출생시 신생아 혈액중의 2,3-DPG 농도

문현석,최병권 중앙대부설한국의과학연구소 1984 한국의과학 Vol.16 No.4

Sodium Nitroprusside 및 Adenosine Triphosphate를 이용한 조절저혈압이 심-혈관계에 미치는 영향

문현석,조형상 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.1

Controlled hypotension is an effective means of decreasing blood loss and of providing a better visible surgical field. Numerous drugs have been developed to lower arterial blood pressure. The ideal hypotensive drug must be effective in reducing blood pressure and at the same time controllable without any undesirable effect to vital organs. Adenosine triphosphate (ATP), a well known intracellular high energy compound, has been reported to be a hypotensive agent similar in effect to sodium nitroprusside (SNP), a drug which is frequently used as a hypotensive agent. To investigate the possibility of clinical use of ATP, we compared the cardiovascular effects of SNP- and ATP-induced hypotension and effects on acid-base balance and blood gas content. The following results were obtained. 1. Controlled hypotension by ATP was stable and rapidly reversible without tachyphylaxis and rebound hypertension. 2 .The heart rate, central venous pressure, pulmonary capillary wedge pressure and pulmonary vascular resistance were unchanged during the SNP- and ATP-induced hypotension. However, hypotension produced by ATP was associated with a greater cardiac output than that induced by SNP (p<0.01) and was also associated with a further decrease in systemic vascular resistance (p<0.01). Left and right ventricular stroke works were more improved during ATP-induced hypotension than those of SNP. The ratepressure product and coronary perfusion pressure were decreased in both groups (p<0.01). The mean pulmonary arterial pressure was increased with ATP (p<0.05). Triple index, which is the product of heart rate, systolic blood pressure, and pulmonary wedge pressure, decreased in SNP group (p<0.05). 3. Bicarbonate and base excess in venous blood were decreased with ATP group (p<0.05). On the basis of this study, compared with SNP, ATP as a hypotensive agent also provide a effective cardiovascular function during controlled hypotension. Therefore, ATP is probably a useful agent for controlled hypotension in a clinical practice.

수술후 소아에서 발생한 간염 : 1예 보고 1 case report

문현석,양홍석,진홍용 중앙대부설한국의과학연구소 1986 한국의과학 Vol.18 No.1

Photoplethysmography를 이용한 手指의 관류상태 측정

문현석,조형상 중앙대부설한국의과학연구소 1986 한국의과학 Vol.18 No.4

3차원 뇌자기공명영상을 이용한 강박증의 뇌형태학적 연구

공석원,송인창,한문희,장기현,류인균,권준수 대한신경정신의학회 2000 신경정신의학 Vol.39 No.6

연구 목적 : 강박증의 생물학적 원인으로 전두엽-선조체 회로의 이상이 알려져 있다. 그러나 형태학적 뇌영상을 이용한 기존의 연구는 전두엽과 미상핵의 용적 변화에 대한 일관된 결과가 없었다. 따라서 본 연구에서는 선형변환을 통한 반자동화된 방법을 이용하여 뇌의 각부위에 대한 형태학적 연구를 위하여 시행되었다. 방 법 : DSM-IV의 기준에 의해 진단한 13명의 강박증 환자와 9명의 정상대조군을 대상으로 하였다. 3차원 뇌자기공명영상을 Spoiled gradient-recalled(SPGR)법으로 얻었다. 3차원으로 재구성된 뇌자기공명영상을 Talairach와 Tournoux의 표준화 좌표에 공간적 정위시킨 후 회질과 백직을 반자동화된 방법으로 분리하였다. 죄표에 의거한 뇌엽의 각 부위에 대한 용적 측정을 하고, 미상핵은 수기로 구획한 후 용적측정을 하였다. 전두엽은 Brodman 의 영역에 의거하여 좌표계에 따른 분할을 하여 배외측전두엽, 안와전두엽, 내측전두엽으로 분할 구획하여 용적을 측정하였다. 결 과 : 강박증군에서 전두엽 회질의 용적이 증가되는 경향을 나타내었다. 다른 부위의 회질과 백질 그리고 미상핵의 용적은 차이가 없었다. 편측성에 의한 차이도 없었으며, 임상적 심각도와 상관관계는 관찰되지 않았다. 결 론 : 본 연구에서는 강박증군에서 전두엽의 용적 증가를 관찰할 수 있었으며, 이것은 기존 연구 중 일부에서 전두엽과 미상핵의 용적 감소를 보고했던 것과 차이가 있다. 강박증이 만성화되고 일정기간 이상이지나 구조적 변화가 오기 전까지 오히려 대사와 혈류 증가에 따른 회질 용적 증가가 관찰되는 것이라 생각된다. Objectives: Neurobiological models for obsessive-compulsive disorder(OCD) have consistently Implicated prefrontal-striatal circuits in the pathophysiology of this disorder. But, prior studies have inconsistently found alteration in caudate and frontal lobe volumes in patients with OCD. This study was undertaken in the hope that semi-automated linear transformation methods would elucidate the morphometric differences of various parts of brain between OCD and normal control group. Methods : Thirteen parients meeting the DSM-IV criteria fro OCD, and 9 psychiatrically normal comparison subjects participated in the study. 3-D brain MRIs using Spoiled gradient-recalled(SPGR) sequence were acquired for each subjects. After spatially normalized according to Talairach and Tournoux's coordinates, the gray and white matters were segmented by semi-automated methods using fuzzy algorithm. Each lobal volumes was measured according to Talairach and Tournoux's coordinates, and the region of interests of caudate nuclei was manually traced. The frontal lobe was divided into 3 subregions ; dorsolateral prefrontal cortex, orbital frontal cortex, mesial frontal cortex accoring to the coordinates and Broadman's cytoarchitectonics. Results : Only the volume of left and right frontal gray matter showed a significant difference between OCD and normal subjects. In OCD, the frontal gray matter volume was increased in tendency. There's no difference in laterality and no coorelation with clinical severities. Conclusion : Findings of increased frontal gray matter volumes in patients implicate a structural abnormality of these brain regions in the pathophysiology of OCD. The increased frontl gray matter volumes reflect a epiphenomena due to increased cerebral blood flows and metabolic rates before the structural changes may occur.

Inadvertent discogram during transforaminal epidural injection in patients with lumbar disc herniation

Hyun Seog Moon,Byung Cheul Shin,Heung Soon Im,Bang Hoon Song,Young Deog Cha 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.58 No.1

The transforaminal epidural injection (TFEI) has been preferred in many cases because it can deliver the injected dose of medication closer to the nerve root and better facilitate ventral epidural flow compared to other methods. However, in patients with deformities not demonstrated on fluoroscopic imaging, the needle may enter unwanted locations. We treated two cases of intradiscal injection of contrast dye, during the TFEI, in patients with lumbar disc herniation. (Korean J Anesthesiol 2010; 58: 104~108)

2,3 - DPG Concentration in Neonatal Blood at Birth

Hyun Seog Moon,Byung Kwon Choi Korean Society of Critical Care Medicine 1987 Acute and Critical Care Vol.2 No.1

Hematocrit and 2,3-DPG(2,3-diphosphoglycerate) in whole blood and packed cell were measured about 19 normal neonates at birth & 34 normal adults, The results were as followed, 1) Hematocrit value was higher in neonates than in adults. 2) 2,3-DPG concentration in whole blood is similar between neonates and adults. 3) 2,3-DPG concentration in packed cell is also similat between neonates and adults. Oxygen disaociation curve of normal fetal blood is deviated to left from normal adults curve. lt seems to survive fetal life which is very low oxygen tension. From this study, 2,3-DPG concentration is not functionated to deviated oxygen dissociation curve, but fetal hemoglobin itself, high carbon dioxide tension and/or low pH can be enfluenced to oxygen dissociation curve

초·중·고 학생들의 근시진행정도에 대한 고찰

심현석(Hyun Seog Shim),심문식(Moon Sik Shim),정주현(Ju Hyun Jung),주석희(Seok Hui Ju) 한국안광학회 2003 한국안광학회지 Vol.8 No.1

Poster Session : PS 1404 ; Hemato-Oncology(Hematology) : Prognostic Significance of Glasgow Prognostic Score in Peripheral T-Cell Lymphoma Patients Treated with Chop-Based Chemotherapy

( Dong Hyun Kim ),( Sung Yong Oh ),( Hyo Jin Kim ),( Suee Lee ),( Ji Hyun Lee ),( Sung Hyun Kim ),( Gyeong Won Lee ),( Moo Kon Song ),( Ho Jin Shin ),( Moon Jin Kim ),( Seok Jin Kim ),( Won Seog Kim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Glasgow prognostic score (GPS), an infiammation-based prognostic score including C-reactive protein (CRP) and albumin, shows significant prognostic value in several types of solid tumors. The prognostic value of GPS in lymphoma remains unclear. The objective of this study was to determine whether the GPS would predict the clinical outcomes in peripheral T-cell lymphoma (PTCL) patients treated with CHOPbased chemotherapy. Methods: We performed a retrospective study of 96 consecutive patients with newly diagnosed PTCL. Patients with both an elevated CRP level and hypoalbuminemia (<35 g/L) were given a score of 2. Patients in whom only one of these two biochemical abnormalities was present were allocated a score of 1. Patients in whom neither of these abnormalities was present received a score of 0. Results: The study population consisted of 96 PTCL patients treated with CHOP or intensive CHOP chemotherapy. They comprised 62 males and 34 females, with a median age of 58 years (range, 20-85 years). The patients with limited stage (I, II) were 27.1% and advanced stage (III, IV) were 72.9%. The IPIs<2 and IPIs≥2 were 56.3% and 43.7%. According to GPS classification, 40.6% of patients had a GPS of 0, 29.2% had a GPS of 1, and 30.2% had a GPS of 2. Three year relapse rates according to GPS group (0, 1, and 2) were 56.9%, 46.6%, and 32.1%, respectively. And 3-year OS of GPS (0, 1, and 2) were 67.4%, 62.7%, and 42.2%, respectively. Low GPS was a good prognostic biomarker of progression free survival (PFS) (p = 0.033) and overall survival (OS) (p = 0.012). Conclusions: This study demonstrates that GPS is a significant prognostic factor for PFS and OS in PTCL patients treated with CHOP-based chemotherapy.

정시안의 조절반응량에 관한 연구

심현석(Hyun Seog Shim),심문식(Moon Sik Shim),주석희(Seog Hee Joo) 한국안광학회 2006 한국안광학회지 Vol.11 No.3