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( Aida Galicia ),( Juan Carlos Anda ),( Maximiliano Garcia ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
A 54-years-old man with history of acute pancreatitis 4 years before and secondary DM, he also had history of primary hypothyroidism and hypertension. He was admitted in hospital in 2010 with sudden and bilateral hearing loss, headache and dizziness. Neuro-otological examination revealed a sensorineural hearing loss (SNHL) and he was given Dexamethasone trans-tympanic, then he was treated with Ganciclovir (12 mg/kg/24 h) for 10 days + prednisone 50 mg/24 h for 4 weeks. At the end, pure tone audiometry confi rmed a SNHL affecting both ears. aCL antibodies were positives and he was send to internal medicine consultation. The diagnosis of microangiopathic antiphospholipid sindrome (MAPS) on the basis of presumed thrombotic cause of SNHL was made and he was formally anticoagulated with warfarin. He has had no additional thrombotic episodes, although SNHL prevails. Full blood count, serum electrolytes, renal function, urinalysis and cerebrospinal fi uid analysis were normal. Coagulation: PT 53. 1”, aPTT 92. 6”, Lupus anticoagulant: 1. 69 (positive<1. 2). Anti-ß2 Gp1 IgM:3350 (negative<8 U/ml), Anti-ß2 Gp1 IgG: 6. 8 (negative<14. 3 U/ml), aCL IgM: >255 (negative<15), aCL IgG: 46. 3 (negative<20). ANAs, Anti-dsDNA, Anti-Sm were negative. MRI of brain on T2 weighted showed white matter hyperintensities and subcortical hyperintensities in frontal and parietal lobes, meaning microangiopathic injury on brain parenchymal. Conclusion: MAPS is a subset of Antiphospholipid Syndrome which occlusive thrombosis of small blood vessels and microangiophaty dominate the clinical picture. Several neurological disorders have been described in association with antiphospholipid antibodies (aPL) without thrombosis of large-vessels like Myelitis Transverse, Multiple Sclerosis-like Disease, Dementia, Chorea, Migraine and Epilepsy. SNHL is a rare syndromethat leads rapidly progressive bilateral hearing loss, and it has been strongly associated with aPL. There are a few cases in medical literature and there is no consensus about appropriate treatment but anticoagulation is widely accepted.
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Argemone species: Potential source of biofuel and high-value biological active compounds
Alejandra Anahi Martinez-Delga,Jose de Anda,Janet Maria Leon-Morales,Juan Carlos Mateos-Diaz,Antonia Gutierrez-Mora,Jose Juvencio Castaneda-Nava 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.2
The Argemone genus includes weed species of great importance in traditional medicine due to biological activities attributed to secondary metabolites, mainly alkaloids, distributed in all tissues of this species. In addition, their seeds contain a large amount of oil (30 to 40%). For this reason, several authors have discussed the potential of this species as a non-edible source to produce multi-purpose raw materials and a low cost-crop for example in the production of biofuels such as biodiesel. Argemone species grows in poor soils with low water and nutrient requirements. This makes the Argemone species an attractive economical and environmentally friendly candidate for biofuels production. Furthermore, the Argemone species can also provide high-value by-products for the agrochemical and pharmaceutical industry. In this work, we compiled the ethnomedical information, biochemical features, and biofuel production efforts that have been published by testing different Argemone species, in order to compare the research efforts and analyze its biotechnological potential. After analyzing the literature, we conclude that the genus has great potential for high-value pharmaceutical products and energy production purposes, and also to control plant pests. We also consider that other species of the genus may have also potential applications in this field.
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