by 10 mM H2O2. These results indicate that resveratrol could be employed to improve and prevent the skin aging through its antioxidative and cellular protective activities.

Ginsenoside Rb1 inhibits ovalbumin-induced airway inflammation in a mouse model of asthma

Ha-Young Jang,Na-Rae Shin,Sei-Ryang Oh,Kyung-Seop Ahn 한국실험동물학회 2012 한국실험동물학회 학술발표대회 논문집 Vol.2012 No.8

Three Cases of Mucocutaneous Angiomyolipoma in the Head and Neck Region with Reference to the HMB-45 and Melan-A Immunohistochemistry

Na Rae Kim(김나래),Dong Young Kim(김동영),Heung Eog Cha(차흥억),Seung Yeon Ha(하승연) 대한두경부종양학회 2009 대한두경부 종양학회지 Vol.25 No.2

혈관근육지 방종은 지방, 평활근, 두꺼운 벽의 혈관이 다양한 비율로 구성된 흔하지 않은 과오종이며, 이는 결정 경화증을 동반하거나 산발적으로 발생한다. 저자들은 혈관근육지방종이 드물게 발생하는 두경부에서 발생한 귓바퀴 1예, 구개점막 2예의 혈관근육지방종을 보고하고자 한다. 병리소견상, 3예 모두에서 성숙지방조직, 불규칙한 혈관, 그리고 HMB-45와 Melan-A에 음성을 보이는 평활근육세포로 이루어진 조직소견을 보였으며, 여러군데에서 림프구 침윤이 3예 모두에서 관찰되었다. 점막피부 혈관근육지방종으로 진단하였다. 세증례 모두 결절경화증은 동반되지 않았다. 점막피부 혈관근육지방종에서는 혈관주변세포가 HMB-45와 Melan-A에서 음성을 보였으며, 이는 간이나 신장의 혈관근육지방종에서의 특징적인 양성반응과는 다른 점이었다. 간이나 신장에서 생긴 혈관근육지방종과 다른 임상병리적 특징을 비교 기술하고자 두경부에서 발생한 점막피부 혈관근육지방종 3예를 보고한다.

Small Cell Carcinoma of Ampulla of Vater: Report of Two Cases

Na Rae Kim,Yeon Ho Park,Yang Suh Koo,Seung-Yeon Ha,Dong-Hae Chung 대한췌담도학회 2010 대한췌담도학회지 Vol.15 No.1

We report a 62-year-old woman and a 66-year-old woman with abdominal pain and acute onset of jaundice, respectively. Preoperative cholangiopancreatography, cholangiography, and ERCP showed masses in the ampulla of Vater. Biopsy showed small cell carcinoma, and the tumor cells were immunoreactive for neuron-specific enolase, chromogranin A, and synaptophysin. Pancreatoduodenectomy or chemotherapy with radiation was performed in each patient. Histopathologic investigation disclosed direct invasion deep to the lamina propria, and infiltration of the pancreatic parenchyma, duodenum, and bile duct in the pancreatoduodenectomized patient. One patient died due to multiple liver metastases of the carcinoma of the ampulla of Vater 7 months after initiation of chemotherapy and radiotheraphy, and the other died 4 months after pancreatoduodenectomy. As in previously reported cases of small cell carcinoma of the ampulla of Vater, the present two cases showed extremely aggressive clinical course with early metastases resulting in fatal outcome.

Case Reports : Intrathoracic Desmoid Tumor Mimicking Pleural Mass

Na Rae Kim,Dong Hae Chung,Jae Ik Lee,Sung Hwan Jeong,Seung Yeon Ha 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5

Desmoid tumor (fibromatosis) is a histologically benign fibrous neoplasm showing locally infiltrating growth. This type of tumor commonly occurs in the abdomen, but intrathoracic desmoid tumor is uncommon. To date, 12 cases of intrathoracic desmoid tumor protruding into the pleural cavity, radiologically mimicking pleural masses, have been reported. Here, we report on a case of intrathoracic desmoid tumor protruding into the pleural cavity, and partially covered by parietal pleura. The main preoperative differential diagnoses included pleural solitary fibrous tumor, inflammatory pseudotumor or malignant mesothelioma. A near-total mass excision was performed. Pathologically, the tumor was composed of a paucicellular arrangement of spindle-shaped cells with fibromyxoid stroma. The resection margin was partially involved with spindle cells present. On histochemical staining, the spindle cells were strongly positive for vimentin and negative for CD34, consistent with a desmoid tumor. The patient was stable without further adjuvant treatment during 6-years of follow-up.

THERMAL HYDRAULIC ISSUES OF CONTAINMENT FILTERED VENTING SYSTEM FOR A LONG OPERATING TIME

Na, Young Su,Ha, Kwang Soon,Park, Rae-Joon,Park, Jong-Hwa,Cho, Song-Won Korean Nuclear Society 2014 Nuclear Engineering and Technology Vol.46 No.6

This study investigated the thermal hydraulic issues in the Containment Filtered Venting System (CFVS) for a long operating time using the MELCOR computer code. The modeling of the CFVS, including the models for pool scrubbing and the filter, was added to the input file for the OPR-1000, and a Station Blackout (SBO) was chosen as an accident scenario. Although depressurization in the containment building as a primary objective of the CFVS was successful, the decontamination feature by scrubbing and filtering in the CFVS for a long operating time could fail by the continuous evaporation of the scrubbing solution. After the operation of the CFVS, the atmosphere temperature in the CFVS became slightly above the water saturation temperature owing to the release of an amount of steam with high temperature from the containment building to the scrubbing solution. Reduced pipe diameters at the inlet and outlet of the CFVS vessel mitigated the evaporation of scrubbing water by controlling the amount of high-temperature steam and the water saturation temperature.