호흡기 감염증에 대한 Roxithromycin(Rulid^(�))의 임상 효과

노흥규,김남재,서지원,김주옥,김선영 최신의학사 1990 最新醫學 Vol.33 No.11

항결핵 6개월 단기요법의 성과 고찰

서지원,정연채,김남재,홍석철,김주옥,김선영,노흥규 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To evaluate the effect of 6-month short term antituberculosis chemotherapy with INH, Rifampin, Ethambutol, and Pyrazinamide(2HREZ/4HRE) in the patients with pulmonary and/or extrapulmonary tuberculosis, the authors prescribed 2HREZ/4HRE regimen in 79 tuberculosis patients for 6 months with measuring the sputum staining for AFB, chest X-ray findings, recurrence rates and possible side reactions of the treatment. The result were as follow; 1. Pulmonary Tuberculosis 1) Among the 56 pulmonary tuberculosis patients who had taken 2HREZ/4HRE regimen. 32 patients showed initial positivity in sputum AFB smear stain(57.2%). Negative conversion occurred usually within 2 months after initiation of chemotherapy and the mean period of negative conversion was 1.4 months. 2) Among the 56 pulmonary tuberculosis patients, chest X-ray finding changed in 41 patients (37.21%). From these 41 patients 39 patients showed continuous improvements in chest X-ray finding, though 3 patients showed initial aggravation in spite of continuous medication. The remainder 2 cases aggravated due to the failure of treatment. 3) Treatment failure occurred in 2 patients (3.57%) during the chemotherapy among 56 patients of pulmonary tuberculosis and they were infected with secondary drug-resistant strains of M. tuberculosis. 2. Extrapulmonary tuberculosis. Among 8 patients with tuberculous pleurisy and 15 patients with superficial tuberculous lymphadenitis, there were no evidence of treatment failure after completion of antituberculosis chemotherapy for 6 months with 2HREZ/4HRE regimen. 3. Follow-up study was performed from 6 months to 50 months after completion of antituberculosis chemotherapy and the relapse was not noted in both pulmonary and extrapulmonary tuberculosis patients group during this period. 4. Serum AST/ALT elevated in 9 patients(11.4%) during the treatment and this occurred usually within 3 months after the initiation of antituberculosis chemotherapy. However treatment interruption occurred in 2 patients (2.5%) due to the development of hepatitisone due to drug-induced hapatitis and the other due to type B viral hepatitis. In conclusion, we could find this 2HREZ/4HRE 6-months short-term antituberculosis regimen is effective and could be recommanded as a promising regimen for the treatment of tuberculosis.

釜山廣域市 共同住宅의 住居改造 類型에 關한 硏究

김로사,정지영 新羅大學校 1999 論文集 Vol.47 No.-

The purpose of this study was to examine into residential alteration with residents' characteristics and investigate into actual conditions of residential alteration. The results of the study were as follows: 1. The frequent pattern of alteration in the apartment dwelling unit were the alteration of widen a space (includes set op or remove a window or door, a wall or papartition, remove a doorsill), storage(includes set upa built in furniture, a storage, a shelf), equipments(includes electric wiring, install a water system, shift a work party of kitchen, shift equipments of bathroom), and decorative installation(includesmodificate size of window or koor, modificate a ceiling or floor, set up a interior garden, a pechka, homebar). The probability patterns of alteration by apartment dwellers were composed of households'characteristecs which included the family type, income, age of househofds, schoof of households, length of dwelling, size of house. 2. There were significane differences in pattern of widen a space by family type, pattern of decorative installation by income and size of house, pattern of storage by schoof of households, widen a space by length of dwelling. 3. There were significant differences in family type by pattern of widen space, school of households and size of house by storage, age of households and size of house by equirmints. 4. Among these characteristics, family type was influential to the widen a space pattern, income and size of house were influential to the decorative installation.

플륨 모니터링에 의한 SM45C 레이저 용접특성 평가

유영태,김재열,노경보,양동조,오용석,임기건,김지환 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.6

With the increased use of lasers in industrial welding applications, techniques for monitoring and controlling these processes become increasingly important. It is very important that we understand the dynamic behaviors of the laser induced plume in welding because the laser induced plume has considerable effects on welding efficiency and the quality of materials. As the plume fluctuation was associated with keyhole instability, unstable vapor plume indicated the process was unstable and would result in poor welds. An Infrared Themal-vision Camera can be utilized compensate for incurracies encountered in real-time monitoring during laser welding. We have results that instabilities of plume are closely dated with hot cracking and defect of laser welding.

CW Nd:YAG 레이저를 이용한 SM45C강의 표면경화특성

김지환,유영태,신호준,노경보 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.1

Laser surface hardening is an effective technique used to improve the tribological properties and also to increase the service life of automobile components such as camshafts, crankshatfs, lorry brake drums and gears. High power CO_(2) lasers and Nd:YAG lasers are employed for localized hardening of materials and hence are of potential application in the automobile industries. The heat is conducted rapidly into the bulk of the specimen causing self-quenching to occur and the formation of martensitic structure. In this investigation, the microstructure features occurring in Nd:YAG laser hardening SM45C steel are discussed with the use of optical microscopic and scanning electron microscopic analysis. Moreover, This paper describes the optimism of the processing parameters for maximum hardened depth of SM45C steel specimens of 4.5㎜, 10㎜ thickness by using CW Nd:YAG laser. Travel speed was varied from 0.6m/min to 1.5m/min. The maximum hardness and case depth of SM54C steel are 76Hv and 0.688㎜ by laser hardening. When the surface of specimens was melted during laser hardening, the surface hardness of SM45C steel was decreased.

제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산

이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.

홉핑동작과 달리기동작의 운동역학적 비교 분석 : Elementary School's Children

김승재,최지영,김로빈 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

The purpose of this study was firstly to investigate to investigate the biomechanical differences of motor developmental process by examining the movement of body segment and joint and the the pattern of ground reaction force and joint moment according to age during standing long jump in elementary school's children and secondly to provide fundamental data for scientific teaching method in physical education subject of teaching field. The subjects were divided into both grade 2 group and grade 6 group. which were consisted of 6 subject respectively. A digital video camera for kinematic data and a force plate for kinetics data were used during standing long jump. For the movement analysis two dimensional cinematographical method(Arial Performance Analysis System : APAS) was used and for the calculation of the kinematic variables a self developed program was used with the LabVIEW 6.1 (Laboratory Virtural Instrument Engineering Workbench) graphical programming (Johnson, 1999) program. independent samples t-test in SPSS package was used to test the biomechanical difference between two variables. The kinematics and kinetics results of this study were as follows. 1. while jumping distance, the horizontal displacement showed significant different between grade 2 group and grade 6 group, 2. Three were no significant difference between grade 2 group and grade 6 group each joint angular displacement however the hip joint and ankle joint showed more extended in grade 6 group. 3. In angular velocity the thigh segment, shank segment and foot segment velocity did not show significant differences. but foot segment angular velocity increased from minimum knee angle to take-off 4. The ground reaction force did not show significant difference between grade 2 group and grade 6 group, but the maximum peak value of the ground reaction force was smaller than 2 grade group. 5. Three were significant difference in hip and knee joint momentum between grade 2 group and grade 6 group.

호흡기감염증에 대한 Cefuroxime Axetil(Zinnat�)의 임상효과

김주옥,홍석철,김남재,서지원,김선영,노흥규 中央醫學社 1991 中央醫學 Vol.56 No.2

To evaluate the efficacy and safety of Zinnat in patients with respiratory tract infections, 20 patients were treated with Zinnat (250 mg b.i.d). Among 20 cases, 5 cases had pneumonia, 5 cases exacerbation of chronic bronchitis, 4 cases acute bronchitis, 3 cases bronchiectasis with infection, and acute tonsilitis, bronchial asthma with infection and emphysema with infection 1 case, respectively. The response was cure in 12 cases, partial response in 6 cases and no response in 2 cases. There were no significant clinical and laboratory side effects except dyspepsia and nausea (1 case) and diarrhea (1 case). Zinnat was considered to be useful agent against bacterial respiratory tract infections.

< 좌장 : 민경업 , 이수영 > ( 9:40 - 10:10 ) : G Protein subunit Gα 12 Enhance Ca2+ - induced Histamine Release in Human Umbilical Cord Blood - derived Mast Cells

(Ji Young Kim),(Jai Youl Ro),(Ji Hee Ha),(Chang Ho Lee) 대한천식알레르기학회 2001 춘계학술대회 초록집 Vol.2001 No.-

N/A

Diagnostic Performance of CT Colonography for the Detection of Colorectal Polyps

Ji-young Yun,Hee Jeong Ro,Jong Beom Park,Jung-Bin Choi,Ji Eun Chung,Yong Jin Kim,Won Hyuck Suh,Jong Kyun Lee 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.6

Objective: To investigate the diagnostic value of CT colonography for the detection of colorectal polyps. Materials and Methods: From December 2004 to December 2005, 399 patients underwent CT colonography and follow-up conventional colonoscopy. We excluded cases of advanced colorectal cancer. We retrospectively analyzed the CT colonography findings and follow-up conventional colonoscopy findings of 113 patients who had polyps more than 6 mm in diameter. Radiologists using 3D and 2D computer generated displays interpreted the CT colonography images. The colonoscopists were aware of the CT colonography findings before the procedure. Results: CT colonography detected 132 polyps in 107 of the 113 patients and conventional colonoscopy detected 114 colorectal polyps more than 6 mm in diameter in 87 of the 113 patients. The sensitivity of CT colonography analyzed per polyp was 91% (41/45) for polyps more than 10 mm in diameter and 89% (101/114) for polyps more than 6 mm in diameter. Thirteen polyps were missed by CT colonography and were detected on follow-up conventional colonoscopy. Conclusion: CT colonography is a sensitive diagnostic tool for the detection of colorectal polyps and adequate bowel preparation, optimal bowel distention and clinical experience are needed to reduce the rate of missing appropriate lesions.