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폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
현경희,오유경,김정애,공경환,김지현,양준호,배명수,김호동,이종달,장현욱,용철순,최한곤 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
Bae Hyeun-Jong 한국자원식물학회 2005 Plant Resources Vol.8 No.3
Thin sections of cellulose fibers were incubated with an endo- and an exoglucanase labeled with gold particles of differing sizes. The hydrolytic sites were then visualized under transmission electron microscopy (TEM). The potential interaction between the β, 4-glucan substrates and the endo- and the exoglucanases was investigated using cellulosic and lignocellulosic substrates. The simultaneous visualization was very successful in distinguishing preferred substrates for each cellulase in lignocellulosic substrates. When plant lignocellulose was preincubated with endocellulase, density of the gold labeling greatly increased suggesting that preliminary exposure of lignocellulosic material to endocellulase may have enhanced the accessibility of the substrate to endocellulase and exocellulase. This result provided a plausible explanation for the observed endo/exo cellulase co-hydrolysis.
ACE Inhibition of the Aqueous Extracts from Fruit Bodies of Ganoderma Iucidum
Hyeun-Jong Bae, Tae-Ho Choi, Yu-Soo Shin, Masakazu Aoyama, Nam-Seok Cho 忠北大學校 農業科學硏究所 2010 農業科學硏究 Vol.26 No.1
To elucidate the chemical properties of antihypertensive components in the crude drug, Ganoderma Iucidum. we have studied the inhibitory effect of the aqueous extracts from the fruit bodies of G Iucidum on angiotensin 1 converting enzyme (ACE) activity. The aqueous extracts moderately inhibited the activity of ACE with respect to Hippuryl-histidyl-leucine(HHL) substrate. G Lucidium obtained from Hwasung showed higher ACE inhibitory activity in terms of higher IC50 values. The kinetics of ACE inhibition by the aqueous extracts from the crude drugs was plotted according to Lineweaver and Burk. The aqueous extracts inhibited the ACE activity. Mannitol and arabitol acting as moderate ACE inhibitors were found in the aqueous extracts. However, these polyhydric alcohols inhibited the ACE activity to a lesser extent compared with the aqueous extracts, suggesting that another type of more potent inhibitors exist in the aqueous extract of the crude drug.
Molecular Identification, Enzyme Assay, and Metabolic Profiling of Trichoderma spp.
( Soo-jung Bae ),( Young-hwan Park ),( Hyeun-jong Bae ),( Junhyun Jeon ),( Hanhong Bae ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.6
The goal of this study was to identify and characterize selected Trichoderma isolates by metabolic profiling and enzyme assay for evaluation of their potential as biocontrol agents against plant pathogens. Trichoderma isolates were obtained from the Rural Development Administration Genebank Information Center (Wanju, Republic of Korea). Eleven Trichoderma isolates were re-identified using ribosomal DNA internal transcribed spacer (ITS) regions. ITS sequence results showed new identification of Trichoderma isolates. In addition, metabolic profiling of the ethyl acetate extracts of the liquid cultures of five Trichoderma isolates that showed the best anti-Phytophthora activities was conducted using gas chromatography-mass spectrometry. Metabolic profiling revealed that Trichoderma isolates shared common metabolites with well-known antifungal activities. Enzyme assays indicated strong cell wall-degrading enzyme activities of Trichoderma isolates. Overall, our results indicated that the selected Trichoderma isolates have great potential for use as biocontrol agents against plant pathogens.
생물학적 발광반응에 의한 액상발효유 내의 유산균 수 측정에 관한 연구
韓錫絃,金鍾培,李承培 건국대학교 1988 새마을연구논문집 Vol.7 No.-
Determination of bacterial ATP based on luciferin-luciferase bioluminescence reaction was applied to the measurement of bacteria in liquid yoghurt as an alternative rapid method. The results are as follows; 1. When the number of bacteria such as Streptococcus thermophilus, Lactobacillus, acidophilus, Lactobacillus bulgaricus were counted by conventional agar plating technique and compared with the concentration of bacterial ATP, it gave a good linear relationship. The content of ATP per bacteria cell was 3.2∼4.6 fM depending on the kinds of lactic acid bacteria. 2. In order to investigate the most efficient method to remove the non-bacterial ATP, the various methods of hydrolyzing with ATPase, filtration and centrifugation were compared. The hydrolyzing method was found to be the most efficient in terms of reproducibility, speed and simplicity. 3. The endogeneous ATP levels of Lactic acid bacteria in liquid yoghurt was determined by the firefly bioluminescence system and compared with the result of conventional agar plating technique. The correlation coefficient was 0.83 between two methods. 4. This new rapid method (<lhr.) bases on the determination of bacterial ATP monitored by luciferin-luciferase bioluminescence reaction can be for the indirect counting of Lactic acid bacteria in liquid yoghugrt.
Ti-Nb 합금강에서 합금성분의 변화에 따른 석출물거동이 고온연성에 미치는 영향
한원배 ( Won Bae Han ),이종호 ( Jong Ho Lee ),김희수 ( Hee Soo Kim ),안현환 ( Hyeun Hwan An ),이승재 ( Seung Jae Lee ),김성우 ( Seong Woo Kim ),서석종 ( Seok Jong Seo ),윤종승 ( Chong Seung Yoon ) 대한금속재료학회 ( 구 대한금속학회 ) 2012 대한금속·재료학회지 Vol.50 No.4
Hot ductility behavior of precipitation-hardened low-carbon iron alloys containing 0.02 wt% Ti and 0.05 wt% Nb was characterized by a hot tensile stress test. Carbon (0.05, 0.1, 0.25 wt%) and boron (0.002 wt%) contents were varied to study the effect of precipitates on the high-temperature embrittlement of the alloys in the temperature range of 600~800℃. Ductility loss was observed at 700℃ for the tested alloys. The cause of the ductility loss was mainly attributed to the carbides and ferrite films formed at the grain boundaries during deformation. Although the carbon content tended to raise the total fraction of Nb (C, N), the precipitates were formed mostly in the grain interior as the precipitation temperature was raised above the deformation temperature by the high carbon content. Hence, carbon in excess suppressed the hot ductility loss. Meanwhile, boron addition improved the hot ductility of the alloys. The improvement is likely due to the boron atoms capturing carbon atoms and thus retarding the carbide formation.