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CIMT compared to Cardiac CT Ca score for estimating atherosclerosis in young fatty liver patient
( Incheol Yoon ),( Hyun-Jin Kim ),( Hyung-Bok Park ),( Yongsung Suh ),( Yoon-Hyeong Cho ),( Tae-Young Choi ),( Eui-Seok Hwang ),( Deok-Kyu Cho ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Background: As a surrogate of atherosclerosis, carotid intima-media thickness (IMT) and coronary artery calcium score (CACS) of over 100 by Cardiac CT scan can predict cardiovascular events. Fatty liver disease as a potential component of the metabolic syndrome is also linked to cardiovascular disease. This study evaluated the differences of the carotid IMT and the CACS in patients with fatty liver disease. Methods: The patients who had performed carotid, abdomen ultrasound and cardiac CT were evaluated retrospectively between Jun 2011 and December 2013. The primary outcome was the difference of the carotid IMT and the CACS between the fatty liver disease patients and patients with normal liver. Results: Among 819 patients (53.3 ±11.2 year), 330 patients had fatty liver disease. Patients with fatty liver disease had significant larger waist circumferences and body mass index. The incidences of hypertension, diabetes, and the dyslipidemia were also higher in patient with fatty liver disease. Furthermore, the carotid IMT was significantly thicker in patients with fatty liver disease than the patients with normal liver (0.79 ± 0.17 mm vs. 0.76 ±0.17 mm, p=0.012), and carotid plaque showed the more common tendency in patient with fatty liver disease (26.7% vs. 21.7%, p=0.099). The incidences of composite of the thick carotid IMT (≥75th percentile) and the plaque presence were significantly higher in fatty liver (43.0% vs. 36.0%, p=0.043). Especially patients under fifty years old, the carotid IMT was significantly thicker in patient with fatty liver than normal liver. Fatty liver disease increased the risk of the composite of the thick carotid IMT and the plaque in young patient (OR 1.83, 95% CI 1.00-3.34, p=0.05). However, the incidences of CACS of over 100 showed no significant difference between two groups. Conclusions: Carotid IMT reflect the worse baseline characteristics of the patients with fatty liver diseases than the CACS. Especially, fatty liver disease increase the risk of atherosclerosis in young patients under 50. Therefore, young patients with fatty liver disease need to perform screening IMT for detecting atherosclerosis and modifying the risk factors.
Translation initiation mediated by nuclear cap-binding protein complex
( Incheol Ryu ),( Yoon Ki Kim ) 생화학분자생물학회 2017 BMB Reports Vol.50 No.4
In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms: cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) and eIF4E-dependent translation (ET). Both translation initiation mechanisms share common features in driving cap- dependent translation; nevertheless, they can be distinguished from each other based on their molecular features and biological roles. CT is largely associated with mRNA surveillance such as nonsense-mediated mRNA decay (NMD), whereas ET is predominantly involved in the bulk of protein synthesis. However, several recent studies have demonstrated that CT and ET have similar roles in protein synthesis and mRNA surveillance. In a subset of mRNAs, CT preferentially drives the cap-dependent translation, as ET does, and ET is responsible for mRNA surveillance, as CT does. In this review, we summarize and compare the molecular features of CT and ET with a focus on the emerging roles of CT in translation. [BMB Reports 2017; 50(4): 186-193]
Ryu, Incheol,Kim, Yoon Ki American Society for Biochemistry and Molecular Bi 2019 The Journal of biological chemistry Vol.294 No.19
<P>Replication-dependent histone (RDH) mRNAs have a nonpolyadenylated 3′-UTR that ends in a highly conserved stem-loop structure. Nonetheless, a subset of RDH mRNAs has a poly(A) tail under physiological conditions. The biological meaning of poly(A)-containing (+) RDH mRNAs and details of their biosynthesis remain elusive. Here, using HeLa cells and Western blotting, qRT-PCR, and biotinylated RNA pulldown assays, we show that poly(A)<SUP>+</SUP> RDH mRNAs are post-transcriptionally regulated via adenylate- and uridylate-rich element–mediated mRNA decay (AMD). We observed that the rapid degradation of poly(A)<SUP>+</SUP> RDH mRNA is driven by butyrate response factor 1 (BRF1; also known as ZFP36 ring finger protein–like 1) under normal conditions. Conversely, cellular stresses such as UV C irradiation promoted BRF1 degradation, increased the association of Hu antigen R (HuR; also known as ELAV-like RNA-binding protein 1) with the 3′-UTR of poly(A)<SUP>+</SUP> RDH mRNAs, and eventually stabilized the poly(A)<SUP>+</SUP> RDH mRNAs. Collectively, our results provide evidence that AMD surveils poly(A)<SUP>+</SUP> RDH mRNAs via BRF1-mediated degradation under physiological conditions.</P>
Yoo Sik Yoon,Incheol Shin,Jin Woo Kim,Ke Won Kang Cheol O Joe 생화학분자생물학회 1995 BMB Reports Vol.28 No.5
The effect of N-methyl-N`-vitro-N-nitrosoguanidine (MNNG) on the intracellular Ca^(2+) level was studied in NIH3T3 fibroblast cells. A reduction of the intracellular Ca^(2+) level was observed after exposure to 300 hM MNNG. However, the intracellular level of IPA, a well-known regulator of Ca^(2+) release from internal storage, was not changed by MNNG treatment. Instead, a reduction of the intracellular NAD level was observed. NAD as well as IP3 stimulated intracellular Ca^(2+) release from permeabilized cells. The treatment of 3-aminobenzamide, which inhibited the MNNG-induced reduction of the NAD level, also prevented the MNNG-induced decrease of the Ca^(2+) level. Our data suggest that MNNG reduces the intracellular Ca^(2+) level by NAD depletion in NIH3T3 cells.
Choe, Junho,Ryu, Incheol,Park, Ok Hyun,Park, Joori,Cho, Hana,Yoo, Jin Seon,Chi, Sung Wook,Kim, Min Kyung,Song, Hyun Kyu,Kim, Yoon Ki National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.43
<P>It has long been considered that intron-containing (spliced) mRNAs are translationally more active than intronless mRNAs (identical mRNA not produced by splicing). The splicing-dependent translational enhancement is mediated, in part, by the exon junction complex (EJC). Nonetheless, the molecular mechanism by which each EJC component contributes to the translational enhancement remains unclear. Here, we demonstrate the previously unappreciated role of eukaryotic translation initiation factor 4AIII (eIF4AIII), a component of EJC, in the translation of mRNAs bound by the nuclear cap-binding complex (CBC), a heterodimer of cap-binding protein 80 (CBP80) and CBP20. eIF4AIII is recruited to the 5'-end of mRNAs bound by the CBC by direct interaction with the CBC-dependent translation initiation factor (CTIF); this recruitment of eIF4AIII is independent of the presence of introns (deposited EJCs after splicing). Polysome fractionation, tethering experiments, and in vitro reconstitution experiments using recombinant proteins show that eIF4AIII promotes efficient unwinding of secondary structures in 5'UTR, and consequently enhances CBC-dependent translation in vivo and in vitro. Therefore, our data provide evidence that eIF4AIII is a specific translation initiation factor for CBC-dependent translation.</P>
응급의료센터의 특성을 반영한 과밀화 지표 개발 및 적용 방안 연구
이영훈(Young Hoon Lee),김정우(Jeong Woo Kim),이윤호(Yoon Ho Lee),김승호(Seung Ho Kim),박유석(Yoo Seok Park),박인철(Incheol Park) 대한산업공학회 2010 대한산업공학회지 Vol.36 No.1
The medical emergency departments are suffering from the crowdness of patients, hence the quality of medical service the patients are receiving are getting poorer. Overcrowding of medical emergency departments may incur the waiting time for the treatment, and the improper treatment in time. For the operational control of the emergency department, the crowding index is commonly used to identify the crowding intensity, with which the operation process is managed, and future process can be expected. In this study the composite crowding index is suggested, in which the trend of inpatients rate, the age and acuity of patients, and resource of ED are considered. The validity of the suggested crowding index is discussed by the regression analysis for the index and the actual number of inpatients, and by the simulation study using the process model and the real data.