마이크로니들의 형태 및 적용방법이 약물의 피부 투과에 미치는 영향

임지호,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-

The purpose of this study is to develop the microneedle using biodegradable and biocompatible polymer and to pioneer the new route of drug delivery through the research to apply the most desirable administration form of small molecules, peptides, proteins, genes, biological products including vaccines. Various biocompatible microneedles were manufactured. To apply drug to microneedle, drug formulation using ethylene vinyl acetate patch or polyacryl acid gel was developed. Drug permeation into rat skin based on the application method of patch or gel with microneedle was studied using Franz diffusion cell system. In vitro drug permeation results showed that the permeation by the application of hollow microneedle was not increased compared with solid microneedle. When G60 or G60*2 microneedle was used, the permeated amount of calcein was increased compared to when solid microneedle was used. The permeated amount of lidocaine HCl in 12 hr was increased when microneedle was used was increased. Skin irritation followed by microneedle showed there was little difference in the decrease of redness after microneedle application based on application time.

Proteome Analysis of Nodule Development in both Sinpaldalkong2 and SS2-2

Lim,Chae-Woo,Park,Ji-Young,Hwang,Cheol-Ho 한국작물학회 2003 한국작물학회 학술발표대회 논문집 Vol.2003 No.-

비소세포 폐암종에서 Epidiermal growth factor receptor(EGFR)의 발현 양상

임석호,이지혜,조현득,오미혜,김의한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

배경: 비소세포 폐암종에서 epidermal growth factor receptor (EGFR)의 발현이 예후에 미치는 영향에 대해서는 아직 일치된 결론에 이르지 못하고 있으며, 비소세포 폐암종의 조직 병리학적 소견으로는 종양의 진행 및 예후에 대해 예측이 불가능하다. 이에 저자들은 종양의 EGFR 발현과 임상 및 병리학적 특징과의 관계를 관찰하였다. 재료 및 방법: 1990년부터 2004년까지 순천향 대학교 천안병원에서 수술로 절제된 95명 환자의 포르말린에 고정한 파라핀 포매 조직을 이용하여 EGFR 항체를 이용한 면역조직화착 검사를 시행하였으며 이의 결과를 환자의 임상양상과 병리학적 소견과 비교 분석하였다. 결과: EGFR 발현과 환자의 생존기간을 비롯한 성별, TNM 임상병기, TU댕기, N-병기와는 관련이 없었으나 조직학적 유형중 편평상피암종은 47예중 43예가 양성 반응을 보여 통계학적으로 의미 있는 상관관계를 보였다(p=0.005). 그 외에 성별, 조직학적 유형, TNM 임상병기, T-병기, N-병기중 어떠한 변수도 생존기간과의 연관성을 보이지 않았다. 결론: 비소세포 폐암종에서 EGFR의 발현은 환자의 생존기간 및 임상병리학적 소견과 유의한 상관관계를 보이지 않으므로 예후인자로서의 이용은 현재로선 불가능하여 좀 더 많은 증례를 통한 연구가 필요할 것으로 사료된다. Background: The prognostic role of epidermal growth factor receptor (EGFR) remains controversial in patients with non-small cell lung cancer (NSCLC). Histopathologic findings cannot adequately predict disease progression, so we investigated the reladonship between EGFR and clinicopathologic feature. Methods: Using immunohistochemical techniques, we retrospecdvely analyzed formalin-fixed, paraffin-embedded samples from 95 padents with resected pathological NSCLCs. Then, we correlated these data with padents' clinical outcome and pathologic finding. Results: No reladonship was found between EGFR overexpression and patient survival when the entire cohort was considered. Multivariate factors including gender, histologic type, TNM stage, T stage and N stage were not correlated to poor outcome. Also, no factors revealed correlation with EGFR overexpression except histologic type. Squamous cell carcinoma showed positive reaction in 43 out of 47 patients(p=0.005). Condusion: This result indicated that EGFR overexpression in NSCLC showed no reladonship with patients' survival. Therefore, EGFR overexpression could not be used as a poor prognostic marker.

항암제 젬시타빈의 경구용 제제 개발을 위한 전략수립

임지호,황지숙,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

동계 난방시 구조체 축열 공조시스템의 축·방열 특성에 관한 연구

임지훈,이시환,차영호,정광섭,이정재 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

It is the plan that storage gets energy done by in structure with what thermal storage of structure changes only supply air duct among the existing HVAC system, and a basic principle coordinates the damper that it was installed makeup air in supply air duct like former HVAC system to an inside at supply and a night by day, and do makeup air supply with in ceiling space of thermal storage of structure HVAC system. This thermal storage of structure HVAC system uses the existing utility system, and energy saving can get structure of building done with energy storage, before air conditioning and peak load cut getting day heat load done.

한번의 간질발작 후 혈청 Neuron-Specific Enolase 농도 변화

최승호,박영춘,이장준,임정근,김지언,이상도 啓明大學校 醫科大學 1999 계명의대학술지 Vol.18 No.4

An increase in neuron-specific enolase (NSE) levels in serum and CSF has been shown to be an useful marker of brain damage after stroke, global ischemia, and coma. We report the changes of serum NSE levels after seizure attacks in epileptic patients compared with the levels in normal controls and epileptic patients without seizure attack at least 7 days (epileptic controls). Twenty-four seizures were included in this study. Blood was drawn within 1 hour, at 12 hour, 24 hour, and 48 hour after seizure attack. Serum NSE levels were measured with radioimmunoassay. The mean NSE levels for normal controls and epileptic controls were 6.94 ng/ml and 7.46 ng/ml, respectively. There were significant increase in level of serum NSE measured within 1 hour after seizure attack in epileptics compared with the level in normal controls (15.10ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (15.10ng/ml versus 7.46ng/ml, p<0.05). Serum NSE measured at 12 hours after seizure also increased compared with normal controls (12.32ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (12.43ng/ml versus 7.46ng/ml, p<0.05). Between normal controls and epileptic controls, there were no significant difference in serum NSE levels. We conclude that serum NSE level was elevated in epileptic patients who had seizure attack within 12 hours. Serum NSE levels can be useful marker for seizure within 12 hours after onser. The elevated serum NSE level after single seizure attack may suggest that the brain was injured in single seizure.

도시거주자의 혈중 카드뮴 농도와 간 및 신장 기능과의 상관성 평가

김호현,임영욱,임종한,양지연,신동천 한국환경독성학회 2003 환경독성보건학회지 Vol.18 No.1

The possibility that liver and kidney function is adversely affected by current levels of environmental exposure to cadmium (Cd) as investigated in adult men and women in the general population in Seoul. From February to August in 2001, blood and morning spot urine samples were collected from 136 not occupationally exposed group (age range 20~75 years) at 4 survey sites throughout Seoul. Liver and kidney function parameters in serum and urine were examined by conventional methods. The questionnaire included factors, i.e. sex, age, smoking, alcohol, diet habit etc. The geometric mean values for Cd in blood (Cd-B) were 1.43 μg/l. It seemed prudent to conclude that liver and kidney function as not disturbed by the current environmental exposure to Cd in study.

초등교사의 열정에 대한 인식: 의미연결망 분석의 활용

임효진 ( Hyo Jin¸ Lim ),최은혜 ( Eun Hye¸ Choi ),박호익 ( Ho Ik¸ Park ),이지현 ( Ji Hyun¸ Lee ) 한국초등교육학회 2021 초등교육연구 Vol.34 No.3

본 연구에서는 초등교사가 가지고 있는 열정에 대한 인식구조를 파악하기 위해 현직 초등교사 131명을 대상으로 설문조사를 실시하였다, 연구에서는 열정, 열정의 장단점, 교사열정에 대한 인식구조를 알아보기 위해 의미연결망 분석을 활용하여 근접 중심성, 연결중심성, 매개중심성, 아이겐벡터 중심성을 위주로 살펴보았다. 연구결과 첫째, 열정에서는 ‘힘’,‘강렬’과 같은 높은 강도나 에너지를 나타내는 단어들이 중요한 역할을 하였으며 커뮤니티 분석 결과 열정의 행동, 정서, 동기 특성에 대한 주제가 분류되었다. 둘째, 열정의 장점에서는 ‘삶’,‘원동력’,‘에너지’등이, 열정의 단점에서는 ‘타인’,‘피로’,‘살피지 못함’등이 중요한 역할을 하는 것으로 보아 기존 이론에 나타난 열정의 특성을 설명하고 있었다. 셋째, 교사열정에서는 ‘학생’,‘수업’과 같은 교수활동의 실천을 나타내는 단어들이 중요한 역할을 하였으며 커뮤니티 분석 결과 교육활동 전반, 학생과 수업, 전문성 개발에 대한 주제가 분류되었다. The purpose of this study was to explore the meaning of passion perceived by elementary school teachers. In order to understand the structure of perception of passion, we surveyed 131 in-service elementary school teachers. Responses to passion, the positive and negative role of passion, and teacher passion were analyzed using a semantic network analysis. We focused on closeness centrality, degree centrality, betweenness centrality and eigenvector centrality. Results showed that first, in passion, words indicating high strength and energy such as‘power’and‘intensity’played an important role in the structure of perception. Themes on behavioral, emotional, and motivational characteristics of passion were classified as sub-factors of passion as a result of community analysis. Secondly,‘life’,‘motivation’, and‘energy’appeared in key-word analysis in the positive role of passion while‘others’,‘fatigue’, and‘not caring for’appeared in the negative role of passion, reflecting the theory on the dualistic model of harmonious and obsessive passion. Third, in teacher passion, words indicating teaching activities and their practices such as‘student’and‘instruction’played an important role in the structure of perception. Themes related to educational activities in general, students and instruction, and professional development were classified as sub-factors of teacher passion.

열처리를 통한 SNCM220강 권축의 피로특성 향상에 관한 연구

이호성,임지우,임병수 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.2

To find out the reason of fracture, specimens were made from the fractured winding shaft and the mechanical properties as well as their microstructures were investigated. Several heat treatments, including caburizing and tempering, were carried out to improve the microstructure, mechanical properties, fatigue crack propagation and rotating bending fatigue characteristics. Through these experiments, following conclusions were obtained, (1) Carburized and tempered specimens showed greatly improved mechanical properties including impact energy, hardness and strength. (2) Crack propagation of the carburized and tempered specimens were faster than that of the original fractured specimens under the same ΔK. However, it was found that, in the early stage, the fatigue crack initiation and growth for the carburized and tempered specimen was more difficult. (3) The fatigue strength of the carburized and tempered specimens increased more than twice than that of the original fractured winding shaft.

수면량과 집중력의 상관관계

김병우,류지근,박우진,박계원,김미정,임지은,백대현,최재덕,최윤호,이가현,이관,김덕수 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

수면, 기억 그리고 학습의 연관성은 실제 매우 복잡하다. 많은 연구에도 불구하고 명확한 연구결과는 아직 없다. 우리는 이 연구에서 평소와는 달리 시험 전날 수면 변화 양상이 집중력에 어느 정도 영향력을 미치는지 알아보고자 하였고, 이를 이용해 효율적인 수면 관리를 할 수 있는 기초자료로 삼고자 하였다. 동국대 의대 본과 1학년생 중 지원자 30명과 본과 2학년생 10명을 대상으로 평상시 상태와 시험 직후 수면이 부족한 상태에서 각각 K-PES TEST를 실시하여 총 8항목에 걸쳐 암기력, 판단력, 단순반응의 변화정도를 검사하였다. 또 설문조사를 병행하여 결과에 영향을 미칠 수 있는 다른 인자들도 파악하였다. 수면량에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 인간의 최대 생리학적 기능은 꼭 수면부족에 의해 좌우되는 것은 아니다. 그러나, 수면감소는 피로를 증가시키고, 동기부여를 감소시키나 단, 새로운 사실을 학습하는 데에는 큰 영향을 끼치지 않는다. 즉, 수면부족으로 장시간 깨어있는 것은 정확성과 반응성을 떨어뜨린다. 흡연에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 니코틴의 수면에 대한 상호관계는 알려지지 않았고, 인간의 감정이나 의식, 인식에 영향을 주는 것으로 알고있지만, 장기적은 측면에서 흡연이나 알코올은 인식능력과 무관한 것 같다. 카페인에 대한 숫자 외우기(암기력)검사 결과, 카페인은 spacial selective attention에는 특별한 영향을 주지 않지만 지각과정이나 주의 집중에 큰 효과를 주며, 인간의 의식 수행에 긍정적인 효과를 준다. 즉 카페인은 활력, 혼란, 피로상태를 변화시키고 visual analog scales에서 휴식상태에 가까운 양상을 나타낸다. 또 48시간 동안 수면을 취하지 않은 사람에게 카페인은 집중력과 장시간의 좋은 기분을 유지하게 하였다. 그러나 규칙적, 비규칙적으로 먹는 사람간에는 인지수행력의 차이를 보이지 않으며 상용자에서는 상당한 내성이 보인다. 수면패턴에 대한 숫자 더하기(순간 판단력)검사 결과, 집중력은 수면패턴에 의해서도 영향을 받고, 수면패턴이 바뀌게 되면 순간판단력을 저하시킨다. This study was performed to evaluate relationship of sleep and attention, and to control sleep effectively. We conducted a K-PES test of 40 medical students. K-PES contains eight elements, for example, simple response, selective response, color pairing, OddEven discrimination, number addition, number-symbol matching, memory, right-tapping, left tapping. Through these, we tested changes of memory, judgement, simple response. And we conducted a questionnaire survey to exclude bias. Results are as follows. As a results of number-symbol matching test, we know that sleeplessness is not complete responsible for physiologic function for humans. But, decreased sleep increases fatigue and decreases motivation, but no influence on learning new materials. So, long term sleeplessness decreases precision and responsibility. As a results of number-symbol matching test on smoking, a relationship of nicotine and sleep is not certain. A point of view in long term period, smoking and drinking is not related cognition, even if we know that those influence mood, consciousness and cognition. As a results of memory work test on caffeine, caffeine does not influence spacial selective attention, but mainly does perception, attention and consiousness process. Namely caffeine changes energetic activities, chaos, fatigue states and shows resting state in visual analog scales In sleeplessness for 48 hours, caffeine produced attention and good mood for a long time. But, in case of cognitive process no significance shows in regular or irregular diet. Regular diet shows high resistance. As a results of number addition test on sleep patterns, seep patterns influence attention, changes of sleep patterns decrease a moment judgement.