뇌성마비 환자의 전신마취 하 치과치료

정준민,서광석,이영은,한희정,한진희,김혜정,신터전,김현정,염광원,장주혜,Chung, Jun-Min,Seo, Kwang-Suk,Yi, Young-Eun,Han, Hee-Jung,Han, Jin-Hee,Kim, Hye-Jung,Shin, Teo-Jeon,Kim, Hyun-Jeong,Yum, Kwang-Won,Chang, Ju-He 대한치과마취과학회 2008 Journal of Dental Anesthesia and Pain Medicine Vol.8 No.1

Background: Cerebral palsy (CP) is non-progressive disorder of motion and posture. In CP patient, there are difficulties in dental treatment because of uncontrolled movement of limb and head, and conjoined disabilities such as cognitive impairment, sensory loss, seizures, communication and behavioral disturbances. It is reported that CP patients have high incidence in caries and a higher prevalence of periodontal disease. But, despite the need for oro-dental care, these patients often are unlikely to receive adequate treatment without sedation or general anesthesia because of uncontrolled movements of the trunk or head. Methods: We reviewed the 58 cases of 56 patients with CP who underwent outpatient general anesthesia for dental treatment at the clinic for the disabled in Seoul National University Dental Hospital. Results: The mean age was 19 (2-54) years. The number of male patient was 40 and that of female was 18. They all had severe spastic cerebral palsy and 22 had sever mental retardation, 15 epilepsy, 8 organic brain disorder, 1 blindness, 2 deafness and cleft palate. For anesthesia induction, 14 cases was needed physical restriction who had sever mental retardation and cooperation difficulty, but 44 cases showed good or moderate cooperation. Drugs used for anesthesia induction were thiopental (37 cases), sevoflurane (14 cases), ketamine (3 cases ) and propofol (4 cases). All patients except one were done nasotracheal intubation for airway management and 4 cases were needed difficult airway management and 1 patient already had tracheostomy tube. Mean total anesthetic time was $174{\pm}56$ min and staying time at PACU was $88{\pm}39$ min. There was no death or long term hospitalization because of severe complications. Conclusion: If general anesthesia is needed, pertinent diagnostic tests and workup about anomaly, and appropriate anesthetic planning are essential for safety.

국산 Lidocaine 알칼리화를 위한 Bicarbonate 혼합시 침전유발 최소량에 대한 고찰

이선호,김현수,곽인숙,안원식,최관호,김광민,손민제 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.5

Background : When local anesthetics for regional anesthesia is used, usually small amounts of bicar-bonate are added for rapid onset. This addition gives the mixed solution a more alkaline pH. The following result is an increased unionized form of the local anesthetic and rapid penetration of the drug into tiissue. Unfortunately, no data about adequate mixing volumes of domestic lidocaine and bicarbonate is available. Methods : We examined six mixing pairs of two kinds of 2% lidocaines and three kinds of 8.4% bicarbonates for minimum volumes of bicarbonate to cause a precipitation of 2% 20 ml lidocaine. Results : The mean volumes of bicarbonate to cause precipitation were 1.54 ml for Kwang-Myung lidocaine with Kwang-Myung bicarbonate, 2.90 ml for Kwang-Myung lidocaine with Dae-Won bicarbonate, 2.73 ml for Kwang-Myung lidocaine with Je-Il bicarbonate, 0.97 ml for Je-Il lidocaine with Kwang-Myung bicarbonate, 1.26ml for Je-Il lidocaine with Dae-Won bicarbonate and 1.39 ml for Je-Il lidocaine with Je-Il bicarbonate. Conclusions : We conclude that the Kwang-Myung lidocaine and the Je-Il lidocaine could cause precipitation when mixing with a smaller bicarbonate volume than foreign textbook recommended. (Korean J Anesthesiol 2000; 39: 726-729)

폴리카보네이트 멤브레인 표면의 불소화 개질에 의한 물 투과도 변화

민광준,설용건,전명석,김홍곤 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.6

균일한 기공을 가진 polycarbonate track etched membrane의 불소화로 인한 표면특성과 물 투과도의 변화를 조사하였다. 반응온도와 반응시간을 각각 상온과 3분으로 일정하게 유지하면서 질소로 희석된 혼합가스의 불소 농도 및 압력을 변화시켜 멤브레인을 불소화하였다. Field emission scanning electron microscopy(FESEM)을 통해 혼합가스의 절대압력이 1.5 bar 이하이고 불소, 질소 혼합비가 1:30으로 희석되었을 때 멤브레인 표면이 손상되지 않음을 알 수 있었다. 또한, 혼합비 1:30의 혼합가스로 1.5 bar에서 불소화한 멤브레인의 물 투과도는 원래 멤브레인의 2배 가까이 증가하였다. 불소화 압력이 낮으면 표면은 친수성을 띈 반면, 불소화 압력이 증가하면 소수성으로 변하였다. X-ray photoelectron spectroscopy(XPS)를 통해 불소 분압이 높아짐에 따라 멤브레인 표면에서 내부로의 불소 침투속도가 증가하는 현상과 불소가 도입된 부분의 산소 함량이 증가한 현상을 볼 수 있었다. 표면이 소수성을 띄는 멤브레인의 물 투과도가 증가한 현상은 기공 표면이 소수성을 띌수록 slip 경계조건에 근접하게 되어 기공을 통한 물 흐름이 원활해졌기 때문으로 해석되었다. The effect of fluorination on the surface characteristics and water permeability of an isopore polycarbonate track etchet membrane was examined. The membrane was fluorinated with gas mixtures containing fluorine and nitrogen of various composition under various pressure at room temperature for 3 minutes. The field emission scanning electron microscopy(FESEM) analysis showed that the shape of the membrane surface was not changed when it was fluorinated with a gas mixture at 1.5 bar which contained a low molar ratio of fluorine to nitrogen such as 1:30. Meanwhile, the membrane fluorinated with a mixture having a F₂:N₂ ratio of 1:30 at 1.5 bar showed an improved water permeability almost twice higher than that the original membrane had. The membrane surface got to possess more hydrophilicity than the original one when it was mildly fluorinated at low pressure. However, it became hydrophobic when it was further fluorinated under higher pressure. X-ray photoelectronospectroscopy(XPS) analysis revealed that the penetration rate of fluorine into the membrane increased along with the increase of the partial pressure of fluorine and that the inner layer containing fluorine possessed more oxygen than that in the original membrane. The phenomenon that the membrane having hydrophobic surface showed high water permeability was due to the slip boundary condition in the pore surface where water droplets pass through hydrophobic pores more easily with less friction resistance than through hydrophilic pores.

방광 크롬친화세포종과 동반된 배뇨후 벼락두통

하윤석,강성진,허소영,이지현,김민정,김종국,김광수 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Thunderclap headache is a hyperacute, severe headache that is so named because the pain strikes suddenly and severely, and is sometimes a sign of a medical emergency. We report a case of pheochromocytoma in the urinary bladder in a 48-year-old woman who presented with recurrent thunderclap headache after voiding and exercise. So we think thunderclap headache during or immediately after micturition may be an important diagnostic clue of bladder pheochromocytoma.

Thermomicrobium roseum 유래 Alcohol Dehydrogenase의 정제 및 특성

윤석영,홍민표,김은호,공광훈 중앙대학교 기초과학연구소 2000 基礎科學硏究所 論文集 Vol.14 No.-

Alcohol dehydrogenase from Thermomicrobium roseum was purified to electrophoretic homogeneity approximately 77-fold with a 38% activity yield by adenosine 5'-monophosphate and Mono Q column chromatography. The molecular weight of the enzyme was determined to be approximately 43,000 by SDS-polyacrylamide gel electrophoresis and 88,000 by gel chromatography, indicating a homodimeric structure. The Km and Vmax values of the enzyme for ethanol were 24.2 mM and 12.8 ㎛ol/min/mg, respectively. Pyrazole notably inhibited the enzymatic activity. Ca2+ ion activated the enzyme activity, but Cu2+ inhibited. The activity of the enzyme was optimal at pH 10.0 and 60℃.

Physicochemical Properties of Fish-meat Gels Prepared from Farmed-fish

Hyung Kwang Kim(김형광),Se Jong Kim(김세종),Fatih Karadeniz(파티카라데니즈),Myeong Sook Kwon(권명숙),Min-Joo Bae(배민주),Ya Gao(고아),Seul-Gi Lee(이슬기),Byeong Guen Jang(장병근),Jun Mo Jung(정준모),Seo yeon Kim(김서연),Chang-Suk Kon 한국생명과학회 2015 생명과학회지 Vol.25 No.11

연제품 제조에 이용되는 어육원료는 저가의 연육이 국내에서 일부 생산되고 있으며 대부분은 동남아산 또는 북아메리카산 등의 수입산에 의존하고 있다. 본 연구에서는 연제품용 어육 원료의 안정적인 수급과 고품질 연제품 개발을 위한 방안으로 우리나라에서 주로 양식되고 있는 어종의 고급 연육 및 연제품 소재로서의 가능성을 검토하였다. 양식어종인 광어(Paralichthys olivaceus), 도미(Pagrus major), 조피볼락(Sebastes schlegeli), 숭어(Mugil cephalus), 도다리(Pleuronichthys cornutus)를 원료로 하여 전통 수세법으로 연육을 제조하였다. 연육의 품질과 등급은 수분함량, 백색도, 겔 강도, 불순물의 함량 등에 의해 결정되어진다. 따라서 이들 해수어 유래 연육의 겔 형성능 및 품질은 겔 강도, 텍스쳐 실험, 백색도, 수분유출정도 및 SDS-page pattern 측정을 통해 검토하였다. 또한 이들 결과는 명태연육(FA급과 RA급)의 겔 특성과 비교하였다. 겔 특성을 검토하기 위해 미리 준비한 5 종류의 해수어 유래 연육에 2% NaCl를 첨가하여 소금갈이를 한 후 전체 수분함량이 84%가 되도록 졸 형태로 제조하였다. 졸형태의 연육을 polyvinylidene chloride 필름에 20-25 cm 길이로 충진한 후 90°C에서 20분간 가열하여 소시지 형태의 어육 겔을 제조하였다. 연육을 이용한 어육 겔의 제조에 의해 연육의 겔 강도와 백도는 증가하였다. 해수어 유래 연육의 겔 특성을 비교한 결과 광어와 도미가 가장 높은 겔 강도와 파단 강도를 나타내었으며, 수분 이수율은 광어에서 가장 낮게 나타났다. 전체적으로 해수어 유래 연육은 RA급 명태연육에 비해 높은 겔 형성능을 나타내었으며, 광어와 도미는 FA급 명태연육과 비슷한 정도의 겔 특성을 나타내었다. 이상의 결과로부터 광어와 도미를 이용한 고품질 연제품의 개발 가능성을 확인할 수 있었다. Fish-meat gel is being produced mostly relying on surimi and raw materials imported from Southeast Asia and North America and present in small amount in local markets. In this study, common farmed local fishes were examined as stable and reliable sources of surimi for fish-meat gel production. For testing, five main farmed-fish of Korea, namely; Bastard halibut (Paralichthys olivaceus), Red sea bream (Pagrus major), Korean rockfish (Sebastes schlegeli), Common mulle (Mugil cephalus), and Finespotted flounder (Pleuronichthys cornutus) were used following a traditional washing process. The quality of the surimi was determined by the values of water content, whiteness index, gel strength and impurity. Accordingly, fish-meat gel and surimi quality experiments were carried out by measuring compressive and texture properties, expressible moisture content, Hunter color scale values and SDS-page protein patterns. Also gel characteristics were compared with that of FA and RA grade surimi (Alaska Pollock). Fish-meat gels were prepared by salt mincing the farmed-fish surimi with NaCl (2% w/w) and moisture adjustment to 84% by ice water adding. Prepared fish-meat paste was filled into 20-25 cm long polyvinylidene chloride casings and heated at 90°C for 20 min. The whiteness values of fish-meat gels produced from surimi were increased by using farmed-fish and became comparable to that of FA Alaska Pollock gel. Among all tested farmed-fish, P. olivaceus and P. major exhibited better properties than RA Alaska Pollock and similar properties to FA Alaska Pollock. Therefore, current data suggests that fish farming can be an efficient and sustainable fish-meat source for fish-meat gel production in Korea.

한국어의 통사적으로 애매한 문장의 의미를 결정하는 운율적 특징 : 일본어와의 대조연구를 위한 기초연구로서

윤정숙,민광준 全北大學校 敎育大學院 1993 敎育論叢 Vol.13 No.-

The purpose of this paper is to investigate which of the prosodic features has a greater effect on the comprehension of a syntactically ambiguous sentences in Korean. The results of an acoustic analysis and perception experiment by synthesized speech show that Fo have the primary role in disambiguating syntactically ambiguous sentences.

圓光醫大 附屬 第2病院 神經精神科 患者에 對한 統計的 考察(Ⅱ)

박민철,장광철,김상원,김한주,유미경,김훈,유용진,김현정,박남진,오상우,이귀행,노승호,백영석 圓光大學校 醫科大學 神經精神科學敎室 1992 圓光精神醫學 Vol.8 No.1

본 연구는 1986년 7월 11일부터 1991년 7월 10일까지 원광의대 부속 제2병원 신경정신과에서 의래 및 입원치료를 받았던 6,072명의 환자를 대상으로 병원 역학조사를 실시하고 그 결과를 1차조사 (박민철 등1986)와 비교했다. 1.전체 환자 중 남자가 54.4%로 여자보다 많았고, 이리와 이리 인접지역이 84.0%로 대부분의 지역을 나타났다. 의료보장상태는 보험환자가 57.1%, 의료보호환자21.8%, 일반환자 21.1%였으며 연령별로는 20대 24.6%, 30대 22.8%로 20대 30대가 절반정도를 차지했다. 2.외래환자에서는 신경중성장애가 46.0%로 가장 많고 정동장애, 경련성장애 순이며, 입원환자에서는 정신분열증이 30.5%로 가장 많고 기질성정신장애, 정동장애의 순이었다. 3.남자는 신경증성쟝애(23.4%), 정신분열증, 기질성정신장애 순이고 여자는 신경증성장애(39.9%), 정동장애, 정신분열증의 순이었다. 남자가 여자보다 많은 진단은 알코올정신장애(94.6%), 기질성정신장애, 소아정신장애 순이고, 여자가 남자보다 많은 진단은 정동장애(64.5%), 신경증성장애였다. 4.진단별 연령분포에서 신경증성장에는 30대(25.3%), 20대, 40대 순이고, 정신분열증은 20대(40.5%), 30대, 40대 순이며, 정동장애는 20대, 30대, 50대 순이나 비교적 비슷한 융이었다. 5.진단별 발병연령에서 신경증성장에는 20대, 30대가 절반이고,정신분열증은 20대(51.3%), 10대, 30대 순이며 정동장애는 20대(30.7%), 30대, 50대 순이었다. 진단별 평균 발병연령은 신경증성장애 32.7세, 정동장애 36.1세, 정신분열증 23.6세였다. 6.진단별 이병기간은 2년이상이 신경증성장에 28.3%, 정신분열증 68.5% 정동장애 43.9%인데 전체적으로 41.0%였다. 진단별 평균 이병기간은 정신분열증 73.2개월, 정동장애 45.5개월, 신경증성장애 29.5개월이었다. We examined epidemiologic study of 6,072 patients who visited Wonkwang Neuropsychiatric hospital since July 11 of 1986 until July 10 of 1991 and compared this results with previous study(Park et al 1986). The study revealed as follows:1. Of total patients males visited this hosptial more than females as 57.1%, Most of them(84.0%) resided Iri and neighbouring Iri. In the point of insurance, insured patients, medicaid patients and uninsured patients were 57.1%, 21.8% and 21.1% respectively. On the distribution of age, the twenties, the thirties were 24.6%, 22.8% respectively and twenties and thirties were about half of total patients. 2. Of outpatients neurotic disorder was the most as 46.0%, secondly mood disorder and thirdly convulsive disorder, but of inpatients schizophrenia was the most as 30.5%, secondly organic mental disorder and thirdly mood disorder. 3. Of males neurotic disorder was the most as 23.4%, secondly schizophrenia, and thirdly organic mental disorder, but of females neurotic disorder was the most as 39.9%, secondly mood disorder and thirdly schizophrenia. alcoholic mental disorder(94.6%), organic mental disorder, child mental disorder were mostly found in males,but mood disorder(64.5%) and neurotic disorder were mostly found in females. 4. On the distribution of age neurotic disorder was found the most in the thirties(25.3%), next in the twenties and in the forties, and schizophrenia was found the most in the twenties(40.5%), next in the thirties and in the forties, but mood disorder was found the most in the twenties, next in the thirties and in the forties but revealed similar rates relatively. 5. On the distribution of age of onset neurotic disorder developed nearly half during the twrnties and the thirties, schizophrenia developed mostly during the twenties (51.3%), secondly the teens and thirdly the thirties, but mood disorder developed firstly the twenties(30.7%), secondly the thirties and thirdly the fifties. on the average age of onset of illness neurotic disorder, mood disorder and schizophrenia were 32.7 years, 36.1 years and 23.6 years respectively. 6. On the duration of illness more than two years was 28.3% in neurotic disorder, 68.5% in schizophrenia and 3.9% in mood disorder and on the average duration of illness schizophrenia, mood disorder and neurotic disorder were 73.2 months, 45.5 months and 29.5 months respectively.

Streptomyces albulus 세정균체에 의한 polylysine의 대량생산

선흥석,김광섭,안치민,박찬영 全南大學校 觸媒硏究所 1997 觸媒硏究 論文集 Vol.19 No.-

Streptomyces albulus 세정균체를 이용하여 항세균물질인 폴리리신의 대량생산 가능성에 대하여 조사하였다. 발효기 배양에서 배양액 pH는 6.8에서 3.2로 감소하는 동안에 pH 4.0에서 4.5사이에서 폴리리신이 최대로 축적되므로 대수말기의 균체를 멸균증류수로 세척하여 마련한 세정균체를 아미노산 생산을 향상할수 있는 구연산을 2%첨가하고 pH를 최적인 4.2로 조정한 배지로 옮겨 배양하였다. 이러한 2단계공정으로 세정균체를 배양한 경우 배양액내의 폴리리신은 일반 1단계 단순 배양에 비하여 최대 6배의 축적량을 나타내었다. The feasibility of mass production of polylysine, an antibacterial substance, employing a washed mycelium of Streptomyces albulus has been investigated. Since the maximum accumulation of polylysine had appeared between 4.0 to 4.5 of pH during fermentor cultivation of which the pH of the broth has declined to 3.2 from 6.8, the strain growing in the broth on late log phase had been washed with sterilized water, then the sole mycelium had been transferred to another medium containing 2% citric acid having pH adjusted with NaOH to optimum of 4.2 to improve the production of the amino acid. The total accumulation of polylysine by washed mycelium of Streptomyces albulus from this two step procedure has exhibited 6 times more than the normal production of the simple one step fermentation.

154kV용 활선 안전 경보기 개발에 관한 연구

정민규,조현광,우종수,안창회,서영석,김응태,박창기,오세득 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

In this report we developed a high voltage alarm for the safety of workers who check and repair the 154kV power line. This high voltage alarm we developed is attached on workers' helmet and alarms automatically in order to let workers know when workers work over the safety distance near 154kV power line. Until now the exact safety distance hasn't been regulated and high voltage alarm we've been using was for the range of 6∼22.9kV power line. We fabricated this high voltage alarm on the basis of electric density and actual measurement of power line. The experimental result was that high voltage alarm at 66kV power line alarmed near 90cm, at 154kV power line alarmed near 160cm from the line. Accordingly, we developed the new high voltage alarm which is operated in the range of 66∼154kV power line.