유전자변형식품의 환경 및 인체 영향에 대한 문헌 고찰

정철,임현술 東國大學校醫學硏究所 2004 東國醫學 Vol.11 No.1

유전자변형농작물(eMO: Genetically modified organism)은 기존의 작물보다 독성 살충제의 사용을 줄일 수 있고 원하는 영양분을 함유한 농작물을 다수확 할 수 있기 때문에 궁극적으로 환경오염을 감소시키고 전 세계를 기아로부터 해방시킬 수 있다고 주장하는 지지자들이 있다. 그러나 비판적인 시각을 가진 사람들은 유전자변형농작물의 잠재적인 위험성에 대해 두려워할 뿐만 아니라, 그 이로움의 정도가 실제로 얼마나 될지를 의심하고 있다. 현재까지 유전자변형농작물의 건강영향이나 환경오염에 대해서 명백하게 밝혀지지 않은 채 양측 입장이 서로 논쟁중이다. 그러나 이 문제는 먹거리에 대한 문제이고 우리의 실생활에 유전자변형농작물이 많은 부분 들어와 있는 현실이므로 무턱대고 논쟁을 지켜보기만 할 문제는 아니다. 유전자변형농산물을 많이 수입하고 있는 우리나라도 더 이상 방관만 하고 있을 수 없는 입장이다. 우리나라에서도 유전자변형농작물을 많이 수입하고 있어서 농림부가 콩, 옥수수, 콩나물에 대한 유전자조작 농산물 표시제를 법제화하였고 식품의약품안전청도 식품에 표시제를 법제화하고 있는 현실이다. 만일 유전자변형농작물의 유해성이 밝혀지고 이에 대한 제한이 있을 경우 수입한 옥수수나 콩 등을 이용하고 있는 국내 식품산업은 물론 제약, 생활용품 및 수출시장에도 막대한 피해를 초래할 것으로 우려하고 있다. 그러나 대다수의 국민들은 유전자변형식품의 소비에 대해 잘 모르고 있는 현실이고 이 같은 시점에서 유전자변형식품의 건강영향에 대한 기존의 연구문헌들을 고찰하여 현재까지의 연구내용들을 정리하는 일은 매우 필요한 일이다. 이는 앞으로 연구들에 있어 기초 자료로 활용할 수 있고 국민들에게 올바른 유전자변형식품 소비에 대한 판단의 근거가 될 수 있을 것이다. There are supporters who assert themselves that the genetically modified organisms can decrease the environmental pollution and emancipate the starving people all over the world by reducing the pesticides use and harvesting the well nourished crops. But, the critics are afraid of latent danger and are doubtful of real advantages of the genetically modified organisms. Until now, there is a controversy on the influence on health and environmental pollution of the genetically modified organisms. We should be concerned about the genetically modified organisms because it penetrates into our dinner table recently and our country imports the large amounts of the genetically modified organisms. The Ministry of Agriculture and Korea Food and Drug Administration lay down the making law of the genetically modified organisms especially about beans, corns and bean sprouts. If it has clarified about the harmfulness of the genetically modified organisms and it has limited in national trade, the Korea industry of food processing, pharmacy, living necessaries and exportation would confronted by the serious damage. But, the majority of people takes no interest in the genetically modified organisms. At this point of time, it requires the literature inquiry about the influence on health of the genetically modified organisms. It should provide the base on decision of consuming the genetically modified foods.

Gullian Barre Syndrome 患者 1例에 대한 症例報告

임승민,안정조,최영,조현경,김민상,유병찬,오병렬,김윤식,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

Gullian Barre Syndrome is an acute symmetric polyradiculoneuropathy that typically presents as a progressive flaccid paralysis. The pathology is believed to be caused by both cellular and humoral immune processes The possibility of death is 3-5% and About 20% of patients require mechanical ventilaton. Recently We have experienced a patient who had suspected Gullian Barre Syndrome for 60days, his condition weakness and pain was impoved through the herb and acupucture Therefore I reported it for the treatment.

관상동맥질환의 중증도와 혈중지질치 및 아포지단백과의 상관관계

임현주,황종현,류재근,정병천,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 관상동맥질환의 위험인자로서 혈청지질 및 혈장 지단백에 대한 관심이 높아지고 있고 또 아포지단백이 관상동맥 질환을 일으키는데 다른 지질보다 더 중요하다는 연구가 많이 발표되고 있으나 우리나라에서는 아포지단백에 대한 연구가 그리 많지 않은 편이다. 이에 저자등은 혈중지질치와 새로운 위험인자로 알려지고 있는 아포지단백치를 측정하고 이들과 관상동맥질환 중증도와의 상관 관계를 알아보았다. 대상 및 방법 : 관상동맥질환이 의심되어 관상동맥조영술을 실시한 69명의 환자를 대상으로 하였으며 12시간 이상 공복후 혈청을 채취하여 총콜레스테롤, 중성지방, HDL-콜레스테롤, 아포지단백 AI (ape AI), 아포지단백 B (ape B)를 측정하였다. 관상동맥조영상 50%이상의 협착이 있는 혈관의 수 (lesion number), 최대협착을 합한 값 (lesion score), 각 분절의 최대협착을 합한 값 (total score), 가장 심한 협착 값 (peak stenosis) 등으로 관상동맥 중증도를 알아본 다음 이들과 혈청지질치, 아포지단백과의 상관 관계를 비교해 보았다. 상관 관계는 Spearman's correlation coefficient를 구하였다. 결과 : 관상동맥질환의 중증도와 각 지질치 간의 상관 관계를 비교해 보았을때 lesion number와 관계있는 것은 연령 (r=0.2789), 중성지방치 (r=0.2829)이며 lesion score와 관계있는 것은 연령(r=0.2911), 중성지방치0 (r=0.3316), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2361), apo B 치(r=0.2759), apo AI과 apo B의 비 (-0.3154)로 나타났다. Total score는 연령 (r=0.3100), 총콜레스테롤치 (r=0.2452), 중성지방치 (r=0.3022), 총콜레스테롤과 HDL-콜레스테롤의 비 (r=0.2770), apo B치 (r=0.2927), apo AI과 apo B의 비 (r=-0.3408)와 연관이 있었고 peak stenosis는 중성지방 치(r=0.3305), ape B 치 (r=0.2968), apo AI과 apo B의 비 (r=-0.3977)와 관계가 있었다. 연령으로 조정하여 partial correlation을 좌면, 관상동맥조영술상 중증도는 중성지방치 (r=0.3408), apo B 치(r=0.2877), apo AI과 apo B의 비 (r=-0.3460)와 유의한 상관 관계가 있었다. 이중 ape AI과 ape B의 비는 lesion score (r=-0.2640), total score (r=-0.3057), peak stenosis (r=-0.3460)와 유의한 상관관계를 보였다. 결론 : 이상의 결과로 보아 apo B치 그리고 apo AI과 apo B의 비가 관상동맥 중증도의 예견인자로 다른 혈중 지질 치보다 더 유용하다는 것을 알 수 있었다. Objectives : Recently, it was reported that the measurements of apolipoprotein levels may be valuable in the clinical assessment of coronary artery disease severity. However there are a few reports regarding to the relationship between coronary artery disease severity and apolipoprotein levels in Korea. Thus, we measured serum lipid and apolipoprotein levels and studied the relationship between coronary artery disease severity and serum lipids and apolipoproteins levels. Subjects and Methods : The 69 patients who underwent coronary angiography to evaluate chest pain were subjected to this study. We measured the levels of serum cholesterol, triglycerides, HDL cholesterol, apolipoprotein AI(apo AI) and apolipoprotein B(Apo B) and measured the severity of coronary artery disease by lesion number, lesion score, total score and peak stenosis. Then, we studied the relationship between coronary artery disease severity and apolipoproteins and calculated the correlation coefficient. Results : The results were as follows. There are significant correlation(r=0.3) between age, triglycerides, apo B levels, apo AI/B ratio and coronary artery disease severity. In controlling for age, tyiglycerides, apo B levels and apo AI/B ratio shows significant correlation(r=0.3) with coronary artery disease severity. Especially, apo AI/B ratio shows significant correlation(r=0.3) with lesion number, total score and peak stenosis. Conclusion : These results suggest that the apo B levels and the ratio of apo AI/B can be used as significant independent predictor for coronary artery disease severity rather than other serum lipid levels.

인터넷을 활용한 초등 영어 수업의 구어 능력 향상에 관한 연구

임정완,구현정 大邱大學校 師範大學 附設 敎育硏究所 2009 學校敎育硏究 Vol.5 No.1

본 논문은 초등 영어 의사소통 능력의 향상에 그 초점을 맞추어 언어의 4가지 영역 듣기, 말하기, 읽기, 쓰기 영역 중에서 의사소통능력과 가장 관련 깊은 듣기, 말하기 부분 향상연구 방안에 초점을 맞추어 보았다. 총 72명의 초등학교 학생들이 본 연구에 참여하였으며, 각각 36명씩 통제반과 실험반으로 나뉘어 약 20주간 실험 관찰되었고, 실험 결과는 SPSS 12.0 으로 분석되었다. 각 과의 내용과 이에 부합하는 인터넷 자료 등을 통해 여러 번의 실험 수업을 거친 결과 학생들의 듣기, 말하기 실력이 향상되는 것을 지켜볼 수 있었다. 듣기와 말하기 실력의 향상 정도는 듣기가 말하기보다 조금 더 유의도에서 의미가 있었다. 즉 듣기가 말하기보다 실력 향상에 있어 조금 더 효과가 있음을 알 수 있었다. 학생들은 다른 매체들에 비해 쉽게 노출되고 또 그만큼 쉽게 즐길 수 있는 매체가 인터넷이라 보다 적극적인 자세로 수업에 임했다. 아직 저학년인 학생들이므로 지금의 영어에 대한 흥미도가 평생의 영어 실력을 결정 할 수 있는 만큼 이 시기의 흥미도는 절대적으로 중요하다는 것을 고려 해볼 때, 학생들이 흥미를 느끼며 동시에 실력까지 향상되어간다는 사실은 주목해 볼 필요가 있다. It is widely known that the Internet-based English teaching can be useful for students since it is not only a way of providing joy for them, but also a means of consolidating and extending their knowledge of the language. The purpose of this study is to investigate the effectiveness of the Internet-based English Teaching for Korean elementary schools students. For this purpose, a review of related literature was carried out to analyze various teaching methods using the Internet. Then the analysis of the elementary school students and curriculum that was performed in English classes was carried out. A total of 72 elementary school students participated in this study and they were divided into one comparison group and one treatment group, consisting of 36 students each. They were observed over 20 weeks and surveyed on their interests about learning English after the treatment was over. Before and after the treatment, students' spoken English ability in each group was also measured and analyzed by the use of SPSS 12.0. The findings of the study were as follows: First, the treatment group showed higher spoken English ability than the control group, especially in terms of listening ability. By being exposed to the Internet-based class activities, the treatment group had more opportunities to listen to and speak in English than the control group. Second, the students' interests about learning English significantly increased after being taught by the Internet-based class activities. In conclusion, it is recommended to design and apply the Internet-based English class that plays a positive role to improve oral English ability for Korean elementary school students.

유리섬유에 의한 피부질환 및 임상적 진단

임현술,김정란,정해관,김수근 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

This study was conducted to evaluate the health hazards and to develop diagnostic methods of glass fiber workers. We examined 40 male glass fiber workers(exposure group) and 57 male non-glass fiber workers (reference group) with a questionnaire, physical examination, chest x-ray and pathological examination in Mar, 1997. Also we examined 65 male glass fiber workers(exposure group) and 42 male non-glass fiber workers(reference group)with the same methods also we did some energy-dispersive x-ray analyses with a scanning electron microscopic examination in Sep, 1997. Most of the clinical symptoms were significantly more frequent among the exposure group than the reference group. Coughing(32.5%), itching of the nose(30.0%), irritation of eyes(27.5%), irritation of the nose(25.0%) and sputum(22.5%) were the major symptoms among the exposure group in Mar, 1997. Only itching of the nose was significantly more frequent in Sep, 1997. No cases of pneumoconiosis were observed among the groups and there were no differences in chest abnormalities between the exposure group with the reference group on both examinations. The prevalence of dermatosis among the exposure group was 20.0% (8cases) and the cumulative prevalence was 72.5%(29 cases) in Mar, 1997. The prevalence of dermatosis among the exposure group was 23.1% (15 cases)and the cumulative prevalence was 58.5%(38 cases) in Sep, 1997. Onset of dermatosis among the exposure group was most frequent within one month after handling. The frequent sites of skin lesions were the hands and arms on both examinations. Glass fiber induced skin lesions can be diagnosed by the scotch tape method or KOH mount and then can be examined under the light, polarizing and phase-contrast microcopies. Glass fibers can be identified by some energy-dispersive x-ray analyses with a scanning electron microscopic examination.

코우크로스로의 방출물에 노출된 근로자에서 발생한 폐암 증례

임현술,최정근,권은혜,김헌 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 소세포성 폐암으로 진단받은 56세 남자에대하여 과거 21년간 코우크스로에서 근무한 작업력과 폐암과의 관련성을 파악하고자 하였다. 방 법 : 증례에 대한 의무기록가 흉부컴퓨터단층촬영 및 조직검사, 세포검사를 검토하였다. 증례의 작업 내역, 공것 작업환경 측정 결과를 파악하였고 작업환경 측정과 동료근로자에 대한 역학조사를 실시하였다. 작업환경측정은 산업안전보건연구원에서 모든 근로자를 대상으로 2회 반복 측정하였으며, 측정시간은 근로자의 작업시간 전체를 포함한 1일 8시간으로 하였다. 시료채취 및 분석방법은 미국 국립산업안전보건연구소의 공정시험법과 미국 노동부 산업 안전보건청의 공정시험법을 이용하였다. 측정결과의 정확도를 높이소 오차를 줄이기 위하여 측정 전후에 적적한 보정을 실시하고 현장 공시료를 포함하였다. 동료 근로자 40명에 대하여 역학조사를 실시하였고 COEs의 노출정도를 평가하기 위하여 PAHs의 대사산물인 1-OHP와 2-naphthol을 소변에서 분석하였다. 결 과 : P제철 부속의원에서 1996년부터 1999년까지 COEs에 대하여 측정한 결과는 0.01-0.39 ㎎/㎥ 범위로 후발성 콜타르피치물질에 대한 노동부의 노출기준인 0.2 ㎎/㎥르 적용할 때 초과하는 경우가 있었다. 1999년 산업안전보건연구원에서 작업환경을 직접 측정한 결과 전체 측정 건수 136건 중 45건 (33.1 %)이 노출기준을 초과하였다. 동료 근로자 40명에 대한 역학조사에서 특별한 COEs에 의한 건강장해를 발견하지 못하였다. K업체와 S업체의 근로자에 대하여 충북대학교 의과대학 예방의학교실에서 측정한 요중 1-OHP와 2-naphthol은 대조군인 대학생에 비하여 유의하게 높았다(P<0.01). 결 론 : 중례는 21년간 코우크스 제조공정에서 COEs에 노출되었으며, 현재 작업환경측정 결과로 판단할 때 노출기준을 초과하여 노출되는 경우도 있다고 추정되며, 흡연은 COEs가 폐암 발생을 가중시키는 요인으로 작용하였다고 추정된다. 그러므로 증례의 폐암은 코우크스 제조공정에서 노출된 COEs와 관련이 있다고 생각하여 직업성암으로 판단하였다. Objectives : We report a case of lung cancer (small cell carcinoma) occurring in a worker exposed to coke oven emissions. Methods : We examined the chest CT and pathologic findings of the patient. We reviewed previous environmental measurements for coke oven emissions at the workers place of employment. Also we measured the airborne concentrations for coke oven emissions and total polycuclic aromatic hydrocarbons in the work area. Finally, we analyzed the 1-hydroxypyrene and 2-naphthol concentrations in the subjects urine and compared this with student controls. Results : This case was a 56-year-old male who had worked in a coke oven plant within a steel manufacturing factory for 21 years (1977-1998). The airborne concentrations of coke oven emissions at the worksite were above the permissible exposure level (0.2 ㎎/㎥) in 45 cases (33.1%) among 136 workers. The concentrations of 1-hydroxypyrene and 2-naphthol in the subjects urine were statistically significantly elevated as compared with those of controls (P<0.01). Conclusions : We confirmed that the lung cancer occurring in this patient was as an occupational disease due to exposure to coke oven emissions. To prevent occupational cancer in coke oven plant workers, we must remodel the engineering procedure, begin comprehensive medical surveillance, educate workers on risks and the benefits of smoking cessation, and increase awareness of safety regulations in the workplace.

리스페리돈과 올란자핀이 투여된 정신과 환자들에서 간 효소 변화에 대한 후?적 연구

임현국,배치운,박석준,김정진,이창욱,이수정,이철,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

TV유아프로그램의 음악적 활용에 대한 연구

임현정 이화여자대학교 교육대학원 2003 이화교육논총 Vol.13 No.-

This study analyzed the music applied to children's hours of main 3 TV broadcasting stations, by component, function, and genre. 10 programs of each TV broadcasting company, 30 TV programs in total, which were broadcasted from February to March in 2002 were selected at random for analysis research. The examination results tell about the frequency and the continuation period of Music/Non-music Segment, instrumental music/vocal music, analysis on music's functions, and so on. Then, the applied music that functions as structural prompt was analyzed in the sides of melody, lyric lines, and tempo. The analysis result tells that the music segment occurs 565 times in total, which means 18.83 times' frequency per program in average, and that the continuation period of time was 30.27 seconds in average, which indicates 92%'s confidence coefficient(reliability). Non-music segment occurred 289 times in total, 9.63 times per program in average, and the mean continuation period of non-music was 30.56 seconds, which signified 92%'s confidence coefficient(reliability). 335 pieces of instrumental music were used in 30 programs in total, the instrumental music pieces were used 11.17 times per program. The vocal music pieces were used 230 times in total, and the average frequency rate was 7.67 times per program. The music that adopted structural prompt occurred 187 times in total; the music pieces included into the learning area occurred 19 times in total, the mean frequency rate was 4.63 times per program. The music pieces belonging to the social area occurred 23 times in total, the mean frequency rate was 0.83 times per program. Finally, The music pieces belonging to the body area occurred 25 times in total, the mean frequency rate was 0.83 times per program. The music applied for the purpose of discriminative stimulation occurred 77 times in total, the mean frequency rate was 2.57 times per program. The number of music pieces used as background music was 301, the mean frequency rate was 10.03 times per program. The music pieces that applied structural prompt were analyzed by lower ranked factors such as melody, lyric lines, and tempo. The analysis results are as follows; the occurrence frequency of the music pieces that adopted the existing structural prompt was 64 times in total(2.13 times per program in average), and the occurrence frequency of the music pieces that adopted the newly created structural prompt was 123 times in total, which means 4.10 times' occurrence per program in average, and the rate of 66.78%. The number of vocal music pieces that deliver their lyric lines at the first time was 177 in total. So the number of vocal music pieces whose lyric lines ware clearly conveyed was 5.9 per program, which means 94.65% 's occupation rate out of the whole frequency rate of the music pieces that applied structural prompt On the contrary, the number of vocal music pieces whose lyric lines were not conveyed was 10 in total(the occupation rate of 5.35%). The music pieces that applied the same melody repeatedly occurred 187 times in total, which means an occupation rate of 84.49% out of the whole structural-prompt-music's percentage. Similarly, the number of music pieces that used the same lyric lines repeatedly was 168, which signifies 89.84%'s occurrence rate With respect to voice colors, the most frequently used one was children's voice, secondly used voice color was that of adult/children, and the next order was male adult solo, female adult solo, adult group, and male children solo. As for the range of Melody, the most frequently used range was 8 degree range(1Octarve), which was used 66 times in total. The next order was 7 degrees, 6 degrees, 9 degrees, and 5 degrees. The degrees of below 4 or over 10 occurred rarely. As for the tempo range, the tempos of 121∼140 was used most frequently, 75 times in total. The next frequency order was 141∼160 range (67 times in total), then 161∼180 range and 101∼120 (19 times in total). Next, a slower range of 80∼100 occurred 6 times, and a very fast one of 180∼200 occurred I time I total. This study analyzed the structural and functional sides of the music pieces applied for children's educational programs on TV. Based on the results obtained this thesis, the main characters of the applied music were examined. Furthermore, the additional aim of this study is to offer basic materials for music therapy that can be used for children in the desirable and useful directions.

갑상선암 예측에 있어 초음파적 변수 분석

임현정,최영식,박요한,오경승,이강대 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: The introduction of high resolution sonography has made it possible to detect nodules in the thyroid gland. However, there has been no reliable sonographic sign for distinguishing between benign and malignant thyroid conditions. The aim of present study was to evaluate ultrasonographic (US) parameters in predicting thyroid cancer. Methods: One hundred fifty three patients who underwent thyroidectomy at Kosin Medical Center from January, 2000 to April, 2002 were included in the study. All patients were checked high resolutional US before surgery. Of the 153 patients 89 were malignant tumors and 64 benign. Malignant US parameters were defined as calcification, irregular margin, more taller than wide, and fat line obliteration. Calcification pattern was classified with single, punctated, and amorphous calcification. The US characteristics to predict malignancy were evaluated by means of multiple logistic regression analysis. Results: All of the malignant sonographic parameters such as calcification, 53 (89.8%) were thyroid carcinoma. The incidence rate of malignancy was 55.9% in solitary nodules and 65.7% in multiple nodules (p=0.303). Even though nodule size was less than 1.5㎝, the incidence of malignant tumor was 69.5% (p=0.04). Of 53 malignant nodules with calcification, the incidence of single, punctated, and amorphous calcification pattern was 6 (11.3%), 22 (41.5%), 25(47.2%), respectively. The sensitivity, specificity, positive and negative predictive value, and accuracy of sonographic parameters were 76.4%, 87.5%, 89.5%, 72.7% and 81.0%, respectively. Upon the correlation of US-guided FNA cytology with pathologic diagnosis, the sensitivity of ultrasound-guided FNA cytology in differentiating benign and malignant nodule was 85.9%, the specificity 100% and overall diagnostic accuracy was 91.2%. The sensitivity, specificity, and accuracy of US parameters associated to follicular neoplasm, all were 75.0%. Conclusion : All the malignant US parameters including calcification, irregular margin, and more tall than wide showed high level of sensitivity, specificity and accuracy. Of these parameter, calcification and irregular margin were more significants. The more presence of calcifications with punctated and amorphous pattern could suggest the higher possibility of malignancy. However, further study is needed for clinical application of malignant US parameters in the thyroid tumors.

에탄 분자의 적외선 스펙트럼의 이론적 합성

鄭玹采,윤대현,임화준,김기선 慶熙大學校 1987 論文集 Vol.16 No.-

The ν_6 band of the ethane gas molecule was theoretically synthesized. The intensity and the frequency of each rotational line were computed with VAX-11 computer. The theoretically synthesized spectrum was compared with the experimentally obtained spectrum, which was taken through FT-IR spectrophotometer MX-3600. The R and P branches of the ν_6 band contour of the ethane gas molecule were different from the regular symmetrie top molecule and rather similar to the linear molecules as if there were no K dependence. The absorbance of the P-branch spectrum was overlapped by the unknown branches of the neighbour bands The intensities and frequencies of the unknown lines were not indentified. The overall band contour of the observed spectrum was quite well coincided with the theoretical spectrum except the P-branch.