http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Min Zhang(Min Zhang),YiRan Wu(YiRan Wu),ZhaoXu Lu(ZhaoXu Lu),MeiYan Song(MeiYan Song),XiaoLan Huang(XiaoLan Huang),LaLa Mi(LaLa Mi),Jian Yang(Jian Yang),Xiaodai Cui(Xiaodai Cui) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
The effect of vitamin D supplementation on individuals with autism spectrum disorder (ASD) is inconclusive. We aimed to conduct a meta-analysis of the available randomized controlled trials (RCTs) to explore whether vitamin D supplementation can improve core symptoms and coexisting conditions in children with ASD. Data were obtained by searching the PubMed, Embase, Web of Science, CINAHL and Cochrane Library databases up to February 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using a random-effects model, mean differences with 95% confidence intervals (CIs) were calculated through a meta-analysis. There were eight RCTs with 266 children with ASD in the present review, among which six RCTs were included in the meta-analysis. Children who received vitamin D supplementation showed a significant improvement in stereotypical behavior scores (pooled mean difference (MD): −1.39; 95% CI: −2.7, −0.07; p = 0.04) with low heterogeneity (I2 = 34%), and there was a trend toward decreased total scores on the Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS, p = 0.05); however, there were no other significant differences in the core symptoms of ASD and coexisting conditions between groups as measured by the Aberrant Behavior Checklist (ABC). Vitamin D supplementation appears to improve stereotypical behaviors but does not improve other core symptoms and coexisting conditions. Further randomized controlled trials with large sample sizes and individualized doses are needed.
A Strategy of Subsea Pipeline Identification with Sidescan Sonar based on YOLOV5 Model
Yan Li,Meiyan Wu,Jiahong Guo,Yan Huang 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
Accurate identification of pipelines is the basis and prerequisite for tracking and inspection of subsea pipelines with the help of autonomous unmanned vehicles. In this paper, we proposed a strategy based on a deep learning model YOLOV5 to extract the subsea pipeline from acoustic images acquired by a Side scan sonar (SSS). Considering the imaging mechanisms of SSS, the formed bar image by SSS in a short certain period is segmented into many sub-images. Subsequently, these sub-images are fed into a pre-trained identification model based on YOLOV5 to extract the subsea pipelines. This strategy ensures the subsea pipeline could be detected with low time consumption and satisfactory accuracy. The average precision (AP) of our proposed subsea pipeline identification strategy achieved 97.62% with 304ms time consumption for the bar image formed in the 10s period. The experimental results demonstrate that the performance of the proposed subsea pipeline identification strategy is superior comparing with other state-of-the-art models in the performance of both identification and real-time.
S-455 Periostin-binding DNA aptamer ameliorates peritoneal dialysis-induced peritoneal fibrosis
( Changhwan Seo ),( Bo Young Nam ),( Meiyan Wu ),( Ji Min Park ),( Jae Eun Um ),( Seonghun Kim ),( Hye-young Kang ),( Seohyun Park ),( Su-young Jung ),( Jong Hyun Jhee ),( Hae-ryong Yun ),( Hyoungnae 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background: Peritoneal fibrosis (PF) is a major complication in patients on peritoneal dialysis (PD). In PD-related PF, the protein expressions of various extracellular matrix including periostin are known to be increased via the transforming growth factor-β1 (TGF-β1) pathway. This study was undertaken to evaluate the impact of periostin inhibition by novel aptamer-based inhibitor on TGF-β1-induced epithelial-mesenchymal transition (EMT). Methods: In vitro, primary HPMCs were exposed to TGF-β1 (2 ng/ml) to induce EMT and fibrosis with or without periostin siRNA (100 nM) or periostin-binding DNA aptamer (200 nM). In vivo, PD catheters were inserted into 48 C57BL/6 mice, and saline (C group, N=24) or 4.25% PD solution (PD group, N=24) was infused for 4 weeks. Twelve mice from each group were treated with periostin-binding DNA aptamer (500 μg/kg/d) (PA). mRNA and protein expressions of periostin, fibronectin, α-smooth muscle actin (α-SMA), snail, and E-cadherin in HPMCs and mouse peritoneum were evaluated by quantitative real-time polymerase chain reaction and western blot analysis, respectively. PF was also assessed by Masson’s trichrome (MT) staining. Results: In vitro, TGF-β1 treatment significantly up-regulated periostin, fibronectin, α-SMA, and snail expressions, while E-cadherin expression was significantly decreased by TGF-β1 in cultured HPMCs (p<0.01). Not only periostin siRNA but also periostin-binding DNA aptamer significantly attenuated TGF-β1-induced periostin, fibronectin, α-SMA, and snail expressions and significantly restored E-cadherin expression in HPMCs (p<0.05). In vivo, the expressions of periostin, fibronectin, α-SMA, and snail were significantly increased, whereas E-cadherin expression was significantly decreased in the peritoneum of PD mice (p<0.05). The thickness of the submesothelial layer and the intensity of MT staining in the peritoneum were significantly higher in PD mice compared to C mice (p<0.05). These changes in the PD group were significantly abrogated by PA treatment (p<0.05). Conclusions: These findings suggest that PA can be a potential therapeutic strategy for PF in PD patients.
S-536 The Effect of PTD-mediated BMP-7 on EMT in Peritoneal Mesothelial Cells
( Min-uk Cha ),( Seonghun Kim ),( Bo Young Nam ),( Hye-young Kang ),( Jae Eun Um ),( Ji Min Park ),( Meiyan Wu ),( Jung Tak Park ),( Seung Hyeok Han ),( Shin-wook Kang ),( Tae-hyun Yoo ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Objective:?We investigated the effect of PTD-mediated BMP-7 (tissue-regeneration polypeptide 2, TRP2) on TGF-β1-induced EMT in cultured human peritoneal mesothelial cells (HPMCs). In addition, we investigated how to deliver the drugs to peritoneum in vivo models. Design and Method:?In vitro, HPMCs were cultured in M199 media containing 5.6 mM glucose (normal glucose, NG), NG + TGF-β1 (2 ng/ml) with or without TRP2 (100 ng/ml). After 72 hours, cells were harvested. In vivo, PD rat-O-port inserted into 11 Sprague-Dawley rats, and saline (control group, n=3), 4.25 % PD solution (PD group, n=3) or 4.25 % PD solution + TRP2 (PD + TRP2 group, n=5) were infused for 4 weeks. After 4 weeks, rats were sacrificed and the peritoneal tissues were removed. E-cadherin, ZO-1, α-smooth muscle actin (α-SMA), snail, vimentin, type I collagen, and fibronectin protein expression in HPMCs and the peritoneum were estimated by western blot analysis, and fibronectin expression was evaluated by immunohistochemistry staining. PF was assessed by Masson’s trichrome (MT) staining. Results:?In vitro, protein expression of E-cadherin and ZO-1 (epithelial marker) were significantly decreased, while α-SMA, snail, vimentin (mesenchymal marker), type I collagen and fibronectin were significantly increased in TGF-β1-stimulated HPMCs compared to control group, and these changes were significantly improved by TRP2 treatment. In vivo, peritoneal EMT and PF were significantly increased in PD rats compared to control rats. The thickness of mesothelial layer and the intensity of MT staining in the peritoneum of PD rats were also significantly higher compared to control rats. These changes of the peritoneum in PD rats were significantly ameliorated by the administration of TRP2. Conclusions:?This study suggests that TRP2 directly inhibits the process of TGF-β1-induced PF via peritoneal EMT in HPMCs. In addition, TRP2 mitigates PF in PD rats. The effect of PTD-mediated recombinant protein delivery system may be a potential therapeutic strategy for prevention of PF in PD patients.