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열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Bo Young Chung ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
The positive studies regarding the association of obesity and atopic dermatitis (AD) has been reported. Obesity is considered to be a risk factor on the development of AD in children with severity dependent manner and also in adult. Meanwhile, Kilpelainen reported only in women, the risk of AD was correlated with increased BMI (body mass index). A 20-year-old female patient suffered from AD since 2 years old. Her symptoms got worse with time 4 months ago. At first visit, her BMI was 26.81 and her waist measurement was 32 inches. EASI score was 16.8 and VAS for pruritus was 7. Physical examination revealed a diffuse erythematous patches and maculopapules with slight crust and scales on her whole body, especially face, back and posterior aspects of thigh. She was referred to the department of family medicine to manage her obesity. In addition to dietary control and exercise prescription were provided. Aerobic exercise with moderate intensity was recommended 150 minutes every week. Total daily calorie intakes were recorded in their food diary by themselves. As antiobestic drug, one table of lorcaserin 10 mg was prescribed twice a day. After 12 weeks, her BMI was 19.91 and her waist measurement was 25.5 inches. EASI score was 10.4 and VAS was 3. In general, her symptoms were improved after her weight loss. There were no significant differences in eosinophil counts and the levels of total IgE after 12 weeks.
( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Bo Young Chung ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Alitretinoin is a novel vitamin A derivative, which binds both retinoic acid receptors and retinoid X receptors. We report two cases of successful treatment of refractory chronic inflammatory skin disease, atopic dermatitis and psoriasis with oral alitretinoin. A 32-year-old man presented with itchy erythematous to brownish skin lesions on the face (periocular), neck, trunk and the flexor surface of both extremities from a year ago. He has had allergic rhinitis since childhood. He had visited oriental medical clinics and local clinics many times over one year. With time, his symptoms got worse even with medications including oral steroid and cyclosporin. For his refractory AD, oral alitretinoin (30mg/d) and topical steroid (betamethasone dipropionate) with calcipotriol monohydrate were subscribed. After four months of treatment, the skin lesions had subsided. A 69-year-old woman presented with diffuse scaly erythematous skin lesions on the whole body surface that she had had since she was a child. She had hypertension, osteoporosis, a history of partial hepatectomy due to gall stones. Due to her old age, hypertension, osteoporosis, history of gall stone and renal stone, prescription of oral cyclosporine or steroid didn`t appear prudent. Oral alitretinoin was started in a dose of 30 mg daily and topical steroid with calcipotriol monohydrate was prescribed. Within five months of treatment, the skin lesions had improved.
( Jee Hee Son ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Coricosteroids are potent anti-inflammatory and antiallergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are especially considered frequent therapy for many skin diseases. Allergic reactions caused by corticosteroids, however, have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year old woman with triamcinolone induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She had atopic dermatitis (AD) since 3 years ago. She had used systemic steroid, cyclosporine and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injecting triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk and both hands. After intravenous injecting dexamethasone, her symptoms got worse. After treated with epinephrine, all symptoms resolved within two hours. We performed provocation test, skin prick test and patch test. She had a positive result only in prick test with triamcinolone and all other steroids showed negative in provocation test and patch test. Oral provocation test will be planned. Dermatologist should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.
FCP 10 Effect of histamine-free diet in adult patients with chronic urticaria
( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Yun Sun Byun ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: In adult patients with chronic urticaria (CU), causal relationship between food and disease exacerbation is relatively weak compared to childhood patients. However, there are many patients who report food-related aggravation of CU, and some of them may have histamine intolerance. Objectives: The aim of this study was to evaluate the role of ingested histamine and to investigate the effect of histamine-free diet in adult patients with CU. Methods: Twenty-two adult patients with CU were enrolled. Foods with high amounts of histamine were prohibited to all patients for 4 weeks. Department of nutrition supplied the reference menu with histamine-free diet and consulted the patients. Severity degree of urticaria using Urticaria Severity Score (USS) and Urticaria Activity Score (UAS) were evaluated. Plasma histamine levels and diamine oxidase (DAO) activity were determined and compared between baseline and after the histamine-free diet. Results: Twenty-two adult patients were recruited and completed the 4 weeks of histamine-free diet. There was a significant difference in plasma histamine level between baseline and after the histamine free-diet (p=0.014). DAO activity did not change after the histamine-free diet (p=0.165). Likewise, both USS and UAS score significantly decreased after the histamine-free diet (p=0.010, p=0.006). Conclusion: Ingested histamine might be related with CU severity and histamine-free diet is helpful for adult patients with CU.
Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis
Son, Jee Hee,Park, Sook Young,Cho, Yong Se,Chung, Bo Young,Kim, Hye One,Park, Chun Wook KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.12
<P>Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year-old woman with triamcinolone-induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She has had atopic dermatitis (AD) for three years. She had used systemic steroid, cyclosporine, and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injection of triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk, and both hands. After intravenous injection of dexamethasone, her symptoms got worse. After treatment with epinephrine, all symptoms resolved within two hours. We performed an open test and skin prick test. She had a positive result only from the prick test with triamcinolone; all other steroids showed negative results from the open tests. Dermatologists should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.</P>
Herpes Zoster Duplex Unilateralis: Two Cases and Brief Literature Review
( Jee Hee Son ),( Bo Young Chung ),( Hye One Kim ),( Hee Jin Cho ),( Chun Wook Park ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.6
Cases involving dermatomal herpes zoster in two or more locations are rare, especially in immunocompetent patients. When two noncontiguous dermatomes are involved, if affected unilaterally, it is called herpes zoster duplex unilateralis; if bilaterally, bilateralis. Here, we report two cases of herpes zoster duplex unilateralis. A 66-year-old man presented with painful erythematous grouped vesicles on his left scalp, forehead, trunk, and back (left [Lt.] V1, Lt. T8). Histologic findings were consistent with herpetic infection. A 33-year-old woman presented with painful erythematous grouped vesicles and crust on her left forehead and neck (Lt. V1, Lt. C5). Both patients were treated with oral administration of famcyclovir 750 mg/day for seven days. (Ann Dermatol 28(6) 757∼761, 2016)
[P326] A case of eccrine spiradenoma on the arm
( Jee Hee Son ),( Yong Won Choi ),( Yong Se Cho ),( Bo Young Chung ),( Hye One Kim ),( Chun Wook Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Eccrine spiradenoma (ES) is a rare benign soft tissue tumor. It occur at any age, but typically affects young adults aged 15-35 years, with no sexual predilection. It presents as a solitary mass localized in the skin and subcutaneous tissue, smaller than 1 cm in size. Paroxysmal pain and tenderness may be present. It tends to arise on the upper part of the body. Rarely, it may be located on the upper and lower extremities. A 40-year-old man presented with a nodule on the extensor surface of his left forearm. He couldn`t remember when it formed. Initially, it showed no symptoms but with time, became painful. Physical examination revealed a slightly bluish to skin colored, hard mobile nodule on the left forearm measuring 1×1 cm in size. The initial clinical suspicion was epidermal cyst, trichilemmal cyst, or lipoma; thus, ultrasonography (US) was done. US results indicated a 10×7×10-mm well-defined oval isoechoic mass in the subcutaneous fat layer, with moderate hyperemia. A complicated epidermoid cyst, or other hypervascular mass, such as vascularized leiomyoma or a sarcoma (e.g., malignant fibrous histiocytoma) was suspected. Excisional biopsy was performed. Microscopic examination showed a deep, well-defined tumor with basophilic lobules, encapsulated by thick connective tissue in the dermis and subcutaneous layer. A trabecular arrangement of basophilic cells was present. Two types of cells were seen and he was diagnosed as ES.