중년기 여성의 상체부 특성

나미향 권윤희 청주대학교 학술연구소 2009 淸大學術論集 Vol.14 No.-

The purpose of study is research on breast shape and suitable bressiere for middle aged women. For this purpose, numerous antropometric measurements and other related data 200 subjects were analyzed by various statistical methods. Changes in the somatotype of the upper body were studied according to age group through classifying middle aged women into three age categories of Aged 35 to 44, Aged 45 to 54, Aged 55 to 64 and the measured anthropometry. It appears that the physical stance of the aging female becomes more bent and their body structures become smaller due to the bending and stretching of upper body during the process of ageing of each somatotype. The results of the comparative analysis of anthropolatric data from three groups(Groups Ⅰ: Aged 35 to 44, Group Ⅱ: Aged 45 to 54, Group Ⅲ: Aged 55 to 64)show that getting older, breast heights are decreased significantly and widths, depths and bust girths are increased. Various length measurements related to the drooping degree of breast are increased.

브래지어 착용 실태조사Ⅲ : 청년기와 중년기의 비교

나미향,권윤희,김미선 청주대학교 학술연구소 2007 淸大學術論集 Vol.9 No.-

This study is aimed at analyzing and comparing the real state of wearing brassiere between youth and mid-aged woman. The result is as follows. 1. In bust type and shape, the rate of wearing conical type in youth is estimated high at 34%,, and in mid-aged woman, that of wearing droopy type is high at 55%. Also it reveals that busts of mid-aged woman are less elastic, compared with those of youth, and bust shapes are gradually open to widen the gap between nipples. It found that mid-aged women feel more shaking their busts, when not wearing brassiere, and the larger the cup of brassiere is, the more shaking of bust they felt. Youths are more likely to wear the size 80A, 75A, and mid-age women are to wear the size 85A, 80A, 75A. And the girth under bust increases due to the obesity of back and bust parts, according as they are turning middle age. In the size of cup, the rate of wearing Cup A(73.6%) is high in youth, and in more than Cup B, the rate of mid-age women is 33.3%, higher than that of 26.4% of youth. 2. It is surveyed the reason for youths and mid-age women to wear brassiere is to prevent from the exposure of bust and its shaking, to bust up droopy breasts, or to wear a kind of habit. The rate of respondents in mid-aged women wearing brassiere to bust up droopy breasts is high, compared with that of youths. 3. Wearing brassiere confirmed the function of bust-up by 50.7%, whose rate in mid-aged women is higher than that of youth. 4. The shift of position at the bands under bust and shoulder was being felt. According to age bracket, the inconvenience of shoulder band was rated high in youths, and in the mid-aged, the shift of position at the bands under breast was high. The complaint on uneasiness was voiced because of the sense of pressure tightened by shoulder band and lateral part of armpit, and the feeling of choking at the due center of bust in which brassiere wire is inserted was complained. The rate of which was high in the mid-aged than that of youths.

Functional maturation of lamina propria dendritic cells by activation of NKT cells mediates the abrogation of oral tolerance

Chang, Jae-Hoon,Lee, Jung-Mi,Youn, Hyun-Jun,Lee, Kyoo-A,Chung, Yeonseok,Lee, Ah-Young,Kweon, Mi-Na,Kim, Ho-Youn,Taniguchi, Masaru,Kang, Chang-Yuil WILEY-VCH Verlag 2008 European journal of immunology Vol.38 No.10

<P>We previously showed that although systemic administration of α-galactosylceramide (αGalCer) or agonistic anti-CD40 induced functional maturation of dendritic cells (DC) in mesenteric lymph nodes, only the former treatment succeeded in breaking the induction of oral tolerance. In this study, we looked for the essential factor responsible for the disruption of oral tolerance. We found that lamina propria (LP)-DC was responsible for the oral OVA presentation and that Peyer's patch was not essential for the induction of oral tolerance. Therefore, we investigated the role of LP-DC. Treatment with αGalCer but not with anti-CD40 induced the full maturation of LP-DC at an early time point. This functional activation of LP-DC was mediated by strong activation of NKT cells that reside abundantly in the small intestinal lamina propria (SI-LP) and interferon-γ partially contributed to the LP-DC activation. LP-DC isolated from αGalCer-treated OVA-fed mice induced the differentiation of naïve CD4<SUP>+</SUP> T cells into Th1 and Th2 and was associated with the reduced Foxp3<SUP>+</SUP> population. In contrast, LP-DC isolated from anti-CD40-treated OVA-fed mice failed to generate Th cell differentiation but induced more Foxp3<SUP>+</SUP> CD4<SUP>+</SUP> T cells. Our results demonstrate that triggered by NKT cells in SI-LP, functional maturation of Ag-capturing DC from SI-LP is necessary for the abrogation of oral tolerance induction.</P>

Immunology Symposium : Intestinal villous M cells: a new antigen entry site in the mucosal epithelium

( Mi Na Kweon ) 한국생화학분자생물학회 (구 한국생화학회) 2004 생화학분자생물학회 춘계학술발표논문집 Vol.2004 No.-

Nutritional Evaluation of Tofu Containing Dried Soymilk Residue (DSR) : 1 . Evaluation of Protein Quality 1 . 단백질의 영양가

Kweon, Mi-Na,Ryu, Hong-Soo,Mun, Jeung-Hye 부경대학교 기초과학연구소 1993 기초과학연구논문집 Vol.4 No.-

두부 제조공정 중의 부산물인 비지의 효율적인 이용을 위하여, 원료 대두 중량의 10%에 해당하는 건조비지를 첨가시킨 두부를 제조하여 이의 영양적 품질을 검토하였다. 일반성분은 수분의 경우 건조비지 첨가 두부가 80.6%, 일반 두부가 77.5%로써 비지 첨가 두부가 다소 높았으며 단백질의 함량은 건조비치 첨가 두부와 일반 두부 각각 38.5%, 45.8%였으며, 지질의 함량은 각각 34.3%, 26.9%로써, 단백질과 지질 함량이 낮은 건조비지 첨가로 인해 일반 두부에 비해 건조비지 첨가 두부가 낮은 함량을 보였다. Trypsin inhibitor(TI) 함량은 비지의 경우 잔존량이 6.9(mg/g시료)정도였고, 건조비지의 경우에도 거의 비슷하였다. 건조비지 첨가 두부에는 원료 대두에 있었던 TI의 12% 정도만 남아있었다. 단백질의 효소소화율(enzyme digestibility)은 비지, 건조비지 각각 87%, 86% 정도로 높았고 건조비지 첨가 두부도 일반 두부와 거의 동일한 91%정도였다. 효소소화율은 TI함량이 저하함에 따라 역상관관계를 가지면서 상승하였다. 구성 아미노산 조성은 일반 두부와 건조비지 첨가 두부는 거의 차이가 없었으며, 총아미노산에 대한 필수 아미노산의 비율은 일반 두부가 40.4%, 비지첨가 두부가 40.6%였으며, lysine 함량이 높은 건조비지로 인하여 건조비지 첨가 두부는 lysine의 보충 효과가 있었다. 단백품질을 Computed Protein Efficiency Ratio(C-PER)로 계산할 때 일반 두부는 1.95, 비지첨가두부는 1.4였으나 Discriminant Computed Protein Efficiency Ratio(DC-PER)로 계산할 때는 오히려 비지 첨가 두부경우가 높았다. 여러 연구자들의 대두가공품에 대한 생체실험 결과와 비교할 때 일반 두부를 제외하고는 두유, 비지 및 비지첨가 두부의 영양평가는 DC-PER 방법이 유리한 것으로 생각되었다. The effect of dried soymilk residue(DSR) on protein quality of tofu was studied. The amount of added DSR into soybean water extract was corresponding 10% (dry basis) of soybean used in tofu manufacturing. Proximate composition and in vitro protein qualities of soybeans at different stages of the conversion into tofu have also been investigated. Partially substituted tofu with DSR (TDSR) had higher moisture content (80.6%) than that of tofu prepared in traditional manner (TT). TDSR contained lower content of protein (38.9%) and total lipid (26.9%) compared to 45.8% of protein and 34.3% of total lipid for TT. A large amount of trypsin inhibitor (TI) in raw soybeans was diminished and extracted through tofu processing, and only 10-1 3%) of T I in raw soybean remained in both tofu products (TDSR and 11). There was not a considerable difference in amino acid profiles between TT and TDSR, but TDSR had a higher content of lysine than that in TT. In witro studies showed that TDSR and TT were comparable in terms of both in vitro digestibilities (90% over for four-enzyme digestibility and predicted digestibility) and discriminant computed protein efficiency ratio (2.07-2.1 4, DC-PER). Unlike those in vitro indices for protein quality, computed protein efficiency rdtio (C-PER) of TDSR was much lower(l.4) than that of TT(1.95). It was revealed that C-PERs of tofu products were not in agreement with rat-PERs (1.7-1.9) in previous reports except for TT. However, DC-PER assay was more recommendable for protein quality of tofu products than C-PER assay.

Nutritional Evaluation of Tofu Containing Dried Soymilk Residue(DSR) - 1. Evaluation of Protein Quality

권미나(Mi-Na Kweon),류홍수(Hong-Soo Ryu),문정혜(Jeung-Hye Moon) 한국식품영양과학회 1993 한국식품영양과학회지 Vol.22 No.3

두부 제조공정 중의 부산물인 비지의 효율적인 이용을 위하여, 원료 대두 중량의 10%에 해당 하는 건조비지를 첨가시킨 두부를 제조하여 이의 영양적 품질을 검토하였다. 일반성분은 수분의 경우 건조비지 첨가 두부가 80.6%, 일반 두부가 77.5%로써 비지 첨가 두부가 다소 높았으며 단백질의 함량은 건조비지 첨가 두부와 일반 두부 각각 38.5%, 45.8%였으며, 지질의 함량은 각각 34.3%, 26.9%로써, 단백질과 지질 함량이 낮은 건조비지 첨가로 인해 일반 두부에 비해 건조비지 첨가 두부가 낮은 함량을 보였다. Trypsin inhibitor(TI) 함량은 비지의 경우 잔존량이 6.9(㎎/g시료)정도였고, 건조비지의 경우에도 거의 비슷하였다. 건조비지 첨가 두부에는 원료 대두에 있었던 TI의 12% 정도만 남아 있었다. 단백질의 효소소화율(enzyme digestibility)은 비지, 건조비지 각각 87%, 86% 정도로 높았고 건조비지 첨가 두부도 일반 두부와 거의 동일한 91% 정도였다. 효소소화율은 TI함량이 저하함에 따라 역상관관계를 가지면서 상승하였다. 구성 아미노산 조성은 일반 두부와 건조비지 첨가 두부는 거의 차이가 없었으며, 총아미노산에 대한 필수 아미노산의 비율은 일반 두부가 40.4%, 비지첨가두부가 40.6%였으며, lysine 함량이 높은 건조비지로 인하여 건조비지 첨가 두부는 lysine의 보충 효과가 있었다. 단백품질을 Computed Protein Efficiency Ratio (C-PER)로 계산할 때 일반 두부는 1.95, 비지 첨가 두부는 1.4였으나 Discriminant Computed Protein Efficiency Ratio (DC-PER)로 계산할 때는 오히려 비지 첨가 두부경우가 높았다. 여러 연구자들의 대두가공품에 대한 생체실험 결과와 비교할 때 일반 두부를 제외하고는 두유, 비지 및 비지첨가 두부의 영양평가는 DC-PER 방법이 유리한 것으로 생각되었다. The effect of dried soymilk residue (DSR) on protein quality of tofu was studied. The amount of added DSR into soybean water extract was corresponding 10% (dry basis) of soybean used in tofu manufacturing. Proximate composition and in vitro protein qualities of soybeans at different stages of the conversion into tofu have also been investigated. Partially substituted tofu with DSR (TDSR) had higher moisture content (80.6%) than that of tofu prepared in traditional manner (TT). TDSR contained lower content of protein (38.9%) and total lipid (26.9%) compared to 45.8% of protein and 34.3% of total lipid for TT. A large amount of trypsin inhibitor (TI) in raw soybeans was diminished and extracted through tofu processing, and only 10~13% of TI in raw soybean remained in both tofu products (TDSR and TT). There was not a considerable difference in amino acid profiles between TT and TDSR, but TDSR had a higher content of lysine than that in TT. In vitro studies showed that TDSR and TT were comparable in terms of both in vitro digestibilities (90% over for four-enzyme digestibility and predicted digestibility) and discriminant computed protein efficiency ratio (2.07~2.14, DC-PER). Unlike those in vitro indices for protein quality, computed protein efficiency ratio (C-PER) of TDSR was much lower (1.4) than that of TT (1.95). It was revealed that C-PERs of tofu products were not in agreement with rat-PERs (1.7~1.9) in previous reports except for TT. However, DC-PER assay was more recommendable for protein quality of tofu products than C-PER assay.

New Animal Model of Shigellosis in the Guinea Pig

권미나(Mi-Na Kweon) 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

A multicenter study of entecavir <i>vs.</i> tenofovir on prognosis of treatment-naïve chronic hepatitis B in South Korea

Kim, Seung Up,Seo, Yeon Seok,Lee, Han Ah,Kim, Mi Na,Lee, Yu Rim,Lee, Hye Won,Park, Jun Yong,Kim, Do Young,Ahn, Sang Hoon,Han, Kwang-Hyub,Hwang, Seong Gyu,Rim, Kyu Sung,Um, Soon Ho,Tak, Won Young,Kweon Elsevier 2019 Journal of hepatology Vol.71 No.3

<P><B>Background & Aims</B></P> <P>It is currently unclear which antiviral agent, entecavir (ETV) or tenofovir disoproxil fumarate (TDF), is superior for improving prognosis in patients with chronic hepatitis B (CHB). Here, we assessed the ability of these 2 antivirals to prevent liver-disease progression in treatment-naïve patients with CHB.</P> <P><B>Methods</B></P> <P>From 2012 to 2014, treatment-naïve patients with CHB who received ETV or TDF as a first-line antiviral agent were recruited from 4 academic teaching hospitals. Patients with decompensated cirrhosis or hepatocellular carcinoma (HCC) at enrollment were excluded. Cumulative probabilities of HCC and death or orthotopic liver transplant (OLT) were assessed.</P> <P><B>Results</B></P> <P>In total, 2,897 patients (1,484 and 1,413 in the ETV and TDF groups, respectively) were recruited. The annual HCC incidence was not statistically different between the ETV and TDF groups (1.92 <I>vs</I>. 1.69 per 100 person-years [PY], respectively; adjusted hazard ratio [HR] 0.975 [<I>p</I> = 0.852] by multivariate analysis). Propensity score (PS)-matched and inverse probability of treatment weighting (ITPW) analyses yielded similar patterns of results (HR 1.021 [<I>p</I> = 0.884] and 0.998 [<I>p</I> = 0.988], respectively). The annual incidence of death or OLT was not statistically different between the ETV and TDF groups (0.52 <I>vs</I>. 0.53 per 100 PY, respectively; adjusted HR 1.202 [<I>p</I> = 0.451]). PS-matched and ITPW analyses yielded similar patterns of results (HR 1.248 [<I>p</I> = 0.385] and 1.239 [<I>p</I> = 0.360], respectively). These findings were consistently reproduced in patients with compensated cirrhosis (all <I>p</I> >0.05).</P> <P><B>Conclusions</B></P> <P>The overall prognosis in terms of HCC and death or OLT was not statistically different between the ETV and TDF groups. Further studies are needed to validate our results.</P> <P><B>Lay summary</B></P> <P>It is currently unclear which antiviral agent, entecavir or tenofovir disoproxil fumarate, is superior for improving prognosis in patients with chronic hepatitis B virus infection. In this analysis we found that there was no difference in terms of overall prognosis, including risk of hepatocellular carcinoma, death, or the need for a liver transplant, in patients receiving either antiviral.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The hepatocellular carcinoma risk was not statistically different between the ETV and TDF groups. </LI> <LI> The death or liver transplant risk was not statistically different between the 2 groups. </LI> <LI> These results were consistently reproduced after adjusting for confounding variables. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Derivation of Cell Adapted Sacbrood Virus from Korean Native Honeybee

Mi-Sun Yoo,Chang-Hee Kweon,Young-Ha Kim,Nam-Hee Kim,Ha-Na Jung,Kondreddy Eswar Reddy,Suk-Chan Jung,Seung-Won Kang 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Sacbrood virus (SBV), a causative agent of larval death in honeybees, is one of the most devastating diseases in bee industry throughout the world. Lately the Korean Sacbrood virus (KSBV) induced great losses in Korean honeybee (Apis cerana) colonies. However, there is no culture system available for honeybee viruses, including SBV, therefore, the research on honeybee viruses is practically limited until present. In this study, we investigated the growth and replication of KSBV in cell cultures. The growth of KSBV was demonstrated by RT-PCR, quantitative real-time PCR, TEM and nucleotide sequence analysis. The results demonstrated that SBVshowed the replication signals in mammalian cell lines, including Vero cells without any signs of cytopathic effect (CPE). The results of RT-PCR, quantitative real-time PCR and in vivo infection with KSBV were also indicated the replication. Phylogenetic tree analysis shows our sequence included in distinct group with other SBV strains from China and Korea. It clearly showed the differenciation between field strain and attenuated strain through cell culture. The results of present study demonstrated for the first time that SBV like other animal viruses could be adapted and attenuated in cells through the sequential passages. The sequential adaptation through cell culture could result in discrepancy of pathogenicity of virus and morphological characterization. For this reason, the present results indicated that the cell adapted SBV could be a valuable tool to study the general properties of this emerging virus, including pathogenicity in the future.

Recent progress in mucosal immunology and vaccine development

Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.3