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- 저자 : ( Joohyang Lee ) (검색결과 4 건)
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( Junsik Park ),( Jung Chul Kim ),( Miran Lee ),( Joohyang Lee ),( Sunghoon Kim ),( Sang Wun Kim ),( Jung-yun Lee ),( Yu Sang Lee ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: A recent series of clinical trials have demonstrated the potential efficacy of immune checkpoint inhibitors (ICIs) for ovarian clear cell carcinoma (OCCC). However, little is known about the immune characteristics of OCCC. In this study, we investigated the immunologic properties of tumor-infiltrating lymphocytes (TILs) in patients with OCCC to elucidate therapeutic responses to ICIs. Methods: We analyzed peripheral blood mononuclear cells (PBMCs) and TILs from patients with ovarian cancer. CD8 and regulatory T (Treg) cells of OCCC (n=25) and high-grade serous carcinoma (HGSC) patients (n=33) were compared using flow cytometry. Results: First, we explored the immune characteristics of OCCC-infiltrating T cells. The % of CD8 and Treg cells were higher in TILs than in PBMCs. CD8 TILs exhibited higher expression of PD-1, CD39, CD103, granzyme B, Ki-67 and TCF-1, compared with peripheral CD8 T cells. Tumor-infiltrating Treg cells were enriched with effector Treg cells and showed higher expression of PD-1, CTLA-4, 4-1BB, OX-40, CD39, and CCR8, compared with peripheral Treg cells. Second, we compared TILs from advanced/recurrent patients with OCCC (n=9) and HGSC (n=33). The expression of PD-1 on CD8 TILs was significantly lower in OCCC than in HGSC. Furthermore, the expression of TCF-1 was significantly higher in OCCC. Meanwhile, the % of tumor-infiltrating Treg cells, especially effector Treg cells was significantly lower in OCCC than in HGSC. Conclusion: Overall, CD8 TILs in OCCC were exhausted similar to those in HGSC. However, CD8 TIL in OCCC showed less exhausted than those in HGSC. Further research is needed to investigate whether the immune properties of TILs in OCCC are actually correlated with the favored responses of ICIs.
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( Junsik Park ),( Jung Chul Kim ),( Miran Lee ),( Joohyang Lee ),( Yoo-na Kim ),( Yong Jae Lee ),( Jung-yun Lee ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: Poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors (PARPi) are becoming the standard of care options for epithelial ovarian cancer (EOC). In the current study, we investigated the immunologic effects of PAPRi on circulating Treg cells during PARPi maintenance therapy. Furthermore, we explored ways in which the addition of PD-1 blockade to PAPRi maintenance therapy enhances survival outcomes in recurrent EOC. Methods: We collected serial peripheral blood mononuclear cells (PBMCs) from EOC patients who responded to their most recent platinum-based chemotherapy (n=27). Peripheral blood was collected before treatment and at 1, 3, and 6 months after treatment initiation. Olaparib or niraparib was used as maintenance therapy. We also collected serial PBMCs from patients treated with PAPRi+anti-PD-1 (n=26, NCT04361370). The peripheral Treg cells were analyzed according to treatment responses using multi-color flow cytometry. PARPi responses were defined according to BRCA status and duration of PARPi treatment. Results: The expression of CTLA-4 and CCR8 on Treg cells significantly decreased after 6 months of PAPRi mono-treatment. PAPRi decreased the expression of FoxP3, CTLA-4, TIGIT, CD39, and CCR8 on Treg cells in vitro, but did not change PD-1 expression. Patients with high percentages of PD-1+Treg cells before PAPRi therapy showed significantly poorer progression-free survival (PFS). In a cohort of individuals treated with PAPRi+anti-PD-1 treatment, the expression of PD-1 on Treg cells was significantly decreased after the addition of anti-PD-1. Among patients with high percentages of PD-1+Treg cells between the two cohorts, those in the PAPRi+anti-PD-1 cohort had significantly longer PFS than those in the PAPRi monotherapy cohort. Conclusion: Peripheral PD-1+Treg cell amounts before PAPRi treatment could predict clinical responses, and targeting PD-1+Treg cells with additional PD-1 blockade during PAPRi treatment could potentially improve survival outcomes.
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Hur, Myung-Haeng,Park, Joohyang,Maddock-Jennings, Wendy,Kim, Dong Oak,Lee, Myeong Soo Heyden & Son 2007 Phytotherapy research Vol.21 No.7
<P>The aim of this study was to explore the effect of an essential oil solution on levels of malodour and production of volatile sulphur compounds (VSC) in patients nursed in intensive care unit (ICU). Thirty two patients received 3 min of oral cleaning using an essential oil solution (mixture of tea tree, Melaleuca alternifolia, peppermint, Mentha piperita and lemon, Citrus limon) on the first day, and Tantum (benzydamine hydrochloride) on the second day. Two trained nurses measured the level of malodour with a 10 cm visual analogue scale (VAS) and VSC with a Halimeter before (Pre), 5 min after (Post I) and 1 h following treatment (Post II). The level of oral malodour was significantly different following the essential oil session, and differed significantly between two sessions at Post I (p < 0.005) and Post II (p < 0.001). Differences between the two sessions were significant (Tantum, p < 0.001; essential oil, p < 0.001) in the level of VSC and significantly lower in the essential oil session than Tantum at the Post II (p < 0.05). These findings suggest that mouth care using an essential oil mixture of diluted tea tree, peppermint and lemon may be an effective method to reduce malodour and VSC in intensive care unit patients. Copyright © 2007 John Wiley & Sons, Ltd.</P>
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온라인 식품 소비자의 가구 형태에 따른 친환경 행동에 관한 연구
유은이(Eunyi Yoo),이민아(Minah Lee),김주향(Joohyang Kim) 한국외식경영학회 2023 외식경영연구 Vol.26 No.6
본 연구는 온라인 식품 구매자의 친환경 행동에 관한 연구를 위해 VBN 이론을 적용하여 온라인 식품 소비자들의 친환경 행동을 분석하고 가구 형태별 조절 효과를 규명하고자 하였다. 본 조사는 전국 20세 이상 성인을 대상으로 하였으며, 총 318부를 통계 분석에 사용하였다. 첫째, 환경 의식의 두 요인인 환경에 대한 인식과 환경에 대한 지식 모두 가치에 정(+)의 영향을 미치는 것으로 나타났다. 둘째, 온라인 식품 소비자의 환경에 대한 가치가 환경에 대한 신념에 정(+)의 영향을 미치고, 환경에 대한 신념이 환경 규범에 정(+)의 영향을 미치는 것으로 나타났다. 셋째, 온라인 식품 소비자의 환경 규범은 친환경 행동에 정(+)의 영향을 미치는 것으로 나타났다. 넷째, 1인가구, 자녀가 없는 부부, 자녀가 있는 부부와 같은 가구 형태는 온라인 식품 소비자의 환경 의식, 가치, 신념, 규범과 친환경 행동 간의 관계를 조절하는 것으로 나타났다. This study analyzed the eco-friendly behavior of online food consumers and identify the moderating effect of each household type by applying the VBN theory. This survey targeted adults aged 20 or older and a total of 318 copies were used for statistical analysis. First, both environmental awareness and environmental knowledge were found to have a positive effect on value. Second, it was found that online food consumers' value in the environment had a positive effect on their beliefs, and their beliefs in the environment had a positive effect on norms. Third, it was found that the norms of online food consumers had a positive effect on eco-friendly behavior. Fourth, household types such as single-person households, married couples with no children, and married couples with children were found to control the relationship between environmental awareness, values, beliefs, norms, and eco-friendly behavior of online food consumers.
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