Ascorbic Acid Alleviates Pancreatic Damage Induced by Dibutyltin Dichloride (DBTC) in Rats

Xin-Liang Lu,Yan-Hua Song,Yan-Biao Fu,Jian-Min Si,Ke-Da Qian 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.6

Purpose: Because previous studies have reported depleted antioxidant capacity in patients with chronic pancreatitis (CP), prevention of free radical production has gained importance in antifibrotic treatment strategies for CP. The aim of this study was to investigate the effects of ascorbic acid on oxidative capacity and pancreatic damage in experimental CP. Materials and Methods: CP was induced in male Sprague-Dawley rats by infusion of dibutyltin dichloride (DBTC) into the tail vein. Ascorbic acid was given intraperitoneally at a daily dose of 10mg/kg body weight. The treatment groups were as follows: group 1, DBTC plus intraperitoneal physiologic saline; group 2, DBTC plus intraperitoneal ascorbic acid; group 3, solvent plus intraperitoneal physiologic saline; group 4, no operation plus intraperitoneal physiologic saline. Each group contained 15 animals. Treatment was started after CP was established. After 4 weeks of treatment, serum hyaluronic acid and laminin levels were determined by radioimmunoassay, pancreatic tissue oxidative stress was analyzed, and the degree of pancreatic damage was determined. Results: Ascorbic acid treatment markedly increased superoxide dismutase (SOD) activity and decreased malondialdehyde (MDA) concentrations in pancreatic tissue (p<0.01 for both). Significant serum hyaluronic acid and laminin reductions were observed in group 2 as compared with group 1 (p<0.05). However, the serum hyaluronic acid and laminin levels remained elevated when compared with those of groups 3 and 4 (p<0.05). Histopathologic scores were also lower in animals with CP that underwent ascorbic acid-treatment (p<0.05). Conclusion: Ascorbic acid treatment alleviated the degree of oxidative stress and pancreatic damage in rat CP. Antioxidant treatment might be considered a potential option to improve the pathologic process in CP.

Effects of Maturity and 1-MCP Treatment on Postharvest Quality and Antioxidant Properties of ‘Fuji’ Apples during Long-term Cold Storage

Xin-gang Lu,Yan-ping Ma,Xing-hua Liu 한국원예학회 2012 Horticulture, Environment, and Biotechnology Vol.53 No.5

Fuji’ apple fruit harvested 10 days before normal harvest (H1) and at normal harvest (H2) were untreated or treated with 1 ㎕·L-1 1-methylcyclopropene (1-MCP) and stored at 0 for up to 30 weeks. Fruits from H1 were firmer and had higher titratable acidity (TA) but lower soluble solids concentrations than those from H2. 1-MCP treatment delayed loss of firmness and TA in fruit from both harvests during storage. Superficial scald incidence was decreased by 1-MCP treatment, but flesh browning was unaffected. H2 fruit had higher total phenolics, flavonoid, and glutathione content as well as total antioxidant activity than H1 fruit at harvest and throughout storage. 1-MCP treated fruit tended to have higher levels of these constituents than untreated fruit in peel, but not in flesh tissues. These results suggest that fruit harvested at the mature stage have better integral quality with 1-MCP treatment.

Analysis of Repeated Measurements on Iowa Gambling Task Study

Xin Lu,이동희,최보승,박만식,안형진 한국자료분석학회 2007 Journal of the Korean Data Analysis Society Vol.9 No.6

To reduce a learning effect or test-retest effect is very important in Iowa Gambling Task(IGT) studies that inspect cognitive components in decision making process since the gambling tasks are repeated over time. To this end, two new tasks, namely K and Q, have been developed and proposed to reduce the learning effect. In this study, we examine the effectiveness of these two tasks on reduction of learning effect based on repeated data collected from 75 healthy subjects. A linear mixed effects model was utilized for the analysis to account for the within-subject correlation. The first order ante dependence variance-covariance structure is selected for the final model after several variance covariance structures are compared based on Akaike information criterion(AIC). The results show that participants performance is similar across the three gambling tasks regardless of learning effect. Therefore, the utilization of the original task A followed by the new tasks K and Q will effectively distinguish the cognitive components from the learning effect in decision making process in gambling task studies.

Transformer fault acoustic identification model based on acoustic denoising and DBO-SVM

Lu Ling,Zhang Xin,Ma Hui,Pu Qiuping,Lu Yang,Xu Hongwei 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.6

In order to address the impact of ambient noise on the acquisition of the transformer body acoustic pattern and completely extract the information contained in the transformer acoustic pattern, This study suggests a transformer core loosening identifi cation technique based on the integration of wavelet threshold denoising and VMD with Identifi cation of transformer core loosening using DBO (Dung Beetle Optimization Algorithm)-optimized SVMs (Support Vector Machine) and the diff erence between the kurtosis value and the mixed acoustic signal is used to get the de-noised signal with a high signal-to-noise ratio. After that, the signal is fed into an optimized support vector machine for training in order to produce the core loosening identifi cation model. By means of the no-load tests conducted on a 500 V transformer and the examination of the acoustic signals gathered with varying levels of core looseness, the fi ndings demonstrate that the transformer core looseness identifi - cation model with the denoised MFCC feature parameters and the dung-beetle algorithm optimized support vector machine in this work achieves an accuracy of 96.25%, hence improving the core looseness fault identifi cation rate.

A composite crack model for concrete based on meshless method

Lu, Xin-Zheng,Jiang, Jian-Jing,Ye, Lie-Ping Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.23 No.3

A crack model for the fracture in concrete based on meshless method is proposed in this paper. The cracks in concrete are classified into micro-cracks or macro-cracks respectively according to their widths, and different numerical approaches are adopted for them. The micro-cracks are represented with smeared crack approach whilst the macro-cracks are represented with discrete cracks that are made up with additional nodes and boundaries. The widely used meshless method, Element-free Galerkin method, is adopted instead of finite element method to model the concrete, so that the discrete crack approach is easier to be implemented with the convenience of arranging node distribution in the meshless method. Rotating-Crack-Model is proved to be preferred over Fixed-Crack-Model for the smeared cracks of this composite crack model due to its better performance on mesh bias. Numerical examples show that this composite crack model can take advantage of the positive characteristics in the smeared and discrete approaches, and overcome some of their disadvantages.

Expression and function analysis of a rice OsHSP40 gene under salt stress

Xin Wang,Huan Zhang,Lu‑Yuan Shao,Xin Yan,Hui Peng,Jie‑Xiu Ouyang,Shao‑Bo Li 한국유전학회 2019 Genes & Genomics Vol.41 No.2

Heat shock proteins (HSPs) play essential roles in both plant growth and abiotic stress tolerance. In rice, OsHSP40 was recently reported to regulate programmed cell death (PCD) of suspension cells under high temperature. However, the expression and functions of OsHSP40 under normal growth or other abiotic stress conditions is still unknown. We reported the expression and function of a rice OsHSP40 gene under salt stress. Homologous proteins of OsHSP40 were collected from the NCBI database and constructed the neighbor-joining (NJ) phylogenetic tree. The expression pattern of OsHSP40 was detected by qRT-PCR under NaCl (150 mM) treatment. Then, identified a rice T-DNA insertion mutant oshsp40. At last, we compared and analyzed the phenotypes of oshsp40 and wild type under salt stress. OsHSP40 was a constitutively expressed small HSP (sHSP) gene and was close related to other plant sHSPs. Moreover, the expression of OsHSP40 was regulated by salt, varying across time points and tissues. Furthermore, the growth of T-DNA insertion mutant of OsHSP40 (designated as oshsp40) was suppressed by NaCl (150 mM) compared with that of the WT at seedling stage. Detailed measurement showed root and shoot length of the oshsp40 seedlings were significantly shorter than those of the WT seedlings under NaCl stress. In addition, the pot experiment results revealed that seedlings of oshsp40 withered more seriously compared with those of WT after NaCl treatment and recovery, and that survival rate and fresh weight of oshsp40 seedlings were significantly reduced. Taken together, these data suggested that OsHSP40 had multiple functions in rice normal growth and abiotic stress tolerance.

The sensitivity of respondent‐driven sampling

Lu, Xin,Bengtsson, Linus,Britton, Tom,Camitz, Martin,Kim, Beom Jun,Thorson, Anna,Liljeros, Fredrik Blackwell Publishing Ltd 2012 JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A- Vol.175 No.1

<P><B>Summary. </B> Researchers in many scientific fields make inferences from individuals to larger groups. For many groups, however, there is no list of members from which to draw a random sample. Respondent‐driven sampling (RDS) is a relatively new sampling methodology that circumvents this difficulty by using the social networks of the groups under study. The RDS method has been shown to provide unbiased estimates of population proportions given certain conditions. The method is now widely used in human immunodeficiency virus related studies among high risk populations globally. We test the RDS methodology by simulating RDS studies on the social networks of a large Lesbian, gay, bisexual and transgender Web community. The robustness of the RDS method is tested by violating, one by one, the conditions under which the method provides unbiased estimates. Simulations indicate that the bias is large if networks are directed or respondents choose to invite people on the basis of characteristics that are correlated with the study outcomes. The bias and variance increase if participants invite close as opposed to more distant friends whereas sampling in denser networks sharply reduces variance. However, the RDS method shows strong resistance to sampling without replacement, low response rates and certain errors in the participants’ reporting of their network sizes, as well as the selection criteria of seeds. The effects of network structure and the number of seeds and coupons are also discussed.</P>

The Smart Eye Frame Based On Internet of Things

Xin Zhenghua,Chen Guolong,Li Hong,Song Qixiang,Xiao Meng,Lu Biao,Lu Hongmei,Shi Yaqi 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.11

Preparation and electrochemical properties of mesoporous Co3O4 crater-like microspheres as supercapacitor electrode materials

Lu Wang,Xiaoheng Liu,Xin Wang,Xujie Yang,Lude Lu 한국물리학회 2010 Current Applied Physics Vol.10 No.6

Mesoporous Co3O4 microspheres with unique crater-like morphology were obtained by utilizing the mesoporous silica material MCM-41 as a template. The analysis results of N2 adsorptionedesorption measurement indicate that the product has a large BrunauereEmmetteTeller (BET) surface area of 60 m2 g-1 and a narrow pore size distribution centering around 3.7 nm. Its electrochemical properties were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS)measurements. The findings reveal that this novel morphology material has a smaller inner resistance of about 0.4 U and a higher onset frequency of 550 Hz. This material can provide a high specific capacitance of 102 F g-1 and a large capacity retention of 74% in 500 continuous cycles test at a sweep rate of 3 mV s-1. More significantly, the mass loading of electroactive species can reach as large as 2 mg cm-2, which is one order of magnitude larger than common amount used.

Efficacy and Safety of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Hepatocellular Carcinomas Compared with Radiofrequency Ablation Alone: A Time-to-Event Meta-Analysis

Xin Wang,Yanan Hu,Mudan Ren,Xinlan Lu,Guifang Lu,Shuixiang He 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.1

Objective: To compare the efficacy and safety of combined radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) with RFA alone for hepatocellular carcinomas (HCC). Materials and Methods: Randomized controlled trial (RCT) studies that compared the clinical or oncologic outcomes of combination therapy of TACE and RFA versus RFA for the treatment of HCC were identified through literature searches of electronic databases (Pubmed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, and Google Scholar). Hazard ratios (HRs) or odds ratios (ORs) with their corresponding 95% confidence interval (CI) were combined as the effective value to assess the summary effects. The strength of evidence was rated by the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Six RCTs with 534 patients were eligible for inclusion in this meta-analysis. The meta-analysis showed that the combination of TACE and RFA is associated with a significantly longer overall survival (HR = 0.62, 95% CI: 0.49–0.78, p < 0.001) and recurrence-free survival (HR = 0.55, 95% CI: 0.40–0.76, p < 0.001) in contrast with RFA monotherapy. The seemingly higher incidence of major complications in the combination group compared with RFA group did not reach statistical significance (OR = 1.17, 95% CI: 0.39–3.55, p = 0.78). Conclusion: In patients with HCC, the combination of TACE and RFA is associated with significantly higher overall survival and recurrence-free survival, as compared with RFA monotherapy, without significant difference in major complications.