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- 저자 : ( Jeong Kyo Yoon ) (검색결과 138 건)
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Jiyoung Kim,JooYeon Jhun,Jin Seok Woo,Seung Hoon Lee,Jeong-Hee Jeong,KyungAh Jung,Wonhee Hur,Seon-Yeong Lee,Jae Yoon Ryu,Young-Mee Moon,Yoon Ju Jung,Kyo Young Song,Kiyuk Chang,Seung Kew Yoon,Sung-Hwan 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Obesity, a condition characterized by excessive accumulation of body fat, is a metabolic disorder related to an increased risk of chronic inflammation. Obesity is mediated by signal transducer and activator of transcription (STAT) 3, which is regulated by genes associated with retinoid interferon-induced mortality (GRIM) 19, a protein ubiquitously expressed in various human tissues. In this study, we investigated the role of GRIM19 in diet-induced obese C57BL/6 mice via intra venous or intramuscular administration of a plasmid encoding GRIM19. Splenocytes from wild-type and GRIM19-overexpressing mice were compared using enzyme-linked immunoassay, real-time polymerase chain reaction, Western blotting, flow cytometry, and histological analyses. GRIM19 attenuated the progression of obesity by regulating STAT3 activity and enhancing brown adipose tissue (BAT) differentiation. GRIM19 regulated the differentiation of mouse-derived 3T3-L1 preadipocytes into adipocytes, while modulating gene expression in white adipose tissue (WAT) and BAT. GRIM19 overexpression reduced diet-induced obesity and enhanced glucose and lipid metabolism in the liver. Moreover, GRIM19 overexpression reduced WAT differentiation and induced BAT differentiation in obese mice. GRIM19-transgenic mice exhibited reduced mitochondrial superoxide levels and a reciprocal balance between Th17 and Treg cells. These results suggest that GRIM19 attenuates the progression of obesity by controlling adipocyte differentiation.
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Design of an LCL-Filter for Three-Parallel Operation of Power Converters in Wind Turbines
Jeong, Hae-Gwang,Yoon, Dong-Keun,Lee, Kyo-Beum The Korean Institute of Power Electronics 2013 JOURNAL OF POWER ELECTRONICS Vol.13 No.3
This paper proposes a design scheme for an LCL-filter used for the three-parallel operation of the power converters in high-capacity wind turbines. The designs of the power devices and grid connected filter are difficult due to the high level voltages and currents in huge-capacity wind turbines. To solve these problem, this paper presents three-parallel operation and LCL-filter design techniques optimized by parallel operation. Furthermore, the design of an inverter side inductance of the LCL-filter is discussed in detail considering the switching modulation method. Simulation and experimental results demonstrate the validity of the designed filter and wind turbines.
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Effect of oxygen plasma treatment on adhesion improvement of Au deposited on Pa-c substrate
Jeong Hoon Lee,Tae Song Kim,Jin Wook Seong,Ki Hyun Yoon,Kyo Seon Hwang,Saeyoung Ahn 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.44 No.52
Adhesion of gold on parylene C (Pa-c) is a major hurdle in achieving reliable and durable performance for biosensor application due to the hydrophobicity of Pa-c. It is, therefore, imperative to put eorts to improve adhesion between Au and Pa-c. In this reseach, oxygen plasma treatment for adhesion improvement was performed on Pa-c surfaces at various plasma powers and times. To analyze the relation of surface energy and roughness to adhesion promotion, we used several techniques such as contact-angle, surface-energy, surface-roughness, and adhesion analyses. As the oxygen plasma power and time were increased, the surface roughness of Pa-c increased. Also, Au lms had larger and more uniform grain sizes as the oxygen plasma power and time were increased. Untreated surfaces revealed a contact angle of 108, but the contact angle drastically decreased in the initial stage of oxygen plasma treatment and slowly decreased with increasing power and time to values of 27.3 and 34, respectively. From the adhesion analysis, adhesion was improved as the plasma power or time was increased. The improvement of adhesion is related to an increase in roughness as well as carbonyl groups.
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