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RISS 인기검색어
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- 저자 : ( Maria Lee ) (검색결과 271 건)
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Makorin Ring Finger Protein 1 as Adjunctive Marker in Liquid-based Cervical Cytology
Lee, Maria,Chang, Min Young,Shin, Ha-Yeon,Shin, Eunah,Hong, Sun Won,Kim, Kyung-Mi,Chay, Doo Byung,Cho, Hanbyoul,Kim, Jae-Hoon Williams & Wilkins Co 2016 Medicine Vol.95 No.3
<P><B>Abstract</B></P><P>To assess the utility of makorin ring finger protein 1 (MKRN1) as a marker of cervical pathology.</P><P>A PROspective specimen collection and retrospective Blinded Evaluation study was conducted. Liquid-based cytology samples were collected from 187 women, embedding all residuals as cell blocks for immunohistochemical staining of MKRN1 and P16 <SUP>INK4a</SUP>. Results of liquid-based cervical cytology, immunostained cell block sections, and human papillomavirus (HPV) hybrid capture (with real-time polymerase chain reaction) were analyzed. Clinical outcomes were analyzed overall and in subsets of specimens yielding atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions.</P><P>Makorin ring finger protein 1 positivity and grades (1–3) of cervical intraepithelial neoplasia (CIN) increased in tandem (CIN1, 32.4%; CIN2, 60.0%; and CIN3, 80.0%), reaching 92.3% in invasive cancer. Sensitivity, specificity, positive predictive value, and negative predictive value in detecting CIN2+ via MKRN1 were 73.8%, 76.8%, 75.6%, and 75.0%, respectively. The performance of liquid-based cytology was poorer by comparison (61.3%, 69.5%, 66.2%, and 64.8%, respectively), and HPV assay (versus MKRN1 immunohistochemical staining) displayed lower specificity (67.7%). Combined HPV + MKRN1 testing proved highest in sensitivity, specificity, positive predictive value, and negative predictive value (71.8%, 85.5%, 82.3%, and 76.5%, respectively), whereas corresponding values for cytology + HPV (60.6%, 81.8%, 75.4%, and 69.2%) and cytology + MKRN1 (58.8%, 84.1%, 78.3%, and 67.7%) were all similar. In instances of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions, the HPV + MKRN1 combination performed best by above measures (100%, 72.7%, 73.9%, and 100%), followed by cytology + MKRN1 (100%, 50.0%, 60.7%, and 100%).</P><P>Makorin ring finger protein 1 displayed greater sensitivity and specificity than liquid-based cytology and proved more specific than HPV assay. In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening.</P>
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Lee, Ji-Woong,Oliveira, Maria Teresa,Jang, Hyeong Bin,Lee, Sungyul,Chi, Dae Yoon,Kim, Dong Wook,Song, Choong Eui The Royal Society of Chemistry 2016 Chemical Society reviews Vol.45 No.17
<P>Due to the tremendous interest in carbon-fluorine bond-forming reactions, research efforts in this area have been dedicated to the development of facile processes to synthesize small fluorine-containing organic molecules. Among others, PET (Positron Emission Tomography) is one of the most important applications of fluorine chemistry. Recognizing the specific requirements of PET processes, some groups have focused on fluorination reactions using alkali metal fluorides, particularly through S(N)2-type reactions. However, a common 'misconception'' about the role of protic solvents and hydrogen bonding interactions in this class of reactions has hampered the employment of these excellent promoters. Herein, we would like to review recent discoveries in this context, showing straightforward nucleophilic fluorination reactions using alkali metal fluorides promoted by protic solvents. Simultaneous dual activation of reacting partners by intermolecular hydrogen bonding and the enhancement of the 'effective fluoride nucleophilicity'', which is Nature's biocatalytic approach with the fluorinase enzyme, are the key to this unprecedentedly successful nucleophilic fluorination.</P>
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( Maria Lee ),( Myung Jae Jeon ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To examine changes in sexual activity and function among younger breast cancer survivors who were sexually active before diagnosis and to investigate risk factors for negative impacts on them. 방법: A prospective observational study enrolled 304 premenopausal and sexually active women diagnosed with early-stage breast cancer. Questionnaires were completed, and sexual activity was measured at two time points: after surgery, to assess sexual activity and function before diagnosis, and then at least 12 months after the completion of chemotherapy or endocrine therapy. For each domain of the Female Sexual Function Index, a score below 3 was classified as indicative of a sexual problem. Each sexual problem was considered to be dysfunctional if it was associated with distress. 결과: The median age at the last survey was 46.0 years (range: 23-57). Of the participants, 35 (11.5%) became sexually inactive after treatment. Among the 269 women who remained sexually active, 31.6% were currently experiencing sexual dysfunction, which was significantly higher compared with the frequency before diagnosis. In the multivariate logistic regression model, chemo-related menopause, thyroid dysfunction, and depression were independent risk factors for sexual inactivity. Chemo-related menopause was a significant risk factor for sexual dysfunction. 결론: Chemo-related menopause was significantly associated with both sexual inactivity and dysfunction after treatment. Thyroid dysfunction and depression were risk factors for sexual inactivity in younger breast cancer survivors.
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Patterns and utility of routine surveillance in stage III-IV endometrial cancer
( Maria Lee ),( Seungmee Lee ),( Hee Seung Kim ),( Hyun Hoon Chung ),( Jae-weon Kim ),( Noh Hyun Park ),( Yong Sang Song ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To evaluate surveillance methods and their utility in detecting recurrence of disease in stage III-IV endometrial cancer. 방법: We performed a retrospective chart review of women diagnosed with advanced stage endometrial cancer between the years 2000 and 2011. Surveillance data was abstracted and analyzed. Surveillance method leading to detection of recurrence was identified and compared by stage of disease and site of recurrence. 결과: Ninety one patients met the criteria for inclusion. At a median follow-up of 71 months, the 5-year rate of relapse was 39% and of death from endometrial cancer was 11%. CA-125 and CT imaging were used frequently in advanced stage patients, but vaginal cytology was utilized less. Thirty-five percent of patients experienced a recurrence and the majority of initial recurrences (40.6%) had a distant component. Modalities that detected cancer recurrences were: symptoms (31.3%), physical exam (6.2%), surveillance CT (56.2%), CA-125 (6.2%), and vaginal cytology (3.1%). The majority of loco-regional and distant recurrences (87.5%) were detected by symptoms or surveillance CT, 12.4% were detected by physical exam or CA 125. One loco-regional recurrence was identified by vaginal cytology but no recurrences with a distant component detected by this modality. 결론: Symptoms and CT identify the majority of advanced endometrial cancer recurrences, while vaginal cytology is the least likely surveillance modality to identify a recurrence. The role and follow-up policy of CT and CA-125 surveillance outside of a clinical trial needs to be further reviewed.
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( Maria Lee ),( Sung Jong Lee ),( Joo Hee Yoon ),( Yong Il Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Cervical carcinoma is one of the most common cancers in females. This cancer begins with precancerous stages and can evolve to carcinoma over 10 years or more. Cervical cancer is a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes, leading to activation of oncogenes and inactivation or loss of tumor suppressor genes. We aimed to identify genetic alterations associated with pre-cancerous stage and also with cervical cancer. For this purpose, microarray comparative genomic hybridization (Illumina 450K and Illumina Expression HT12 Human CGH Whole-Genome Arrays) was performed with 16 cases of cervical intraepithelial neoplasia (CIN) of different stages and 3 cases of carcinoma. We identified epigenetic inactivation of TSGs by hyper- or hypo-methylation which has been recognized as an important and alternative mechanism in tumorigenesis. Here we discuss these epigenetic alterations in cervical intrapeithelial neoplasia and cervical cancer focusing on DNA methylation.
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Copy number alterations affecting pre-cancerous and carcinoma stage of cervical cancer
( Maria Lee ),( Sung Jong Lee ),( Joo Hee Yoon ),( Yong Il Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Cervical cancer is one of the common cancers in females. This cancer begins with pre-cancerous stages and can evolve to carcinoma over 10-15 years or more. We aimed to identify genetic alterations associated with pre-cancerous stage and also with carcinoma stage of cervical cancer. For this purpose, microarray comparative genomic hybridization (array-CGH) was performed with 37 normal samples, 55 cases of cervical intraepithelial neoplasia (CIN) of different stages, 6 cases of carcinoma and 7 unknown stage samples. We identified 5 significant CNV regions (P<0.05) and performed the validation test with genomic quantitative polymerase chain reaction (qPCR) to confirm these regions. As a result, copy number alterations on 1p36.22 and 12q21.33 loci identified by array- CGH were consistently appeared in array-CGH and genomic qPCR analysis. The 1p36.22 region showed increased copy number losses in carcinoma, compared with normal samples. On the contrary, 12q21.33 region presented increased copy number gains in carcinoma and CINs, compared with normal samples. Immunohistochemistry analysis also found increased PDG expression in cervical intraepithelial neoplasia and cervical cancer tissues. Confirmed loci will be applied as clinical diagnosis markers of cervical cancer.
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Film Session Q&A 2 : Adhesion prevention in total laparoscopic hysterectomy
( Maria Lee ),( Yong Il Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Others. Adhesion formation is a well-known complication of abdominal surgery. Little is known about adhesions in the TLH setting. Various surgical techniques for reducing adhesion formation following TLH have been investigated. The relative benefits of peritoneal closure are areas of continued research and debate.Adhesion prevention products (Interceed, Medicurtain, Seprafilm) are also becoming more commonplace in gynecologic surgery. After application with Medicurtain, postoperative adhesions development was assessed at second-look laparoscopy. Intraperitoneal administration of hyaluronic acid (Medicurtain) decreased post- hysterectomy adhesions. Our data show that laparoscopic application of Medicurtain after hysterectomy may be effective for reducing postoperative adhesion development.
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