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( Zheng Jun Li ),( Dae Kyoung Choi ),( Kyung Cheol Sohn ),( Seul Ki Lim ),( Myung Im ),( Young Lee ),( Young Joon Seo ),( Chang Deok Kim ),( Jeung Hoon Lee ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.5
Background: Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand. Recently, it has been demonstrated that keratinocytes play an important role in the pathogenesis of psoriasis. Objective: To investigate the potential role of keratinocytes, we examined whether TLR9 ligand CpG induces IL-17A expression in keratinocytes. Methods: We used HaCaT keratinocytes as a model system, and determined CpG-induced IL-17A using enzyme-linked immunosorbent assay and Western blot. Results: When HaCaT keratinocytes were treated with CpG, the expression of several cytokines including IL-17A, tumor necrosis factor-α and CCL20 was markedly increased. Treatment with nuclear factor (NF)-κB inhibitor significantly blocked the CpG-induced IL-17A production, indicating that CpG induced IL-17A expression through the NF-κB signaling pathway. In addition, IL-17A secreted from keratinocytes stimulated the CD4+ T cells, resulting in strong induction of IL-22 production. Conclusion: Since IL-22 is an important mediator for psoriatic inflammation, our data suggest that keratinocytes can participate in the pathogenesis of psoriasis via the TLR9-dependent IL-17A production. (Ann Dermatol 28(5) 579∼585, 2016)
Jun Zheng,Xuwei Lai,Xingjian Zhou,Ankai Chen,Wang Zheng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.5
The scientific and reasonable prediction of energy consumption in WEDM process is the key for energy-saving optimization of wire-cutting process in the design stage. The existing research about WEDM energy-saving studies mainly focus on the pulsed power control strategies. And, the research on non-pulsed energy consumption of WEDM is deficient. The non-pulsed energy consumption takes up a larger proportion in the whole WEDM process through theoretical analysis and case verification, and the energy consumption characteristics are equally representative. Therefore, the paper analyzes the energy characteristics based on non-pulsed energy consumption subunits of WEDM. A non-pulsed auxiliary energy consumption and feeding energy prediction model is established, and a WEDM machine tool is used for the experiment. The accuracy of the prediction model proposed in this paper can reach more than 96%. The raise and establishment of the model provides the basis for energy saving optimization of the subsequent wire cutting process.
Jun-Hui Zheng,Jian-Fen Liu 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.3
In this paper, a robust kalman filter is designed for the uncertainty time-varying discrete systems with state delay in process and output matrices combined with the possibility of missing measurements. The uncertainties are expected in the process, output and white noise covariance matrices. A formula for a candidate upper bound on the actual state estimation error variances for all admissible parameter uncertainties and possible missing measurements is obtained. The filter parameters are optimized to give a minimal upper bound on the state estimation error covariance for all admissible uncertainties and missing measurements.
Zheng Jun,Huang Ju,Zhang Liang,Wang Mengna,Xu Lihong,Dou Xiaoyun,Leng Xiaojing,Fang Mingxiao,Sun Yang,Wang Zhigang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Although programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy demonstrates great promise in cancer treatment, poor infiltration of T cells resulted from tumor immunosuppressive microenvironment (TIME) and insufficient accumulation of anti-PD-L1 (αPD-L1) in tumor sites diminish the immune response. Herein, we reported a drug-loaded microbubble delivery system to overcome these obstacles and enhance PD-L1 blockade immunotherapy.Docetaxel (DTX) and imiquimod (R837)-loaded microbubbles (RD@MBs) were synthesized via a typical rotary evaporation method combined with mechanical oscillation. The targeted release of drugs was achieved by using the directional "bursting" capability of ultrasound-targeted microbubble destruction (UTMD) technology. The antitumor immune response by RD@MBs combining αPD-L1 were evaluated on 4T1 and CT26 tumor models.The dying tumor cells induced by DTX release tumor-associated antigens (TAAs), together with R837, promoted the activation, proliferation and recruitment of T cells. Besides, UTMD technology and DTX enhanced the accumulation of αPD-L1 in tumor sites. Moreover, RD@MBs remolded TIME, including the polarization of M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, and reduction of myeloid-derived suppressor cells (MDSCs). The RD@MBs + αPD-L1 synergistic therapy not only effectively inhibited the growth of primary tumors, but also significantly inhibited the mimic distant tumors as well as lung metastases.PD-L1 blockade immunotherapy was enhanced by RD@MBs delivery system.
Zheng, Liang Jun,Kang, Dong Hee,Kim, Na Kyong,Youn, Young Jik,Kang, Hyun Wook Elsevier 2019 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.143 No.-
<P><B>Abstract</B></P> <P>Theoretical model of thermoelectric generator (TEG) cooled by direct evaporative cooling technology is developed. In the theoretical model, thermoelectric material properties depending on temperature change and effects of heat loss by radiation, conduction, and Thomson phenomenon are considered. To investigate the effect of evaporative cooling to the efficiency of TEG, the simulation conditions are set as hot-side temperature of 40–120 °C and 1 mm thickness of thin water film covering for cold-side. The ambient temperature is 25 °C and the relative humidity of the air is set from 25% to 75%. Based on the developed theoretical model, the output power of TEG is increased as increasing hot side temperature under fixed relative humidity or as decreasing relative humidity under fixed hot-side temperature. Consequently, the maximum output power of 130.69 W m<SUP>−2</SUP> and an efficiency of 1.63% are obtained with 25% relative humidity and 120 °C for the hot-side temperature condition. The results show that the output power and efficiency are increased 100.53 and 10.53 times higher than without evaporative cooling (natural convection case, output power of 1.30 W m<SUP>−2</SUP> and efficiency of 0.1548%), respectively.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Theoretical model of TEG cooled by direct evaporative cooling technology. </LI> <LI> Thermophysical relations in TEG system and cooling process at theoretical model. </LI> <LI> Analyzing thermal resistance network for quantifying heat flow rates and heat dissipation rates. </LI> <LI> Increasing TEG performance by applying evaporative cooling technology. </LI> <LI> TEG performance evaluation based on hot-side temperature and relative humidity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jun-Cheng Guo,Yi-Jun Yang,Jin-Fang Zheng,Jian-Quan Zhang,Min Guo,Xiang Yang,Xiang-Ling Jiang,Li Xiang,You Li,Huang Ping,Liu Zhuo 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, but its molecular mechanisms are not yet well characterized. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis, including that of HCC. However, the role of homeobox A11 antisense (HOXA11-AS) in determining HCC stem cell characteristics remains to be explained; hence, this study aimed to investigate the effects of HOXA11-AS on HCC stem cell characteristics. Initially, the expression patterns of HOXA11-AS and HOXA11 in HCC tissues, cells, and stem cells were determined. HCC stem cells, successfully sorted from Hep3B and Huh7 cells, were transfected with short hairpin or overexpression plasmids for HOXA11-AS or HOXA11 overexpression and depletion, with an aim to study the influences of these mediators on the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo. Additionally, the potential relationship and the regulatory mechanisms that link HOXA11-AS, HOXA11, and the Wnt signaling pathway were explored through treatment with Dickkopf-1 (a Wnt signaling pathway inhibitor). HCC stem cells showed high expression of HOXA11-AS and low expression of HOXA11. Both HOXA11-AS silencing and HOXA11 overexpression suppressed the self-renewal, proliferation, migration, and tumorigenicity of HCC stem cells in vivo, as evidenced by the decreased expression of cancer stem cell surface markers (CD133 and CD44) and stemness-related transcription factors (Nanog, Sox2, and Oct4). Moreover, silencing HOXA11-AS inactivated the Wnt signaling pathway by decreasing the methylation level of the HOXA11 promoter, thereby inhibiting HCC stem cell characteristics. Collectively, this study suggested that HOXA11-AS silencing exerts an antitumor effect, suppressing HCC development via Wnt signaling pathway inactivation by decreasing the methylation level of the HOXA11 promoter.
Jun Zheng,Dongsong Sun,Tingdi Chen,Ruocan Zhao,Yuli Han,Zimu Li,Anran Zhou,Nannan Zhang 한국광학회 2018 Current Optics and Photonics Vol.2 No.2
A Scanning Rayleigh Doppler lidar for wind profiling based on a non-polarized beam splitter cube optically contacted FPI is developed for wind measurement from high troposphere to low stratosphere in 5-35 km. Non-polarized beam splitter cube optically contacted to the FPI are used for a stable optical receiver. Zero Doppler shift correction is used to correct for laser or FPI frequency jitter and drift and the timing sequence is designed. Stability of the receiver for Doppler shift discrimination is validated by measuring the transmissions of FPI in different days and analyzed the response functions. The maximal relative wind deviation due to the stability of the optical receiver is about 4.1% and the standard deviation of wind velocity is 1.6% due to the stability. Wind measurement comparison experiments were carried out in Jiuquan (39.741°N, 98.495°E), Gansu province of China in 2015, showing good agreement with radiosonde result data. Continuous wind field observation was performed from October 16th to November 12th and semi-continuous wind field of 19 nights are presented.