40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

Isolation and Characterization of Antimicrobial Substance Macrolactin A Produced from Bacillus amyloliquefaciens CHO104 Isolated from Soil

( Seung Je Lee ),( Jeong Yong Cho ),( Jung Il Cho ),( Jae Hak Moon ),( Ki Deok Park ),( Young Ju Lee ),( Keun Hyung Park ) 한국미생물생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.3

鹽化鐵處理 活性炭에 의한 NO₃-N 除去

鄭京勳,崔炯一,趙榮燦 嶺南大學校 環境問題硏究所 1999 環境硏究 Vol.19 No.1

항생제 혼합 시멘트 정을 이용한 장관골 감염성 불유합의 이단계 치료

조세현,정순택,박형빈,황선철,하용찬,황인환 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적: 장관골 감염성 불유합의 치료 시 항생제 혼합 시멘트 정을 이용한 이단계 재건술의 결과를 분석하고자 한다. 대상 및 방법: 1998년 1월부터 2002년 9월까지 장관골 감염성 불유합으로 이단계 재건 수술을 받은 41예 (대퇴골 26예, 경골 15예)를 대상으로 하였다. 일단계 수술에서는 광범위한 변연 절제술, 부골 제거 및 세척술과 기존 고정 장치의 제거 또는 외고정 장치로의 교환을 시행한 후 시공 (dead space)과 불유합 주변 연부조직 내 항생제 혼합 시멘트 정을 삽입하였다. 임상적 감염 증상이 호전된 평균 8.7주 (3주~32주) 후 이단계 재건술로서 Ⅰ군은 내고정 장치 (금속판 5예, 골수강내 금속정 8예), Ⅱ군은 외고정 장치 (Ilizarov 25예, Monofixator 3예)로 각각 고정하고 17예에서는 골내 이동술이나 골 연장술을 시행하였다. 양군 모두 필요한 경우 골 이식과 시멘트 정의 교환을 추가하였다. 추시 기간은 16개월에서 최장 71개월로 평균 45개월 이었다. 치료 결과는 골유합 기간 및 Paley 방법에 의한 방사선상 골유합 상태와 하지 기능으로 평가하였다. 결과: Ⅰ군 13예 전부와 Ⅱ군 28예 중 26예에서 감염의 치료와 골유합을 얻었다. 이단계 재건술 후 골 이식술, 골 소파술, 외고정 핀 교환과 각변형 교정술, 피부 이식 또는 근육 피판 회전술 등의 보조적 시술이 Ⅰ군은 평균 2회, Ⅱ군은 평균 6.2회 추가되었다. 평균 골유합 기간은 Ⅰ군이 19.3주이고 Ⅱ군이 23.1주로 내고정군이 더 빨랐다. 방사선상 Paley 골유합 상태는 Ⅰ군이 우수 8예, 양호 5예이었고, Ⅱ군이 우수 18예, 양호 7예, 보통 1예, 불량 2예 이었다 (p=0.492). 기능적 결과는 Ⅰ군에서 우수 6예, 양호 6예, 보통 1예 이었고, Ⅱ군에서는 우수 10예, 양호 13예, 보통 3예, 불량 2예 이었다 (p=0.267). 결론: 항생제 혼합 시멘트 정의 골수염 치료 효과가 관찰되었으며, 감염이 호전된 후 내고정 장치로 교환해 준 군이 외고정을 유지한 군에 비하여 추가 수술 횟수가 적고, 골유합 기간도 빨랐다. Purpose: To evaluate treatment results between internal na external fixation groups in two-stage reconstruction of infected nonunion of long bones using antibiotics-impregnated cement beads. Materials and Methods: In the first stage, preexisting hardwares were removed and radical debridement was done. The dead space was filled with antibiotics -impregnated cement beads and the nonunion sits was immobilized by external fixation, cast or skeletal traction. In the second stage, all cases were divided into two groups; the nonunion was fixed by internal fixation in group Ⅰ versus external fixation in group Ⅱ. The intervening period between the first and second stage was average 8.7 weeks (range, 3~23 weeks). Results: The follow-up period was average 45 months (range, 16~71 months). Infection control and bone union were achieved in all 13 cases of group Ⅰ. Infection recurred in two of 28 cases in group Ⅱ, one underwent above-knee amputation and the other case was lost in follow-up. The mean number of supportive operations including repeated curettage, augmentation and change of infected pins, angular correction, and soft tissue flap was average 2 and 6.2 times respectively in group Ⅰ and group Ⅱ. Bony union period was average 19.3 and 23.1 weeks in each group. According to Paley's classification, group Ⅰ was similar to group Ⅱ in bony and functional result (p>0.05). Conclusion: Antibiotics-impregnated cement beads provided positive effect on infection control. Internal fixation group showed less number of additional operations and earlier bony union than external fixation group.

조절 저혈압이 수축기 간격에 미치는 영향

류정석,조형상 중앙대학교 의과대학 의과학연구소 1986 中央醫大誌 Vol.11 No.4

The present experiments is to evaluate the possibility of replacing the invasive method by the noninvasive one, namely systolic time interval method for monitoring hemodynamic changes occuring during the induced hypotension employed in clinic for the safety measure. For this purpose, various hemodynamic parameters were measured by both invasive and noninvasive STI methods simultaneously in mongrel dogs following the induction of hypotensive state by drugs, nitroprusside and nitroglycerin or bleeding procedure. The data obtained by these two different methods were analysed for the above purpose of this study. The following results were obtained. 1) In the hemodynamic changes checked by the invasive method, there were marked in preload and systemic vascular resistance (p<0.05 and p<0.01) in all induced hypotensive groups, but no significant changes in heart rate in those groups. Cardiac output was not changed in nitroprusside and bled groups, but markedly increased in nitroglycerin group (p<0.01). 2) Comparing the data of invasive method with those of noninvasive STI method, correlation coefficient of tension time index(TTI) to rate-pressure product(RPP) was 0.85, and that of endocardial viability ratio(EVR) to diastole/systole(dT/sT) was 0.96. Therefore RPP and dT/sT are supposed to be the useful indices of cardiac function monitoring in the use of induced hypotensive method.

셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝

박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

백내장 환자의 시기능지표 : 사전 연구를 중심으로 Pilot study

강형곤,박은철,최윤정,김한중,홍영재,조우현,손명세,임승정 한국의료QA학회 1998 한국의료질향상학회지 Vol.5 No.1

Background : There is increased recognition that rigorous approach to functional assessment will complement the assessment of clinical status. This study is to develop the appropriate visual function index in Korean patients with cataracts by the assessment of the reliability, validity of visual function indexes including VF-14. Methods : An prospective study was performed with 92 patients who had undergone either one eye or both eye cataract surgery by 3 ophthalmologists practicing at a university-hospital. Patients were interviewed, and clinical data were obtained. Doctors were questioned with self-entered questionnaire forms. Medical record was examined to understand surgery-process. The survey was conducted at 1-2 days before cataract surgery. Results : We used following measures : 7 visual function indexes, global measures of patients' trouble and satisfaction with vision, and best-corrected visual acuity (VA) in each eye. 7 visual function indexes showed a high internal consistency reliability (Cronbach's alpha coefficients ≥0.86). The better visual acuity(operated eye. better eye), the higher patient satisfaction with vision, the lower symptom score, the lower patient trouble with vision was correlated with preoperative visual function index scores. Among 7 indexes, VF-12 with the exclusion of 2 items drivings from VF-14 is a high Cronbach's alpha coefficient and correlation coefficient and the highest R². Conclusion : We conclude that VF-12 is reliable and valid in Korea. So we suggest that in Korea, all items of VF-14, the visual function index, which is in use internationally, ought to be surveyed and VF-12 which has been excluded by 2 items of drivings from VF-14 ought to beused for analysis.

뇌경색 환자의 혈중 호모시스틴치 (예비 연구)

정두신,송인욱,조상걸,성기범,박형국,신현길,장성근 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

뇌간 경색증 후 핵간 안근마비를 동반한 수구증후군

정두신,이보람,조상걸,박형국,신현길,성기범 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

개별배치모델을 적용한 정신장애인 '의국비서' 직종 취업사례고찰

이형열,조정원 한국장애인고용촉진공단 고용개발원 2004 장애와 고용 Vol.14 No.1

본 연구는 한국장애인고용촉진공단에서 정신장애인의 고용활성화를 위해 개별배치모델을 적용하여 현장지향적 측면에서 실시한 정신장애인의' 의국비서' 직종 취업사례를 분석· 평가하여 그 함의를 바탕으로 정신장애인의 고용확대를 도모하는데 목적이 있다. 본 연구는 부산시립정신병원으로부터 직업재활이 가능하다고 판단되는 정신장애인 1명을 추천받아 부산시립정신병원의 병원비서직무(의국비서)로 훈련을 실시하였으며, 진행과정은「장애인고용촉진및직업재활법」제12조(지원고용)에 근거하여 한국장애인고용촉진공단에서 지침으로 규정한" 중증장애인지원고용프로그램"에 따라" 개별배치모델"을 적용하여 진행되었다. 연구결과 나타난 함의는 아래와 같다. 첫째, 정신장애인의 지원고용에 있어서는 정신장애인의 특성상 3일간의 사전훈련 이전에 중분한 사회복귀훈련이나 직업 준비훈련이 전제가 되어야 하고, 둘째, 정신장애인을 대상으로 한 직업능력평가는 정신장애인의 특성을 감안한 도구를 위주로 평가되어져야 한다는 것, 셋째, 대상자의 직업능력 및 적성을 고려하여 직무조사를 실시하고 이 를 토대로 사업체 선정 및 직업배치를 하여야 하며, 넷째, 사업체 직무성격 및 대상 장애유형에 따라 지원고용모델이 적용되나 '의국비서' 직종의 경우「개별배치모델」이 효과적이었음이 입증되었으며, 다섯째, 지속적인 고용안정을 위해서는 사후지도 및 관리방식의 개발이 필요하다는 것과, 여섯째, 직무지도원의 단계별 개입이 훈련의 효과성을 높일 수 있다는 것이다. The purpose of this study is to enhance employment opportunity for person with psychiatric disabilities In order to this, this study applied individual placement modeI for person with psychiatric disabilities in hospital setting. This research worked with a person with the psychiatric disability who is able to accomplish vocational rehabilitation pragrams. This job seeker is referred to psychiatric hospital in Busan. The process of program is accomplished by the guideline of supported employment program for person with siginificant disabilities in Section 12 of Employment Promotion and Vocational Rehabilitation Act. The major findings of this study are as follows. First, a person with psychiatric disabilities needs 3days pre-employment programs or social returning programs before starts main program. Second, person with psychiatric disabilities must be used by vocational evaluation tools which are designed for person with psychiatric disabilities. Third, job analysis is important step for matching jobs and job placement. Forth, individual placement is effective approach in hospitaI setting. Fifth it is necessary for person with psychiatric disabilities to provide follow-up service and management development for sustaining employment. Finally, The intervention of job coach is important role to upgrade the effectiveness of training.